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A ROBUST DISCRETIZATION OF THE REISSNER-MINDLIN PLATE WITH ARBITRARY POLYNOMIAL DEGREE

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Journal of Computational Mathematics 2020年第1期38卷 1-13页

作者： dietmar Gallistl Mira Schedensack Friedrich-schiller-Universitdt Jena 07737 JenaGermany Universitat Leipzig PF 10092004009 LeipzigGermany

A numerical scheme for the Reissner-Mindlin plate model is *** method is based on a discrete Helmholtz decomposition and can be viewed as a generalization of the nonconforming finite element scheme of Arnold and Falk[SIAM ***.,26(6):1276-1290,1989].The two unknowns in the discrete formulation are the in-plane rotations and the gradient of the vertical *** decomposition of the discrete shear variable leads to equivalence with the usual Stokes system with penalty term plus two Poisson equations and the proposed method is equivalent to a stabilized discretization of the Stokes system that generalizes the Mini *** method is proved to satisfy a best-approximation result which is robust with respect to the thickness parameter t.

关键词： Reissner-Mindlin plate Nonconforming finite element Discrete Helmholtz decomposition Robustness

UNIFORM SUPERCONVERGENCE OF A FINITE ELEMENT METHOD WITH EDGE STABILIZATION FOR CONVECTION-DIFFUSION PROBLEMS

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Journal of Computational Mathematics 2010年第1期28卷 32-44页

作者： Sebastian Franz Torsten Linβ Hans-Grg Roos Sebastian schiller Department of Mathematics and Statistics University of Limerick Institut für Numerische Mathematik Technische Universitt Dresden

In the present paper the edge stabilization technique is applied to a convection-diffusion problem with exponential boundary layers on the unit square, using a Shishkin mesh with bilinear finite elements in the layer regions and linear elements on the coarse part of the mesh. An error bound is proved for ‖πu-u^h‖Е, where πu is some interpolant of the solution u and uh the discrete solution. This supercloseness result implies an optimal error estimate with respect to the L2 norm and opens the door to the application of postprocessing for improving the discrete solution.

关键词： Convection-diffusion problems Edge stabilization FEM Uniform convergence Shishkin mesh.

Potential role of metabolomics in diagnosis and surveillance of gastric cancer

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World Journal of Gastroenterology 2014年第36期20卷 12874-12882页

作者： Angela W Chan Richdeep S Gill Daniel schiller Michael B Sawyer Daniel schiller Division of General Surgery University of Alberta Edmonton Alberta T6G 2B7 Canada Division of Medical Oncology Cross Cancer Institute University of Alberta Edmonton Alberta T6G 1Z2 Canada

Gastric cancer is one of the deadliest cancers worldwide, and is especially prevalent in Asian countries. With such high morbidity and mortality, early diagnosis is essential to achieving curative intent treatment and long term survival. Metabolomics is a new field of study that analyzes metabolites from biofluids and tissue samples. While metabolomics is still in its infancy, there are numerous potential applications in oncology, specifically early diagnosis. Only a few studies in the literature have examined metabolomics’ role in gastric cancer. Various fatty acid, carbohydrate, nucleic acid, and amino acid metabolites have been identified that distinguish gastric cancer from normal tissue and benign gastric disease. However, findings from these few studies are at times conflicting. Most studies demonstrate some relationship of cancer cells to the Warburg Effect, in that glycolysis predominates with conversion of pyruvate to lactate. This is one of the most consistent findings across the literature. There is less consistency in metabolomic signature with respect to nucleic acids, lipids and amino acids. In spite of this, metabolomics holds some promise for cancer surveillance but further studies are necessary to achieve consistency and validation before it can be widely employed as a clinical tool.

