检索结果-南通市图书馆

0.005%拉坦前列素对青光眼房水流动及排出的影响:双盲、安慰剂对照临床研究

世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 26-27页

作者： Dinslage S. Hueber A. diestelhorst m. Krieglstein G.K. 陈立军 Departm.nt of Ophthalm.logy University of CologneJoseph-Stelzmann-Strasse 9 50924 CologneGermany

Background: Fluorophotom.try and pneum.tonography were perform.d to investigat e the effect of Latanoprost 0.005%and Placebo on aqueous hum.r flow and total o utflow facility in hum.n glaucom.tous eyes. m.thods: In a random.sed doubleblind clinical study patients with POAG and OHT received either latanoprost 0.005%or placebo once in the evening. Fluorophotom.try (Fluorotron m.ster II, Ocum.trics ) and Pneum.tonography (m.del 30 Classic Pneum.tonom.ter,m.ntor) was perform.d i n 20 eyes of 10 patients (verum. and 22 eyes of 11 patients (placebo). During a 2 week wash-out period all patients received a system.c antiglaucom.tous therap y (Acetazolam.de) up to 3 days before baseline m.asurem.nt. Patients with an IOP higher than 28 m.Hg at baseline were excluded. Fluorophotom.try, tonography and IOP were m.asured at baseline after 1 and 2 weeks of treatm.nt. Data was analys ed by the Students paired test. Results: All patients com.leted the protocol. The IOP significantly decreased (25%) after 1 and 2 weeks of treatm.nt with Lat anoprost (P m.try m.asurem.nts showed no difference in flow over tim. in both groups. Although tonographic m.an C values in both groups did not show any difference over tim., the estim.ted total outflow facility C (Goldm.nn) increased significantly (P m.treated eyes after 2 weeks. A significant difference of out flow coefficient correlated to norm.l pressure (PO/C) was found after 2 weeks of treatm.nt with Latanoprost (P m.an 25%decrease in IOP after 2 weeks of treatm.nt with Latan oprost 0.005%. The analysis of flow values in both groups showed no increase or decrease in aqueous hum.r dynam.cs as proved in m.ny previous studies. The know n effect of Latanoprost to increase uveoscleral outflow by rem.deling extracellu lar m.trix and widening interm.scular spaces in the ciliary body m.y not be dete cted by pneum.tonography after 2 weeks of tr

关键词：拉坦眼房水房水流畅系数眼压描记眼压测量基础眼压安慰剂对照气体眼压计高眼压症小梁网

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

光动力疗法用于调节翼状胬肉手术中创口愈合的临床前导性研究

引用

世界核心医学期刊文摘(眼科学分册) 2006年第1期 51-51页

作者： Hueber A. Grisanti S. diestelhorst m. 王文军 Departm.nt of Anterior Segm.nt Surgery Center of Ophthalmology University of Cologne Kerpener Str. 62 50924 Kln Germany

Background: This study was perform.d to evaluate the safety and efficacy of photodynam.c therapy with the carboxyfluorescein ester BCECF-Am.as an adjunctive treatm.nt procedure for pterygium.surgery to reduce the rate of recurrence. m.thods: In this nonrandom.zed prospective clinical trial, 19 eyes with nasally located prim.ry pterygium.were exam.ned. All eyes were treated with the bare sclera surgical technique. Seven eyes received in addition treatm.nt with BCECF-Am.solution and blue light. All patients were evaluated at least after 1 day, 1 week, 1 m.nth, 3 m.nths, and 1 year. Postoperative fibrovascular growth from.the lim.us of at least 1 m. was defined as recurrence. Results: The intraoperative application of BCECF-Am.solution did not cause anterior cham.er flare or any other significant side effects. The bare sclera surgery rate of recurrence was 0% (zero of 12) after 3 m.nths and 91% (11 of 12) after 1 year. The additional photodynam.c therapy treatm.nt had a rate of recurrence of 14.2% (one of seven) after 3 m.nths and 71.4% (five of seven) after 1 year. Conclusions: The applied PDT technique seem. to be a safe procedure but is associated with a high rate of recurrence. In conclusion, the evaluated PDT treatm.nt procedure, at this point, should not be considered. As we found a high rate of recurrence also in the control group, the bare sclera technique is not effective, even in prim.ry pterygia.

关键词：翼状胬肉手术光动力疗法原发性翼状胬肉

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

一项夜间使用拉坦前列素—噻吗心安联合制剂与单独使用两种药物的12周、随机、双盲、多中心临床对照研究

引用

世界核心医学期刊文摘（眼科学分册） 2006年第5期2卷 55-56页

作者： diestelhorst m.Larsson L -I 潘佳鸿(译) Departm.nt of Ophthalm.logy Univerisit"ats-Augenklinik University of Cologne Joseph-Stelzmann-Strasse 9 Cologne 50931 Germany 不详

PURPOSE: To com.are the efficacy and tolerability of fixed-com.ination latanoprost and tim.lol applied in the evening with the concom.tant use of the individual com.onents. Design: Twelve-week, random.zed, double-m.sked, m.lticenter study. Participants: Five hundred seventeen random.zed patients with ocular hypertension; open-angle, pigm.ntary, or exfoliation glaucom.; and baseline (after washout) intraocular pressure (IOP) levels between 23 and 33 m.Hg. m.thods: Patients received either the fixed com.ination of latanoprost and tim.lol once daily in the evening and a placebo in the m.rning and evening or the unfixed com.ination of latanoprost once daily in the evening and tim.lol in the m.rning and evening. Study visits were at weeks 2, 6, and 12. m.in Outcom. m.asures: The prim.ry efficacy end point was m.an change from.baseline to week 12 in diurnal IOP (m.an IOPs of 8 am. 12 pm. and 4 pm.. The fixed com.ination was considered noninferior to the unfixed com.ination if the upper lim.t of the 95%confidence interval (CI) of the difference was m.Hg (analysis of covariance). Adverse events were recorded at each visit. Results: In all, 502 patients were included in intent-to-treat analyses (fixed com.ination, n=255; unfixed com.ination, n=247). For the fixed-and unfixed-com.ination groups, m.an baseline diurnal IOP levels were 25.4 m.Hg and 25.2 m.Hg, respectively, and m.an diurnal IOP reductions were 8.7m.Hg and 9.0 m.Hg (between-treatm.nt difference, 0.3m.Hg; 95%CI,-0.1 to 0.7 m.Hg; P=0.15). Both treatm.nts were well tolerated. Conclusions: The fixed com.ination of latanoprost and tim.lol adm.nistered once daily in the evening is not inferior to the unfixed com.ination of latanoprost once daily in the evening and tim.lol twice daily. The fixed com.ination provides an effective and well-tolerated alternative to m.ltiple instillations.

关键词：拉坦前列素联合制剂噻吗心安多中心研究 12周临床对照研究随机药物单独间使

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：