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Nerve growth factor catches copper in neuronal inning

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Neural Regeneration Research 2020年第4期15卷 665-666页

作者： diego La Mendola Department of Pharmacy University of Pisa

The physiological effect of neurotrophic factors and their role in Alzheimer’s disease(AD):Neurotrophins(NTs)are a family of homologues proteins that play an essential role in neuronal cells growth,survival and *** proteins include the nerve growth factor(NGF),the brain derived neurotrophic factor(BDNF),NT-3 and NT-3,also known as NT-4/5.

关键词： Alzheimer copper differentiation.

Two methodological approaches to assess the seismic vulnerability of masonry bridges

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第1期6卷 49-64页

作者： diego Maria Barbieri Department of Civil and Environmental Engineering Norwegian University of Science and Technology Department of Civil Constructional and Environmental Engineering Sapienza University of Rome

This work describes the seismic vulnerability assessment of a railway masonry arch *** conservation state is initially investigated by means of a thorough field and laboratory test campaign, comprising destructive and non-destructive tests. Two different methods are used to evaluate the bridge seismic vulnerability. The first method adopts a deterministic approach and corresponds to a single non-linear static analysis, performed as described in the Eurocodes. The second method employs a probabilistic approach and considers the variability of the involved mechanical parameters(structure geometry and properties of the building materials) and seismic parameters(intensity of the action and site conditions). This method associates the probabilistic values of ground acceleration exceedance to the estimated seismic vulnerability. This is shown by means of fragility curves, which allow to take into consideration the uncertainty of the various components involved in the definition of the seismic vulnerability and display the seismic damage scenarios. Currently no code requires to perform this calculation procedure. In addition,this work compares the values of masonry mechanical properties specified in the Eurocodes with those obtained in an extensive investigation campaign involving more than one hundred masonry bridges. Compressive strength and longitudinal elasticity modulus are the relevant mechanical parameters investigated. The outcomes of this research can contribute to the development of a more efficient maintenance system of the masonry bridges belonging to the railway network. This has an important role when it comes to establishing the priority order of assets intervention.

关键词： Railway masonry arch bridge Bridge maintenance and conservation Masonry mechanical parameters Non-linear static analysis Seismic fragility Finite element analysis

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艺术中的秩序与变化互动装置RHUBARB

室内设计与装修 2024年第10期 144-145页

作者：无 Chris Jary(摄影) diego Albo Martinez(摄影) Alexandre Carpentier(摄影) Atelier DARN(摄影) 西竹(译) Atelier DARN 不详

2024年活跃建筑节(Festivaldes Architectures Vives)公布了其公众奖得主--由Atelier DARN设计的互动装置RHU/BARB。该装置将建筑、体育、艺术、文学与环保意识等元素交织在一起,搭建在法国蒙彼利埃的18世纪历史古迹奥雷斯酒店(Hotel d... 详细信息

2024年活跃建筑节(Festivaldes Architectures Vives)公布了其公众奖得主--由Atelier DARN设计的互动装置RHU/BARB。该装置将建筑、体育、艺术、文学与环保意识等元素交织在一起,搭建在法国蒙彼利埃的18世纪历史古迹奥雷斯酒店(Hotel d’Aures)的庭院中。

关键词：蒙彼利埃历史古迹互动装置环保意识 RH

Orbit orientation in didelphid marsupials （Didelphimorphia： Didelphidae）

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Current Zoology 2017年第4期63卷 403-415页

作者： Patricia PILATTI diego ASTUA Laboratorio de Mastozoologia Departamento de Zoologia Universidade Federal de Pernambuco. Av. Prof. Moraes Rego S/N Cidade Universitaria Recife PE 50670-901 Brazil

