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Peroxisome proliferator-activated receptor-alpha activation and dipeptidyl peptidase-4 inhibition target dysbiosis to treat fatty liver in obese mice

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World Journal of Gastroenterology 2022年第17期28卷 1814-1829页

作者： Flavia Maria Silva-Veiga Carolline Santos miranda Isabela Macedo Lopes Vasques-Monteiro henrique Souza-Tavares Fabiane Ferreira Martins Julio Beltrame Daleprane Vanessa Souza-Mello Department of Anatomy Institute of BiologyState University of Rio de JaneiroLaboratory of MorphometryMetabolism and Cardiovascular DiseasesRio de Janeiro 20551-030Brazil Department of Clinical and Toxicology Analysis State University of Rio de JaneiroNutrition InstituteState University of Rio de JaneiroNutrition InstituteUniversity of Sao PauloRio de Janeiro 20551-030Brazil

BACKGROUND Obesity and comorbidities onset encompass gut dysbiosis,altered intestinal permeability,and *** that target gut dysbiosis can cope with obesity and nonalcoholic fatty liver disease(NAFLD)*** proliferator-activated receptor(PPAR)-alpha activation and dipeptidyl-peptidase-4(DPP-4)inhibition alleviate NAFLD,but the mechanism may involve gut microbiota modulation and merits further *** To address the effects of PPAR-alpha activation and DPP-4 inhibition(isolated or combined)upon the gut-liver axis,emphasizing inflammatory pathways in NAFLD management in high-fat-fed C57BL/6J *** Male C57BL/6J mice were fed a control diet(C,10%of energy as lipids)or a highfat diet(HFD,50%of energy as lipids)for 12 wk,when treatments started,forming the groups:C,HF,HFA(HFD+PPAR-alpha agonist WY14643,2.5 mg/kg body mass),HFL(HFD+DPP-4 inhibitor linagliptin,15 mg/kg body mass),and HFC(HFD+the combination of WY14643 and linagliptin).RESULTS The HFD was obesogenic compared to the C *** treatments elicited significant body mass loss,and the HFC group showed similar body mass to the C *** treatments tackled oral glucose intolerance and raised plasma glucagon-like peptide-1 *** metabolic benefits restored Bacteroidetes/Firmicutes ratio,resulting in increased goblet cells per area of the large intestine and reduced lipopolysaccharides concentrations in treated *** the gene level,treated groups showed higher intestinal Mucin 2,Occludin,and Zo-1 expression than the HFD *** reduced endotoxemia suppressed inflammasome and macrophage gene expression in the liver of treated *** observations complied with the mitigation of liver steatosis and reduced hepatic triacylglycerol,reassuring the role of the proposed treatments on NAFLD *** PPAR alpha activation and DPP-4 inhibition(isolated or combined)tackled NAFLD in dietinduced obese mice by restoration of gut-liver axis

关键词： Nonalcoholic fatty liver disease High-fat diet Peroxisome proliferator-activated receptor-alpha Dipeptidyl-peptidase-4-inhibitor Dysbiosis Inflammation

Peroxisome proliferator-activated receptors as targets to treat metabolic diseases:Focus on the adipose tissue,liver,and pancreas

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World Journal of Gastroenterology 2023年第26期29卷 4136-4155页

作者： henrique Souza-Tavares Carolline Santos miranda Isabela Macedo Lopes Vasques-Monteiro Cristian Sandoval Daiana Araujo Santana-Oliveira Flavia Maria Silva-Veiga Aline Fernandes-da-Silva Vanessa Souza-Mello Department of Anatomy Rio de Janeiro State UniversityRio de Janeiro 20551030Brazil Escuela de Tecnología Médica Facultad de SaludUniversidad Santo TomásOsorno 5310431Chile Departamento de Ciencias Preclínicas Universidad de la FronteraTemuco 4780000Chile

The world is experiencing reflections of the intersection of two pandemics:Obesity and coronavirus disease *** prevalence of obesity has tripled since 1975 worldwide,representing substantial public health costs due to its *** adipose tissue is the initial site of obesity *** excessive energy intake,it undergoes hyperplasia and hypertrophy until overt inflammation and insulin resistance turn adipocytes into dysfunctional cells that send lipotoxic signals to other *** pancreas is one of the organs most affected by *** lipotoxicity becomes chronic,there is an increase in insulin secretion by pancreatic beta cells,a surrogate for type 2 diabetes mellitus(T2DM).These alterations threaten the survival of the pancreatic islets,which tend to become dysfunctional,reaching exhaustion in the long *** for the liver,lipotoxicity favors lipogenesis and impairs beta-oxidation,resulting in hepatic *** silent disease affects around 30%of the worldwide population and can evolve into end-stage liver *** therapy for hepatic steatosis remains to be defined,peroxisome proliferator-activated receptors(PPARs)activation copes with T2DM *** PPARs are transcription factors found at the intersection of several metabolic pathways,leading to insulin resistance relief,improved thermogenesis,and expressive hepatic steatosis mitigation by increasing mitochondrial *** review aimed to update the potential of PPAR agonists as targets to treat metabolic diseases,focusing on adipose tissue plasticity and hepatic and pancreatic remodeling.

