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Traits associated with winter wheat grain yield in Central and West Asia

Journal of Integrative Plant Biology 2014年第7期56卷 673-683页

作者： Marta Silva Lopes didem saglam Mutlu Ozdogan Matthew Reynolds CIMMYT University of Ahi Evran Faculty of Agriculture Department of Plant Protection Center for Sustainability and the Global Environment University of Wisconsin‐Madison

Improved adaptation of winter wheat （Triticum aestivum L.） to drought and heat may be influenced by days to heading, plant height, biomass, canopy temperature （CT） at grain fil ing, and rate of senescence. This study shows that, under supplemental irrigation or rainfed conditions, days to heading and plant height together explain up to 68%of grain yield （GY） variation, and these associations were further confirmed in several locations across West and Central Asia. Days to heading can be slightly reduced below that of check line Karahan to further improve GY while avoiding the effect of late frosts. Plant height has been decreased in recent germplasm, but further reductions below that of check line Karahan could stil improve GY in a wide range of environ-ments. However, in Iranian sites, tal er genotypes showed better adaptation with higher biomass and increased reserves＆amp;nbsp;for grain fil ing. Canopy temperature and rate senescence were not associated with GY. A normalized difference vegetation index, used to estimate biomass （Feekes stages 4-5）, had intermediate heritability across environments and correlated positively with GY under low plant density and should be explored further as a tool for early selection.

关键词： Biomass GxE earliness phenology plant height NDVI rain-fed yield

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Neoadjuvant intermediate-course versus long-course chemoradiotherapy in T3-4/N0+rectal cancer:Istanbul R-02 phase II randomized study

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Oncology Research 2023年第5期31卷 689-696页

作者： SUKRAN SENYUREK SEZER saglam ESRA KAYTAN saglam HAKAN YANAR KAAN GOK didem TASTEKIN CANAN KOKSAL AKBAS NERGIZ DAGOGLU SAKIN GULBIZ DAGOGLU KARTAL EMRE BALIK METIN KESKIN YASEMIN SANLI MINE GULLUOGLU ZULEYHA AKGUN Department of Radiation Oncology Koc University School of MedicineIstanbul34450Türkiye Department of Medical Oncology Demiroglu Bilim University Faculty of MedicineIstanbul34394Türkiye Department of Radiation Oncology Istanbul University Oncology InstituteIstanbul34093Türkiye Department of General Surgery Istanbul University Istanbul Faculty of MedicineIstanbul34093Türkiye Department of Medical Oncology Istanbul University Oncology InstituteIstanbul34093Türkiye Department of Medical Physics Istanbul University Oncology InstituteIstanbul34093Türkiye Department of Radiology Istanbul University Istanbul Faculty of MedicineIstanbul34093Türkiye Department of General Surgery Koc University School of MedicineIstanbul34450Türkiye Department of Nuclear Medicine Istanbul University Istanbul Faculty of MedicineIstanbul34093Türkiye Department of Pathology Istanbul University Istanbul Faculty of MedicineIstanbul34093Türkiye Department of Radiation Oncology Memorial Sisli HospitalIstanbul34384Türkiye

Radiation therapy(RT)is typically applied using one of two standard approaches for preoperative treatment of resectable locally advanced rectal cancer(LARC):short-course RT(SC-RT)alone or long-course RT(LC-RT)with concurrent fluorouracil(5-FU)*** Phase II single-arm KROG 11-02 study using intermediate-course(IC)(33 Gy(Gray)/10 fr(fraction)with concurrent capecitabine)preoperative chemoradiotherapy(CRT)demonstrated a pathologically complete response rate and a sphincter-sparing rate that were close to those of *** current trial aim to compare the pathological/oncological outcomes,toxicity,and quality of life results of LC-CRT and IC-CRT in cases of *** prescribed dose was 33 Gy/10 fr for the IC-CRT group and 50.4 Gy/28 fr for the LC-CRT *** chronomodulated capecitabine(Brunch regimen)1650 mg/m2/daily chemotherapy treatment was applied in both *** European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Colorectal Cancer Module(EORTC QLQ-CR29)was administered at baseline and at three and six months after CRT.A total of 60 patients with LARC randomized to receive IC-CRT(n=30)or LC-CRT(n=30)were included in this phase II randomized *** significant difference was noted between groups in terms of pathological outcomes,including pathological response rates(ypT0N0-complete response:23.3%vs.16.7%,respectively,and ypT0-2N0-downstaging:50%for each;p=0.809)and Dworak score-based pathological tumor regression grade(Grade 4-complete response:23.3 vs.16.7%,p=0.839).The 5-year overall survival(73.3 vs.86.7%,p=0.173)rate was also *** acute radiation dermatitis(p<0.001)and any hematological toxicity(p=0.004)rates were significantly higher in the LC-CRT group,while no significant difference was noted between treatment groups in terms of baseline,third month,and sixth month EORTC QLQ-CR29 scores.