Usually considered a morphologically conservative group, didelphid marsupials present consider- able variation in ecology and body size, some of which were shown to relate to morphological structures. Thus, changes on orbit morphology are likely and could be related to that variation. We calculated orbit orientation in 873 specimens of 16 Didelphidae genera yielding estimates of orbits convergence （their position relative to midsagittal line） and verticality （their position relative to frontal plane）. We then compared similarities in these variables across taxa to ecological, morpho- logical and phylogenetic data to evaluate the influencing factors on orbit orientation in didelphids. We found an inverse relation between convergence and verticality. Didelphids orbits have low ver- ticality but are highly convergent, yet orbit orientation differs significantly between taxa, and that variation is related to morphological aspects of the cranium. Rostral variables are the only morpho- logical features correlated with orbit orientation： increasing snout length yields more convergent orbits, whereas increase on snout breadth imply in more vertical orbits. Size and encephalization quotients are uncorrelated with orbit orientation. Among ecological data, diet showed significant correlation whereas locomotion is the factor that less affects the position of orbits. Phylogeny is uncorrelated to any orbital parameters measured. Ecological factors seemingly play a more import- ant role on orbit orientation than previously expected, and differentiation on orbit orientation seems to be more functional than inherited. Thus, despite the apparent homogeneity on didelphid morphology, there is subtle morphological variability that may be directly related to feeding behavior.

关键词： convergence Didelphidae frontation orbit orientation verticality.

An Integrated Approach for Optimal Design of Micro Gas Turbine Combustors

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Journal of Thermal Science 2009年第2期18卷 173-184页

作者： Luca Fuligno diego Micheli Carlo Poloni EnginSoft s.p.a. Dipartimento di Ingegneria Meccanica Universita degli Studi di Trieste Dipartimento

The present work presents an approach for the optimized design of small gas turbine combustors, that integrates a0-D code, CFD analyses and an advanced game theory multi-objective optimization algorithm. The output of the0-D code is a baseline design of the combustor, given the required fuel characteristics, the basic geometry (tubularor annular) and the combustion concept (i.e. lean premixed primary zone or diffusive processes). For the optimizationof the baseline design a simplified parametric CAD/mesher model is then defined and submitted to a CFDcode. Free parameters of the optimization process are position and size of the liner hole arrays, their total area andthe shape of the exit duct, while different objectives are the minimization of NOx emissions, pressure losses andcombustor exit Pattern Factor. A 3D simulation of the optimized geometry completes the design procedure. As afirst demonstrative example, the integrated design process was applied to a tubular combustion chamber with alean premixed primary zone for a recuperative methane-fuelled small gas turbine of the 100 kW class.

关键词： micro gas turbine combustor optimized design

Statistical Superposition of Crosstalk Effects in Cable Bundles

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China Communications 2013年第11期10卷 119-128页

作者： diego Bellan Sergio A.Pignari Department of Electronics Information and Bioengineering Politecnico di Milano

This paper deals with the analytical derivation of phasor-domain statistical properties of crosstalk in random wire cables due to the superposition of several sources of electromagnetic *** this study,statistical characterization of crosstalk in cable bundles,which is available in literature for the case of one source of interference,is extended to the case of several sources operating *** superposition of crosstalk effects is analysed in statistical terms,also taking into account the correlation between crosstalk contributions.A further random contribution,which is included in the proposed statistical model,is given by the phase relationship between the sources of *** approximate expressions for the crosstalk mean value,variance,and probability density function are derived as functions of the cable bundle features and sources.

关键词： crosstalk multiconductor transmi-ssion lines cable bundles statistical modelling

Correlation of powder flow properties to interparticle interactions at ambient and high temperatures

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Particuology 2014年第1期12卷 90-99页

作者： Igino Tomasetta diego Barletta Massimo Poletto Dipartimento di Ingegneria Industriale Università degli Studi di Salerno

A combination of a continuum approach and a particleparticle approach to describe the multiscale nature of the mechanical properties of bulk solids may be beneficial to scientific and engineering applica tions. In this paper, a procedure is proposed to estimate the interparticle forces beginning with the bulk flow properties as measured with standardized techniques. In particular, the relationship between inter particle forces and bulk solid tensile strength is adopted based on the microscale approaches of Rumpf （1970） and Molerus （1975）. The flow properties of fluid cracking catalyst （FCC）, corundum and glass bead powders were all characterized with a modified Schulze ring shear cell capable of operating at tempera tures up to 500 ~C. The powder test conditions were selected such that the van der Waals forces were the most significant particleparticle interactions. The model equations describe two cases, in which either elastic or plastic deformation of the contact points is assumed. The results indicate that the model pro vides the correct order of magnitude for the values of the tensile strength when proper values for the mean curvature radius at the contact points are taken into account. A sensitivity analysis for the main parameters in the model was performed. This analysis indicated that the assumption of plastic deforma tion at contact surfaces coupled with a decrease in porosity justified an increase of the tensile strength with consolidation stress. Furthermore, the effect of temperature on the measured flow behavior can be explained as a change in the strength of the material.

