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Antioxidant role of zinc in diabetes mellitus

World Journal of Diabetes 2015年第2期6卷 333-337页

作者： Kyria Jayanne Clímaco Cruz Ana Raquel Soares de Oliveira dilina do nascimento marreiro Department of Nutrition Center of Health SciencesFederal University of Piauí

Chronic hyperglycemia statue noticed in diabetes mellitus favors the manifestation of oxidative stress by increasing the production of reactive oxygen species and/or by reducing the antioxidant defense system *** plays an important role in antioxidant defense in type2 diabetic patients by notably acting as a cofactor of the superoxide dismutase enzyme,by modulating the glutathione metabolism and metallothionein expression,by competing with iron and copper in the cell membrane and by inhibiting nicotinamide adenine dinucleotide phosphate-oxidase *** also improves the oxidative stress in these patients by reducing chronic *** indeed promotes phosphorylation of insulin receptors by enhancing transport of glucose into ***,several studies reveal changes in zinc metabolism in individuals with type 2 diabetes mellitus and controversies remain regarding the effect of zinc supplementation in the improvement of oxidative stress in these *** with the serious challenge of the metabolic disorders related to oxidative stress in diabetes along with the importance of antioxidant nutrients in the control of this disease,new studies may contribute to improve our understanding of the role played by zinc against oxidative stress and its connection with type 2 diabetes mellitus *** could serve as a prelude to the development of prevention strategies and treatment of disorders associated with this chronic disease.

关键词： Diabetes mellitus Type 2 Oxidative stress Zinc Superoxide dismutase Metabolism

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Cardiovascular Risk of Community-Dwelling Elderly from a City in Northeastern Brazil: Correlations with Vitamin D and Parathormone

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Food and Nutrition Sciences 2014年第11期5卷 1056-1064页

作者： Lídia Ribeiro de Carvalho Cecília Maria R.G.de Carvalho Sandra M.L.Ribeiro Ivone F.de Oliveira C.Nunes Raquel Galvao Figueredo Amanda marreiro Barbosa Francisco Erasmo de Oliveira dilina do nascimento marreiro Marcos David Figueiredo de Carvalho José Machado Moita Neto Federal University of Piaui(UFPI) TeresinaBrazil School of Arts Sciences and HumanitiesUniversity of Sao PauloSao PauloBrazil Laboratório Med Imagem TeresinaBrazil

We investigated the cardiovascular disease (CVD) risk of the elderly in a city in northeastern Brazil, and the correlation of this risk with vitamin D and PTH status. We studied 359 elderly, both genders, from Piauí-Teresina-Brazil. Variables investigated: body mass index, waist circumference, systolic and diastolic blood pressure. A subsample (n = 100) was investigated for biochemical analyses: PTH and 25(OH)-vitamin D levels;total, HDL and LDL-cholesterol;and fasting glucose. High blood pressure, abdominal obesity, sedentarism, high total cholesterol, high triacylglycerol levels, as well as low vitamin D levels, were, among the investigated variables, the most prevalent. Visceral adiposity and low vitamin D were found to be more prevalent in women than in men, whilst alcohol intake and smoking were more prevalent in men. The correlation between vitamin D, PTH and the investigated risk variables, under our study conditions, were not significant.

关键词： Cardiovascular Diseases Risk Factors Elderly Vitamin D PTH

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