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临床皮肤科杂志 2010年第7期39卷 414-416页

作者： saint OLIVE BAQUE Celine 顾巍 saint-leger didier 欧莱雅中国研发中心上海201206

目的:了解头发的自然老化过程以及与头发生长期相关的一些具体参数。方法:采用宏观物理性能表征,电子显微镜观察,化学及生物化学分析等方法对1例生长26年、长4.3 m,近乎自然的中国女性长发进行研究。结果:从该例超长头发的分析显示,头... 详细信息

目的:了解头发的自然老化过程以及与头发生长期相关的一些具体参数。方法:采用宏观物理性能表征,电子显微镜观察,化学及生物化学分析等方法对1例生长26年、长4.3 m,近乎自然的中国女性长发进行研究。结果:从该例超长头发的分析显示,头发并无任何异于其他中国人头发的特别之处。然而,头发随时间的自然老化过程却相当明显:在从发根开始的最初1 m范围内,头发保持着较好的物理及化学特性;而在随后的1 m范围内,所有的宏观及微观特性急剧下降。结论:头发自然老化的过程中,毛小皮首先受到影响,紧接着皮质层基质(KAP)受到破坏,最终破坏达角蛋白网络。

关键词：生长期头发自然老化

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World Journal of Gastroenterology 2008年第40期14卷 6115-6121页

作者： didier Merlin Department of Medicine Division of Digestive DiseasesEmory University School of Medicine

Recently, inflammatory bowel disease （IBD） has been the subject of considerable research, with increasing attention being paid to the loss of intestinal epithelial cell barrier function as a mechanism of pathogenesis. Ste20-related proline/alanine-rich kinase （SPAK） is involved in regulating barrier function. SPAK is known to interact with inflammation-related kinases （such as p38, JNK, NKCC1, PKCS, WNK and MLCK）, and with transcription factor AP-1, resulting in diverse biological phenomena, including cell differentiation, cell transformation and proliferation, cytoskeleton rearrangement, and regulation of chloride transport. This review examines the involvement of Ste20-1ike kinases and downstream mitogen-activated protein kinases （MAPKs） pathways in the pathogenesis and control of intestinal inflammation. The primary focus will be on the molecular features of intestinal inflammation, with an emphasis on the interaction between SPAK and other molecules, and the effect of these interactions on homeostatic maintenance, cell volume regulation and increased cell permeability in intestinal inflammation.

关键词： Inflammatory bowel diseases WNK NKCCl Barrier function Ste20-related proline/alanine-rich kinase

Preliminary study of mollusk fossils in the Qinan Miocene loess-soil sequence in western Chinese Loess Plateau

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Science China Earth Sciences 2006年第7期49卷 724-730页

作者： Denis-didier Rousseau Université Montpellier II Institut des Sciences de l’Evolution (UMR CNRS 5554) Case 61 Place E. Bataillon 34095 Mont-pellier Cedex 05 France Lamont-Doherty Earth Observatory of Columbia University Palisades New York 10964 USA

The first near continuous mollusk fossil record from the Qinan Miocene loess-soil se-quence is presented. Results show that mollusk species are abundant in the QA-I section between 22 and 6.2 Ma, and both loess layers and soil layers yield mollusk fossil individuals. All mollusk species are terrestrial and well preserved in the section. Most species are identical to those identified in the Quaternary loess-soil sequence of the Loess Plateau. The thermo-humidiphilous group generally is distributed in soil layers, whereas cold-aridiphilous group can be observed in loess layers. From the Miocene to Quaternary, the occurrence and divergence of new species of Metodontia and Cathaica correspond to the crucial periods of regional and global environmental changes, indicating that mol-lusk species are sensitive to environmental variations. Preliminary study on the QA-I mollusk record indicates that the Qinan Miocene loess-soil sequence may have a similar sedimentary environment to the Quaternary loess-soil sequence of the Loess Plateau.

关键词： mollusk fossils, Miocene loess, Loess Plateau, mollusk evolution, sedimentary environment.