关键词： Obesity Insulin resistance Peroxisome proliferator-activated receptors Pancreas Hepatic steatosis Adipose tissue

Parasitoids of dipterous collected in cattle dung in the Regions Southern and Central of Goiás, Brazil

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Advances in Entomology 2014年第1期2卷 20-23页

作者： Carlos henrique Marchiori Ligia miranda Ferreira Borges Lorena Lopes Ferreira Federal University of Goiás Goiania Brazil Institute Federal Goiano Federal University of Goiás Goiania Brazil

This study had the objective of determining the species of parasitoids of Diptera from May 2003 to June 2004 in the Region Southern and from March 2012 to February 2013 in the Region Central of (Goiania) Goiás, Brazil. The dipterous pupae were obtained by the flotation method. They were individually placed in gelatin capsules until the emergence of the flies and/or their parasitoids. The percentage of parasitism in the Region South was 12.4% and in the Region Central was 6.4%. The species more frequent were: Gnathopleura quadridentata Wharton, 1986 (Hymenoptera: Braconidae) with 25.6% in the Region Southern and Aleochara notula Erichson, 1839 (Coleoptera: Staphylinidae) with 26.1% in the Region Central.

关键词： Diptera Hymenoptera Biocontrol Two Regions

Rabies outbreak in Brazil: first case series in children from an indigenous village

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Infectious Diseases of Poverty 2023年第4期12卷 103-103页

作者： Dilceu Silveira Tolentino Júnior Maryana Santos Vasconcelos Marques Amanda Krummenauer Magda Machado Saraiva Duarte Silene Manrique Rocha Mariana Gontijo de Brito Ludmila Ferraz de Santana Roberto Carlos de Oliveira Eliseu miranda de Assis Kellyn Kessiene de Sousa Cavalcante Carlos henrique Alencar Postgraduate Program in Technology Environment and SocietyFederal University of the Jequitinhonha e Mucuri ValleysTeófilo OtoniMGBrazil Special Indigenous Health District of Minas Gerais and Espírito Santo Ministry of HealthGovernador ValadaresMGBrazil Brazil Field Epidemiology Training Program Ministry of HealthHealth and Environment Surveillance SecretariatBrasíliaDFBrazil Health Surveillance Secretariat Ministry of HealthBrasíliaDFBrazil State Department of Health of Minas Gerais Coordination of ZoonosesBelo HorizonteMGBrazil Postgraduate Program in Integrated Territory Management Vale do Rio Doce UniversityGovernador ValadaresMGBrazil Federal Institute of Bahia EunápolisBABrazil Postgraduate Program in Public Health Federal University of CearáFortalezaCEBrazil

BackgroundHuman rabies outbreak transmitted by bats continues to be a relevant public health problem not only in the Amazon region. The disease has affected one of the areas with the greatest poverty in southeastern Brazil, a region inhabited by the Maxakali indigenous *** presentationWe describe four cases of rabies among indigenous children that occurred in the indigenous village of Pradinho, municipality of Bertópolis, Minas Gerais, Brazil. Cases were notified between April and May 2022, all of whom died on average eight days after the first symptoms. All cases were observed in rural residents under 12 years of age. The probable form of exposure was through bat bites. The predominant symptoms were prostration, fever, dyspnea, sialorrhea, tachycardia, and altered level of consciousness. Half of the cases underwent late and/or incomplete post-exposure rabies prophylaxis, however, the other half underwent pre-exposure rabies prophylaxis, with only one case completing the scheme and another undergoing the adapted Milwaukee Protocol (Recife Protocol). All cases ended in *** was the first rabies outbreak among indigenous people in Brazil. Among the manifested clinical forms in the series, there was a disease atypical presentation in at least one case. We suggest active surveillance and an intercultural educational campaign to prevent new cases.

