检索结果-南通市图书馆

Acute hepatitis C in a chronically HIV-infected patient:Evolution of different viral genomic regions

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2003年第7期9卷 1496-1500页

作者： diego Flichman Veronica Kott Silvia Sookoian Rodolfo Campos Catedra de Virologia Facultad de Farmacia y BioquimicaUniversidad de Buenos AiresArgentina Unidad de Higado Hospital"Dr.Cosme Argerich"Argentina

AIM: To analyze the molecular evolution of different viral genomic regions of HCV in an acute HCV infected patient chronically infected with HIV through a 42-month ***: Serum samples of a chronically HIV infected patient that seroconverted to anti HCV antibodies were sequenced, from the event of superinfection through a period of 17 months and in a late sample (42nd month). Hypervariable genomic regions of HIV (V3 loop of the gp120) and HCV (HVR-1 on the E2 glycoprotein gene) were studied. In order to analyze genomic regions involved in different biological functions and with the cellular immune response, HCV core and NS5A were also chosen to be sequenced. Amplification of the different regions was done by RT-PCR and directly sequenced. Confirmation of sequences was done on reamplified material. Nucleotide sequences of the different time points were aligned with CLUSTAL W 1.5, and the corresponding amino acid ones were ***: Hypervariable genomic regions of both viruses (HVR1 and gp120 V3 loop) presented several nonsynonymous changes but, while in the gp120 V3 loop mutations were detected in the sample obtained right after HCV superinfection and maintained throughout, they occurred following a sequential and cumulative pattern in the HVR1. In the NS5A region of HCV, two amino acid changes were detected during the follow-up period, whereas the core region presented several amino acid replacements, once the HCV chronic infection had been ***: During the HIV-HCV superinfection, each genomic region analyzed shows a different evolutionary *** of the nucleotide substitutions observed are nonsynonymous and clustered in previously described epitopes,thus suggesting an immune-driven evolutionary process.

关键词： Acute Disease Adolescent Amino Acid Sequence Female Genome, Viral HIV HIV Envelope Protein gp120 HIV Infections Hepacivirus Hepatitis C Humans Molecular Sequence Data Research Support, Non-U.S. Gov't Superinfection Viral Nonstructural Proteins Viral Proteins

Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第10期14卷 1707-1708页

作者： diego S. Ojeda Andreas Till Jorge Quarleri Instituto de Investigaciones Biomedicas en Retrovirus y SIDA (INBIRS) Universidad de Buenos Aires-CONICETArgentina Institute of Reconstructive Neurobiology Life & Brain CenterUniversity of BonnBonnGermany

Acquired immune deficiency syndrome is associated with the death of CD4+ T lymphocytes. The entry of the human immunodeficiency virus (HIV) into the central nervous system leads to a broad spectrum of HIV-associated neurocognitive disorders (HAND) ranging from mild to severe dementia. Inside the central nervous system, HIV establishes infection in astrocytes - the predominant cell type in the brain, thus causing neuropathology, but the underlying mechanisms remain unknown.

关键词： Acquired immune broad spectrum remain unknown

Erratum to:Recent Advances of Chimp Optimization Algorithm:Variants and Applications

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2024年第3期21卷 1618-1618页

作者： Mohammad Sh.Daoud Mohammad Shehab Laith Abualigah Mohammad Alshinwan Mohamed Abd Elaziz Mohd Khaled Yousef Shambour diego Oliva Mohammad A.Alia Raed Abu Zitar College of Engineering Al Ain University112612 Abu DhabiUnited Arab Emirates College of Computer Sciences and Informatics Amman Arab UniversityAmman 11953Jordan Computer Science Department Prince Hussein Bin Abdullah Faculty for Information TechnologyAl Al-Bayt UniversityMafraq 25113Jordan Hourani Center for Applied Scientific Research Al-Ahliyya Amman UniversityAmman 19328Jordan MEU Research Unit Middle East UniversityAmman 11831Jordan Applied Science Research Center Applied Science Private UniversityAmman 11931Jordan School of Computer Sciences Universiti Sains Malaysia11800 Pulau PinangMalaysia Faculty of Information Technology Applied Science Private UniversityAmman 11931Jordan Department of Mathematics Faculty of ScienceZagazig UniversityZagazig 7120001Egypt The Custodian of the Two Holy Mosques Institute for Hajj and Umrah Research Umm Al-Qura UniversityMakkah 24382Saudi Arabia Depto.de Innovacio′n Basada en la Informacio′n y el Conocimiento Universidad de GuadalajaraCUCEI45129 GuadalajaraMexico Cyber Security Department Faculty of Science and Information TechnologyAl Zaytoonah University of JordanAmman 11733Jordan Sorbonne Center of Artificial Intelligence Sorbonne University-Abu Dhabi38044 Abu DhabiUnited Arab Emirates School of Engineering and Technology Sunway University Malaysia27500 Petaling JayaMalaysia

Erratum to:J Bionic Eng https://***/10.1007/*** this article the statement in the Funding information section was incorrectly given as‘22UQU4361183DSR03’and should have read‘23UQU4361183DSR03’.

