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Emerging micro-additive manufacturing technologies enabled by novel optical methods

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Photonics Research 2020年第12期8卷 1827-1842页

作者： WEI LIN dihan chen SHIH-CHI chen Department of Mechanical and Automation Engineering The Chinese University of Hong KongShatinHong KongChina Tianjin Key Laboratory of Micro-scale Optical Information Science and Technology Institute of Modern OpticsNankai UniversityTianjin 300071China

This paper presents a comprehensive review of recent advances in micro-additive manufacturing enabled by novel optical methods with an emphasis on photopolymerization-based printing *** manufacturing,also known as three-dimensional(3D)printing,has become an important engineering solution to construct customized components or functional devices at low *** a green manufacturing technology,3D printing has the advantages of high energy efficiency,low material consumption,and high *** rapid advancement of 3D printing technology has broadened its applications from laboratory research to industrial ***,3D objects to be printed are constructed digitally[e.g.,via computer-aided design(CAD)programs]by connecting a 3D dot array,where a dot is defined as a voxel through mechanical,electrical,or optical *** voxel size ranges from a few orders of magnitude of the wavelength of light to the sub-diffraction limit,achieved by material nonlinearity and precise power *** recent years,extensive research in optical additive manufacturing has led to various breakthroughs in quality,rate,and *** this paper,we review various micro-3D printing techniques,including single-photon and two-photon processes,with a focus on innovative optical methods,e.g.,ultrafast beam shaping,digital holography,and temporal *** also review and compare recent technological advances in serial and parallel scanning systems from the perspectives of resolution,rate,and repeatability,where the strengths and weaknesses of different methods are discussed for both fundamental and industrial applications.

关键词： additive printing breakthrough

Performance Evaluation of RTK-GNSS with Existing Sensors in Dense Urban Areas

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Journal of Geodesy and Geomatics Engineering 2014年第1期1卷 18-28页

作者： Nobuaki Kubo chen dihan Faculty of Marine Technology Tokyo University of Marine Science and Technology Tokyo 1358533 Japan Veriserve Corporation Tokyo 1600023 Japan

The increasing demand for navigation and automation has led to the development of a number of accurate and precise navigation applications that make use of the GPS （Global Positioning System） and other sensors. However, GPS tends to suffer from multipath error, especially in urban environments. To overcome this problem, a method was developed for improving RTK-GPS （real-time kinematic GPS） using a low-cost IMU （inertial measurement unit） and conventional vehicle speed sensors. Additionally, RTK-GNSS （Global Navigation Satellite System） was also evaluated to improve the RTK performance using GPS, QZSS （Quasi-Zenith Satellite System） and BeiDou. In this study, it was found that a suitable measurement quality check is required to obtain better direction information. The results of the experiment demonstrate that, to some extent, our proposed method is beneficial as an alternative to the conventional RTK-GPS in an urban environment.

关键词： GNSS RTK IMU Multipath ITS.

形态单元视角下中原地区乡村空间格局研究——以裴城村为例

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华中建筑 2024年第2期42卷 81-84页

作者：张东陈笛菡郑州大学建筑学院

乡村形态是乡村立足于典型历史阶段社会结构的综合体现,积淀了丰富且复杂的历史信息,如何清晰地识别乡村肌理、空间发展脉络,划分乡村形态单元并在此基础上进行社会属性的量化模型分析是一种有效的手段。该文以裴城村为例,借鉴康泽恩形... 详细信息

乡村形态是乡村立足于典型历史阶段社会结构的综合体现,积淀了丰富且复杂的历史信息,如何清晰地识别乡村肌理、空间发展脉络,划分乡村形态单元并在此基础上进行社会属性的量化模型分析是一种有效的手段。该文以裴城村为例,借鉴康泽恩形态分析方法进行乡村形态单元的划分,在此基础上进行模型量化分析。研究结果表明:裴城村典型的乡村空间是以核心区域为中心,圈层式向外发展的空间格局,其中核心区始终是乡村空间的中心、寨墙区是点轴发展的重点区域、边缘带区是乡村内在驱动力发展的末梢。通过裴城村的研究发现,划分乡村形态单元,构建量化模型是研究乡村空间格局的有力工具,并为乡村空间转型方向提供了启示。

