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Survival and comorbidities in lung cancer patients:Evidence from administrative claims data in Germany

Oncology Research 2022年第4期30卷 173-185页

作者： diego HERNANDEZ CHIH-YUAN CHENG KARLA HERNANDEZ-VILLAFUERTE MICHAEL SCHLANDER Division of Health Economics German Cancer Research Center(DKFZ)HeidelbergGermany Medical Faculty Mannheim Heidelberg UniversityMannheimGermany

Lung cancer is the most common cancer type worldwide and has the highest and second highest mortality rate for men and women respectively in ***,the role of comorbid illnesses in lung cancer patient prognosis is still *** analyzed administrative claims data from one of the largest statutory health insurance(SHI)funds in Germany,covering close to 9 million people(11%of the national population);observation period was from 2005 to *** cancer patients and their concomitant diseases were identified by ICD-10-GM *** were classified according to the Charlson Comorbidity Index(CCI).Incidence,comorbidity prevalence and survival are estimated considering sex,age at diagnosis,and place of *** Meier curves with 95%confidence intervals were built in relation to common *** identified 70,698 lung cancer incident cases in the *** and survival figures are comparable to official statistics in *** prevalent comorbidities are chronic obstructive pulmonary disease(COPD)(36.7%),followed by peripheral vascular disease(PVD)(18.7%),diabetes without chronic complications(17.4%),congestive heart failure(CHF)(16.5%)and renal disease(14.7%).Relative to overall survival,lung cancer patients with CHF,cerebrovascular disease(CEVD)and renal disease are associated with largest drops in survival probabilities(9%or higher),while those with PVD and diabetes without chronic complications with moderate drops(7%or lower).The study showed a negative association between survival and most common comorbidities among lung cancer patients,based on a large sample for *** research needs to explore the individual effect of comorbidities disentangled from that of other patient characteristics such as cancer stage and histology.

关键词： Lung Cancer Comorbidities Survival Administrative data Statutory health insurance

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Architectural typology of rural housing in Jaen,Peru

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Built Heritage 2022年第1期6卷 76-93页

作者： Floiran PeÑa-Huaman diego Sifuentes-Rivera Cristian Yarasca-Aybar Escuela Profesional de Arquitectura Universidad Peruana UnionLimaPeru

Jaén is one of the most important cities in the northern highlands of Peru due to its strategic location,commerce,and agricultural ***én has more than 185 thousand inhabitants,of which 48%live in rural areas,representing approximately 31 thousand rural *** research aims to determine the types of rural housing in Jaen,showing the possible variations and architectural manifestations due to the territorial and cultural characteristics.A field observation sheet has been used to study the rural dwellings of populated centres previously classified by altitudinal *** results show six architectural types of rural housing classified into two groups:"rural-residential housing"and"rural-agricultural housing"'These architectural types are generally located near water sources,within agricultural plots,and on *** architectural program is characterised by agricultural activity and family composition,which has grown over *** most commonly used construction systems are"pirca"and"quincha"',using natural materials such as"ichu"and *** is also evidence of cultural traditions rooted in the construction,such as"cambio de fuerzas""paracaico",and"minga".Therefore,the relevance of Jaen's rural housing is its geographical reading of the territory through the architectural and cultural legacy of these buildings.

关键词： Architectural typologies Peru Rural architecture Vernacular architecture Rural housing

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Subjective scar assessment scales in orthopaedic surgery and determinants of patient satisfaction: A systematic review of the literature

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中华创伤杂志:英文版 2023年第5期26卷 276-283页

作者： diego A Abelleyra Lastoria Clerin K Benny Caroline B Hing Institute for Medical and Biomedical Education St George's University of LondonLondonSW17 OREUnited Kingdom Faculty of Medicine Medical University of SofiaSofia1641Bulgaria Department of Trauma and Orthopaedics St George's University Hospitals NHS Foundation TrustLondonSW17 OQTUnited Kingdom

