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World Journal of Gastroenterology 2024年第9期30卷 994-998页

作者： Nikolaos papadopoulos Eleni-Myrto Trifylli The Second Department of Internal Medicine 401 General Army Hospital of AthensAthens 11525Greece The First Department of Internal Medicine 417 Share Army Fund HospitalAthens 11521Greece

In this editorial,we comment on the article by Lyu et al published in the recent issue of the World Journal of Gastroenterology(2023;2219-2840).Hepatocellular carcinoma(HCC)is a frequently encountered and highly aggressive primary liver cancer,which remains the third-commonest cause of cancer-related death despite the current therapeutic *** is urgency in developing novel thera-peutic approaches,such as by manipulating extracellular vesicles,which con-stitute a highly heterogeneous nanoparticle population that contains various *** cargoes have a pivotal role in cell-to-cell communication and can modify the functional level of the recipient cells via their uptake by other recipient *** non-coding RNAs have particular evolving significance in HCC,such as circular RNAs,which have been found differentially expressed in normal hepatic and HCC *** aberrations in their expression levels have a key role in the HCC development and progression and the overall *** this editorial,we will shed light on the emerging role of exosomal circular RNAs in HCC development and progression,focusing on the oncogenic or potentially tumor suppressive effect of mesenchymal stem cells-derived exosomal non-coding RNAs.

关键词： circular sponge progression

Extending the decision-making process during yellow phase from human drivers to autonomous vehicles:A microsimulation study with safety considerations

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第2期11卷 362-379页

作者： Efthymis papadopoulos Anastasia Nikolaidou Emmanouil Lilis Ioannis Politis Panagiotis Papaioannou Transport Engineering Laboratory School of Civil EngineeringFaculty of EngineeringAristotle University of ThessalonikiThessaloniki 54124Greece

One of the main factors affecting the safety of signalised intersections is the stop/go behaviour during the yellow *** previous research has exhaustively examined drivers’stop/go decision-making,the expected autonomous vehicles’(AVs’)stop/go behaviour has not yet been thoroughly *** a series of simulation experiments developed for conventional and autonomous vehicles using different carfollowing,lane-changing,lateral placement and stop/go model parameter values,we examine here whether the default VISSIM stop/go parameter values can adequately replicate the observed drivers’behaviour at the considered intersection and assess the suitability of using the currently available options,albeit referring to human drivers,to simulate the expected stop/go behaviour of *** also propose a policy framework for determining the desired behaviour of AVs in yellow interval,which is integrated into an AVs logic and achieved in the last simulation to explore the effect of automation on the stop/go outcome and,hence,on the safety level of signalised *** data analysis and modeling techniques were used for the formulation of certain scenarios,including binary choice *** default stop/go parameter values were found unfit to replicate the observed stop/go behaviour and subjected to *** to the currently available options,the proposed AVs logic proved to produce the most accurate results,in terms of the stop/go simulation *** the impact of automation on the stop/go outcome,the simulation experiments showed that AVs preferred a more conservative behaviour in favor of road safety,as indicated by the significant reduction(≈15%)in the number of vehicles crossing the stop line during the yellow light and zero instances of red light ***,compared to the conservative drivers represented by the default stop/go parameter values,AVs preferred a more rational behaviour in favor of intersection capacit

关键词： Driver behaviour AVs behaviour Signalised intersection Choice model Micro-simulation Policy framework

Grafts in Peyronie’s surgery without the use of prostheses:a systematic review and meta-analysis

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Asian Journal of Andrology 2024年第3期26卷 250-259页

作者： Anastasios Natsos Vasileios Tatanis Stavros Kontogiannis Sharon Waisbrod Kristiana Gkeka Mohamed Obaidad Angelis Peteinaris Konstantinos Pagonis Costas papadopoulos Panagiotis Kallidonis Evangelos Liatsikos Petros Drettas Department of Urology University of PatrasPatras 26500Greece Uroclinic Pfaeffikon 8808Switzerland Department of Medical Physics University of PatrasPatras26500Greece Department of Urology Medical University of ViennaVienna 1090Austria

Peyronie’s disease(PD)is characterized by abnormal penile curvature,and various surgical methods have been developed usingdifferent graft ***,there is currently no universal agreement on which type of graft is the *** objective of thisreview was to evaluate the available literature and identify the most effective graft material for penile curvature correction in PD.A literature search was conducted using electronic databases,including PubMed,Scopus,and the Cochrane *** patients,intervention,comparison,and outcome(PICO)approach was used to define the eligibility of *** authors independentlyselected studies,evaluated them,and extracted ***-effect models using the DerSimonian–Laird method were *** were single-arm studies and had a high risk of *** mucosa grafts(BMG)were found to result in the highest penilestraightening rates and were associated with the least de novo erectile *** grafts demonstrated a high successrate in straightening despite a higher mean preoperative curvature,while Tutoplast grafts had a higher incidence of postoperativeerectile *** had the highest percentage of postoperative penile ***,the TachoSil graft showed thebest performance when preoperative curvature is taken into *** on the available literature,BMG appear to be the mosteffective for penile curvature correction in PD,but this is offset by the requirement for low preoperative *** TachoSilgraft shows the best overall performance when preoperative curvature is *** randomized clinical trials arestill needed to determine graft superiority.