关键词：乡村形态单元层次递进边界

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中原地区典型乡村姓氏形态单元划分与空间格局演变研究

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现代城市研究 2024年第5期39卷 34-41页

作者：张东陈笛菡石子璇张小星郑州大学建筑学院华南理工大学建筑学院

文章将康泽恩形态学理论与中原乡村聚落的典型特征相结合,划分乡村姓氏形态单元,构建量化模型与评估方法,分析乡村形态单元之间的差异,研究乡村空间格局。研究结果表明,主姓宗族的发展影响了乡村的空间结构和突破点,裴城村的乡村空间是... 详细信息

文章将康泽恩形态学理论与中原乡村聚落的典型特征相结合,划分乡村姓氏形态单元,构建量化模型与评估方法,分析乡村形态单元之间的差异,研究乡村空间格局。研究结果表明,主姓宗族的发展影响了乡村的空间结构和突破点,裴城村的乡村空间是以彭氏核心街坊为中心、圈层式向外发展。然后基于量化模型与评估方法划定乡村保护管理单元,对乡村空间提出分区域、分类型的精准保护策略,以实现对乡村形态的精细化保护与管理。

关键词：姓氏宗族康泽恩形态学乡村形态单元乡村保护管理单元

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受干扰机器人网络控制系统事件驱动控制研究

西华大学学报（自然科学版） 2021年第6期40卷 50-57页

作者：陈帝翰刘霞西华大学电气与电子信息学院四川成都610039

针对受干扰的机器人网络控制系统,结合干扰观测器和事件触发机制,设计了一种事件驱动控制方法,在考虑网络中存在随机时延的同时,对干扰进行补偿。事件驱动能够大大减少网络阻塞和控制器的计算负担,节约网络通信信道带宽。控制器在判定... 详细信息

针对受干扰的机器人网络控制系统,结合干扰观测器和事件触发机制,设计了一种事件驱动控制方法,在考虑网络中存在随机时延的同时,对干扰进行补偿。事件驱动能够大大减少网络阻塞和控制器的计算负担,节约网络通信信道带宽。控制器在判定被控机器人的输出误差是否满足预设事件的同时,接收到来自干扰观测器的干扰观测值,当控制器判定系统输出误差不满足预设事件时,控制器利用系统输出误差和干扰观测值,计算出新的控制输入来替换原来的控制输入信号,否则控制器保持上一时刻的控制输入。理论证明了机器人网络控制系统的稳定性与收敛性。最后以双关节机器人网络控制系统为例进行仿真,其结果表明,该方法能够对外部干扰进行观测,使被控机器人在受到外部干扰以及网络时延的影响下仍具有良好的位置跟踪效果。

关键词：机器人网络控制系统干扰观测器事件驱动干扰补偿

Highly sensitive nanozyme strip:An effective tool for forensic material evidence identification

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Nano Research 2024年第3期17卷 1785-1791页

作者： Juanji Hong Zhanjun Guo dihan Duan Yi Zhang Xin chen Yongjiu Li Zheng Tu Lei Feng Lei chen Xiyun Yan Lizeng Gao Minmin Liang Demin Duan Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China College of Bioscience and Biotechnology Shenyang Agricultural UniversityShenyang 110866China Chongqing kangjuquanhong biology science and technology Co. ltdChongqing 400026China Key Laboratory of Forensic Genetics Institute of Forensic ScienceMinistry of Public SecurityBeijing 100038China CAS Engineering Laboratory for Nanozyme Key Laboratory of BiomacromoleculesInstitute of BiophysicsChinese Academic of ScienceBeijing 100101China