Purpose:Scar assessment tools can be utilized during the post-operative period to monitor scar *** primary aim of this systematic review was to evaluate current subjective scar assessment scales utilized in orthopaedic *** secondary aim was to identify determinants of patients'satisfaction with their scars and evaluate current measurement ***:The preferred reporting items for systematic reviews and meta-analyses checklist was *** databases,curently registered studies,conference proceedings and the reference lists of included studies were *** were no constraints based on language or publication status.A narrative synthesis provided a description and evaluation of scales utilized in orthopaedic *** of patient satisfaction were identified along with the scales used to measure ***:A total of 6059 records were screened in the initial ***-six articles satisfied the inclusion criteria,assessing 7130 *** the literature,six validated subjective scar scales were identified,including the Vancouver scar scale,patient and observer scar assessment scale,Manchester scar scale,Stony Brook scar evaluation scale,visual analogue scale,and Hollander wound evaluation *** utilizing these scales to evaluate scars following orthopaedic procedures did so *** were total hip arthroplasty,total knee arthroplasty,and limb *** scales demonstrated satisfactory *** outcomes such as restoration of movement ranked among patients'highest *** cosmesis was found to be amongst patients'lowest ***:Subjective scar assessment scales identified in the literature were not designed specifically for orthopaedic ***,these were able to appropriately assess scars in the studies identified in this *** evidence suggests the effect of scar cosmesis on patient satisfaction with orthopaedic procedures is li

关键词： Scar Cosmesis Orthopaedics Patient satisfaction

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The ALMA-QUARKS Survey.Ⅰ.Survey Description and Data Reduction

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Research in Astronomy and Astrophysics 2024年第2期24卷 104-124页

作者：刘训川 Tie Liu Lei Zhu Guido Garay Hong-Li Liu Paul Goldsmith Neal Evans Kee-Tae Kim Sheng-Yuan Liu Fengwei Xu Xing Lu Anandmayee Tej Xiaofeng Mai Leonardo Bronfman Shanghuo Li diego Mardones Amelia Stutz Ken'ichi Tatematsu Ke Wang Qizhou Zhang Sheng-Li Qin Jianwen Zhou Qiuyi Luo Siju Zhang Yu Cheng Jinhua He Qilao Gu Ziyang Li Zhenying Zhang Suinan Zhang Anindya Saha Lokesh Dewangan Patricio Sanhueza Zhiqiang Shen Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Departamento de Astronomía Universidad de ChileLas Condes7591245 SantiagoChile School of Physics and Astronomy Yunnan UniversityKunming 650091China Jet Propulsion Laboratory California Institute of Technology4800 Oak Grove DrivePasadena CA 91109USA Department of Astronomy The University of Texas at AustinTX 78712-1205USA Korea Astronomy and Space Science Institute 776 Daedeokdae-roYuseong-guDaejeon 34055Republic of Korea Institute of Astronomy and Astrophysics Academia SinicaRoosevelt RoadTaipei 10617China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China Indian Institute of Space Science and Technology Thiruvananthapuram 695547KeralaIndia Max Planck Institute for Astronomy Königstuhl 17D-69117 HeidelbergGermany Departamento de Astronomía Universidad de ConcepciónCasilla 160-CConcepciónChile Nobeyama Radio Observatory National Astronomical Observatory of JapanNational Institutes of Natural Sciences462-2 NobeyamaMinamimakiMinamisakuNagano 384-1305Japan Center for Astrophysics∣Harvard&Smithsonian 60 Garden StreetCambridgeMA 02138USA Max-Planck-Institut für Radioastronomie Auf dem Hügel 69D-53125 BonnGermany School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China National Astronomical Observatory of Japan 2-21-1 OsawaMitakaTokyo181-8588Japan Yunnan Observatories Chinese Academy of SciencesKunming 650216China Physical Research Laboratory NavrangpuraAhmedabad-380009India Astronomical Science Program The Graduate University for Advanced StudiesSOKENDAI2-21-1 OsawaMitakaTokyo 181-8588Japan University of Science and Technology Korea(UST)217 Gajeong-roYuseong-guDaejeon 34113Republic o

