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Chinese Annals of Mathematics,Series B 2009年第5期30卷 505-512页

作者： Angel CASTRO diego CóRDOBA Instituto de Ciencias Matemticas CSIC-UAM-UC3M-UCMConsejo Superior de Investigaciones Científicas

The authors construct self-similar solutions for an N-dimensional transport equation,where the velocity is given by the Riezs *** solutions imply nonuniqueness of weak *** addition,self-similar solution for a one-dime... 详细信息

关键词： Hilbert transform Riesz transform Transport equations Self-similar solutions

Enhanced sampling for lipid-protein interactions during membrane dynamics

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BIOCELL 2023年第1期47卷 1-14页

作者： diego MASONE Instituto de Histología y Embriología de Mendoza(IHEM)-Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Universidad Nacional de Cuyo(UNCuyo)Mendoza5500Argentina Facultad de Ingeniería Universidad Nacional de Cuyo(UNCuyo)Mendoza5500Argentina

The inflexible concept of membrane curvature as an independent property of lipid structures is today *** bilayers behave as many-body entities with emergent properties that depend on their interactions with the *** particular,proteins exert crucial actions on lipid molecules that ultimately condition the collective properties of the *** this review,the potential of enhanced molecular dynamics to address cell-biology problems is *** cases of membrane deformation,membrane fusion,and the fusion pore are analyzed from the perspective of the dimensionality reduction by collective *** lipid-protein interactions as fundamental determinants of large membrane remodeling events are also ***,novel strategies merging cell biology and physics are considered as future lines of research.

关键词： Membrane bending Membrane fusion Fusion stalk Hemifusion diaphragm Fusion pore Molecular dynamics Collective variables Collective behavior Emergent properties

Analysis of Bone Remodeling Under Piezoelectricity Effects Using Boundary Elements

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Journal of Bionic Engineering 2017年第4期14卷 659-671页

作者： Miguel Cerrolaza Vannessa Duarte diego Garzon-Alvarado National Institute of Bioengineering Central University of Venezuela Caracas Venezuela International Center for Numerical Methods in Engineering ( CIMNE) Polytechnic University of Catalonia Barcelona Spain Virtual Rooms Program ( CIMNE) Polytechnic University of Catalonia Barcelona Spain Laboratory of Biomimetics Group of Mechanobiology of Organs and Tissues Biotechnology Institute Department of Mechanical Engineering and Mechatronics National University of Colombia Bogota Colombia

Piezoelectric materials exhibit a response to mechanical-electrical coupling, which represents an important contribution to the electrical-mechanical interaction in bone remodeling process. Therefore, the study of the piezoelectric effect on bone re- modeling has high interest in applied biomechanics. The effects of mechano-regulation and electrical stimulation on bone healing are explained. The Boundary Element Method （BEM） is used to simulate piezoelectric effects on bones when shearing forces are applied to collagen fibers to make them slip past each other. The piezoelectric fundamental solutions are obtained by using the Radon transform. The Dual Reciprocity Method （DRM） is used to simulate the particular solutions in time-dependent problems. BEM analysis showed the strong influence of electrical stimulation on bone remodeling. The examples discussed in this work showed that, as expected, the electrically loaded bone surfaces improved the bone deposition. BEM results confirmed previous findings obtained by using the Finite Element Method （FEM）. This work opens very promising doors in biomechanics research, showing that mechanical loads can be replaced, in part, by electrical charges that stimulate strengthening bone density. The obtained results herein are in good agreement with those found in literature from experimental testing and/or other simu- lation approaches.

关键词： bone remodeling numerical methods piezoelectricity boundary element anisotropy

Autoimmune paediatric liver disease

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World Journal of Gastroenterology 2008年第21期14卷 3360-3367页

作者： Giorgina Mieli-Vergani diego Vergani Institute of Liver Studies King's College London School of Medicine at King's College HospitalLondon SE5 9RSUnited Kingdom