During criminal case investigations,blood evidence tracing is critical for criminal ***,the blood stains are often cleaned or covered up after the crime,resulting in trace residue and difficult ***,a highly sensitive and specific method for the rapid detection of human blood stains remains *** solve this problem,we established a nanozyme-based strip for rapid detection of blood evidence with high sensitivity and *** construct reliable nanozyme strips,we synthesized CoFe_(2)O_(4) nanozymes with high peroxidase-like activity by scaling up to gram level,which can be supplied for six million tests,and conjugated antibody as a detection probe in nanozyme *** developed CoFe_(2)O_(4) nanozyme strip can detect human hemoglobin(HGB)at a concentration as low as 1 ng/mL,which is 100 times lower than the commercially available colloidal gold strips(100 ng/mL).Moreover,this CoFe_(2)O_(4) nanozyme strip showed high generality on 12 substrates and high specificity to human HGB among 13 animal blood ***,we applied the developed CoFe_(2)O_(4) nanozyme strip to successfully detect blood stains in three real cases,where the current commercial colloidal gold strip failed to *** results suggest that the CoFe_(2)O_(4) nanozyme strip can be used as an effective on-scene detection method for human blood stains,and can further be used as a long-term preserved material evidence for traceability inquiry.

关键词： CoFe_(2)O_(4)nanozyme nanozyme strip peroxidase-like activity human hemoglobin blood evidence

Injectable Nanorobot-Hydrogel Superstructure for Hemostasis and Anticancer Therapy of Spinal Metastasis

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Nano-Micro Letters 2024年第12期16卷 59-80页

作者： Qing chen Miao Yan Annan Hu Bing Liang Hongwei Lu Lei Zhou Yiqun Ma Chao Jia dihan Su Biao Kong Wei Hong Libo Jiang Jian Dong Department of Orthopaedic Surgery Zhongshan HospitalFudan UniversityShanghai 200032People’s Republic of China Department of Chemistry Fudan UniversityShanghai 200438People’s Republic of China Department of Surgery Yong Loo Lin School of MedicineNational University of Singapore1E Kent Ridge RoadSingapore 119228Singapore Department of Geriatrics and Gerontology Huadong HospitalFudan UniversityShanghai 200438People’s Republic of China State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai 200438People’s Republic of China Department of Orthopaedic Surgery Zhongshan Hospital Wusong Branch Fudan UniversityShanghai 200940People’s Republic of China

Surgery remains the standard treatment for spinal ***,uncontrolled intraoperative bleeding poses a significant challenge for adequate surgical resection and compromises surgical *** this study,we develop a thrombin(Thr)-loaded nanorobothydrogel hybrid superstructure by incorporating nanorobots into regenerated silk fibroin nanofibril *** superstructure with superior thixotropic properties is injected percutaneously and dispersed into the spinal metastasis of hepatocellular carcinoma(HCC)with easy bleeding characteristics,before spinal surgery in a mouse *** near-infrared irradiation,the self-motile nanorobots penetrate into the deep spinal tumor,releasing Thr in a controlled ***-induced thrombosis effectively blocks the tumor vasculature and reduces bleeding,inhibiting tumor growth and postoperative recurrence with Au nanorod-mediated photothermal *** minimally invasive treatment platform provides a novel preoperative therapeutic strategy for HCC spinal metastasis effectively controlling intraoperative bleeding and tumor growth,with potentially reduced surgical complications and enhanced operative outcomes.

关键词： Silk fibroin Nanofibril hydrogels Nanorobots Thrombin Spinal metastasis

Broad phenotypic alterations and potential dysfunction of lymphocytes in individuals clinically recovered from COVID-19

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Journal of Molecular Cell Biology 2021年第3期13卷 197-209页

