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Common Movement Disorders in Children: Diagnosis, Pathogenesis and Management

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Neuroscience & Medicine 2012年第1期3卷 90-100页

作者： Isabelle korn-Lubetzki Israel Steiner Department of Neurology Rabin Medical Center Beilinson Campus Petah Tiqva Israel Department of Neurology Shaare Zedek Medical Center Jerusalem Israel

Movement disorders in childhood are a heterogeneous group of diseases with presentations that vary according to etiopathogenesis and age of onset. While sharing certain characteristics with the conditions that affect adults, they also have unique features that are determined by the metabolic, physiological and environmental distinctiveness of the developing brain. This context makes the nervous system of children vulnerable to various insults such as birth trauma, infections and toxicity. Some inborn errors of metabolism and genetic conditions selectively affect the young brain and psychological adaptation may also contribute to the occurrence and severity of certain conditions at this age group. The present review outlines the pathophysiology, clinical presentation and course, diagnosis and therapy of movement disorders in children. We also emphasize, when available, preventive and prophylactic measures and conclude by suggesting several avenues for future research in aspects that are currently not well understood.

关键词： Movement Disorder Children

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三苯三戊并烯及其衍生物的合成研究进展

有机化学 2007年第8期27卷 946-957页

作者：张陶香周岭曹小平 KUCK dietmar 兰州大学化学化工学院功能有机分子化学国家重点实验室 Department of Chemistry Bielefeld UniversityUniversittsstraβe 25D-33615 BielefeldGermany

三苯三戊并烯类化合物含三个相互稠合的茚满单元具有独特的刚性骨架,C_(3v)对称性,凹凸杯状结构.该类化合物的合成研究具有重要的理论意义和应用前景.结合自己的研究工作综述了近年来三苯三戊并烯类化合物的合成进展.

关键词：三苯三戊并烯茚满单元凹凸杯状分子合成

Ensemble Deep Learning Framework for Situational Aspects-Based Annotation and Classification of International Student’s Tweets during COVID-19

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Computers, Materials & Continua 2023年第6期75卷 5355-5377页

作者： Shabir Hussain Muhammad Ayoub Yang Yu Junaid Abdul Wahid Akmal Khan dietmar P.F.Moller Hou Weiyan School of Information Engineering Zhengzhou UniversityZhengzhouChina School of Computer Science and Engineering Central South UniversityChangshaChina Department of Data Science The Islamia University of BahawalpurBahawalpurPakistan Clausthal University of Technology Clausthal-ZellerfeldGermany

As the COVID-19 pandemic swept the globe,social media plat-forms became an essential source of information and communication for *** students,particularly,turned to Twitter to express their struggles and hardships during this difficult *** better understand the sentiments and experiences of these international students,we developed the Situational Aspect-Based Annotation and Classification(SABAC)text mining *** framework uses a three-layer approach,combining baseline Deep Learning(DL)models with Machine Learning(ML)models as meta-classifiers to accurately predict the sentiments and aspects expressed in tweets from our collected Student-COVID-19 *** the pro-posed aspect2class annotation algorithm,we labeled bulk unlabeled tweets according to their contained aspect ***,we also recognized the challenges of reducing data’s high dimensionality and sparsity to improve performance and annotation on unlabeled *** address this issue,we proposed the Volatile Stopwords Filtering(VSF)technique to reduce sparsity and enhance classifier *** resulting Student-COVID Twitter dataset achieved a sophisticated accuracy of 93.21%when using the random forest as a *** testing on three benchmark datasets,we found that the SABAC ensemble framework performed exceptionally *** findings showed that international students during the pandemic faced various issues,including stress,uncertainty,health concerns,financial stress,and difficulties with online classes and returning to *** analyzing and summarizing these annotated tweets,decision-makers can better understand and address the real-time problems international students face during the ongoing pandemic.

