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World Journal of Gastroenterology 2014年第31期20卷 10984-10993页

作者： Claudia Roeder Sabine Jordan Julian Schulze zur Wiesch Heike pfeiffer-Vornkahl dietrich Hueppe Stefan Mauss Elmar Zehnter Sabine Stoll Ulrich Alshuth Ansgar W Lohse Stefan Lueth Department of Medicine Ⅰ University Hospital Hamburg Eppendorf Factum - company for statistics scientific information and communication mbH Center of Gastroenterology Wiescherstrasse 20 44623 Herne Germany Center for HIV and Hepatogastroenterology Grafenberger Allee 128a 40237 Duesseldorf Germany Center of Gastroenterology Am Oelpfad 12 44263 Dortmund Germany Virology Roche Pharma AG Emil-Barell-Stra?e 1 79639 Grenzach-Wyhlen Germany

AIM: To evaluate the safety and efficacy of pegylated interferon alfa-2a and ribavirin therapy in elderly patients with chronic hepatitis C ***: Patients characteristics, treatment results and safety profiles of 4859 patients with hepatitis c virus(HCV) infection receiving treatment with pegylatedinterferon alfa-2a and ribavirin were retrieved from a large ongoing German multicentre non-interventional study. Recommended treatment duration was 24 wk for GT 2 and GT 3 infection and 48 wk for GT 1 and GT 4 infection. Patients were stratified according to age(< 60 years vs ≥ 60 years). Because of limited numbers of liver biopsies for further assessment of liver fibrosis APRI(aspartate aminotransferase- platelet ratio index) was performed using pre-treatment laboratory ***: Out of 4859 treated HCV patients 301(6.2%) were ≥ 60 years. There were more women(55.8% vs 34.2%, P < 0.001) and predominantly GT 1(81.4% vs 57.3%, P < 0.001) infected patients in the group of patients aged ≥ 60 years and they presented more frequently with metabolic(17.6% vs 4.5%, P < 0.001) and cardiovascular comorbidities(32.6% vs 6.7%, P < 0.001) and significant fibrosis and cirrhosis(F3/4 31.1% vs 14.0%, P = 0.0003). Frequency of dose reduction and treatment discontinuation were significantly higher in elderly patients(30.9% vs 13.7%, P < 0.001 and 47.8% vs 30.8%, P < 0.001). Main reason for treatment discontinuation was "virological non-response"(26.6% vs 13.6%). Sustained virological response(SVR) rates showed an age related difference in patients with genotype 1(23.7% vs 43.7%, P < 0.001) but not in genotype 2/3 infections(57.7% vs 64.6%, P = 0.341). By multivariate analysis, age and stage of liver disease were independent factors of ***: Elderly HCV patients differ in clinical characteristics and treatment outcome from younger patients and demand special attention from their practitioner.

关键词： Hepatitis C virus infection Older patients Patient

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液氮温区单级大功率斯特林型脉管制冷机工作特性研究（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2015年第7期16卷 577-585页

作者： Jiu-ce SUN Marc dietrich Li-min QIU Guenter THUMMES Institute of Refrigeration and Cryogenics Zhejiang University Institute of Applied Physics University of Giessen Trans MIT-Centre for Adaptive Cryotechnology and Sensors

目的:探索充气压和运行频率等工作特性对大功率脉管制冷机最低制冷温度、制冷量以及回热器温度不均匀性的影响,期望进一步提升制冷机工作性能。方法:1.通过理论计算模拟工作频率在40–70 Hz,充气压力在1.5–2.5 MPa下工作特性对制冷机... 详细信息