关键词： Rabies Outbreak Indigenous population Low income Brazil

Pathogenesis and clinical management of Helicobacter pylori gastric infection

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World Journal of Gastroenterology 2019年第37期25卷 5578-5589页

作者： Breno Bittencourt de Brito Filipe Ant?nio Fran?a da Silva Aline Silva Soares Vinícius Afonso Pereira Maria Luísa Cordeiro Santos Mariana miranda Sampaio Pedro henrique Moreira Neves Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da Bahia

Helicobacter pylori(***)is a gram-negative bacterium that infects approximately 4.4 billion individuals ***,its prevalence varies among different geographic areas,and is influenced by several *** infection can be acquired by means of oral-oral or fecal-oral transmission,and the pathogen possesses various mechanisms that improve its capacity of mobility,adherence and manipulation of the gastric microenvironment,making possible the colonization of an organ with a highly acidic *** addition,*** presents a large variety of virulence factors that improve its pathogenicity,of which we highlight cytotoxin associated antigen A,vacuolating cytotoxin,duodenal ulcer promoting gene A protein,outer inflammatory protein and gamma-glutamyl *** host immune system,mainly by means of a Th1-polarized response,also plays a crucial role in the infection *** most ***-positive individuals remain asymptomatic,the infection predisposes the development of various clinical conditions as peptic ulcers,gastric adenocarcinomas and mucosa-associated lymphoid tissue *** and non-invasive diagnostic methods,each of them with their related advantages and limitations,have been applied in *** ***,bacterial resistance to antimicrobial therapy is a major challenge in the treatment of this infection,and new therapy alternatives are being tested to improve *** *** but not least,the development of effective vaccines against *** infection have been the aim of several research studies.

关键词： Helicobacter pylori Virulence factors Immune response Antibiotics Vaccines

Orthognathic Surgery Combined with Partial Lipectomy of the Buccal Fat Pad： Case Report on Optimization of Esthetic Outcome

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Journal of Pharmacy and Pharmacology 2017年第8期5卷 565-571页

作者： Daniel Amaral Alves Marliere Caio Bellini Lovisi Alan Robert Moreira Schmitt Bruno Salles Sotto-Maior henrique Duque de miranda Chaves Netto MSc in Clinical Dentistry- Juiz de Fora Dental School Federal University of Juiz de Fora Juiz de Fora 36036-300 Brazil MSc in Dentistry - Dental School University of the State of Rio de Janeiro Rio de Janeiro 20551-030 Brazil Lecturer in Dentistry- Juiz de Fora Dental School Federal University of Juiz de Fora Juiz de Fora 36036-300 Brazil

Orthognathic surgery involves correction of functional and often esthetic disharmonies. The purpose of this case report is topresent the case of a 22 years-old female with class III dentofacial deformity that required orthognathic surgery to treat hermalocclusion and buccal fat pad excision for optimizing soft-tissue facial contour. Treatment planning involved a counterclockwiserotation of the maxilomandibular complex with genioplasty based on digital 3D surgical planning using the Dolphin Imaging 11.7 3DPremium software. Prototyping splints allowed surgical procedures （bilateral sagital mandibular osteotomy associated to a Le fort Iosteotomy） that corrected position of the gnathic bones. In the same surgical procedure, the buccal fat pad was partially removed for asharp cheek contour giving a slimmer appearance to her face. After 5 months, the patient was reassessed and reported no complaintsregarding esthetics or function. This case illustrates that a combination oforthognathic surgery and an esthetic procedure can result in astable and harmonious facial as well as occlusal outcomes.

关键词： Orthognathic surgery, occlusal plane, malocclusion, buccal fat pad, aesthetic procedure.

Risk of Surgical Site Infection in Patients Undergoing Total Knee Arthroplasty

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Open Journal of Orthopedics 2018年第7期8卷 305-315页

作者： Paulo Cezar Vidal Carneiro de Albuquerque Alvaro Antonio Bandeira Ferraz Clarissa miranda Carneiro de Albuquerque Olbertz Jose Miguel Francisco da Silva Souza Alessandro henrique da Silva Santos Paula Eduarda miranda Carneiro de Albuquerque Federal University of Pernambuco RecifeBrazil Sarah Kubistckeck Hospital BrasiliaBrazil IMIP RecifeBrazil

The aim of this study was to determine the participation of risk factors in the infection in patients who underwent total knee arthroplasty. This is a prospective longitudinal study, descriptive and analytical, that was carried out between January 2013 and December 2015. Eighty-one procedures were performed in 78 individuals, 16 males and 62 females. Three subjects underwent the procedure on both knees. The following predictive factors of infection were identified: Age, gender, comorbidities, evaluation of functional physical status using the American Society of Anesthesiologists Physical Status Classification System (ASAPS), length of hospital stay, use of prophylactic antibiotics and duration of surgery. The data was tabulated in a database using a Microsoft Excel spreadsheet. For statistical analysis, the chi-square test, chi-square test for independence and Fischer’s exact test were applied, all at a significance level of 5% (0.05). Surgical site infection was more prevalent in males (23.5%), age over 70 years (25.0%), for left gonarthrosis (17.9%), in the presence of comorbidities (17.9%), when hospital stay was 6 or more days (27.8%), in total arthroplasties of left knee (17,9%), in surgical times of up to 2 hours (20%), in the use of prophylactic antibiotics (16.7%) and in level II classification in the ASAPS (18.8%). The independence test was not significant in any of the evaluated factors (p-value greater than 0.05). The most prevalent bacteria identified in cases of infection was Staphylococcus aureus (33.2%). The risk factors studied were not statistically significant.