关键词： Shear testingYield locusvan der Waals forcelnterparticle interactionsPowder consolidationHigh temperature

A comparison between powder flow property testers

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Particuology 2017年第3期15卷 10-20页

作者： Hamid Salehi diego Barletta Massimo Poletto Dipartimento di lngegneria lndustriale Universita degli Studi di Salerno Via Giovanni Paolo II 132 84084 Fisciano SA Italy

In this work, three different shear testers-the Jenike shear cell tester, the Schulze ring shear tester, and the Brookfield powder flow tester-were compared in terms of the raw shear stress time series, yield loci points, angle of internal friction, cohesion, and unconfined yield strength. The three different powders of dolomitic lime, calcium lactate, and calcium carbonate were used for these comparisons. These three powders were characterized into different flowability classes using the ]enike classification, wherein dolomitic lime falls into the cohesive range, calcium lactate falls into the free-flowing range, and calcium carbonate falls into the very cohesive range. Results showed that the best agreement between the testers was found with moderately cohesive powders such as dolomitic lime. Furthermore, the free-flowing material tends to produce more consistent data between the three testers in terms of shear stresses and yield loci. It should be noted that the pre-shear data of free-flowing powder obtained by the Jenike shear cell must be appropriately interpreted. The largest differences between the testers are found with calcium carbonate, which is a highly compressible powder. The ways in which a high powder compressibility can differently affect the results obtained with the different testers were discussed.

关键词： Powder flow property Shear tester Flowability Jenike tester Schulze tester Brookfield powder flow tester

Aetiopathogenesis of autoimmune hepatitis

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World Journal of Gastroenterology 2008年第21期14卷 3306-3312页

作者： diego Vergani Giorgina Mieli-Vergani Institute of Liver Studies King's College London School of Medicine at King's College HospitalLondon SE5 9RSUnited Kingdom Institute of Liver Studies King’s College London School of Medicine at King’s College HospitalLondon SE5 9RSUnited Kingdom

The histological hallmark of autoimmune hepatitis（AIH） is a dense portal mononuclear cell infiltrate that invades the surrounding parenchyma and comprises T and B lymphocytes,macrophages,and plasma *** unknown but powerful stimulus must be promoting the formation of this massive inflammatory cellular reaction that is likely to initiate and perpetuate liver *** autoimmune attack can follow different pathways to inflict damage on *** damage is likely to be orchestrated by CD4^＋ T lymphocytes recognizing an autoantigenic liver *** trigger an autoimmune response,the peptide must be embraced by an HLA class Ⅱ molecule and presented to naive CD4^＋ T helper（Th0） cells by professional antigen presenting cells,with the co-stimulation of ligand-ligand fostering interaction between the two ***0 cells become activated,differentiate into functional phenotypes according to the cytokines prevailing in the microenvironment and the nature of the antigen,and initiate a cascade of immune reactions determined by the cytokines produced by the activated T ***1 cells,arising in the presence of the macrophage-derived interleukin（IL） -12,secrete mainly IL-2 and interferon-gamma（IFN-γ）,which activate macrophages,enhance expression of HLA classⅠ（increasing liver cell vulnerability to a CD8^＋ T cell cytotoxic attack）,and induce expression of HLA class Ⅱ molecules on ***2 cells,which differentiate from Th0 if the microenvironment is rich in IL-4,produce mainly IL-4,IL-10,and IL-13 which favour autoantibody production by B ***,Th1 and Th2 antagonize each ***17 cells,a recently described population,arise in the presence of transforming growth factor beta（TGF-β） and IL-6 and appear to have an important effector role in inflammation and *** of autoantigen recognition is strictly controlled by regulatory mechanisms,such as those exerted by CD4^＋CD25^＋ regulatory T cells,which derive from Th0 in the

关键词： Autoimmune hepatitis Aetiopathogenesis Lymphocyte, Cellular immune attack Histocompatibility lymphocyte antigen