目的:探索充气压和运行频率等工作特性对大功率脉管制冷机最低制冷温度、制冷量以及回热器温度不均匀性的影响,期望进一步提升制冷机工作性能。方法:1.通过理论计算模拟工作频率在40–70 Hz,充气压力在1.5–2.5 MPa下工作特性对制冷机性能的影响;2.实验研究充气压力为1.7–2.4 MPa,并在谐振频率附近工作时制冷机性能以及回热器温度不均匀性随充气压力、运行频率以及输入功率的变化。结论:1.制冷机运行在1.9–2.1 MPa充气压力下,因平衡了制冷温度和焓流损失,故能取得优异性能,且每一个充气压力对应一个最优的工作频率;2.通过优化充气压力和工作频率,脉管制冷机能够达到46.9 K的最低制冷温度,此时工作频率为56.5 Hz,充气压力为2.0 MPa。在8.9 k W输入功率下制冷机能够在72 K时提供304 W制冷量。

关键词：斯特林型脉管制冷机大功率工作特性温度不均匀性

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细胞分裂素和硝酸铵对欧洲云杉不定芽伸长的影响(英文)

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林业科学 2007年第1期43卷 28-34页

作者： dietrich Ewald 胡建军德国联邦林业及林产品研究中心林木遗传育种研究所中国林业科学研究院林业研究所国家林业局林木培育重点实验室北京100091

报道细胞分裂素和硝酸铵对欧洲云杉不定芽伸长过程的影响。采用5年生的欧洲云杉1个无性系不定芽丛来研究玉米素和硝酸铵对不定芽生长的影响。试验3种诱导类型(玉米素浓度分别为6·84、13·68、20·52μmol·L-1,激动素浓度0·69μmol·L... 详细信息

报道细胞分裂素和硝酸铵对欧洲云杉不定芽伸长过程的影响。采用5年生的欧洲云杉1个无性系不定芽丛来研究玉米素和硝酸铵对不定芽生长的影响。试验3种诱导类型(玉米素浓度分别为6·84、13·68、20·52μmol·L-1,激动素浓度0·69μmol·L-1,培养4周),玉米素最高浓度处理诱导的伸长芽数量最多,在4个无生长调节剂继代培养过程中,加入了1个硝酸铵浓度逐渐增加的继代培养过程。经不含生长调节剂的低浓度的硝酸铵(2·5mmol·L-1)培养基的继代培养后转入含有细胞分裂素的诱导培养基,下一个继代培养基补充的硝酸铵浓度分别为2·5、7·5、12·5、17·5mmol·L-1,8周(2个继代培养)后转入含有硝酸铵浓度为2·5mmol·L-1的培养基培养。硝酸铵浓度为7·5mmol·L-1的处理可形成数量最多的不定芽,这对于采用不同浓度的玉米素进行诱导的处理结果是一致的,但随着硝酸铵的浓度增至12·5mmol·L-1和17·5mmol·L-1时则不定芽的数量减少。欧洲云杉的胚轴外植体经1次或多次诱导后,细胞分裂素(BA、激动素、玉米素、2iP)促进了不定芽的分化和发育,其中BA由于可诱导产生大量的不定芽而成为最有效的细胞分裂素。玉米素虽然诱导不定芽相对弱一些,却在BA多次诱导后可促进芽的伸长。这对获得具有形成不定芽能力并可扩繁的芽丛非常重要。

关键词：欧洲云杉不定芽细胞分裂素硝酸铵

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S-21007,强效5-羟色胺3受体部份激动剂,对小鼠焦虑的作用(英文)

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Acta Pharmacologica Sinica 1999年第9期 39-46页

作者： Philippe DELAGRANGE,René MISSLIN,Thomas W SEALE,Bruno pfeiffer,Sylvain RAULT,Rierre RENARD Institut de Recherches Internationales Servier 92415 Courbevoie Cdex France Laboratoire d'Ethologie et de Neurobiologie-URA CNRS 1295 Universit Louis Pasteur 67000 Strasbourg France Department of Pediatrics University of Oklahoma Health Oklahoma City OK 73190 USA Institut de Recherches Internationales Servier 92415 Courbevoie Cdex France CERMN Universit de Caen 14032 Caen Cdex France Institut de Recherches Internationales Servier 92415 Courbevoie Cdex France