关键词： erectile function penile curvature penile grafts Peyronie’s disease

Incidence, risk factors and clinical outcome of multidrug-resistant organisms after heart transplantation

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World Journal of Transplantation 2024年第2期14卷 107-118页

作者： Sophia Hatzianastasiou Paraskevas Vlachos Georgios Stravopodis dimit.ios Elaiopoulos Afentra Koukousli Josef Papaparaskevas Themistoklis Chamogeorgakis Kyrillos papadopoulos Theodora Soulele Despoina Chilidou Kyriaki Kolovou Aggeliki Gkouziouta Michail Bonios Stamatios Adamopoulos Stavros Dimopoulos Microbiology Department and Infection Control Office Onassis Cardiac Surgery CenterAthens 17674Greece Heart Transplantation Unit Onassis Cardiac Surgery CenterAthens 17674Greece Cardiac Surgery Intensive Care Unit Onassis Cardiac Surgery CenterAthens 17674Greece

BACKGROUND Transplant recipients commonly harbor multidrug-resistant organisms(MDROs),as a result of frequent hospital admissions and increased exposure to antimi-crobials and invasive *** To investigate the impact of patient demographic and clinical characteristics on MDRO acquisition,as well as the impact of MDRO acquisition on intensive care unit(ICU)and hospital length of stay,and on ICU mortality and 1-year mortality post heart *** This retrospective cohort study analyzed 98 consecutive heart transplant patients over a ten-year period(2013-2022)in a single transplantation *** was collected regarding MDROs commonly encountered in critical *** Among the 98 transplanted patients(70%male),about a third(32%)acquired or already harbored MDROs upon transplantation(MDRO group),while two thirds did not(MDRO-free group).The prevalent MDROs were Acinetobacter baumannii(14%),Pseudomonas aeruginosa(12%)and Klebsiella pneumoniae(11%).Compared to MDRO-free patients,the MDRO group was characterized by higher body mass index(P=0.002),higher rates of renal failure(P=0.017),primary graft dysfunction(10%vs 4.5%,P=0.001),surgical re-exploration(34%vs 14%,P=0.017),mechanical circulatory support(47%vs 26%P=0.037)and renal replacement therapy(28%vs 9%,P=0.014),as well as longer extracorporeal circulation time(median 210 vs 161 min,P=0.003).The median length of stay was longer in the MDRO group,namely ICU stay was 16 vs 9 d in the MDRO-free group(P=0.001),and hospital stay was 38 vs 28 d(P=0.006),while 1-year mortality was higher(28%vs 7.6%,log-rank-χ2:7.34).CONCLUSION Following heart transplantation,a predominance of Gram-negative MDROs was *** acquisition was associated with higher complication rates,prolonged ICU and total hospital stay,and higher post-transplantation mortality.

关键词： Heart transplantation Multi drug resistant organisms Transplantation complications Transplantation outcome

Recent Developments in the Treatment of Wet Age-related Macular Degeneration

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Current Medical Science 2020年第5期40卷 851-857页

作者： Zois papadopoulos Department of Ophthalmology Massachusetts Eye and Ear InfirmaryHarvard Medical SchoolBostonMassachusettsUSA

Age-related macular degeneration(AMD)is the most common cause of irreversible blindness and visual impairment in individuals over the age of 50 years in western *** than 25 million people currently suffer from this illness in the world,with an additional 500000 every year,*** is a multifactorial ocular disease that affects the maculae due to a late-onset progressive neurodegeneration and dysfunction of photoreceptors and retinal pigment epithelium(RPE).There are many subtypes of AMD but basically two broad forms:the nonneovascular(dry,nonexudative)and neovascular(wet,exudative).Exudative AMD is the less common form(about 15%)but tends to progress more *** the moment,wet AMD is treated primarily on the basis of anti-vascular endothelial growth factor(VEGF)agents,which have led to massive improvement in the prognosis of the disease since they were first *** article focuses on the latest treatment approaches to neovascular *** extensive literature review was performed in order to illustrate the effectiveness of current and future anti-VEGF agents as well as the landmark clinical studies that have been carried out to establish these drugs as a gold standard in the therapy of wet AMD.

关键词： neovascular age-related macular degeneration exudative AMD medical retina retinal diseases neovascularization angiogenesis vascular endothelial growth factor

A Hybrid Immersed Boundary/Coarse-Graining Method for Modeling Inextensible Semi-Flexible Filaments in Thermally Fluctuating Fluids Dedicated to Professor Karl Stark Pister for his 95th birthday

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Computer Modeling in Engineering & Sciences 2021年第12期129卷 1243-1258页

作者： Magdalini Ntetsika Panayiotis papadopoulos Department of Mechanical Engineering University of CaliforniaBerkeleyCA94720-1740USA

A new and computationally efficient version of the immersed boundary method,which is combined with the coarse-graining method,is introduced for modeling inextensible filaments immersed in low-Reynolds number *** is used to represent actin biopolymers,which are constituent elements of the cytoskeleton,a complex network-like structure that plays a fundamental role in shape *** extension of the traditional immersed boundary method to include a stochastic stress tensor is also proposed in order to model the thermal fluctuations in the fluid at smaller *** way of validation,the response of a single,massless,inextensible semiflexible filament immersed in a thermally fluctuating fluid is obtained using the suggested numerical scheme and the resulting time-averaged contraction of the filament is compared to the theoretical value obtained from the worm-like chain model.