This paper presents an overview of the QUARKS survey,which stands for Querying Underlying mechanisms of massive star formation with ALMA-Resolved gas Kinematics and Structures."The QUARKS survey is observing139 massive clumps covered by 156 pointings at Atacama Large Millimeter/submillimeter Array(ALMA)Band 6(λ~1.3 mm).In conjunction with data obtained from the ALMA-ATOMS survey at Band 3(λ~3 mm),QUARKS aims to carry out an unbiased statistical investigation of massive star formation process within protoclusters down to a scale of 1000 *** overview paper describes the observations and data reduction of the QUARKS survey,and gives a first look at an exemplar source,the mini-starburst Sgr B2(M).The wide-b and width(7.5 GHz)and high-angular-resolution(~0."3)observations of the QUARKS survey allow for the resolution of much more compact cores than those could be done by the ATOMS survey,and to detect previously unrevealed fainter filamentary *** spectral windows cover transitions of species including CO,SO,N_(2)D^(+),SiO,H_(30)α,H_(2)CO,CH_(3)CN,and many other complex organic molecules,tracing gas components with different temperatures and spatial *** aims to deepen our understanding of several scientific topics of massive star formation,such as the mass transport within protoclusters by(hub-)filamentary structures,the existence of massive starless cores,the physical and chemical properties of dense cores within protoclusters,and the feedback from already formed high-mass young protostars.

关键词： stars formation-stars kinematics and dynamics-ISM clouds-ISM molecules

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Soil and vegetation water content identify the main terrestrial ecosystem changes

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National Science Review 2023年第5期10卷 167-179页

作者： diego Bueso Maria Piles Philippe Ciais Jean-Pierre Wigneron álvaro Moreno-Martínez Gustau Camps-Valls Image Processing Laboratory Universitat de València Laboratoire des Sciences du Climat et de l'Environnement Université Paris Saclay INRA Centre de Bordeaux Aquitaine Image Processing Laboratory Universitat deValència

Environmental change is a consequence of many interrelated *** vegetation responds to natural and human activity still needs to be well establishe d,quantified and *** cent satellite missions providing hydrologic and ecological indicators enable better monitoring of Earth system changes,yet there is no automatic way to address this issue directly from ***,we develop an observation-based methodology to capture evidence of changes in global terrestrial ecosystems and attribute these changes to natural or anthropogenic *** use the longest time record of global microwave L-band soil moisture and vegetation optical depth as satellite data and build spatially explicit maps of change in soil and vegetation water content and biomass reflecting large ecosystem changes during the last decade,*** of prominent trends(from-8% to 9% per year) are observed,especially in humid and semi-arid *** further combine such trends with land cover change maps,vegetation greenness and precipitation variability to assess their relationship with major documented ecosystem *** regions emerge from our *** cluster changes according to human activity drivers,including deforestation(Amazon,Central Africa) and wildfires(East Australia),artificial reforestation(South-East China),abandonment of farm fields(Central Russia) and climate shifts related to changes in precipitation variability(East Africa,North America and Central Argentina).Using the high sensitivity of soil and vegetation water content to ecosystem changes,microwave satellite observations enable us to quantify and attribute global vegetation responses to climate or anthropogenic activities as a direct measure of environmental changes and the mechanisms driving them.

关键词： soil moisture vegetation water content ecosystem trend remote sensing soil moisture and ocean salinity satellite

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Risk stratification of patients who present with chest pain and have normal troponins using a machine learning model

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World Journal of Cardiology 2022年第11期14卷 565-575页

作者： Muhammad Shafiq diego Robles Mazzotti Cheryl Gibson Division of General and Geriatric Medicine Department of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160United States Division of Medical Informatics&Division of Pulmonary Critical Care and Sleep Medicine Department of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160United States

