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Effect of the Aqueous Extract of <i>Schumanniophyton magnificum</i>Harms on Sexual Maturation and Fertility of Immature (K. schum) Female Rat

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Pharmacology & Pharmacy 2018年第10期9卷 415-427页

作者： Emma F. Bend Pierre C. Oundoum Oundoum Marie I. Ngaha Njila Brice L. Koloko Camille D. Nyonseu Samuel H. Mandengue Paul Moundipa Theophile Dimo dieudonne massoma lembè Department of Animal Sciences Faculty of Science University of Douala Douala Cameroon Department of Animal Biology and Physiology Faculty of Science University of Yaounde I Yaounde Cameroon

The aim of the study was to bring scientific evidence of the curative action of the stem bark aqueous extract of Schumanniophyton magnificum (ASMa) on the sexual maturation and fertility of the immature female Wistar rat. Forty immature female rats were randomized and divided into 4 groups of ten animals each and orally treated with the ASMa at doses of 0 (distilled water), 200 mg/kg, 400 mg/kg and 800 mg/kg /BW/day for 30 consecutive days. Body weight and food intake were recorded throughout the experimental period. The precocity of the puberty onset in treated animals was evaluated through the determination of their age at vaginal opening. At the end of the experimental period, 5 animals in each group were sacrificed and blood samples were collected for hormonal assay. Their ovaries and uteri were removed, blotted, weighted and prepared for biochemical analysis. The remaining rats (5 per group) were crossed with males of proven fertility. After laparotomy (ten days after mating) and delivery, fertility and gestational parameters were recorded. It was noticed that, body weight gain increased significantly at all doses although there was no significant difference in food intake. The sexual maturation of treated animal was reduced to 5 days when compared to control. This was associated with the simultaneous elevation of FSH and LH (p < 0.0001) at dose of 800 mg/kg and FSH alone (p mg/kg. However, the ovarian cholesterol significantly decreased (p < 0.0001) at all doses while the uterine protein significantly increased (p < 0.05;p mg/kg and 800 mg/kg. The animal treated at doses of 400 mg/kg and 800 mg/kg exhibited an early fertilization (2 - 3 days) when compared to the control one (9 - 14 days). The number of implantation site significantly increased (p < 0.05;p mg/kg and 800 mg/kg) after laparotomy as well as the number of alive fetuses after delivery and gestational rate (80% and 100%) respectively. These results provide the strong evidence on the induction of the

关键词： Schumanniophyton magnificum Sexual Maturation Hormone Level Fertility

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Antifertility Effects of Aqueous Roots Extract of <i>Alchornea cordifolia</i>(Euphorbiaceae) on Female Albino Rats

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Pharmacology & Pharmacy 2014年第8期5卷 838-845页

作者： dieudonne massoma lembè Larice E. Njoh Njoh Emma F. Bend Brice L. Koloko Pierre C. Oundoum Oundoum Marie I. Ngaha Njila Hubert Kenmogne Cyprien M. Hambe Marie C. Tchamadeu Judith Domkam Theophile Dimo Gustavo F. Gonzales Department of Animal Biology and Physiology Faculty of Science University of Yaounde I Yaounde Cameroon Department of Animal Sciences Faculty of Science University of Douala Douala Cameroon Laboratory of Endocrinology and Reproduction Faculty of Sciences and Philosophy Alberto Cazorla Talleri Universidad Peruana Cayetano Heredia Lima Peru

Aqueous roots extract of Alchornea cordifolia was studied to evaluate its traditional antifertility claim. Antifertility effect of Alchornea cordifolia was evaluated according to the stages of pregnancy of female rats. In the first stage, forty female rats were randomly divided into four groups (10 rats/group) and respectively treated with 1 ml distilled water (control), 100, 200 and 400 mg/kg body weight (BW) per day of Alchornea cordifolia. After laparotomy and at parturition, sites of implantation and resorption on the uterine horns were determined. The ovaries and uterus were collected and weighed. Blood samples were collected for hormonal assay. In the second and third stage of pregnancy, treatment schedule and antifertility parameters were assessed as above for the first stage. Treated groups received daily 400 mg/kg bw of extract of Alchornea cordifolia while Control group received distilled water. It was observed in the first stage of pregnancy that, the number of resorption sites significantly (p < 0.05) decreased at 100 and 200 mg/kg. No implantation site was observed at dose 400 mg/kg after laparotomy as well as the number of pups at parturition at all doses. The body weight of ovaries and uterine horns at dose 400 mg/kg significantly (p < 0.05) decreased when compared to the control. The extract dose dependently decreased significantly the concentrations of serum progesterone. In the second stage of pregnancy after laparotomy and at parturition, the number of live fetus and the survival ratio significantly (p < 0.001) decreased and were associated with the vaginal discharge and bleeding of animals. In the third stage of pregnancy, the extract caused an early parturition associated with a decreased number of live fetus and the survival ratio with p The results indicate that aqueous roots extract of Alchornea cordifolia could induce inhibitory effects on reproductive functions in female albino rats.

关键词： Implantation Embryo Development Abortion Hormone Level

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