关键词： Chemoradiotherapy Rectal cancer Neoadjuvant therapy

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Multi-institutional analysis of cervical esophageal carcinoma patients treated with definitive chemoradiotherapy: TROD 01-005 study

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Oncology Research 2023年第3期31卷 299-306页

作者： OZAN CEM GULER EZGI OYMAK GOZDE YAZICI OZLEM OZKAYA AKAGUNDUZ OGUZ CETINAYAK PETEK ERPOLAT ATIL AKSOY MURSEL DUZOVA BERNA AKKUS YILDIRIM MERAL KURT EMINE CANYILMAZ GULER YAVAS SERAP AKYUREK didem COLPAN OKSUZ ESRA KAYTAN saglam OMUR KARAKOYUN CELIK ENIS OZYAR MUSTAFA CENGIZ CEM ONAL Department of Radiation Oncology Faculty of MedicineBaskent UniversityAdana Dr.Turgut Noyan Research and Treatment CenterAdanaTurkey Radiation Oncology Unit Iskenderun Gelisim HospitalHatayTurkey Department of Radiation Oncology Faculty of MedicineHacettepe UniversityAnkaraTurkey Department of Radiation Oncology Faculty of MedicineEge UniversityIzmirTurkey Department of Radiation Oncology Faculty of Medicine9 Eylul UniversityIzmirTurkey Department of Radiation Oncology Faculty of MedicineGazi UniversityAnkaraTurkey Department of Radiation Oncology Faculty of MedicineAkdeniz UniversityAntalyaTurkey Department of Radiation Oncology Faculty of MedicineSelcuk UniversityKonyaTurkey Radiation Oncology Unit Prof.Dr.Cemil Tascioglu HospitalİstanbulTurkey Department of Radiation Oncology Faculty of MedicineUludag UniversityBursaTurkey Department of Radiation Oncology Faculty of MedicineKaradeniz Technical UniversityTrabzonTurkey Department of Radiation Oncology Faculty of MedicineBaskent UniversityAnkaraTurkey Department of Radiation Oncology Faculty of MedicineAnkara UniversityAnkaraTurkey Department of Radiation Oncology Faculty of MedicineIstanbul University CerrahpasaIstanbulTurkey Radiation Oncology Unit Memorial Sisli HospitalIstanbulTurkey Department of Radiation Oncology Faculty of MedicineCelal Bayar UniversityManisaTurkey Department of Radiation Oncology Acibadem University Maslak HospitalIstanbulTurkey

The aim of this study was to examine the prognostic factors and treatment outcomes of cervical esophageal carcinoma(CEC)patients who underwent definitive chemoradiotherapy(CRT).The clinical data of 175 biopsyconfirmed CEC patients treated with definitive CRT between April 2005 and September 2021 were retrospectively *** prognostic factors predicting overall survival(OS),progression-free survival(PFS),and local recurrence-free survival(LRFS)were assessed in uni-and multivariable *** median age of the entire cohort was 56 years(range:26–87 years).All patients received definitive radiotherapy with a median total dose of 60 Gy,and 52%of the patients received cisplatin-based concurrent *** 2-year OS,PFS,and LRFS rates were 58.8%,46.9%,and 52.4%,respectively,with a median follow-up duration of 41.6 ***’performance status,clinical nodal stage,tumor size,and treatment response were significant prognostic factors for OS,PFS,and LRFS in univariate ***-complete treatment response was an independent predictor for poor OS(HR=4.41,95%CI,2.78–7.00,p<0.001)and PFS(HR=4.28,95%CI,2.79–6.58,p<0.001),whereas poor performance score was a predictor for worse LRFS(HR=1.83,95%CI,1.12–2.98,p=0.02)in multivariable ***-two patients(29.7%)experienced grade II or higher *** this multicenter study,we demonstrated that definitive CRT is a safe and effective treatment for patients with *** radiation doses were found to have no effect on treatment outcomes,but a better response to treatment and a better patient performance status did.

关键词： Esophageal cancer Chemoradiotherapy Radiotherapy Local control Toxicity Survival

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