检索结果-南通市图书馆

Detailed Design of a High Speed Switched Reluctance Starter/Generator for More/All Electric Aircraft

Chinese Journal of Aeronautics 2010年第2期23卷 216-226页

作者：宋受俊刘卫国 dieter peitsch Uwe Schaefer 西北工业大学自动化学院柏林工业大学电气工程及计算机科学学院柏林工业大学机械及交通工程学院

The basic concepts and advantages of more/all electric aircraft （M/AEA） are briefly addressed. The combined starter/generator （CS/G） system is introduced as a key technology to enable M/AEA. Some important performance requirements for CS/G system are obtained. Based on these requirements, a high speed switched reluctance machine （SRM） is designed to operate as a starter/generator. The entire design process is mainly divided into two stages： electromagnetic design and thermal design. In electromagnetic design stage, the electromagnetic structure and dimensions of the machine and the number of phase winding turns per pole are obtained; the topology and main technical details of the converter are briefly introduced as well. In thermal design stage, a liquid-cooling system is designed based on the thermal analysis of the machine. In the end, the performances of the designed SRM are basically verified by simulation. To get high performances, the exciting angles are optimized in two different operating modes respectively, and the optimized performances in the motoring mode are given as well.

关键词： aircraft more/all electric aircraft combined starter/generator system reluctance motors electromagnetic design thermalanalysis control optimization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pre-malignant processes of smoking-induced lung adenocarcinoma development: A conceptual biological model

引用

Advances in Lung Cancer 2013年第2期2卷 32-53页

作者： Frank Tobin Gregory Vuillaume Marja Talikka Gaelle Diserens Gaelle Diserens Manuel C. peitsch Julia Hoeng Philip Morris International R&D Philip Morris Products S.A. Neuchatel Switzerland Tobin Consulting LLC Newton Square PA USA

Chronic exposure to cigarette smoke is the leading cause of human lung cancer and its most prevalent form, adenocarcinoma. However, the mechanisms by which smoking induces adenocarcinoma are largely inferred from the analysis of fully developed tumors. The current work focuses on the early events that precede the existence of clinically detectable tumors and where the progressive mechanisms are believed to be different from the ones driving established tumor growth. Biological information was drawn from the literature and generalized into a conceptual model, or framework, which describes and integrates the main processes involved in the early stages of smoking-induced lung adenocarcinoma development. No such integrative representation currently exists. The biological framework presented here is based on the “field of injury” of the lung. It covers the smoking-induced stepwise transition of unexposed (naive) lung tissue to the first appearance of neoplastic cells through defined tissue states referred to as pre-field and field. Each tissue state exhibits its own formalized characteristics (or phenotype properties), which evolve as a result of the combined effects of smoking, the interactions between the different tissue properties, and the local environment represented in the framework as lung inflammation and immune surveillance. The resulting network of influences between the lung tissue states and properties provides a good understanding of the early events involved in lung adenocarcinoma triggered by smoking. The resulting conceptual model—an integrative mechanistic hypothesis—can explain a broad range of cigarette smoking and smoking cessation scenarios.

关键词： Lung Adenocarcinoma Cigarette Smoke Field Cancerization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

猪呼吸道上皮宿主蛋白酶激活A型流感病毒的研究

引用

中国畜牧兽医 2014年第12期41卷 243-243页

作者： peitsch C 李杰农业部规划设计研究院北京102206

猪是A型流感病毒的重要天然宿主,因为其对猪、鸟类和人类病毒易感,可作为病毒中间宿主,利于病毒适应性和基因重组。宿主细胞蛋白酶可促使流感病毒表面的糖蛋白血凝素(HA)裂解,HA裂解对于病毒传染必不可少。包括人类和猪类病毒在内的大... 详细信息

猪是A型流感病毒的重要天然宿主,因为其对猪、鸟类和人类病毒易感,可作为病毒中间宿主,利于病毒适应性和基因重组。宿主细胞蛋白酶可促使流感病毒表面的糖蛋白血凝素(HA)裂解,HA裂解对于病毒传染必不可少。包括人类和猪类病毒在内的大多数流感病毒,在一元HA裂解点被激活。前期研究结果显示TMPRSS2和HAT是存在于人呼吸道的相关蛋白酶。本试验研究了猪主要气管和支气管上皮细胞(PTEC和PBEC)的蛋白酶活性。由于人类H1N1和H3N2流感病毒在PTEC和PBEC中能有效增殖,含有裂解的HA的病毒被感染细胞释放,在感染初期这些细胞支持HA蛋白酶活性。本研究发现猪蛋白酶与TMPRSS2和HAT类似,特定的swTMPRSS2和swAT分别在猪呼吸道某些部位表达。在共表达的一元裂解点发现,从原始PBEC中克隆得到的2种蛋白酶能激活HA,并促使流感病毒多周期复制。swAT作为活性蛋白酶主要分布在细胞膜上,能介导病毒激活。相比之下,swTMPRSS2在反式高尔基体网络上对HA进行裂解。本研究结果表明,猪呼吸道HA活性可能通过类似的蛋白酶实现,其与人呼吸道病毒生命周期类似。

关键词： A型流感病毒猪蛋白酶

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

高嗜酸性粒细胞增多性皮炎:一个被忽略的诊断?

引用

世界核心医学期刊文摘（皮肤病学分册） 2006年第2期2卷 54-55页

作者： Kemmler N. peitsch W.K. Glorer E. Goerdt S. 李政霄 Klinik fü r Dermatologie Venerologie und Allergologie Klinikum Mannheim gGmbH Ruprecht- Karls- Universit t Heidelberg Theodor- Kutzer- Ufer 1- 3 68135 Mannheim GermanyDr.

Background. The idiopathic hypereosinophilic syndrome is a rare systemic disease characterized by blood and tissue eosinophilia of unknown etiology, in which multiple organs may be affected. In hypereosinophilic dermatitis the only affected organ besides the blood is the skin. Patients. We present a series of seven patients with hypereosinophilic dermatitis who were treated in our hospital between 2002 and 2003. Results. All patients initially showed characteristic, therapy- resistant, polymorphic skin lesions, presenting with a combination of erythematous, pruritic and urticarial papules and plaques. All had blood eosinophilia without evidence of allergic, parasitic or other causes. The histology showed tissue eosinophilia only in half of the cases; the other histological findings were non- specific. We observed a good response to therapy with systemic corticosteroids, dapsone and light therapy, applied as UVA- 1 irradiation or as shower photochemotherapy. Conclusions. The diagnosis “ hypereosinophilic dermatitis” should be based primarily on the characteristic clinical picture together with “ idiopathic” peripheral eosinophilia, whereas the histological findings are not always indicative. Because of the multiplicity of possible differential diagnoses and the often non- revealing histology,we assume that the diagnosis “ hypereosinophilic dermatitis” is often overlooked.

关键词：特应性组织学检查光疗法多器官受累多形性系统性疾病光化学疗法非特异性改变氨苯砜抵抗性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：