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Stem cell application for osteoarthritis in the knee joint: A minireview

World Journal of Stem Cells 2014年第5期6卷 629-636页

作者： Kristin Uth dimitar trifonov University of Oxford Old Road Campus Research Building Old Road Campus Oxford OX3 7DQ United Kingdom BioDiscovery Dundee Science Press Scotland DD6 8NR United Kingdom

Knee osteoarthritis is a chronic, indolent disease that will affect an ever increasing number of patients, especially the elderly and the obese. It is characterized by degeneration of the cartilage substance inside the knee which leads to pain, stiffness and tenderness. By some estimations in 2030, only in the United States, this medical condition will burden 67 million people. While conventional treatments like physiotherapy or drugs offer temporary relief of clinical symptoms, restoration of normal cartilage function has been difficult to achieve. Moreover, in severe cases of knee osteoarthritis total knee replacement may be required. Total knee replacements come together with high effort and costs and are not always successful. The aim of this review is to outline the latest advances in stem cell therapy for knee osteoarthritis as well as highlight some of the advantages of stem cell therapy over traditional approaches aimed at restoration of cartilage function in the knee. In addition to the latest advances in the field, challenges associated with stem cell therapy regarding knee cartilage regeneration and chondrogenesis in vitro and in vivo are also outlined and analyzed. Furthermore, based on their critical assessment of the present academic literature the authors of this review share their vision about the future of stem cell applications in the treatment of knee osteoarthritis.

关键词： Multipotent adult mesenchymal stem cells Osteoarthritis Knee joint Clinical trial

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Computer Simulation of CD-Based Injection-Moulded Micro-Patterned Polymer Substrates for Cell Immobilization

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材料科学与工程（中英文版） 2011年第1期5卷 110-119页

作者： dimitar trifonov Kostadin Kostadinov Muhammed Al-Wahab Vladimir Kotev Institute of Mechanics Bulgarian Academy of Sciences Sofia 1113 Bulgaria Institute of Mobile Systems University Otto-von-Guericke Magdeburg 39106 Germany

The paper presents implementation of CD technology in injection moulding of micro-pattern polymer substrates for application in microfluidic device used for cell immobilization, manipulation and subsequent investigation. The paper aims to develop a design concept of the micro-pattern polymer substrates with specially located thin-sections. Microstructure for positioning of cells is located in the thin sections and is consistent with the possibility the substrate to be produced by injection molding. For this purpose an appropriate microstructure and the thickness of the substrate thin-sections are chosen according the impact of geometrical parameters and the location of microstructure. They are optimized by study their dependence on the parameters of the gate system and the substrate thickness on the process of mould filling. By the CD-based models developed a series of values of microstructure parameters and thin-section parameters were obtained. Relevant versions of the substrate design with cell-grooves are achieved. Results obtained states that the reduction the cell-grooves size and increasing the number of the thin-sections makes the mould filling difficult or impossible. In this case, it is advisable, the polymer substrate and thin-sections to be molded by injection molding, then cell-grooves can be further shaped by hot embossing.

关键词：细胞固定化聚合物基质注塑成型光盘图案计算机基板设计仿真

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