关键词： Semiflexible biopolymers immersed boundary method coarse-graining actin filaments fluid-structure interaction thermal fluctuations persistence length

Safety aware fuzzy longitudinal controller for automated vehicles

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第4期8卷 568-581页

作者： Konstantinos Mattas George Botzoris Basil papadopoulos Department of Civil Engineering Democritus University of ThraceXanthi 67100Greece

Vehicle automation holds significant opportunities in the efforts for safer road *** lower levels of automation like adaptive cruise control(ACC)systems have great *** from safety benefits,ACC systems could improve the efficiency of traffic ***,contemporary ACC systems are designed to be comfortable,but not guaranteed to be ***,according to recent literature studies,they have been found to be conservative and string unstable,with traffic oscillations being amplified when traveling *** to those issues,severe problems can arise in the traffic flow and the efficiency of road traffic networks may *** the vehicles’longitudinal movement through ADAS systems offers new opportunities in improving the safety conditions on the roads by designing more consistent *** the present paper,a fuzzy controller is developed for automated longitudinal vehicle *** controller is validated through simulation and real-world data of ACC systems that are currently available in the *** fuzzy surrogate safety metrics,the controller becomes aware of the safety level of any situation and can react ***,the driving behavior is efficient for the traffic flow,comfortable and string stable,dampening traffic shockwaves that travel *** prove the robustness of the proposed solution.

关键词： Road safety Traffic simulation Fuzzy inference system Adaptive cruise control Vehicle automation

A Knowledge Graph-Based Deep Learning Framework for Efficient Content Similarity Search of Sustainable Development Goals Data

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Data Intelligence 2023年第3期5卷 663-684页

作者： Irene Kilanioti George A.papadopoulos School of Electrical and Computer Engineering National Technical University of Athens9 Heroon Polytechneiou St.Zografou Campus Athens15780Greece Department of Computer Science University of Cyprus1 University AvenueAglantziaCY-2109NicosiaCyprus

Sustainable development denotes the enhancement ofliving standards in the present without compromising future generations'*** Development Goals(SDGs)quantify the accomplishment of sustainable development and pave the way for a world worth living in for future *** can contribute to the achievement of the SDGs by guiding the actions of practitioners based on the analysis of SDG data,as intended by this *** propose a framework of algorithms based on dimensionality reduction methods with the use of Hilbert Space Filling Curves(HSFCs)in order to semantically cluster new uncategorised SDG data and novel indicators,and efficiently place them in the environment of a distributed knowledge graph ***,a framework of algorithms for insertion of new indicators and projection on the HSFC curve based on their transformer-based similarity assessment,for retrieval of indicators and loadbalancing along with an approach for data classification of entrant-indicators is ***,a thorough case study in a distributed knowledge graph environment experimentally evaluates our *** results are presented and discussed in light of theory along with the actual impact that can have for practitioners analysing SDG data,including intergovernmental organizations,government agencies and social welfare *** approach empowers SDG knowledge graphs for causal analysis,inference,and manifold interpretations of the societal implications of SDG-related actions,as data are accessed in reduced retrieval *** facilitates quicker measurement of influence of users and communities on specific goals and serves for faster distributed knowledge matching,as semantic cohesion of data is preserved.

关键词： Content similarity Distributed knowledge graphs Sustainable Development Goals Hilbert space filling curves Deep learning

25.6% Certificated Efficiency of Perovskite Solar Cells Achieved

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Bulletin of the Chinese Academy of Sciences 2022年第3期36卷 173-174页

作者： ios ios

Perovskite solar cells(PSCs)have gained significant attention due to their low cost and high-efficiency *** explosive development within the decade,the efficiency of single-junction PSCs and multi-junction perovskite-... 详细信息

关键词： Solar gained Efficiency

Methodology for Online Identification of Dynamic Behavior of Power Systems with an Increased Amount of Power Electronics Interface Units

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CSEE Journal of Power and Energy Systems 2019年第2期5卷 171-180页

作者： Panagiotis N.papadopoulos Jovica V.Milanovic School of Electrical and Electronic Engineering The University of ManchesterManchesterM601QDU.K.

A methodology for online and offline dynamic stabil-ity assessment,suitable for power systems with high penetration of power electronics interface units is presented in this *** increasing penetration of renewable energy resources as well as changing market operations,new types of loads and storage technologies,are causing significant changes to power systems dynamic *** generator groups and generators exhibiting poorly damped oscillatory behavior are identified online,opening the possibility to corrective control actions in order to stabilize the ***,statistical analysis of the abundant data from simulations provides information on the overall impact of power electronics interface units on system stability.

关键词： Decision trees dynamicsecurityassessment probabilistictransientstability