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A 4-year retrospective study of add-on therapy to the fixed combination of dorzolamide/timolol for the treatment of POAG

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 330-334页

作者： Curt Hartleben-Matkin diddier prada Rafael Mancilla-Vences Glaucoma Service Instituto de Oftalmología Fundación Conde de Valenciana Unidad de Investigación Biomédica en Cáncer Instituto Nacional de Cancerología de México Departamento de Informática Biomédica Faculty of Medicine Universidad Nacional Autónoma de México(UNAM) Laboratory of Environmental Epigenetics Harvard School of Public Health

AIM:To evaluate the long-term response to the fixed combination of dorzolamide/timolol in patients with primary open angle glaucoma(POAG)and the addition of other intraocular pressure(IOP)lowering medications such as prostaglandin analogs and ***:A retrospective,non-randomized,and descriptive clinical study was performed with 182 eyes diagnosed with *** were divided into three groups:a group with fixed combination of dorzolamide/timolol only,a second group with prostaglandin analogs plus fixed combination of dorzolamide/timolol,and a third group with the addition of brimonidine to the same fixed *** data were gathered retrospectively and the differences between groups were ***:IOP was reduced satisfactorily in all three groups;however,a progressive IOP reduction was noted in the group with the fixed combination plus prostaglandin *** this group,a progressive,significant and more homogeneous response of the reduction was noted in comparison with the other ***:IOP reduction was efficacious in all three *** addition of prostaglandin analogs showed progressive IOP reduction,progressive responseand absence of long-term *** did not show a significant additive effect.

关键词： fixed combination, Cosopt® , dorzolamide/timolol, prostaglandin analogs, brimonidine, glaucoma

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Mutational landscape of gastric adenocarcinoma in Latin America: A genetic approach for precision medicine

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Genes & Diseases 2022年第4期9卷 928-940页

作者： Dennis Cerrato-Izaguirre Yolanda I.Chirino Claudia M.García-Cuellar Miguel Santibáñez-Andrade diddier prada Angélica Hernández-Guerrero Octavio Alonso Larraga Javier Camacho Yesennia Sánchez-Pérez Subdirección de Investigación Básica Instituto Nacional de Cancerología(INCan)TlalpanCiudad de MéxicoCP 14080Mexico Departamento de Farmacología Centro de Investigación y de Estudios Avanzados del I.P.N.(CINVESTAV)Ciudad de MéxicoCP 07360Mexico Unidad de Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoLos Reyes IztacalaTlalnepantla de BazEstado de MéxicoCP 54090Mexico Departamento de Informática Biomédica Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoCoyoacánCiudad de MéxicoCP 04510Mexico Department of Environmental Health Science Mailman School of Public HealthColumbia UniversityNew YorkNY 10027USA Servicio de Endoscopía Instituto Nacional de Cancerología(INCan)TlalpanCiudad de MéxicoCP 14080Mexico

Latin-America (LATAM) is the second region in gastric cancer incidence;gastric adenocarcinoma (GA) represents 95% of all cases. We provide a mutational landscape of GA highlighting a) germline pathogenic variants associated with hereditary GA, b) germline risk variants associated with sporadic GA, and c) somatic variants present in sporadic GA in LATAM, and analyze how this landscape can be applied for precision medicine. We found that Brazil, Chile, Colombia, Mexico, Peru, and Venezuela are the countries with more published studies from LATAM explicitly related to GA. Our analysis displayed that different germline pathogenic variants for the CDH1 gene have been identified for hereditary GA in Brazilian, Chilean, Colombian, and Mexican populations. An increased risk of developing somatic GA is associated with the following germline risk variants: IL-4, IL-8, TNF-α, PTGS2, NFKB1, RAF1, KRAS and MAPK1 in Brazilian;IL-10 in Chilean;IL-10 in Colombian;EGFR and ERRB2 in Mexican, TCF7L2 and Chr8q24 in Venezuelan population. The path from mutational landscape to precision medicine requires four development levels: 1) Data compilation, 2) Data analysis and integration, 3) Development and approval of clinical approaches, and 4) Population benefits. Generating local genomic information is the initial padlock to overcome to generate and apply precision medicine.

关键词： Ethnicities Genome Latin America Mutati on Precisi on medicine Stomach neoplasms

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Neurophysics Assessment of the Muscle Bioenergy Generated by Transcranial Magnetic Stimulation

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Research 2019年第1期2019卷 1077-1085页

作者： Fidias E.Leon-Sarmiento Alexander Gonzalez-Castaño Carlos V.Rizzo-Sierra Juan Aceros Daniel S.Leon-Ariza Juan S.Leon-Ariza diddier G.prada William Bara-Jimenez Zeng Y.Wang Smell and Taste Center Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA Human Motor Control Section NINDSNational Institutes of HealthBethesdaMDUSA Mediciencias Research Group LouisvilleKYUSA Universidad Internacional de la Rioja Spain Neurophysics Unit Corporacion Universitaria Minuto de Dios-UNIMINUTOColombia Charity Association for Person Centered Medicine Moral EntityItaly School of Engineering University of North FloridaJacksonvilleFLUSA Faculty of Health Sciences Santander UniversityUDESColombia Department of Neurosurgery Johns Hopkins UniversityBaltimoreMAUSA Harvard T.H.Chan School of Public Health Harvard UniversityBostonMAUSA Unidad de Investigacion Biomedica en Cancer Instituto Nacional de CancerMexico DFMexico Neuromuscular Division Department of NeurologyUniversity of LouisvilleLouisvilleKYUSA

Te content of the rectifed motor evoked potential(MEP)induced by transcranial magnetic stimulation(TMS)has ambiguously been assessed without the precision that energy calculation *** fact has misled data interpretation and misguided biomedical *** defnitively fll the gap that exits in the neurophysics processing of these signals,we computed,in Walls(̂�),the bioenergy within the rectifed MEP recorded from the human frst digitorum index(FDI)muscle at rest and under isometric *** also gauged the biowork exerted by this *** we show that bioenergy and biowork can accurately and successfully be assessed,validated,and determined in̂�from MEP signals induced by TMS,regardless of knowing the mathematical expression of the function of the *** novel neurophysics approach represents a dramatic paradigm shif in analysis and interpretation of the content of the MEP and will give a true meaning to the content of rectifed ***,this innovative approach allowed unveiling that women exerted more bioenergy than men at the magnetic stimulations used in this *** of conclusions drawn from studies published elsewhere assessing rectifed EMG signals that have used ambiguous units is strongly recommended.

关键词： stimulation gauge allowed

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