作者： Jingyi Yang Maohua Zhong Ejuan Zhang Ke Hong Qingyu Yang dihan Zhou Jianbo Xia Yao-Qing chen Mingbo Sun Bali Zhao Jie Xiang Ying Liu Yang Han Mengxin Xu Xi Zhou Chaolin Huang You Shang Huimin Yan Shanghai Public Health Clinical Center Fudan UniversityShanghai 201508China Institute of Infection Immunology and Tumor MicroenvironmentHubei Province Key Laboratory of Occupational Hazard Identification and ControlMedical CollegeWuhan University of Science and TechnologyWuhan 430065China Joint Laboratory of Infectious Diseases and Health Wuhan Institute of Virology&Wuhan Jinyintan HospitalWuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430023China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China Center for Translational Medicine Jinyintan HospitalWuhan 430023China Joint Laboratory of Infectious Diseases and Health Wuhan Institute of Virology&Wuhan Jinyintan HospitalWuhan Jinyintan HospitalWuhan 430023China Department of Laboratory Medicine Maternal and Child Health Hospital of Hubei ProvinceTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430070China School of Public Health(Shenzhen) Sun Yat-sen UniversityShenzhen 518107China Institute of Medical Biology Chinese Academy of Medical Sciences&Peking Union Medical CollegeKunming 650018China University of Chinese Academy of Sciences Beijing 100049China The Office of Drug Clinical Trial Institution Jinyintan HospitalWuhan 430023China Department of Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Although millions of patients have clinically recovered from COVID-19,little is known about the immune status of lymphocytes in these *** this study,the peripheral blood mononuclear cells of a clinically recovered(CR)cohort were comparatively analyzed with those of an age-and sex-matched healthy donor *** found that CD8^(+)T cells in the CR cohort had higher numbers of effector T cells and effector memory T cells but lower Tc1(IFN-γ^(+)),Tc2(IL-4^(+)),and Tc17(IL-17A^(+))cell *** CD4^(+)T cells of the CR cohort were decreased in frequency,especially the central memory T cell ***,CD4^(+)T cells in the CR cohort showed lower programmed cell death protein 1(PD-1)expression and had lower frequencies of Th1(IFN-γ^(+)),Th2(IL-4^(+)),Th17(IL-17A^(+)),and circulating follicular helper T(CXCR5^(+)PD-1^(+))***,the proportion of isotype-switched memory B cells(IgM−CD20^(hi))among B cells in the CR cohort showed a significantly lower proportion,although the level of the activation marker CD71 was *** CD3−HLA-DR−lymphocytes in the CR cohort,in addition to lower levels of IFN-γ,granzyme B and T-bet,the correlation between T-bet and IFN-γ was not ***,by taking into account the number of days after discharge,all the phenotypes associated with reduced function did not show a tendency toward recovery within 4-11 *** remarkable phenotypic alterations in lymphocytes in the CR cohort suggest that severe acute respiratory syndrome coronavirus 2 infection profoundly affects lymphocytes and potentially results in dysfunction even after clinical recovery.

关键词： COVID-19 recovered individuals lymphocyte subsets phenotypic alteration potential dysfunction

Longitudinal Characteristics of T Cell Responses in Asymptomatic SARS-CoV-2 Infection

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Virologica Sinica 2020年第6期35卷 838-841页

作者： Jingyi Yang Ejuan Zhang Maohua Zhong Qingyu Yang Ke Hong Ting Shu dihan Zhou Jie Xiang Jianbo Xia Xi Zhou Dingyu Zhang Chaolin Huang You Shang Huimin Yan Joint Laboratory of Infectious Diseases and Health Wuhan Institute of Virology and Wuhan Jinyintan HospitalWuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of Sciences(CAS)Wuhan 430023China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceCASWuhan 430071China Center for Translational Medicine Jinyintan HospitalWuhan 430023China Joint Laboratory of Infectious Diseases and Health Wuhan Institute of Virology and Wuhan Jinyintan HospitalWuhan Jinyintan HospitalWuhan 430023China Department of Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Laboratory Medicine Maternal and Child Health Hospital of Hubei ProvinceTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430070China University of Chinese Academy of Sciences Beijing 100049China

Dear Editor,SARS-Co V-2 causes a spectrum of illness,ranging from an asymptomatic state to life-threatening multi-organ failure,and imposes a high socioeconomic burden on its sufferers and on society(chen et al.2020;P... 详细信息

关键词： al. Asymptomatic illness