BACKGROUND Risk stratification tools exist for patients presenting with chest pain to the emergency room and have achieved the recommended negative predictive value(NPV)of 99%.However,due to low positive predictive value(PPV),current stratification tools result in unwarranted investigations such as serial laboratory tests and cardiac stress tests(CSTs).AIM To create a machine learning model(MLM)for risk stratification of chest pain with a better *** This retrospective cohort study used de-identified hospital data from January 2016 until November *** criteria were patients aged>21 years who presented to the ER,had at least two serum troponins measured,were subsequently admitted to the hospital,and had a CST within 4 d of *** criteria were elevated troponin value(>0.05 ng/mL)and missing values for body mass *** primary outcome was abnormal ***,coronary artery disease(CAD)history,hypertension,hyperlipidemia,diabetes mellitus,chronic kidney disease,obesity,and smoking were evaluated as potential risk factors for abnormal *** were also categorized into a high-risk group(CAD history or more than two risk factors)and a low-risk group(all other patients)for *** analysis was performed using a χ^(2) test or Fisher’s exact *** was compared by t *** regression(BR),random forest,and XGBoost MLMs were used for *** was used for the internal validation of prediction *** was also used for *** criterion was set at 0.05 for all statistical tests.R software was used for statistical *** The final cohort of the study included 2328 patients,of which 245(10.52%)patients had abnormal *** adjusted for covariates in the BR model,male sex[risk ratio(RR)=1.52,95%confidence interval(CI):1.2-1.94,P<0.001],CAD history(RR=4.46,95%CI:3.08-6.72,P<0.001),and hyperlipidemia(RR=3.87,95%CI:2.12-8.12,P<0.001)remained statistically ***

关键词： Machine learning Chest pain Risk stratification Risk factors Cardiac stress test Cardiac catheterization

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Perspective:Advances in liver transplantation for hepatocellular carcinoma-A prototype for transplant oncology

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Hepatobiliary & Pancreatic Diseases International 2023年第1期22卷 4-6页

作者： John Fung diego DiSabato Chih-Yi Liao Osmanuddin Ahmed Anjana Pillai Liver Tumor Center The University of Chicago MedicineChicago 60637ILUSA

In his 1969 book,Experience in Hepatic Transplantation,Thomas E Starzl wrote:“the unequivocal indication for the operation of liver replacement was originally considered to be primary hepatic malignancy which could not be treated with conventional techniques of subtotal liver resection”[1].Thus,it was not surprising that many cases in the early reported series of orthotopic liver transplantation(OLT)were for malignant indications[2-4].

关键词： liver hepatic Hepatic

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国土空间保护下茶马古道大理珥西段区域空间特征研究

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住区 2024年第1期 127-136页

作者：王连迭戈·萨尔梅隆程海帆周峰越昆明理工大学建筑与城市规划学院城乡规划系昆明理工大学瑞士LEP规划咨询公司

以大理市国土空间总体规划专题研究之茶马古道修复及保护利用为例,探讨茶马古道洱西段(龙首关-龙尾关)沿线“点-线-面”文化空间廊道特征,综合评估划定沿线文化空间,量化分析与描述沿线空间形态,提出沿线分段保护修复及发展建议,探索再... 详细信息

以大理市国土空间总体规划专题研究之茶马古道修复及保护利用为例,探讨茶马古道洱西段(龙首关-龙尾关)沿线“点-线-面”文化空间廊道特征,综合评估划定沿线文化空间,量化分析与描述沿线空间形态,提出沿线分段保护修复及发展建议,探索再现茶马古道沿线区域空间特征。在新时代国土空间规划“一张图”体系及地理信息系统建设基础上,研究贯穿了建立历史道路名录信息库的科学方法,并为茶马古道“点-线-面”全要素集及保护修复提出一点参考。

关键词：滇藏茶马古道大理洱西段古驿道文化遗产空间特征线性文化遗产网络古驿道信息入库

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Taenidium barretti ichnofabric and rainfall seasonality:Insights into dryland suites of Scoyenia ichnofacies

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Journal of Palaeogeography 2023年第1期12卷 28-49页

