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Is the Use of Frozen Section Indispensable in the Surgical Treatment of Endometrial Hyperplasia?

Open Journal of Obstetrics and Gynecology 2015年第4期5卷 219-225页

作者： Ceyhun Numanoglu dilek marangoz chapman Aysun Fendal Tunca Aysu Akca Agahan Han Volkan Ulker Ozgur Akbayir Oncology Unit Department of Obstetrics and Gynecology Kanuni Sultan Suleyman Training and Research Hospital Istanbul Turkey Ethica Incirli Hospital Istanbul Turkey Department of Obstetrics and Gynecology Kanuni Sultan Suleyman Training and Research Hospital Istanbul Turkey

Objective: To evaluate the reliability and accuracy of frozen section (FS) compared with final pathology and to determine whether they should be obligatory in every patient with atypical endometrial hyperplasia (AEH). Methods: We retrospectively assessed the medical records of 192 patients whose endometrial biopsy results were endometrial hyperplasia and underwent hysterectomy at our center. Results: Twenty-two (11.4%) of the 192 patients in our study had concurrent endometrial carcinoma (EC). Of these, 21 (95.5%) were EC and 1 (4.5%) was non-endome- trioid. Of the 140 patients with AEH, 20 (14.3%) had concurrent EC. Overall, 157 patients had FS. Two (1%) patients’ EC was higher than grade 1B and needed lymphadenectomy. The positive and negative predictive value, specifity and sensitivity of FS were found to be 77.8%, 95.7%, 97% and 70%, respectively. Conclusion: Patients who have AEH without high-risk comorbidities do not have to be referred to oncology centers and can undergo hysterectomy in community hospitals without FS.

关键词： Endometrial Hyperplasia Coexisting Endometrial Cancer Atypical Endometrial Hyperplasia Frozen Section Hysterectomy

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