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A comprehensive profile of TCF1^(+)progenitor and TCF1−terminally exhausted PD-1^(+)CD8^(+)T cells in head and neck squamous cell carcinoma:implications for prognosis and immunotherapy

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International Journal of Oral Science 2022年第1期14卷 91-99页

作者： dikan wang Juan Fang Shuqiong Wen Qunxing Li Jinming wang Lisa Yang Wenxiao Dai Huanzi Lu Junyi Guo Zhongyan Shan Wenqiang Xie Xiangqi Liu Liling Wen Jie Shen Anxun wang Qianming Chen Zhi wang Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-Sen UniversityGuangzhouChina Hospital of Stomatology Key Laboratory of Oral Biomedical Research of Zhejiang ProvinceSchool of StomatologyZhejiang University School of MedicineHangzhouChina Department of Oral and Maxillofacial Surgery First Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina

The heterogeneity of exhausted T cells(Tex)is a critical determinant of immune checkpoint blockade therapy ***,few studies have explored exhausted T cell subpopulations in human *** the present study,we examined samples from two cohorts of 175 patients with head and neck squamous cell cancer(HNSCC)by multiplex immunohistochemistry(mIHC)to investigate two subsets of Tex,CD8+PD1+TCF1+progenitor exhausted T cells(TCF1+Texprog)and CD8+PD1+TCF1−terminally exhausted T cells(TCF1−Texterm).Moreover,fresh tumor samples from 34 patients with HNSCC were examined by flow cytometry and immunohistochemistry to further investigate their properties and cytotoxic capabilities and their correlation with regulatory T cells(Tregs)in the tumor immune microenvironment(TIME).mIHC and flow cytometry analysis showed that TCF1−Texterm represented a greater proportion of CD8+PD1+Tex than TCF1+Texprog in most ***1+Texprog produced abundant TNFα,while TCF1−Texterm expressed higher levels of CD103,TIM-3,CTLA-4,and ***1−Texterm exhibited a polyfunctional TNFα+GZMB+IFNγ+phenotype;and were associated with better overall survival and recurrence-free *** results also indicated that larger proportions of TCF1−Texterm were accompanied by an increase in the proportion of ***,it was concluded that TCF1−Texterm was the major CD8+PD1+Tex subset in the HNSCC TIME and that these cells favor patient survival.A high proportion of TCF1−Texterm was associated with greater Treg abundance.

关键词： PD1 progenitor squamous

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唾液中白细胞介素与口腔癌的关系

华西口腔医学杂志 2018年第3期36卷 325-330页

作者：王迪侃廖贵清中山大学光华口腔医学院.附属口腔医院广东省口腔医学重点实验室广州510055

唾液用于疾病的诊断越来越受到重视,由于口腔癌(OCC)发生部位的特点,唾液中白细胞介素(IL)可作为OCC诊断的生物标志物,并与OCC的发生、发展、侵袭、转移密切相关。本文对唾液中IL的检测方法及其与OCC发生、发展的关系等方面的研究进展... 详细信息

唾液用于疾病的诊断越来越受到重视,由于口腔癌(OCC)发生部位的特点,唾液中白细胞介素(IL)可作为OCC诊断的生物标志物,并与OCC的发生、发展、侵袭、转移密切相关。本文对唾液中IL的检测方法及其与OCC发生、发展的关系等方面的研究进展进行综述。

关键词：唾液白细胞介素口腔癌生物标志物

Prognostic value of tertiary lymphoid structure and tumour infiltrating lymphocytes in oral squamous cell carcinoma

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Prognostic value of tertiary lymphoid structure and tumour i...

HPV阳性口咽癌患者预后与T细胞浸润和新抗原负荷相关性分析

2020年全国口腔颌面-头颈肿瘤学术大会暨中华口腔医学会口腔颌面-头颈肿瘤专业委员会学术年会——创新超越、共赢未来

作者： Qunxing Li Xiangqi Liu dikan wang Zhi wang Jinsong Li Sun Yat-sen Memorial Hospital of Sun Yat-sen University Hospital of Stomatology Guanghua School of Stomatology Sun Yat-Sen University

Purpose/Background:Tertiary lymphoid structures(TLS) are ectopic lymphoid structures in cancers that are largely associated with favourable prognosis. However, the prognostic value of TLSs in oral squamous cell carcinoma(OSCC) is largely unknown, and the association between tumour infiltrating lymphocytes(TILs) and TLSs has been rarely explored in OSCC. In this study, we investigated the clinical significance of TLS in OSCC.