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Electron spectroscopies and their use for materials characterization

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Nuclear Science and Techniques 2003年第1期14卷 28-48页

作者： didier SBILLEAU Bat.11C France Laboratoire PALMS UMR CNRS-Universite 6627 Universite de Rennes-1 35042 Rennes-Cedex

We present here a general overview of electron spectroscopies from a practical point of view. The most frequently used ones are described and the type of structural information they can provide on materials is explained in relation to the physical processes on which they are based. Furthermore, we explore critically and in detail various tools that have been developed to allow a systematic solving of structures by these spectroscopies.

关键词： Electron spectroscopy Materials characterization Surface analysis

On the Motion Law of Fronts for Scalar Reaction-Diffusion Equations with Equal Depth Multiple-Well Potentials

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Chinese Annals of Mathematics,Series B 2017年第1期38卷 83-148页

作者： Fabrice BETHUEL didier SMETS UPMC-Paris6 UMR 7598 LJLLParisF-75005France

Slow motion for scalar Allen-Cahn type equation is a well-known phenomenon,precise motion law for the dynamics of fronts having been established first using the socalled geometric approach inspired from central manifold theory(see the results of Carr and Pego in 1989). In this paper, the authors present an alternate approach to recover the motion law, and extend it to the case of multiple wells. This method is based on the localized energy identity, and is therefore, at least conceptually, simpler to implement. It also allows to handle collisions and rough initial data.

关键词： Reaction-diffusion systems Parabolic equations Singular limits

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Capabilities and limitations of 3D printed microserpentines and integrated 3D electrodes for stretchable and conformable biosensor applications

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Microsystems & Nanoengineering 2020年第1期6卷 1078-1092页

作者： Charles didier Avra Kundu Swaminathan Rajaraman Nanoscience Technology Center(NSTC) University of Central FloridaOrlandoFL 32826USA Burnett School of Biomedical Sciences University of Central FloridaOrlandoFL 32827USA Department of Materials Science&Engineering University of Central FloridaOrlandoFL 32816USA Department of Electrical&Computer Engineering University of Central FloridaOrlandoFL 32816USA

We explore the capabilities and limitations of 3D printed microserpentines(µserpentines)and utilize these structures to develop dynamic 3D microelectrodes for potential applications in in vitro,wearable,and implantable microelectrode arrays(MEAs).The device incorporates optimized 3D printedµserpentine designs with out-of-plane microelectrode structures,integrated on to a flexible Kapton®package with micromolded PDMS *** flexibility of the optimized,printedµserpentine design was calculated through effective stiffness and effective strain equations,so as to allow for analysis of various designs for enhanced *** optimized,down selectedµserpentine design was further sputter coated with 7–70 nm-thick gold and the performance of these coatings was studied for maintenance of conductivity during uniaxial strain ***/conforming analysis of the final devices(3D MEAs with a Kapton®package and PDMS insulation)were performed to qualitatively assess the robustness of the finished device toward dynamic MEA applications.3D microelectrode impedance measurements varied from 4.2 to 5.2 kΩduring the bending process demonstrating a small change and an example application with artificial agarose skin composite model to assess feasibility for basic transdermal electrical recording was further demonstrated.

关键词： microelectrode insulation utilize

The supramolecular redox functions of metallomacromolecules

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Journal of Leather Science and Engineering 2020年第1期2卷 129-145页

作者： didier Astruc ISM UMR CNRS 5255Univ.Bordeaux351 Cours de la Liberation33405 Talence CedexFrance

Metallomacromolecules are frequently encountered in redox proteins including metal-tanned hide collagen and play crucial roles involving supramolecular properties in biological electron-transfer *** are also currently found in non-natural families,such as:metallopolymers,metallodendrimers and metallodendronic *** mini-review discusses the supramolecular redox functions of such nanomaterials developed in our research ***-transfer processes are first examined in mono-,bis-and hexa-nuclear ferrocenes and other electron-reservoir organoiron systems showing the influence of supramolecular and reorganization aspects on their *** applications of electron-transfer processes using these same organoiron redox systems in metallomacromolecules and their supramolecular functions are discussed including redox recognition/sensing,catalysis templates,electrocatalysis,redox catalysis,molecular machines,electrochromes,drug delivery device and nanobatteries.

关键词： Ferrocene electron reservoir Polymer Dendrimer Redox catalyst Redox sensor Molecular machine Supramolecular template Electrochrome Drug delivery device Battery