检索结果-南通市图书馆

World Journal of Gastroenterology 2019年第31期25卷 4414-4426页

作者： Luísa Leite barros Alberto Queiroz Farias Ali Rezaie department of Gastroenterology University of Sao Paulo School of MedicineSao Paulo 05403-000Brazil Division of Gastroenterology Department of MedicineCedars Sinai Medical CenterLos AngelesCA 90048United States

Inflammatory bowel diseases(IBD),Crohns disease and ulcerative colitis,are chronic conditions associated with high morbidity and healthcare *** natural history of IBD is variable and marked by alternating periods of flare and *** though the use of newer therapeutic targets has been associated with higher rates of mucosal healing,a great proportion of IBD patients remain symptomatic despite effective control of *** symptoms may include but not limited to abdominal pain,dyspepsia,diarrhea,urgency,fecal incontinence,constipation or *** this setting,commonly there is an overlap with gastrointestinal(GI)motility and absorptive *** recognition of these conditions greatly improves patient care and may decrease the risk of ***,in this review we describe the prevalence,diagnosis and treatment of GI motility and absorptive disorders that commonly affect patients with IBD.

关键词： Inflammatory bowel diseases Crohn’s disease Ulcerative colitis Gastrointestinal motility and absorptive disorders Irritable bowel syndrome Small intestinal bacterial overgrowth Small intestinal fungal overgrowth Dyssynergic defecation Fecal incontinence Chronic intestinal pseudo-obstruction

H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas:Correlation with p53 mutation and c-Myc,Bcl-2 and Bax expression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第6期14卷 884-891页

作者： Valeska Portela Lima Marcos Antonio Pereira de Lima Angela Rosa André Márcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa barros Sílvia Helena Barem Rabenhorst departament of Pathology and Forensic Federal University of Ceará State Brazil Saint House of Mercy in Fortaleza Brazil

AIM: To investigate the interrelationship between H pylori and Epstein-Barr virus (EBV) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-Myc, Bcl-2 and Bax expression. METHODS: seventy-one gastric carcinoma tissues were assessed by polymerase chain reaction (PCR) for H pylori and in situ hybridization for EBV. c-Myc, Bcl-2 and Bax expression were detected by immunohistochemistry and single-stranded conformational polymorphism (SSCP) for p53 mutation. RESULTS: The positivity rates for H pylori and EBV were 94.4% and 8.45%, respectively. The majority of the cases displayed only the H pylori presence. All EBV positive cases were also H pylori positive. None infectious agent was observed in 5.55% of the cases. The intestinal type tumor was more frequent in the co-infected and non-infected groups. The female predominated in the non-infected group showing statistical significance (70.4% vs 29.6%, P=0.039). The Bcl-2 was only detected in the group exclusively infected by H pylori. However, c-Myc and Bax were detected in the three groups but with a low frequency in the co-infected group. Mutation of p53 was present in all groups, with the highest frequencies in the H pylori positive groups. CONCLUSION: The frequency of H pylori infection in gastric carcinomas was high. The presented data indicated that gastric carcinogenesis has different pathways depending of the presence of the two investigated infectious agents, suggesting a possible involvement of H pylori with apoptotic process. The low expression of c-Myc and Bax in the EBV-positive groups suggests that EBV may inhibit the expression of these proteins. Nevertheless, p53 mutation shows to be a relevant alteration, independent of both infectious agents.

关键词： Gastric carcinoma Helicobacter pylori Epstein-Barr virus, p53, Bax, Bcl-2, c-Myc

Classification of Abandoned Areas for Solar Energy Projects Using Artificial Intelligence and Quantum Mechanics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geographic Information System 2021年第3期13卷 318-339页

作者： David Gabriel de barros Franco Maria Teresinha Arns Steiner Undergraduate Program in Logistics Universidade Federal do Tocantins (UFT) Araguaína Brasil Graduate Program in Industrial Engineering and Systems Pontifícia Universidade Católica do Paraná (PUC-PR) Curitiba Brasil

The increasing demand for energy has intensified recently, requiring alternative sources to fossil fuels, which have become economically and environmentally unfeasible. On the other hand, the increasing land occupation in recent centuries is a growing problem, demanding greater efficiency, particularly in the reuse of abandoned areas, which has become an alternative. An interesting alternative would be installing energy facilities like solar, wind, biomass, and geothermal, in these areas. The objective of this paper is to develop a classification methodology, based on Artificial Intelligence (AI) and Quantum Theory (QT), to automatically carry out the classification of abandoned areas suitable for the settlement of these power plants. Artificial Neural Networks (ANNs) improved by the hybrid algorithm Quantum-behaved Particle Swarm Optimization (QPSO) together with the Levenberg-Marquardt Algorithm (LMA) were used for the classification task. In terms of Mean Squared Error (MSE), the QPSO-LMA approach achieved a decrease of 19.6% in relation to the classical LMA training with random initial weights. Moreover, the model’s accuracy showed an increase of 7.3% for the QPSO-LMA over the LMA. To validate this new approach, it was also tested on six different datasets available in the UCI Machine Learning Repository and seven classical techniques established in the literature. For the problem of installing photovoltaic plants in abandoned areas, the knowledge acquired with the solar dataset can be extrapolated to other regions.