关键词： Gastric cancer Metabolomics Screening Biomarkers Surveillance

Comparison of Granules for Prescription and Classical Decoctions by High-performance Thin-layer Chromatography-fingerprint Analysis

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World Journal of Traditional Chinese Medicine 2018年第1期4卷 1-7页

作者： Katharina schiller Jorg Heilmann Detlef Manns Gerhard Franz Department of Pharmaceutical Biology Institute of PharmacyUniversity of Regensburg Federal Institute for Drugs and Medicinal Devices(BfArM)

Objective: The so?called granules for prescription have been developed about 20 years ago as a new form of modernizing and simplification of the classical decoction common in Traditional Chinese Medicine (TCM) practice. Due to actual problems in Germany/Europe, which are caused by the lack of quality monographs and judicial classification of granules for prescription, the aim of the study was a comparison of the chemical composition of commercial granules versus decoctions. Taking an example, decoctions, commercial granules, and organic extracts of two well?established TCM herbal drugs, Scrophulariae Radix and Xanthii Fructus, were examined in their specific composition. Methods: Using high?performance thin?layer chromatography (HPTLC) for fingerprint analysis of different batches of herbal drugs and samples from various suppliers of Xanthii Fructus and Scrophulariae Radix were critically examined. The decoctions were prepared according to traditional rules, while the granules were dissolved in water in accordance with actual regulations. Furthermore, organic extracts of the plant material were examined and compared with aqueous extracts. Results: It could be demonstrated, that in some cases, there are remarkable differences in the specific composition between granules from different suppliers, the classical aqueous decoction and the organic extract used for the HPTLC fingerprinting. On the other hand, few examples exist for good comparability of decoctions and commercial granules. Conclusion: After critical evaluation of the above results, it can be questioned, if there is a so?called phytoequivalence between decoctions and commercial granules for prescription used in TCM practice.

关键词： Granules for prescription phytoequivalence quality control quality monographs Scrophulariae Radix Xanthii Fructus

Natural epitope variants of the hepatitis C virus impair cytotoxic T lymphocyte activity

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World Journal of Gastroenterology 2010年第16期16卷 1953-1969页

作者： Shuping Wang Rico Buchli Jennifer schiller Jianen Gao Rodney S VanGundy William H Hildebrand David D Eckels Department of Pathology University of Utah Pure Protein L.L.C. Oklahoma CityOK 73104United States Jennifer SchillerJianen GaoDepartment of PediatricsMedical College of Wisconsin Department of Pediatrics Medical College of Wisconsin Pure Protein L.L.C. Department of Microbiology and Immunology Health Sciences CenterUniversity of Oklahoma

AIM:To understand how interactions between hepatitis C virus(HCV) and the host's immune system might lead to viral persistence or effective elimination of ***:Nucleotides 3519-3935 of the non-structural 3(NS3) region were amplified by using reverse transcription polymerase chain reaction(PCR).PCR products of the HCV NS3 regions were integrated into a PCR T7TOPO TA vector and then sequenced in both directions using an automated DNA *** major histocompatibility complex binding levels of wild-type and variant peptides were performed by fluorescence polarization-based peptide competition *** with wild type and variant sequences of NS3 were synthesized locally using F-moc chemistry and purified by high-performance liquid *** cytotoxic T lymphocytes(CTLs) clones toward HCV NS3 wild-type peptides were generated through limiting dilution *** CTL clones specifically recognizing HCV NS3 wild-type peptides were tested by tetramer staining and flow *** activity of CTL clones was measured using target cells labeled with the fluorescence enhancing ligand,DELFIA ***:The pattern of natural variants within three human leukocyte antigen(HLA)-A2-restricted NS3 epitopes has been examined in one patient with chronic HCV infection at 12,28 and 63 mo *** obtained may provide convincing evidence of immune selection pressure for all epitopes *** analysis of the extensive sequence variation found within these NS3 epitopes favors a Darwinian selection model of variant *** within the epitopes coincided with the decline of CTL responses,and peptide-binding studies suggested a signif icant impact of the mutation on T cell recognition rather than peptide presentation by HLA *** most variants were either not recognized or elicited low responses,such could antagonize CTL responses to target cells pulsed with wild-type ***:Cross-

关键词： Epitopes Human T Cells Cytotoxic Anergy Viral

Punschlied Im Norden zu singen

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德语学习 2006年第5期 4-5页

作者： Friedrich schiller

Women in the Musical Culture of Danzig in the First Half of the 20th Century

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Cultural and Religious Studies 2023年第1期11卷 1-8页