关键词： Tertiary lymphoid structures Oral cancer detection Prognostic markers Cancer microenvironment

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遗传 2019年第8期41卷 725-735页

作者：卢涣滋王迪侃王智中山大学光华口腔医学院.附属口腔医院广东省口腔医学重点实验室

口咽癌是头颈鳞癌中重要的癌种之一,与人类乳头瘤状病毒(human papillomavirus, HPV)感染有关,其发病率逐年上升。但在临床治疗过程发现,HPV 阳性口咽癌患者整体预后好于 HPV 阴性患者。目前,导致这一现象发生的分子机制尚不明确。本研... 详细信息

口咽癌是头颈鳞癌中重要的癌种之一,与人类乳头瘤状病毒(human papillomavirus, HPV)感染有关,其发病率逐年上升。但在临床治疗过程发现,HPV 阳性口咽癌患者整体预后好于 HPV 阴性患者。目前,导致这一现象发生的分子机制尚不明确。本研究利用 TCGA 数据库,对 HPV 阳性和阴性患者的免疫细胞浸润和效应功能以及新抗原负荷进行了生物信息学分析。结果发现,HPV 阳性患者的总体生存率比 HPV 阴性患者显著提高。对肿瘤组织中的免疫细胞相对丰度进行分析显示,HPV 阳性患者的 CD8+ T 细胞较 HPV 阴性患者显著提高,其效应分子 IFN-γ和 Granzyme B 表达量显著升高。同时对新抗原数目进行分析发现,HPV 阳性患者肿瘤组织中新抗原较 HPV 阴性患者低。本研究结果为 HPV 相关口咽癌的治疗提供了一定的基础理论支撑。

关键词：口咽癌人类乳头瘤状病毒生物信息学分析 T细胞浸润新抗原负荷

Skull base lesions evaluation and management

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Skull base lesions evaluation and management

2017全国口腔颌面——头颈肿瘤外科学术研讨会

作者： Sien Zhang Le Yang dikan wang Yujie Liang Guangsen Zheng Xiaomei Lao Guiqing Liao Department of Oral and Maxillofacial surgery Guanghua hospital of stomatologySun Yat-sen university

Objective:Skull base surgery is one of the most challenged *** of the complex anatomy in the cranial base,structure violation and functional lesion are difficult to *** surgical approach to resect the tumors and multi...

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白色念珠菌影响口腔黏膜癌变的机制进展

国际口腔医学杂志 2019年第6期46卷 705-710页

作者：文书琼郭君怡戴文晓王迪侃王智中山大学光华口腔医学院·附属口腔医院黏膜科广东省口腔医学重点实验室

微生物感染是癌症发生的重要因素,目前,越来越多的研究支持这样的观点:机会性白色念珠菌通过患者的免疫抑制状态,增加患者患癌的概率和肿瘤转移的风险。最近的研究结果表明,白色念珠菌可能通过以下几种机制来促进癌症发生:产生致癌副产... 详细信息

微生物感染是癌症发生的重要因素,目前,越来越多的研究支持这样的观点:机会性白色念珠菌通过患者的免疫抑制状态,增加患者患癌的概率和肿瘤转移的风险。最近的研究结果表明,白色念珠菌可能通过以下几种机制来促进癌症发生:产生致癌副产物、引发炎症以及诱导辅助性T细胞17反应。本文就白色念珠菌影响口腔黏膜癌变机制的研究进展作一综述,以期能够进一步阐明白色念珠菌和癌症发生之间的关系,有望为预防和治疗口腔黏膜癌变提供新思路。

关键词：白色念珠菌致癌物质癌变炎症辅助性T细胞17免疫反应

Swarm intention identification via dynamic distribution probability image

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Chinese Journal of Aeronautics 2024年第10期37卷 380-392页

作者： Yinhan wang Jiang wang Shaoming HE Fei wang Qi wang School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China