关键词： Solar Energy Soil Reuse Artificial Neural Networks Quantum-Behaved Particle Swarm Optimization

NK cell dysfunction in severe COVID-19:TGF-β-induced downregulation of integrin beta-2 restricts NK cell cytotoxicity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第2期7卷 346-348页

作者： Joana barros-Martins Reinhold Förster Berislav Bošnjak Institute of Immunology Hannover Medical School30625 HannoverGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical School30625 HannoverGermany German Centre for Infection Research(DZIF) Partner site HannoverHannoverGermany

In a recent study published in Nature,Witkowski et *** that in patients with severe forms of coronavirus disease 2019(COVID-19)deranged tumor growth factor-beta(TGF-β)secretion counteracts interferon-alpha(IFN-α)-induced activation of NK cells by decreasing expression of transcription factor ***,NK cells fail to upregulate the adhesion molecule integrin beta-2(-ß2),which impedes their attachment to and killing of SARS-CoV-2 infected cells.

关键词： interferon cytotoxicity

Influence of the Freshwater Discharge on the Hydrodynamics of Patos Lagoon, Brazil

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Geosciences 2014年第9期5卷 925-942页

作者： Gustavo Pessoa de barros Wiliam Correa Marques Eduardo de Paula Kirinus Institute of Mathematics Statistics and Physics Federal University of Rio Grande Rio Grande Brazil Institute of Oceanography Federal University of Rio Grande Rio Grande Brazil

Patos Lagoon is a very dynamic environment presenting hydrodynamic fluctuations from synoptic to decadal timescales. Thus, understanding the processes that determine the long term variability is fundamental for the correct coastal planning and management of this region. The main objective of this study is to understand how the freshwater discharge of the main tributaries controls the estuarine hydrodynamics of the Patos Lagoon, when considering long term timescales. Two numerical simulations were carried out using the TELEMAC3D numerical model, the former using freshwater discharge from 1940 to 1973 year (simulation A), and the second simulation using data between 1974 and 2006 year (simulation B). These two periods were selected because before (after) 1973 year, the annual mean freshwater discharge was lower (higher) than the mean value for the whole period (1080 m3/s). The navigational channel discharge, water level, salinity and current velocity differences between both simulations were analyzed. Ebb conditions prevailed over flood conditions for both simulations, but simulation B presented a higher volume of freshwater exported through the coastal zone. Water level differences demonstrated higher values (0.08 meters) close to the Guaiba River, which is the main tributary of the study region, and lower values were observed near to the Patos Lagoon mouth (0 meters). The most significant differences in the mean bottom and surface salinity were observed in the central zone of the estuary and at the Barra Breakwaters. Simulation A presented higher saline intrusion due to lower freshwater discharge, while simulation B showed an increase in the coastal plume intensity, caused by the higher freshwater discharge. The hydrodynamical simulations demonstrated with precision that the freshwater discharge intensity determine the vertical stratification of the estuary.

关键词： Estuarine Hydrodynamics Freshwater Discharge Hydrodynamical Modeling

Helicobacter pylori and EBV in gastric carcinomas:Methylation status and microsatellite instability

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第3期16卷 312-319页

作者： Adriana Camargo Ferrasi Nídia Alice Pinheiro Silvia Helena Barem Rabenhorst Otávia Luisa Caballero Maria Aparecida Marchesan Rodrigues Fabrício de Carvalho Celso Vieira de Souza Leite Marcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa barros Maria Inês de Moura Campos Pardini Blood Transfusion Center Botucatu Medical SchoolUNESP-Sao Paulo State University department of Pathology-Federal University of Ceara Ludwig Institute of Cancer Research department of Pathology Medical SchoolUNESP-Sao Paulo State University department of Gastroenterology Surgery Medical SchoolUNESP-Sao Paulo State University