Liver disorders with a likely autoimmune pathogenesis in childhood include autoimmune hepatitis(AIH),autoimmune sclerosing cholangitis(ASC),and de novo AIH after liver *** is divided into two subtypes according to seropositivity for smooth muscle and/or antinuclear antibody(SMA/ANA,type 1) or liver kidney microsomal antibody(LKM1,type 2).There is a female predominance in ***1 positive patients tend to present more acutely,at a younger age,and commonly have partial IgA deficiency,while duration of symptoms before diagnosis,clinical signs,family history of autoimmunity,presence of associated autoimmune disorders,response to treatment,and long-term prognosis are similar in both *** most common type of paediatric sclerosing cholangitis is *** clinical,biochemical,immunological,and histological presentation of ASC is often indistinguishable from that of AIH type *** both,there are high IgG,non-organ specific autoantibodies,and interface *** is made by *** with ASC respond to immunosuppression satisfactorily and similarly to AIH in respect to remission and relapse rates,times to normalization of biochemical parameters,and decreased inflammatory activity on follow up liver ***,the cholangiopathy can *** may be evolution from AIH to ASC over the years,despite *** novo AIH after liver transplantation affects patients not transplanted for autoimmune disorders and is strikingly reminiscent of classical AIH,including elevated titres of serum antibodies,hypergammaglobulinaemia,and histological findings of interface hepatitis,bridging fibrosis,and *** classical AIH,it responds to treatment with prednisolone and *** novo AIH postliver transplantation may derive from interference by calcineurin inhibitors with the intrathymic physiological mechanisms of T-cell maturation and *** this condition is a distinct entity or a form of atypical rejection

关键词： Autoimmune hepatitis Autoimmunesclerosing cholangitis Liver transplant Children

Forecasting Zonda Wind Occurrence with Vertical Sounding Data

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Advances in Atmospheric Sciences 2022年第1期39卷 161-177页

作者： Federico OTERO diego C.ARANEO Instituto Argentino de Nivología Glaciología y Ciencias Ambientales(IANIGLA)CCT Mendoza-CONICET Av.Ruiz Leal s/n.Parque Gral.San MartínMendoza 5500Argentina

Zonda wind is a typical downslope windstorm over the eastern slopes of the Central Andes in Argentina,which produces extremely warm and dry conditions and creates substantial socioeconomic *** aim of this work is to obtain an index for predicting the probability of Zonda wind *** Principal Component Analysis(PCA)is applied to the vertical sounding data on both sides of the *** the use of a binary logistic regression,the PCA is applied to discriminate those soundings associated with Zonda wind events from those that are not,and a probabilistic forecasting tool for Zonda occurrence is *** index is able to discriminate between Zonda and non-Zonda events with an effectiveness close to 91%.The best model consists of four variables from each side of the *** an eventbased statistical perspective,the probability of detection of the mixed model is above 97%with a probability of false detection lower than 7%and a missing ratio below 1%.From an alarm-based perspective,models exhibit false alarm rate below 7%,a missing alarm ratio lower than 1.5%and higher than 93%for the correct alarm *** zonal component of the wind on both sides of the Andes and the windward temperature are the key variables in class *** vertical structure of Zonda wind includes two wind maximums and an unstable lapse rate at midlevels on the lee side and a wind maximum at 700 h Pa accompanied by a relatively stable layer near the mountain top.

关键词： Zonda wind foehn downslope windstorm forecasting

Use of family structure information in interaction with environments for leveraging genomic prediction models

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The Crop Journal 2020年第5期8卷 843-854页

作者： Reyna Persa Hiroyoshi Iwata diego Jarquin Department of Agronomy and Horticulture University of Nebraska-LincolnLincolnNE 68583USA Graduate School of Agricultural and Life Sciences The University of TokyoBunkyoTokyo 113-8657Japan

The characterization of genomes with great detail offered by the modern genotyping platforms have opened a venue for accurately predicting the genotype-by-environment interaction(GE)effects of untested genotypes in different environmental *** developed statistical models have shown the advantages of including the GE interaction component in the prediction context using molecular markers,pedigree,or *** order to leverage the family information of highly structured populations when pedigree data is not available,we developed a model that uses the family membership *** proposed model extends the reaction norm model by including the interaction between families and environments(FE).A representative fraction of a soybean Nested Association Mapping population(16,187 grain yield records)comprising 38 bi-parental families(1358 genotypes)observed in 18 environments(2011,2012,and 2013)was used to contrast the proposed model with three conventional prediction *** crossvalidation scenarios(prediction of tested[CV2]and untested[CV1]genotypes)with a twofold design(50%for training and testing sets)were used for mimicking prediction situations that breeders face in *** showed that the family factor in interaction with environments explains a sizable amount of the phenotypic *** helped to improve the predictive ability with respect to the main effects model(GBLUP)around 41%(CV2)and 49%(CV1),and about 17%with respect to the conventional reaction norm *** inclusion of the FE term not only improved the global results but also significantly increased the prediction accuracy of those environments where the conventional models showed a very poor *** results show the importance of taking into consideration the family structure existing in breeding programs for improving the selection strategies in multi-parental populations.