关键词： COVID-19 pandemic situational awareness ensemble learning aspect-based text classification deep learning models international students topic modeling

Fast magnetic energy dissipation in relativistic plasma induced by high order laser modes

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High Power Laser Science and Engineering 2016年第2期4卷 85-89页

作者： Y.J.Gu Q.Yu O.Klimo T.Zh.Esirkepov S.V.Bulanov S.Weber G.korn Institute of Physics of the ASCR Institute of Modern Physics Fudan University FNSPE Czech Technical University in Prague Kansai Photon Science Institute Japan Atomic Energy Agency

Fast magnetic field annihilation in a collisionless plasma is induced by using TEM(1,0) laser pulse. The magnetic quadrupole structure formation, expansion and annihilation stages are demonstrated with 2.5-dimensional particle-in-cell simulations. The magnetic field energy is converted to the electric field and accelerate the particles inside the annihilation plane. A bunch of high energy electrons moving backwards is detected in the current sheet. The strong displacement current is the dominant contribution which induces the longitudinal inductive electric field.

关键词： high order laser mode laser–plasma interaction magnetic annihilation

Moving toward an understanding of the metastatic process in hepatocellular carcinoma

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World Journal of Gastroenterology 2001年第6期7卷 777-778页

作者： W.Michael korn Division of Gastroenterology and Comprehensive Cancer Canter,University of California San Francisco,San Francisco,CA 94143-0128,USA Division of Gastroenterology and Comprehensive Cancer Center University of California San Francisco 94143-0128 USA. mkorn@cc.ucsf.edu

INTRODUCTIONClinical factors contributing to the therapeutic challenge of hepatocellular carcinoma (HCC) are manifold :tumors arise often in patients with compromised liver function ,therefore limiting therapeutic options ;symptoms develop only at later stages of tumor progression ,and tumors tend to invade normal stuctures or occur in multiple locations simultaneously.

关键词： Animals Carcinoma, Hepatocellular Humans Liver Neoplasms Neoplasm Metastasis

Sino-German Computational and Applied Mathematics

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Journal of Computational Mathematics 2020年第1期38卷 I0001-I0002页

作者： Carsten Carstensen dietmar Gallistl Jun Hu Xuejun Xu Humboldt-Universitat zu Berlin 10099 BerlinGermany Friedrich-Schiller-Universitat Jena 07737 JenaGermany LMAM and School of Mathematical Sciences Peking UniversityBeijing 100871China LSEC ICMSECAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China

This short article is the epilog of the 11 preceding papers in this issue of *** contributions are authored by participants of the 6th Sino-German Workshop on Computational and Applied Mathematics at Shanghai.

关键词： Sino Applied German

Humanized bone facilitates prostate cancer metastasis and recapitulates therapeutic effects of zoledronic acid in vivo

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Bone Research 2019年第4期7卷 388-398页

作者： Marietta Landgraf Christoph ALahr Alvaro Sanchez-Herrero Christoph Meinert Ali Shokoohmand Pamela MPollock dietmar WHutmacher Abbas Shafiee Jacqui AMcGovern Centre in Regenerative Medicine Institute of Health and Biomedical InnovationQueensland University of TechnologyBrisbaneAustralia School of Biomedical Science Institute of Health and Biomedical InnovationTranslational Research InstituteQueensland University of TechnologyBrisbaneAustralia Australian Research Council(ARC)Training Centre in Additive Biomanufacturing Queensland University of TechnologyBrisbaneAustralia UQ Diamantina Institute Translational Research InstituteThe University of QueenslandBrisbaneQLDAustralia

Advanced prostate cancer(PCa)is known for its high prevalence to metastasize to bone,at which point it is considered *** significant effort,there is no animal model capable of recapitulating the complexity of PCa bone *** humanized mouse model for PCa bone metastasis used in this study aims to provide a platform for the assessment of new drugs by recapitulating the human–human cell interactions relevant for disease development and *** humanized tissueengineered bone construct(hTEBC)was created within NOD-scid IL2rgnull(NSG)mice and was used for the study of experimental PC3-Luc bone *** was confirmed that PC3-Luc cells preferentially grew in the hTEBC compared with murine *** translational potential of the humanized mouse model for PCa bone metastasis was evaluated with two clinically approved osteoprotective therapies,the non-species-specific bisphosphonate zoledronic acid(ZA)or the human-specific antibody Denosumab,both targeting Receptor Activator of Nuclear Factor Kappa-Β***,but not Denosumab,significantly decreased metastases in hTEBCs,but not murine *** results highlight the importance of humanized models for the preclinical research on PCa bone metastasis and indicate the potential of the bioengineered mouse model to closely mimic the metastatic cascade of PCa cells to human ***,it will enable the development of new effective antimetastatic treatments.