AIM:To verify the methylation status of CDH1, DAPK, COX2, hMLH1 and CDKN2A genes and to evaluate their association with Helicobacter pylori (H. pylori)-cagA+ and Epstein Barr virus (EBV) infections in gastric ***: Methylation-specific PCR (MSP) assay was performed in 89 primary gastric carcinomas (intestinal and diffuse types). Microsatellite instability (MSI) analysis was performed using the BAT26 primer set and PCR products were analyzed with the ABI PRISM 3100 Genetic Analyzer using Genescan 3.7 software (Applied Biosystems). detection of H. pylori and genotyping were performed by PCR, using specifi c primers for ureaseC and cagA genes. The presence of EBV was assessed by in situ hybridization. Statistical analyses were performed using the χ2 or Fisher's exact ***: The most frequent hypermethylated gene was COX-2 (63.5%) followed by DAPK (55.7%), CDH1 (51%), CDKN2A (36%) and hMLH1 (30.3%). Intestinal and diffuse adenocarcinomas showed different methylation profiles and there was an association between methylation of E-CDH1 and H. pylori-cagA+ in the intestinal adenocarcinoma type. MSI was correlated with hMLH1 methylation. There was an inverse correlation between DAPK hypermethylation and ***: We found a strong association between CDH1 methylation and H. pylori-cagA+ in intestinal-type gastric cancer, association of MSI and better prognosis and an heterogeneous COX-2 overexpression.

关键词： Gastric cancer Methylation Microsatellite instability Helicobacter pylori Epstein Barr virus

Out of Sight, Out of Mind, Right? Not in COVID-19 Shock or Anaerobic and Exhaustive Shock versus Septic Shock Dilemma That Means to Live or Die. Emergency Attention and a Necessity of Trials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Emergency Medicine 2022年第1期10卷 19-47页

作者： Luiz Gonzaga Francisco de Assis barros D’Elia Zanella Infectious Diseases department (MI-HSPE) Hospital do Servidor Público do Estado de S&#227 o Paulo S&#227 o Paulo Brazil PhD Program in Allergy and Immunopathology School of Medicine University of S&#227 o Paulo S&#227 o Paulo Brazil Emergency and Urgency department University Hospital of University of S&#227 o Paulo Butant&#227 S&#227 o Paulo Brazil

Background: COVID-19 brought challenges that did not end after a two-year pandemic. From more straightforward changes in habits to studying to understand the enigmatic parasite-host relationship, we can better manage the patient infected with SARS-CoV-2 even with a vaccine full of doubts and antivirals that do not correctly cover the viral period. SARS-CoV-2 brought the chronic inflammation now called “The Long COVID-19 Syndrome” (LCS), something still little talked about, but we already see deaths due to non-identification of this inflammatory syndrome that can lead to shock. Theory: LCS Shock is due to a long period of metabolic stress, reflecting the shift from inflammation to oxidative stress and innate immunity, and does not respond to antimicrobials, as its main component is inflammatory, although there may be conjoined bacterial translocation. Thus, we are losing patients to a new syndrome confused with sepsis and septic shock. While septic shock (SS) responds to antimicrobials, Inflammatory Shock (ISc) does not respond to antimicrobials alone, requiring high doses of corticosteroids. Review: This study shows that we need to differentiate SS and ISC, as the treatment is different. The review shows that Lactate, LDH and the presence of new/recent cardiac changes and bradycardia in the face of a status where there should be tachycardia as the usual response can differ ISC from SS. Maybe the main responsible for high LDH is Warburg Effect. Conclusion: We have a dilemma that requires clinical studies that routinely match high doses of corticosteroids (until there is something better to be done) and bring laboratory and imaging differences to diagnose SS vs ISc better.

关键词： Acute Respiratory Distress Syndrome Cardiovascular System Critical Care COVID-19 Lactate

Residual Stress and Fracture Toughness Study in A516 Gr70 Steel Joints Welded and Repaired by Arc Processes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering（科研） 2023年第11期15卷 749-758页

作者： Régis de Matos Curvelo de barros Mauricio David Martins das Neves Center for Materials Science and Technology-IPEN Energetyc and Nuclear Research Institute (IPEN) S&atildeo Paulo University S&atildeo Paulo Brazil

Structural components made of steel are used in several areas and require welding for assembly. In some situations, repair of the weld bead, also performed by electric arc welding, can be used to correct, and eliminate any discontinuities. However, electric arc welding causes the presence of residual stresses in the joint, which can impair its performance and not meet specific design requirements. In this paper, welded joints made of ASTM A 516 GR 70 steel plates, with a thickness of 30.5 mm, welded by the MAG—Metal Active Gas process (20% CO2) and using a “K” groove were analysed. The joints were manufactured with seven welding passes on each side of the groove. After welding, one batch underwent repair of the bead by TIG welding (Tungsten Insert Gas) and another batch underwent two repairs by TIG welding. Were presented results of the behaviour of the residual stress profile measured by X-ray diffraction and the Vickers microhardness profile in the joints as well the fracture toughness in the conditions only welded and submitted to repairs. The results indicated that the greater number of repair passes reduced the residual compressive stress values obtained in the material manufacturing process and caused a stabilization on the Vickers hardness values. It was concluded that compressive residual stresses did not play a major role in the R-curve results. The presence of discontinuities in the welded joint caused greater influence on the behaviour of the R curve.

