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Association between homeobox protein transcript antisense intergenic ribonucleic acid genetic polymorphisms and cholangiocarcinoma

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World Journal of Clinical Cases 2021年第8期9卷 1785-1792页

作者： dimitra ioanna lampropoulou Konstantinos Laschos Gerasimos Aravantinos Konstantinos Georgiou Konstantinos Papiris George Theodoropoulos Maria Gazouli Dimitrios Filippou Medical Oncology General Oncology Hospital of Kifissia“Agioi Anargiroi”Athens 14564Greece 1st Department of Propaedeutic Surgery Hippokration General Hospital of AthensAthens Medical SchoolNational and Kapodistrian University of AthensAthens 11527Greece Endoscopic Surgery Department Hippokration General HospitalAthens 11527Greece Basic Medical Sciences Athens Medical SchoolNational and Kapodistrian University of AthensAthens 11527Greece Anatomy and Surgical Anatomy Medical SchoolNational and Kapodistrian University of AthensAthens 11527Greece

BACKGROUND Cholangiocarcinoma(CCA)represents a rare but highly aggressive malignancy that is often challenging to diagnose,especially in early *** role of existing tumor biomarkers for CCA diagnosis,remains controversial due to their low sensitivity and *** evidence has implicated long non-coding ribonucleic acid polymorphisms with cancer susceptibility in a variety of tumor *** association between long non-coding ribonucleic acid homeobox protein transcript antisense intergenic ribonucleic acid(HOTAIR)polymorphisms and CCA risk has not been reported *** To investigate the influence of HOTAIR variants on the risk of CCA *** We conducted a case-control study in which three HOTAIR single nucleotide polymorphisms(rs920778,rs4759314 and rs7958904)were genotyped in a Greek *** study population included 122 CCA patients(80 males and 42 females)and 165 healthy *** polymorphisms under investigation were examined in peripheral blood *** HOTAIR rs4759314 AG and GG genotypes were associated with a significantly increased CCA risk[P=0.004,odds ratio:3.13;95%confidence interval:1.65-5.91 and P=0.005,odds ratio:12.31;95%confidence interval:1.48-101.87,respectively].However,no significant associations of HOTAIR rs920778,and rs7958904 were ***,we found no significant associations between rs4759314 AA genotype and CCA *** HOTAIR rs4759314 AG and GG genotypes may be implicated with CCA development and may serve as a potential diagnostic biomarker.

关键词： Cholangiocarcinoma Homeobox protein transcript antisense intergenic ribonucleic acid polymorphisms Rs920778 Rs4759314 Rs7958904

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Exosomal noncoding RNAs in cholangiocarcinoma:Laboratory noise or hope?

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World Journal of Gastrointestinal Surgery 2020年第10期12卷 407-424页

作者： Konstantinos Laschos dimitra ioanna lampropoulou Gerasimos Aravantinos Maria Piperis Dimitrios Filippou George Theodoropoulos Maria Gazouli Department of Medical Oncology General Oncology Hospital of Kifissia“Agioi Anargiroi”Athens 14564Greece Radiation Therapy Department IatropolisAthens 15231Greece Department of Anatomy and Surgical Anatomy Medical SchoolNational and Kapodistrian University of AthensAthens 11527Greece 1st Propaedeutic University Surgery Clinic Hippocratio General HospitalMedical SchoolNational and Kapodistrian University of AthensAthens 11527Greece Department of Basic Medical Sciences Laboratory of BiologyMedical SchoolNational and Kapodistrian University of AthensAthens 11527Greece

Currently,extracellular vesicles and particularly exosomes have gained a lot of research interest due to their unique roles in several biological *** RNAs(microRNAs,long noncoding RNAs and circular RNAs)represent a class of functional RNA with distinct regulatory roles in tumorigenesis and cancer *** is a rare but highly aggressive type of malignancy that is very challenging to diagnose,especially in early stages;surgical resection still represents the sole potentially curative treatment ***,there is an urgent need for the discovery of novel diagnostic and prognostic ***,we provide a comprehensive review of the most recent discoveries that focus on exosomal noncoding RNAs in cholangiocarcinoma with the aim to identify new molecular players that could be used as biomarkers and therapeutic targets.

关键词： :Cholangiocarcinoma Long noncoding RNAs MicroRNAs Circular RNAs Piwi-interacting RNAs Exosomes Extracellular vesicles

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