In the realm of decision-making for defense and security applications,it is paramount to swiftly and accurately identify the intentions of incoming *** identification methods predominantly focus on single-target applications and overlook the perturbations introduced by measurement *** this study,we propose a novel concept:the Dynamic Distribution Probability(DDP)image,which is constructed using the estimated state and its covariance *** grayscale pixel value within the image signifies the probability of the presence of the agent within the *** proposed identification scheme integrates the use of Extended Kalman Filter(EKF),Convolutional Neural Network(CNN),Back Propagation(BP)network,and Gated Recurrent Unit(GRU)***,the DDP image is processed through a CNN to distill the formation characteristics,and the estimated swarm state from EKF is inputted into a BP network to deduce the kinematic *** outputs from both networks are summed and subsequently channeled into a GRU network to capture temporal *** numerical simulations and flight experiments are presented to demonstrate the robust anti-noise capability of the proposed scheme compared with conventional methods,as well as its superior training efficiency.

关键词： Intention Identification Kalman filters Convolutional neural networks Swarm intelligence

The reformation of catalyst:From a trial-and-error synthesis to rational design

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Nano Research 2024年第4期17卷 3261-3301页

作者： Ligang wang Jiabin Wu Shunwu wang Huan Liu Yao wang Dingsheng wang Department of Chemistry Tsinghua UniversityBeijing 100084China

The appropriate catalysts can accelerate the reaction rate and effectively boost the efficient conversion of various molecules,which is of great importance in the study of chemistry,chemical industry,energy,materials and environmental ***,efficient,environmentally friendly,and easy to operate synthesis methods have been used to prepare various types of *** previous studies have reported the synthesis and characterization of the aforementioned catalysts,more still remain in trial and error methods,without in-depth consideration and improvement of traditional synthesis ***,we comprehensively summarize and compare the preparation methods of the trial-and-error synthesis strategy,structure–activity relationships and density functional theory(DFT)guided catalysts rational design for nanomaterials and atomically dispersed *** also discuss in detail the utilization of the nanomaterials and single atom catalysts for converting small molecules(H_(2)O,O_(2),CO_(2),N_(2),etc.)into value-added products driven by electrocatalysis,photocatalysis,and ***,the challenges and outlooks of mass preparation and production of efficient and green catalysts through conventional trial and error synthesis and DFT theory are featured in accordance with its current development.

关键词： trial-and-error synthesis structure–activity relationships density functional theory(DFT)guidance nanomaterials atomically dispersed catalysts

Numerical Analysis of PRISM-PY Calculations for Hard-and Soft-Core Generic Polymer Models

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Chinese Journal of Polymer Science 2024年第4期42卷 532-543页

作者： Qiang wang Department of Chemical and Biological Engineering Colorado State University1370 Campus DeliveryFort CollinsCO80523-1370USA

Generic polymer models capturing the chain connectivity and excluded-volume interactions between polymer segments can be classified, according to whether or not the 3D integral of the latter diverges, into hard- and soft-core models. Taking homogeneous systems of compressible homopolymer melts (or equivalently homopolymer solutions in an implicit, good solvent) in the continuum as an example, we recently compared the correlation effects on the structural and thermodynamic properties of the hard- and soft-core models given by the polymer reference interaction site model (PRISM) theory with the Percus-Yevick (PY) closure (Polymers 2023, 15, 1180). Here we analyzed in detail the numerical errors and behavior of the interchain pair correlation functions (PCFs) given by the PRISM-PY calculations of these models using an efficient numerical approach that we proposed. Our numerical approach has the least number of independent variables to be iteratively solved, analytically treats the discontinuities caused by the non-bonded pair potential (such as that of the hard spheres) and takes only the inverse Fourier transform of the interchain indirect PCF between polymer segments (which is continuous and decays towards 0 with increasing wavenumber much faster than both the interchain direct and total PCFs), and is essential for us to accurately solve the PRISM-PY theory for chain length N as large as 106. To capture the correlation-hole effect, the real-space cut-off in the PRISM calculations should be proportional to the square root of N.

关键词： Generic polymer models Soft potentials Polymer reference interaction site model theory