关键词： Weld Repair Weld Fatigue Weld J Integral Residual Stress Microharness

Prognosis of forest production using machine learning techniques

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Information Processing in Agriculture 2023年第1期10卷 71-84页

作者： Jeferson Pereira Martins Silva Mayra Luiza Marques da Silva Adriano Ribeiro de Mendonca Gilson Fernandes da Silva Antoˆnio Almeida de barros Junior Evandro Ferreira da Silva Marcelo Otone Aguiar Jeangelis Silva Santos Nı´vea Maria Mafra Rodrigues Federal University of Espirito Santo UFESDepartment of Forestry and Wood ScienceAvenue Governor Lindemberg31629550-000 Jeroˆnimo MonteiroESBrasil b Departamento de Cieˆncias Agra´riasUniversidade Federal de Sa o Joa del-Rei Sete Lagoas CampusHighway MG 424-Km 47Sete LagoasMinas Gerais 35701-970Brazil Federal University of Para(UFPA) University Campus of AltamiraStreet Cel.Jose Porfırio2515Sa o Sebastiao68372-040 AltamiraPABrazil

Forest production and growth are obtained from statistical models that allow the generation of information at the tree or forest stand *** the use of regression models is common in forest measurement,there is a constant search for estimation procedures that provide greater ***,machine learning techniques have been used with satisfactory performance in measuring ***,methods such as Adaptive NeuroFuzzy Inference System(ANFIS)and Random Forest are relatively poorly studied for predicting the volume of wood in eucalyptus plantations in ***,it is essential to check whether these techniques can provide gains in terms of ***,this study aimed to evaluate the use of Random Forest and ANFIS techniques in the prognosis of forest *** data used come from continuous forest inventories carried out in stands of eucalyptus *** data were divided into 70%for training and 30%for *** algorithms used to generate rules in ANFIS were Subtractive Clustering and ***,training was done with the hybrid algorithm(descending gradient and least squares)with the number of seasons ranging from 1 to *** RFs were trained,varying the number of trees from 50 to 850 and the number of observations by five leaves to *** neural networks and decision trees were also trained to compare the feasibility of the *** evaluation of the estimates generated by the techniques for training and validation was calculated based on the following statistics:correlation coefficient(r),relative Bias(RB),and the relative root mean square error(RRMSE)in *** general,the techniques studied in this work showed excellent performance for the training and validation data set with RRMSE values*** RF presented inferior statistics about the ANFIS for the prognosis of forest *** Subtractive Clustering(SC)and Fuzzy-C-Means(FCM)algorithms provide accurate baseline

关键词： Artificial Intelligence Ensemble Learning Forest Measurement Forest inventory Artificial Neural Networks Regression

Petit-Suisse Cheese Production with Addition of Probiotic <i>Lactobacillus</i><i>casei</i>

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food and Nutrition Sciences 2014年第18期5卷 1756-1764页

作者： Ludmilla Santana Soares e barros Nelson de Carvalho delfino Universidade Federal do Recô ncavo da Bahia Centro de Ciências Agrárias Ambientais e Biológicas Laboratório de Investiga&#231 o Analítica de Alimentos e de água Rua Rui Barbosa 710 Centro. Cruz das Almas Brazil

Growing concern to increase life expectancy has promoted several studies in the field of nutrition, especially those on food and their effects on the human body. Assays have been performed to improve their nutritional quality. In fact, there is considerable interest in encouraging development of new ingredients, with the innovation in food products and the establishment of new market niches for these ingredients. The global market for functional foods is growing and always envisages new products with functional technological and physiological characteristics. The petitsuisse cheese is a product of high nutritional value, rich in calcium, phosphorus and fat-soluble vitamins, with a high percentage of milk proteins, coupled to excellent digestion and assimilation by the human body. Current assay describes the production of a petit-suisse cheese to which was added the probiotic Lactobacillus casei BGP 93, and determines the physical, chemical and microbiological viability of lactobacilli in cheese during storage period. Levels of protein, fat in the dry extract, moisture and pH were analyzed for physical and chemical parameters;likewise, detection of coliforms, Staphylococcus, Salmonella, Listeria monocytogenes, and yeasts and molds was performed for microbiological parameters;monitoring of the viability of Lactobacillus casei BGP 93 during its life time was conducted. The petit-suisse cheese proved to be a good vehicle for the addition of probiotic microorganism. Lactobacillus casei remained viable during shelf life even with decreasing pH, and may be considered a functional product during 30 days of storage.

关键词： Cheese Probiotic Lactobacillus casei