作者： Joanna schiller-Rydzewska Stanislaw Moniuszko Academy of Music in Gdańsk GdańskPoland

The musical culture of pre-war Danzig/Gdansk remains an area that is not well enough recognized in the scholarly *** traces of this musical life are preserved in the collections of the Gdansk Library of the Polish Academy of *** collection ranges from scholarly publications and scores to an extensive number of concert programs and *** collection testifies to the dynamism and diversity of the city’s pre-war musical *** among the collected materials is the role of female figures-composers,singers,and instrumentalists who made significant contributions to the shape of Gdansk musical *** this article,I will present forgotten profiles of musically committed women:Martha Reincke,Ella Mertins,and Lotte *** light of the surviving materials,it can be assumed that they were significant figures in the musical culture and social life of the city.

关键词： 20th century music in Gdansk/Danzig women in musical culture Gdansk Library musical culture of Gdansk/Danzig

A dual positional specific lipoxygenase functions in the generation of flavor compounds during climacteric ripening of apple

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Horticulture Research 2015年第1期2卷 280-292页

作者： Doreen schiller Carolina Contreras Jörg Vogt Frank Dunemann Bruno G Defilippi Randolph Beaudry Wilfried Schwab Biotechnology of Natural Products Technische Universität MünchenLiesel-Beckmann-Str.1D-85354 FreisingGermany Department of Horticulture Michigan State University1066 Bogue StreetEast LansingMI 48824USA Julius Kühn-Institut(JKI)–Federal Research Centre for Cultivated Plants Institute for Breeding Research on Fruit CropsPillnitzer Platz 3aD-01326 DresdenGermany Julius Kühn-Institut(JKI)–Federal Research Centre for Cultivated Plants Institute for Breeding Research on Horticultural CropsErwin-Baur-Str.27D-06484 QuedlinburgGermany INIA La Platina PO Box 439-9SantiagoChile

Lipoxygenase(LOX)is an important contributor to the formation of aroma-active C6 aldehydes in apple(Malus×domestica)fruit upon tissue disruption but little is known about its role in autonomously produced aroma volatiles from intact *** explored the expression of 22 putative LOX genes in apple throughout ripening,but only six LOXs were expressed in a ripening-dependent *** LOX1:Md:1a,LOX1:Md:1c,LOX2:Md:2a and LOX2:Md:2b proteins showed 13/9-LOX,9-LOX,13/9-LOX and 13-LOX activity with linoleic acid,*** products of LOX1:Md:1c and LOX2:Md:2b were S-configured,LOX1:Md:1a and LOX2:Md:2a formed 13(R)-hydroperoxides as major ***-directed mutagenesis of Gly567 to an alanine converted the dual positional specific LOX1:Md:1a to an enzyme with a high specificity for 9(S)-hydroperoxide *** high expression level of the corresponding MdLOX1a gene in stored apple fruit,the genetic association with a quantitative trait locus for fruit ester and the remarkable agreement in regio-and stereoselectivity of the LOX1:Md:1a reaction with the overall LOX activity found in mature apple fruits,suggest a major physiological function of LOX1:Md:1a during climacteric ripening of *** LOX1:Md:1c,LOX2:Md:2a and LOX2:Md:2b may contribute to aldehyde production in immature fruit upon cell disruption our results furnish additional evidence that LOX1:Md:1a probably regulates the availability of precursors for ester production in intact fruit tissue.

关键词： specific autonomous probably

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An Goethe

德语学习 2005年第2期 4-5页

作者： F.schiller

FRIEDRICH schiller Jena, 23. August 1794 Man brachte mir gestern die angenehme Nachricht, dass Sie von Ihrer Reise wieder zuriickgekommen seien. Wir haben also wieder Hoffnung, Sie vielleicht bald einmal bei uns zu sehen, welches ich an meinem Teil herzlich wtinsche. Die neulichen Unterhaltungen mit Ihnen haben meine ganze Ideenmasse in Bewegung gebracht.

关键词：文学欣赏德语读物阅读欣赏