关键词： Knee Arthroplasty Knee Debridement Infection Joint Prosthetic Joint Infection/Diagnosis Infection Therapy

Six-Minute Walk Test in Patients with Rheumatoid Arthritis

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Open Journal of Rheumatology and Autoimmune Diseases 2019年第1期9卷 14-24页

作者： Sandor Balsamo Ana Paula Monteiro Gomides Licia Maria henrique da Mota Frederico Santos de Santana Raphaela Franco miranda Talita Yokoy Luciana Muniz Leopoldo Luiz Santos-Neto Universidade de Brasília (UnB) Brasília Brazil Laboratório de Aptidã o Física e Reumatologia do Hospital Universitário de Brasília (LAR/HUB) Brasília Brazil Grupo de Estudo e Pesquisa em Exercício de Forç a e Saúde (GEPEEFS) Brasília Brazil Curso Superior de Educaç o Física Centro Universitário UNIEURO Brasília Brazil Ambulatório de Reumatologia Hospital Universitário de Brasília (HUB) Brasília Brazil

Background: The 6-minute walk test (6TC) was initially used as an instrument for assessing physical and cardiorespiratory capacity, but is currently being used to monitor treatments, and compare physical interventions and prognostic evaluation. Although already recognized as a research method in several specialties, 6TC has not been used in rheumatology. Patients with rheumatoid arthritis (RA) may have impaired functional capacity as well as increased cardiovascular mortality. An adequate functional evaluation of these patients is necessary and the 6TC may be useful in this sense. Objective: The aim of this study was to perform the 6-minute walk test in RA patients and to compare the performance with a control group. Method: A cross-sectional study was carried out in which the sample consisted of 85 women, 46 patients with rheumatoid arthritis and 39 healthy controls. A descriptive analysis of the data was performed. One-Way ANOVA methodology was used to compare the patient and control groups followed by the graphic analysis. Results: The distance walked on the 6TC by RA patients was on average 522.2 meters. In the distance control group found in the 6TC was on average 628.8 meters, the difference being statistically significant. Conclusion: In this study the distance covered in 6TC by women with RA was lower than that of healthy women of the same age.

关键词： 6-Minute Walk Test Rheumatoid Arthritis Functional Capacity Physical Capacity Cardiorespiratory Capacity Person Performed

Effect of a hydrogymnastics program on the serum levels of high-sensitivity C-reactive protein amongst elderly women

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Health 2014年第1期6卷 80-85页

作者： Javier Arturo Hall-López Paulina Yesica Ochoa-Martínez Edgar Ismael Alarcón-Meza Fernando Israel Anaya-Jaramillo Ana María miranda Botelho Teixeira José Moncada-Jiménez José Carlos Ferreira-Reis Estélio henrique Martin Dantas Centre for Research in Human Movement Sciences University of Costa Rica San Jose Costa Rica Euro-American Network of Human Kinetics (REMH) Rio de Janeiro Brazil Laboratory of Human Motricity Biosciences (LABIMH) Federal University of State of Rio de Janeiro Rio de Janeiro Brazil Faculty of Sports Science and Physical Education University of Coimbra Coimbra Portugal School of Sports Autonomous University of Baja California (UABC) Mexicali Mexico Euro-American Network of Human Kinetics (REMH) Rio de Janeiro Brazil School of Sports Autonomous University of Baja California (UABC) Mexicali MexicoEuro-American Network of Human Kinetics (REMH) Rio de Janeiro Brazil

The aim of this study was to evaluate the effect of a hydrogymnastics training program on highsensitivity C-reactive protein in elderly women. The subjects were randomly divided into the experimental group who participates in the hydrogymnastics training program and the control group who was not involved in the training and remained sedentary. The serum levels of highsensitivity C-reactive protein were determined by immunoturbidimetry using C-reactive protein (CRP), the training protocol consisted of hydrogymnastics sessions 5 times per week during 12 weeks of intervention, executed in a pool of 1.3 meters divided into three phases: a 10-minute warm-up, 30 minutes of aerobic exercise at 50%-60% of maximum heart rate (monitored by heart rate monitor) and a 10-minute cool down. As a statistical method to compare the results between groups of variables pre and post training, the analysis of variance (ANOVA) mixed 2 × 2 (group × measurement) test was done using SPSS version 17. The founds showed significant changes in the level of high-sensitivity C-reactive protein, and a greater percentage decrease of hs-CRP (Δ%= -37%, p = 0.001) in the experimental group in relation to the control ***, it can be inferred that a hydrogymnastics program is effective in reducing the metabolic rate of high-sensitivity C-reactive protein amongst elderly women.

关键词： Elderly hs-CRP Hydrogymnastics