作者： diego Luciano Nascimento Renata Guimaraes Netto Alessandro Batezelli Francisco Sergio bernardes Ladeira Daniel Sedorko ICHNOS Research Group Geology Graduate ProgramUnisinos UniversityAv.Unisinos95010 Sao LeopoldoRS93022-750Brazil Campinas State University Geology and Natural Resources DepartmentZeferino Vaz University CityBarao GeraldoCampinasSP13083-970Brazil Laboratory of Pedology(LABPED) Department of GeographyGeosciences InstituteGeosciencesState University of CampinasCampinasSP13083-855Brazil Museu Nacional Departamento de Geologia e PaleontologiaUniversidade Federal do Rio de Janeiro.Horto BotanicoParque Quinta da Boa VistaR.Gen.Herculano Gomes1340Sao CristovaoRio de JaneiroRJ20940-040Brazil

The present work analyzes the monotypic Taenidium barretti ichnofabric developed in abandoned channels and floodplains to understand its paleoecological significance in highly seasonal fluvial *** data come from the Cretaceous paleosols of the Marília Formation(Bauru Basin,SE Brazil),in which the *** ichnofabric and rhizoliths represent the biotic *** larvae are considered to be the most likely *** tracemakers in these *** intensity and recurrence of bioturbation suggest that the windows of opportunity for beetle population growth were very short and controlled by the progressive substrate desiccation after flood *** characteristics of the trace fossil assemblage suggest soil colonization by r-strategic organisms triggered by flooding events that provided the resource inputs necessary for their living during rainy *** results also show that in fluvial systems with high discharge variations,the boundaries between a“pre-desiccation suite”and a“desiccation suite”in the Scoyenia ichnofacies can be diffuse due to the short duration of colonization windows and progressive terrestrialization of floodplains and ***,the frequency of flooding events,the lowered water table,and the rapidity of substrate desiccation constrained colonization by other burrowers and may be considered as firstorder factors controlling the generation of a monotypic *** ***,the monotypic Taenidium ichnofabric in the Scoyenia ichnofacies context is an ichnomarker of brief windows for colonization in highly seasonal environments.

关键词： Ichnology Paleopedology Continental ichnofacies Meniscate burrows Ichnofabric

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Insights into induction of the immune response by the hepatitis B vaccine

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World Journal of Gastroenterology 2022年第31期28卷 4249-4262页

作者： Federico Alejandro Di Lello Alfredo Pedro Martínez diego Martín Flichman Microbiology Universidad de Buenos Aires.Facultad de Farmacia y Bioquímica.Instituto de Investigaciones en Bacteriología y Virología MolecularBuenos Aires C1113AADArgentina Consejo Nacional de Investigaciones Científicas y Técnicas Buenos Aires C1425FQBArgentina Virology Section Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno“CEMIC”Buenos Aires C1431FWOArgentina Microbiology Universidad de Buenos AiresInstituto de Investigaciones Biomédicas en Retrovirus y Síndrome de Inmunodeficiencia AdquiridaBuenos Aires C1121ABGArgentina

After more than four decades of hepatitis B virus(HBV)vaccine implementation,its safety and efficacy in preventing HBV infection have been proven and several milestones have been *** countries have included HBV immunization schedules in their health policies and progress has been made regarding universalization of the first HBV vaccine dose at *** of these actions have significantly contributed to reducing both the incidence of HBV infection and its related ***,there are still many drawbacks to *** main concerns are the deficient coverage rate of the dose at birth and the large adult population that has not been reached timely by universal ***,the current most widely used second-generation vaccines do not induce protective immunity in 5%to 10%of the population,particularly in people over 40-years-old,obese(body mass index>25 kg/m2),heavy smokers,and patients undergoing dialysis or infection with human immunodeficiency *** developed and approved novel vaccine formulations using more potent adjuvants or multiple antigens have shown better performance,particularly in difficult *** advances re-launch the expectations of achieving the World Health Organization’s objective of completing hepatitis control by 2030.

关键词： Hepatitis B virus Vaccine Immune response Antibodies Neutralizing

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