关键词： statement section correctly

Autoimmmune hepatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2022年第2期19卷 158-176页

作者： Benedetta Terziroli Beretta-Piccoli Giorgina Mieli-Vergani diego Vergani Epatocentro Ticino&Facoltàdi Scienze Biomediche Universitàdella Svizzera ItalianaLuganoSwitzerland Institute for Research in Biomedicine BellinzonaSwitzerland. King’s College London Faculty of Life Sciences&Medicine at King’s College Hospital LondonUK. Paediatric Liver GI and Nutrition CentreMowatLabsKing’s College HospitalLondonUK. Institute of Liver Studies MowatLabsKing’s College HospitalLondonUK.

Autoimmune hepatitis(AIH)is a T-cell mediated,inflammatory liver disease affecting all ages and characterized by female preponderance,elevated serum transaminase and immunoglobulin G levels,positive circulating autoantibodies,and presence of interface hepatitis at liver *** type 1,affecting both adults and children,is defined by positive anti-nuclear and/or antismooth muscle antibodies,while type 2 AIH,affecting mostly children,is defined by positive anti-liver-kidney microsomal type 1 and/or anti-liver cytosol type 1 *** the autoantigens of type 2 AIH are well defined,being the cytochrome P4502D6(CYP2D6)and the formiminotransferase cyclodeaminase(FTCD),in type 1 AIH they remain to be ***-1 predisposition is conferred by possession of the MHC class II HLA DRB1*03 at all ages,while DRB1*04 predisposes to late onset disease;AIH-2 is associated with possession of DRB1*07 and DRB1**** majority of patients responds well to standard immunosuppressive treatment,based on steroid and azathioprine;second-and third-line drugs should be considered in case of intolerance or insufficient *** review offers a comprehensive overview of pathophysiological and clinical aspects of AIH.

关键词： Autoimmune Hepatitis Immunopathophysiology Treatment Genetic Predisposition

Particle flow code simulation of intact and fissured granitic rock samples

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2020年第5期12卷 960-974页

作者： Uxía Castro-Filgueira Leandro R.Alejano diego Mas Ivars Department of Natural Resources and Environmental Engineering University of VigoVigoSpain Department of Geology and Geological Engineering Colorado School of MinesGoldenCOUSA Swedish Nuclear Fuel and Waste Management Company(SKB) StockholmSweden Division of Soil and Rock Mechanics Royal Institute of Technology(KTH)StockholmSweden

This study presents a calibration process of three-dimensional particle flow code(PFC3D)simulation of intact and fissured granite ***,laboratory stressestrain response from triaxial testing of intact and fissured granite samples is ***,PFC3D is introduced,with focus on the bonded particle models(BPM).After that,we present previous studies where intact rock is simulated by means of flatjoint approaches,and how improved accuracy was gained with the help of parametric ***,models of the pre-fissured rock specimens were generated,including modeled fissures in the form of“smooth joint”type ***,triaxial testing simulations of 1 t 2 and 2 t 3 jointed rock specimens were *** show that both elastic behavior and the peak strength levels are closely matched,without any additional fine tuning of micro-mechanical *** the postfailure behavior,models reproduce the trends of decreasing dilation with increasing confinement and ***,the dilation values simulated are larger than those observed in *** is attributed to the difficulty in modeling some phenomena of fissured rock behaviors,such as rock piece corner crushing with dust production and interactions between newly formed shear bands or axial splitting cracks with pre-existing joints.

关键词： Numerical methods Artificially fissured samples Rock mass behavior Particle flow code Parallel bond Flat-joint Smooth-joint

When Disaster Risk Management Systems Fail: The Case of Cyclone Idai in Chimanimani District, Zimbabwe

在线全文

学校读者我要写书评

暂无评论

International Journal of Disaster Risk Science 2021年第5期12卷 689-699页

作者： Edson Munsaka Chipo Mudavanhu Lucy Sakala Pepukai Manjeru diego Matsvange Institute of Development Studies National University of Science and TechnologyBulawayoZimbabwe Faculty of Humanities University of JohannesburgJohannesburgSouth Africa Bindura University of Science Education BinduraZimbabwe Midlands State University GweruZimbabwe DanChurch Aid(DCA) BulawayoZimbabwe

On 14 March 2019,Zimbabwe was hit by Cyclone Idai,leaving immeasurable destruction of unprecedented magnitude in its *** Chimanimani District,many lives were lost,many people were reported missing,and others were *** question that immediately comes to mind is:Was the country prepared to manage the Cyclone Idai disaster?Reflecting on the community experiences,the purpose of this research was to interrogate the strength of the disaster risk reduction legislation and institutions in Zimbabwe in the face of meteorological *** research also evaluated the extent of the impact Cyclone Idai had on the Chimanimani communities and the factors that increased the vulnerability to the cyclone.A mixed method approach that involved 1180 participants was *** study found that disaster risk management legislation and institutions in Zimbabwe are *** Idai resulted in the loss of many human lives,loss of livelihoods,and massive damage to *** cyclone exposed capacity and policy gaps in Zimbabwe’s disaster risk management *** study makes a number of recommendations,including strengthening disaster legislation and policy,and disaster risk *** the communities’response to the disaster occurrence,the study also recommends strengthening social capital.

