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Expression of bc(?)-2 gene family during resection induced liver regeneration:Comparison between hepatectomized and sham groups

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World Journal of Gastroenterology 2004年第2期10卷 279-283页

作者： Kamil Can Akcali Aydin Dalgic Ahmet Ucar Khemaeis Ben Haj dilek guvenc Department of Molecular Biology and Genetics Bilkent UniversityAnkara 06800Turkey Department of Surgery Gazi University Medical SchoolAnkara 06510Turkey Department of Mathematics Bilkent UniversityAnkara 06800Turkey

AIM:During liver regeneration cellular proliferation and apoptosis result in tissue remodeling to restore normal hepatic mass and *** regulators of the apoptotic machinery are the Bcl-2 family proteins but their roles are not well defined throughout the liver *** aimed to analyze the expression levels of bcl-2gene family members during resection induced liver regeneration. METHODS:We performed semi-quantitative RT-PCR to examine the expression level of bak,bax,bcl-2 and bcl-x_L in 70% hepatectomized rat livers during the whole regeneration process and compared to that of the sham and normal groups. RESULTS:The expression of bak and bax was decreased whereas that of bcl-2and bd-X_L was increased in hepatectomized animals compared to normal liver at most time *** also reported for the first time that sham group of animals had statistically significant higher expression of bak and bax than hepatectomized *** addition,the area under the curve (AUC) values of these genes was larger in sham groups than the hepatectomized groups. CONCLUSION:The expression changes of bak,bax,bcl-2 and bcl-X_L genes are altered not only due to regeneration, but also due to effects of surgical operations.

关键词： Bcl-2基因肝切除术肝再生细胞增殖细胞凋亡逆转录聚合酶链反应

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