AIM: To study the effect of S-21007, a 5-HT3partial agonist in different animal models of anxiety inmice. METHODS: S-21007 effects were evaluatedin the behavior tests after intraperitioneal and oral acutetreatment or in the light/dark test after both acute andchronic treatments. RESULTS: S-21007 presentedanxiolytic-like properties after acute administration inthe light/dark box test, the mirrored chamber test, andthe elevated plus-maze at be doses 10 ng·kg-1-100μg·kg-1, 1-100 μg·kg-1and 10-100 μg·kg-1,respectively. In the light/dark box test, S-21007 wasactive orally after acute treatment at 100 ng·kg-1-10mg·kg-1and after chronic treatment （14 d） at 1-10μg·kg-1. S-21007 was devoid of sedative or stimula-

关键词： S-21007 血清素激动药焦虑动物行为迷宫学习运动活动探究行为选择行为

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Chronic hepatitis C:Treat or wait? Medical decision making in clinical practice

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World Journal of Gastroenterology 2012年第12期18卷 1339-1347页

作者： Claus Niederau dietrich Hüppe Elmar Zehnter Bernd Mller Renate Heyne Stefan Christensen Rainer Pfaff Arno Theilmeier Ulrich Alshuth Stefan Mauss Katholische Kliniken Oberhausen St.Josef HospitalKlinik für Innere MedizinOberhausen 46045Germany Medical Office for Gastroenterology and Hepatology Herne 44623Germany Medical Office for Gastroenterology and Hepatology Dortmund 44263Germany Medical Office for Gastroenterology and Hepatology Berlin 10969Germany Center for Interdisciplinary Medicine Münster 48143Germany Medical Office for Gastroenterology and Hepatology Gie en 35392Germany Medical Office for Gastroenterology and Hepatology Mnchengladbach 41239Germany Pharma AG Medical Management Virology Grenzach-Wyhlen 79639Germany Center for HIV and Hepatogastroenterology Düsseldorf 40237Germany

AIM:To analyzes the decision whether patients with chronic hepatitis C virus (HCV) infection are treated or ***:This prospective cohort study included 7658 untreated patients and 6341 patients receiving pegylated interferon α2 a/ribavirin,involving 434 physicians/institutions throughout Germany (377 in private practice and 57 in hospital settings).A structured questionnaire had to be answered prior to the treatment decision,which included demographic data,information about the personal life situation of the patients,anamnesis and symptomatology of hepatitis C,virological data,laboratory data and data on concomitant diseases.A second part of the study analyzes patients treated with pegylated interferon α*** questionnaires included reasons against treatment mentioned by the ***:Overall treatment uptake was 45%.By multivariate analysis,genotype 1/4/5/6,HCV-RNA ≤ 520 000 IU/mL,normal alanine aminotransferase (ALT),platelets ≤ 142 500/μL,age > 56 years,female gender,infection length > 12.5 years,concomitant diseases,human immunodeficiency virus co-infection,liver biopsy not performed,care in private practice,asymptomatic disease,and unemployment were factors associated with reduced treatment *** and sustained viral response rates in migrants (1/3 of cohort) were higher than in German natives although 1/3 of migrants had language *** rate and liver biopsy were higher in clinical settings when compared to private practice and were low when ALT and HCV-RNA were ***:Some reasons against treatment were medically based whereas others were related to fears,socio-economical problems,and information deficits both on the side of physicians and patients.

关键词：丙型肝炎病毒临床实践治疗慢性决策医疗 HCV

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Return to Sports after Lower Extremity Injuries:Assessment of Movement Quality

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Health 2017年第10期9卷 1416-1426页

作者： Christiane Wilke Lucie pfeiffer Ingo Frobose Institute of Health Promotion and Clinical Movement Science German Sport University CologneCologneGermany Birkle-Clinic UberlingenGermany

Numerous high performance athletes experience further damage or recurrent injuries even after successful rehabilitation. This is often caused by an insufficient movement quality, which has been very rarely assessed by test protocols which determine the point of reintegration into high performance sports (Return-to-Play, RTP). In order to assess the movement quality both objective and subjective test protocols exist. Objective methods like 3D-movement analysis are viewed as international gold standard, but are not the most practicable solutions for daily training routine. This study aims at reviewing the available literature on reliability and validity of existing subjective test protocols. Further their use within high-performance sports is evaluated. Up to now subjective methods fail to match sufficient validity. However some practical approaches for assessment of movement quality after injury are known. Based on selected criteria first recommendations for the use of different subjective screening test methods are given. In summary further research focusing on the validity of subjective tests is needed. The subjective testing methods should be used in combination with additional tests (e.g. strength testing) in order to identify other risk factors. Recurrent pre-injury screenings on movement quality should be carried out to enhance injury prevention.