关键词： metastasis PC3 drugs

Mitogenomes of historical type specimens unravel the taxonomy of sportive lemurs(Lepilemur spp.)in Northwest Madagascar

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Zoological Research 2021年第4期42卷 428-432页

作者： Christian Roos Roberto Portela Miguez Richard Sabin Edward E.Louis Jr Michael Hofreiter dietmar Zinner Gene Bank of Primates and Primate Genetics Laboratory German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Natural History Museum London SW7 BDUK Center for Conservation and Research Omaha’s Henry Doorly Zoo and AquariumOmahaNebraska 68107USA Institute for Biochemistry and Biology University of PotsdamPotsdam 14476Germany Cognitive Ethology Laboratory German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Leibniz Science Campus Primate Cognition Goettingen 37077Germany Department of Primate Cognition Georg-August-UniversityGoettingen 37083Germany

Accurate information on name-bearing types,including corresponding type localities,is essential for proper ***,such geographic information is often missing or *** localities of type specimens collected 100–200 years ago can be difficult to trace due to changes in local names or simple *** a case can be found for the gray-backed sportive lemur(Lepilemur dorsalis),with its type locality imprecisely fixed as Northwest *** recent years,eight species have been newly described for the Inter-River-Systems(IRSs)of this region,however the designation of *** remains controversial due to a lack of a precise type ***,we sequenced the complete mitochondrial genomes(mitogenomes)of type specimens of *** and ***,which is currently recognized as a synonym of *** and compared their sequences with those of samples of known provenance from different *** showed that the two type specimens of *** and *** had identical mitogenome sequences and clustered closely with samples collected in IRS V,indicating that the type locality could be fixed to IRS ***,*** occurs in IRS V,and *** and *** are junior synonyms of *** finding demonstrates the value of type specimens for clarifying phylogeographic and taxonomic questions and clarifies the taxonomy of sportive lemurs in Northwest Madagascar.

关键词： precise identical finding

Decoding earth’s plate tectonic history using sparse geochemical data

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Geoscience Frontiers 2020年第1期11卷 265-276页

作者： Michael G.Tetley Zheng-Xiang Li Kara J.Matthews Simon E.Williams R.dietmar Müller EarthByte Group School of GeosciencesUniversity of SydneyNSWAustralia Seismological Laboratory California Institute of TechnologyPasadenaCAUSA Data61 CSIROAustralian Technology ParkNSWAustralia Earth Dynamics Research Group The Institute for Geoscience Research(TIGeR)School of Earth and Planetary SciencesCurtin University of TechnologyGPO Box U1987PerthWA 6845Australia

Accurately mapping plate boundary types and locations through time is essential for understanding the evolution of the plate-mantle system and the exchange of material between the solid Earth and surface ***,the complexity of the Earth system and the cryptic nature of the geological record make it difficult to discriminate tectonic environments through deep *** we present a new method for identifying tectonic paleo-environments on Earth through a data mining approach using global geochemical *** first fingerprint a variety of present-day tectonic environments utilising up to 136 geochemical data attributes in any available combination.A total of 38301 geochemical analyses from basalts aged from 5-0 Ma together with a well-established plate reconstruction model are used to construct a suite of discriminatory models for the first order tectonic environments of subduction and mid-ocean ridge as distinct from intraplate hotspot oceanic environments,identifying 41,35,and 39 key discriminatory geochemical attributes,*** training and validation,our model is applied to a global geochemical database of 1547 basalt samples of unknown tectonic origin aged between 1000-410 Ma,a relatively ill-constrained period of Earth’s evolution following the breakup of the Rodinia supercontinent,producing 56 unique global tectonic environment predictions throughout the Neoproterozoic and Early *** are used to discriminate between three alternative published Rodinia configuration models,identifying the model demonstrating the closest spatio-temporal consistency with the basalt record,and emphasizing the importance of integrating geochemical data into plate *** approach offers an extensible framework for constructing full-plate,deeptime reconstructions capable of assimilating a broad range of geochemical and geological observations,enabling next generation Earth system models.

关键词： Plate tectonics Geochemistry Geodynamics Supercontinents Rodinia Big data