关键词： Cyclone disasters Disaster management policies Early warning systems Zimbabwe

Globalization and Glocalization in the History of Chinese Medicine

在线全文

学校读者我要写书评

暂无评论

Chinese Medicine and Culture 2023年第4期6卷 313-318,F0002页

作者：张勇安 diego Armus Department of History Shanghai UniversityShanghai 200444China Department of History Swarthmore CollegeSwarthmore 19081USA

The globalization of Chinese medicine, forged through successive waves of migration, cultural exchanges, and economic imperatives, constitutes a nuanced and intricate process with historical roots extending over millennia. It stands as the culmination of interconnected historical events that reverberated beyond the confines of China, emerging as a phenomenon characterized by the adjustment of Chinese medical theories, clinical practices, and materia medica to indigenous customs and healthcare traditions prevalent in both proximate and distant regions. In these glocalized processes, the global and the local intersect and mix. The frameworks of globalization and glocalization allow a critical interpretation of the many hybridizations that have shaped overseas Chinese medicine's history and present.

关键词： Chinese medicine Global history Glocalization COVID-19

Distribution and Ecology of the Western Ecuador Frog Leptodactylus labrosus (Amphibia: Anura: Leptodactylidae)

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2006年第3期27卷 225-234页

作者： diego F. Cisneros-Heredia College of Biological and Environmental Sciences Universidad San Franciscode Quito Casilla Postal 17-12-841QuitoEcuador

Leptodactylus labrosus is a terrestrial sit-and-wait predator; its diet includes ground-level, fossorial, and flying insects, and ants numerically predominate. Bothrops asper is recorded as a predator of L. labrosus. L. labrosus lives mainly in deciduous and semi-deciduous forests, where it is restricted to wet microhabitats, and occasionally in evergreen forests. L. labrosus inhabits northern, central, and southern regions of western coastal Ecuador and northern and central western coastal Peru up to 700 m, and into the dry interandean valleys of southern Ecuador and northern Peru up to 1 300 m. Its distribution encompasses moistly seasonally dry forest in coastal Ecuador and Peru. It also occupies moister areas towards the slopes of the Andes where it is sympatric with three other congeneric species, but at sites of sympatry the species show habitat segregation. The distribution pattern of L. labrosus is shared by several other range-restricted am- phibians corresponding to the Tumbesian region, which should be recognized as an endemic Amphibian area. The zone between the Choco and Tumbesian regions, where L. labrosus gets in sympatry with other Leptodactylus species, possess ecological and climatic characteristics that have shaped a unique fauna, including several endemic taxa; and it should be recognized as the west Ecuadorian endemic region.

关键词： Leptodactylus Distribution Endemism area Ecuador

Framework for automatic generation of facades on free-form surfaces

在线全文

学校读者我要写书评

暂无评论

Frontiers of Architectural Research 2017年第3期6卷 273-289页

作者： diego Andrade Mikako Harada Kenji Shimada Mechanical Engineering Department Carnegie Mellon University Pittsburgh PA 15213 United States Autodesk Manchester NH 03101 United States

New design tools have created a growing interest for presenting complex geometries and patterns. The need to form curved geometries of facades, without incurring high construction costs and time increases, presents one of the most complex design challenges for any project. In this paper, we present and demonstrate a new computational framework for the creation of patterns on top of facades, via cladding of panels and honeycomb structures. The tool describes a given region on a base model; dealing particularly with location, size and orientation of general geometric features on the surface of such model. The user inputs curves that manifest the desired user＇s intention for the panels and a set of seed features that correspond to the initial boundary conditions of a Riemannian metric tensor field. The system interpolates the tensors defined by input features and input curves by solving a Laplace-Beltrami partial differential equation over the entire domain. We show a fast clustering and search operations for correct panel utilization based on size quantization as design variable and implemented via Voronoi segmentation. We present honeycomb structures that can be retrieved from the fundamental mesh producing another option for facade creation and ideation. The system connects to a geometric modeling kernel of a commercial CAD package; the system places features on top of the base model facade using boolean operations from the core geometdc engine via its programming interface calls. With this computational tool, thousands of dad panels can be visualized and developed within minutes.

关键词： Computer graphics Eltipsoidal packing Supporting structures Architectural geometry Computationat geometry Generative designalgorithms