关键词： interaction structure instead

Recent advances in uniportal video-assisted thoracoscopic surgery

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Chinese Journal of Cancer Research 2015年第1期27卷 90-93页

作者： diego Gonzalez-Rivas Coru?a University Hospital (CHUAC) and Minimally Invasive Thoracic Surgery Unit (UCTMI)

Thanks to the recent improvements in video-assisted thoracoscopic techniques （VATS） and anesthetic procedures, a great deal of complex lung resections can be performed avoiding open surgery. The experience gained through VATS techniques, enhancement of the surgical instruments ,improvement of high definition cameras and avoidance of intubated general anesthesia have been the greatest advances to minimize the trauma to the patient. Uniportal VATS for major resections has become a revolution in the treatment of lung pathologies since initially described 4 years ago. The huge number of surgical videos posted on specialized websites, live surgery events and experimental courses has contributed to the rapid learning of uniportal major thoracoscopic surgery during the last years. The future of the thoracic surgery is based on evolution of surgical procedures and anesthetic techniques to try to reduce the trauma to the patient. Further development of new technologies probably will focus on sealing devices for all vessels and fissure, refined staplers and instruments, improvements in 3D systems or wireless cameras, and robotic surgery. As thoracoscopic techniques continue to evolve exponentially, we can see the emergence of new approaches in the anesthetical and the perioperative management of these patients. Advances in anesthesia include lobectomies performed without the employment of general anesthesia, through maintaining spontaneous ventilation, and with minimally sedated patients. Uniportal VATS resections under spontaneous ventilation probably represent the least invasive approach to operate lung cancer.

关键词： Uniportal surgery awake lobectomy single-port robotic non-intubated lung cancer

Evolving thoracic surgery: from open surgery to single port thoracoscopic surgery and future robotic

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Chinese Journal of Cancer Research 2013年第1期25卷 4-6页

作者： diego Gonzalez-Rivas Corua University Hospital (CHUAC) and Minimally Invasive Thoracic Surgery Unit (UCTMI) Corua Spain

Thoracic Surgery is a continuous evolving specialty. In the past, thoracic surgeons had to make large incisions in order to operate any pathology inside the chest. This often meant big, painful and ugly scars and long recovery times after surgery. But he history of thoracic surgery changed since the begining of video-assisted thoracoscoDic surgery （VATg3

关键词： from open surgery to single port thoracoscopic surgery and future robotic VATS Evolving thoracic surgery Figure

CD147/Basigin:a Warburg oncogene in hepatocellular carcinoma?

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Chinese Journal of Cancer Research 2016年第3期28卷 377-379页

作者： diego Francesco Calvisi Institute of Pathology University Medicine of Greifswald

Hepatocellular carcinoma （HCC） is one of the most common malignancies worldwide, ranking fifth in incidence and second in mortality （1）. Although HCC cases mainly occurred in South-East Asia and Southern Africa in the past, the incidence of this disease has been on the rise in the Western countries over the forty last years （1）. Despite the advances in the diagnostic techniques and novel therapies, HCC remains a tumor with a dismal prognosis （2-4）. While the detection of HCC at an early stage allows the employment of potentially curative treatments, such as liver transplantation, surgical resection and tumor ablation, over two thirds of patients are diagnosed at a late stage of the disease, when conventional therapeutic approaches are ineffective （2-4）. Furthermore, administration of the multikinase inhibitor Sorafenib, the only drug approved by the Food and Drug Administration （FDA） for targeted therapy of advanced HCC, provides only limited benefits to HCC patients in terms of overall survival （2-4）. Thus, in order to improve significantly the effectiveness of therapeutic strategies against liver cancer, a deeper understanding of the molecular pathogenesis of this deadly disease is necessary.

关键词： HCC CD147/Basigin