关键词： Lower Extremity Injury Movement Quality Subjective Assessment

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挪威云杉及杂种落叶松稳定胚性细胞系及体胚再生系统的建立(英文)

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林业科学 2003年第3期39卷 53-62页

作者： dietrich Ewald 胡建军德国联邦林业及林产品研究中心中国林业科学研究院林业研究所北京100091

本文报道了挪威云杉 (Piceaabies)和杂种落叶松 (Larixdeciduas×L .kaempferi)人工授粉种子诱导胚性细胞系及植株的再生。挪威云杉在德国SaxonOre山区被选为对空气污染有抗性的树种并种植在位于Waldsieversdorf的林木遗传育种研究所的... 详细信息

本文报道了挪威云杉 (Piceaabies)和杂种落叶松 (Larixdeciduas×L .kaempferi)人工授粉种子诱导胚性细胞系及植株的再生。挪威云杉在德国SaxonOre山区被选为对空气污染有抗性的树种并种植在位于Waldsieversdorf的林木遗传育种研究所的种植园中。对挪威云杉测试了几个不同亲本组合的种子形成胚性细胞系的能力。这些云杉种子于 1992 0 1采收 ,含有干燥的成熟合子胚。作为对照 ,相同的亲本组合云杉种子于1993 0 8和 1998 0 8采收 ,合子胚处于成熟中。杂种落叶松则只有一个人工授粉组合 ,大田试验证实幼苗生长良好。分别于 1995和 1996年采收含有未成熟合子胚的未成熟种子。诱导愈伤形成用附加细胞分裂素 (激动素和或BAP)和生长素 (NAA ,2 ,4 D)及有机氮源 (水解酪蛋白和谷氨酰胺 )的标准培养基 (SPE和MSG) ,于黑暗下培养。尽管在建立培养体系后 5～ 12周产生了大量胚性愈伤组织 ,诱导率超过 2 5 % ,但 1a后只有超过1%的胚性愈伤组织稳定生长。挪威云杉稳定胚性细胞系的数量与成熟合子胚的采收季节及建立细胞系的时间 (8月或 1月 )无关 ,但在 8月收获的合子胚在挪威云杉 5～ 12周后胚性愈伤组织诱导率要高些 ,然而能在悬浮培养中生长及随后成熟体胚能顺利再生植株的稳定胚性细胞系的数量有限。

关键词：挪威云杉杂种落叶松胚性细胞系体胚再生系

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Posthorax<sup>®</sup>Prevents Sternal Dehiscence and Instability: Preliminary Results of a Prospective Randomized Multicenter Trial

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Open Journal of Thoracic Surgery 2013年第2期3卷 23-29页

作者： Santarpino Giuseppe Fischlein Theodor Steffen pfeiffer Department of Cardiac Surgery Klinikum Nürnberg Nuremberg Germany

Aim: A Prospective Randomized Multicenter Trial is ongoing to evaluate Posthorax and prevention of sternal dehiscence/instability: clinical percept is optimistic for Posthorax use. The aim of this mono-center analysis is to give a preliminary result of Posthorax support vest after sternotomy. Methods: One hundred and eighty three cases elective patients were consecutive operated and included in this study conducted in our department since June 2009. Patients were randomized as following: 68 patients were treated with the Posthorax support vest and 115 received a standard bandage postoperatively. The primary endpoints were the Infective Events. Secondary endpoints included a composite of postoperative clinical variables and mortality. Results: The two groups are homogeneous for these characteristic except sex (more women in Control Group, p = 0.022). Operative data were comparable in both groups. Deep sternal infections occurred in four patients, all in Control Group (3.5% vs 0%, p = 0.153). At Follow up, we recorded 2 cases of superficial infection in the control group versus 0 (1.7%, p = 0.394) and 1 case of wound dehiscence always in Control Group versus 0 (0.9%, p = 0.628). Cumulative Infective Events are statistically more in Control Group (7 cases 6.1% versus 0 cases, p = 0.036*). According to the secondary endpoints, there were also no differences between the two compared groups except length of hospitalization (10.6 ± 4 days versus 13.4 ± 9.5, p = 0.019*). Conclusion: Preliminary results show the Posthorax sternum support vest as a valuable adjunct to prevent sternum-related complications: We record a statistical reduction of length of hospital stay and infective events using the support vest in a 3-month follow-up.

关键词： Chest Wall Device Wound Dehiscence Wound Infection Postoperative Care

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The AME2012 atomic mass evaluation(Ⅱ).Tables,graphs and references

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Chinese Physics C 2012年第12期36卷 1287-1602页

作者： M.Wang G.Audi A.H.Wapstra F.G.Kondev M.MacCormick X.Xu B.pfeiffer Institute of Modem Physics CAS509 Nanchang Rd.Lanzhou 730000China Centre de Spectrométrie Nucléaire et de Spectrométrie de Masse CSNSMCNRS/IN2P3Universite Paris-SudBt.108F-91405 Orsay CampusFrance Max-Planck-Institut fr Kernphysik Saupfercheckweg 1D-69117 HeidelbergGermany National Institute of Nuclear Physics and High-Energy Physics NIKHEF1009DB AmsterdamThe Netherlands Argonne National Laboratory 9700 S.Cass AvenueArgonneIL 60439USA Institut de Physique Nucléaire CNRS/IN2P3Universite Paris-SudF-91406 Orsay cedexFrance Graduate University of Chinese Academy of Sciences Beijing100049People's Republic of China GSI Helmholtzzentram fr Schwerionenforschung Planckstr.1D-64291 DarmstadtGermany

This paper is the first of two articles （Part I and Part II） that presents the results of the new atomic mass evaluation, AME2012. It includes complete information on the experimental input data （including not used and rejected ones）, as well as details on the evaluation procedures used to derive the tables with recommended values given in the second part. This article describes the evaluation philosophy and procedures that were implemented in the selection of specific nuclear reaction, decay and mass-spectrometer results. These input values were entered in the least-squares adjustment procedure for determining the best values for the atomic masses and their uncertainties. Calculation procedures and particularities of the AME are then described. All accepted and rejected data, including outweighed ones, are presented in a tabular format and compared with the adjusted values （obtained using the adjustment procedure）. Differences with the previous AME2003 evaluation are also discussed and specific information is presented for several cases that may be of interest to various AME users. The second AME2012 article, the last one in this issue, gives a table with recommended values of atomic masses, as well as tables and graphs of derived quantifies, along with the list of references used in both this AME2012 evaluation and the NUBASE2012 one （the first paper in this issue）.

关键词： AME Tables,graphs and references

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Contact dynamics of two floating cable-bounded bodies

Contact dynamics of two floating cable-bounded bodies

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第六届全国随机振动理论与应用学术会议

作者： F.pfeiffer Institute of Applied Mechanics TU MunichGarchingD-85748Germany

We consider two ship-like bodies connected by six cables and excited by *** cables might be under tension,or they might be slack,thus forming a unilateral system generating possible *** impact forces can reach 20000 KN,being able to cause damage to a *** order to avoid these large impact forces acting on the ships,anti-shock buffers may be *** design requires knowledge of the impact *** evaluate them by multibody theory with unilateral contacts in combination with classical ship dynamics,which allows modeling the contact dynamics of two floating bodies in an *** on an optimization algorithm a method by means of an artificial neural network (NNW) has been developed,to determine the combination of possible constraints at each step. The results of a numerical example compare reasonably well with *** have thus established a theoretical basis for further buffer design.

关键词： dynamics of ship non-smooth dynamics optimization artificial neural network

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