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Rectal cancer treatment: improving the picture

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World Journal of Gastroenterology 2007年第44期13卷 5805-5812页

作者： Juan A diaz-Gonzalez Leire Arbea Javier Aristu Department of Oncology Clinica Universitaria Universtity of Navarra Pamplona 31080 Spain

Multidisciplinary approach for rectal cancer treatment is currently well defined. Nevertheless, new and promising advances are enriching the portrait. Since the US NIH Consensus in the early 90's some new characters have been added. A bird's-eye view along the last decade shows the main milestones in the development of rectal cancer treatment protocols. New drugs, in combination with radiotherapy are being tested to increase response and tumor control outcomes. However, therapeutic intensity is often associated with toxicity. Thus, innovative strategies are needed to create a better-balanced therapeutic ratio. Molecular targeted therapies and improved technology for delivering radiotherapy respond to the need for accuracy and precision in rectal cancer treatment.

关键词： Rectal cancer Chemoradiotherapy Intensitymodulated radiation therapy Molecular targeted therapy

Some Comments on Zonal Polynomials and Their Expected Values with respect to ***

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Acta Mathematicae Applicatae Sinica 2017年第3期33卷 567-574页

作者： Jose A.diaz-Garcia Ramon Gutierrez-Jaimez Department of Statistics and Computation Universidad Autonoma Agraria Antonio Narro25350 BuenavistaSaltilloCoahuilaMexico Department of Statistics and O.R University of GranadaGranada 18071Spain

In this paper, we give alternative proofs of some results in [15] （Li R.,1997） about the expected value of zonal polynomials.

关键词： elliptical matrix distributions random matrices zonal polynomials generalised Wishart distribution

The Beauty of Being a Variant： H2A.Z and the SWR1 Complex in Plants

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Molecular Plant 2009年第4期2卷 565-577页

作者： Rosana March-diaz Jose C. Reyes Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER) CSIC Americo Vespucio s/n E-41092 Sevilla Spain

Numerous studies have shown that the nucleosome is a dynamic structure that strongly influences gene expression. Dynamism concerns different nucleosomal characteristics, including position, posttranslational modifications, and histone composition. Thus, within the nucleosome, canonical histones can be exchanged by histone variant proteins with specific functions--a process known as ‘histone replacement＇. The histone variant H2A.Z has an important function in transcription and, during the last few years, its role in plant development and immune response has become evident. Compiling genetic and biochemical studies from several laboratories has revealed that plants contain a multiprotein complex, similar to the SWR1/SRCAP complex from yeast and animals, involved in H2A.Z deposition. Despite intense research in different organisms, the mechanism by which H2A.Z influences transcription is still unknown. However, recent results from Arabidopsis have shown a strong inverse correlation between H2A.Z and DNA methylation, suggesting that H2A.Z might protect genes from silencing.

关键词： Chromatin structure and remodeling epigenetics gene regulation floral induction.

Comparative transcriptomics reveals hidden issues in the plant response to arthropod herbivores

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Journal of Integrative Plant Biology 2021年第2期63卷 312-326页

作者： M.Estrella Santamaria Alejandro Garcia Ana Amaiz Irene Rosa-diaz Gara Romero-Hernandez Isabel diaz Manuel Martinez Centro de Biotecnologia y Genomica de Plantas Instituto Nacional de Investigacion y Tecnologia Agraria y AlimentariaUniversidad Politecnica de MadridMadridSpain Departamento de Biotecnologia-Biologia Vegetal Escuela Tecnica Superior de Ingenierfa AgronomicaAlimentaria y de BiosistemasUniversidad Politecnica de MadridMadridSpain

Plants experience different abiotic/biotic stresses,which trigger their molecular machinery to cope with them. Besides general mechanisms prompted by many stresses, specific mechanisms have been introduced to optimize the response to individual threats. However, these key mechanisms are difficult to identify. Here, we introduce an in-depth species-specific transcriptomic analysis and conduct an extensive meta-analysis of the responses to related species to gain more knowledge about plant responses. The spider mite Tetranychus urticae was used as the individual species, several arthropod herbivores as the related species for meta-analysis, and Arabidopsis thaliana plants as the common host. The analysis of the transcriptomic data showed typical common responses to herbivory, such as jasmonate signaling or glucosinolate biosynthesis. Also, a specific set of genes likely involved in the particularities of the Arabidopsis-spider mite interaction was discovered. The new findings have determined a prominent role in this interaction of the jasmonateinduced pathways leading to the biosynthesis of anthocyanins and tocopherols. Therefore, tandem individual/general transcriptomic profiling has been revealed as an effective method to identify novel relevant processes and specificities in the plant response to environmental stresses.

关键词： Arabidopsis thaliana arthropod herbivore comparative transcriptomics plant defense Tetranychus urticae

An Invitation to Friendly Testing

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Journal of Computer Science & Technology 1998年第6期13卷 531-535页

作者： DaviddeFrutos－Escring LuisLlana－diaz 等 Dept.deSistemasInformaticosyProgramacionUniversidadComplutensedeMadrid E－28040MadridSpain Dept.deSis

We present a new testing semantics, called friendly testing, whose main property is thatthe induced preorder between processes fr is consistent with the conformance relation, andso we have, for instance, a b fr a fr a + b. The new theory is strongly based on De Nicola& Hennessy's work on testing. Friendly tests are defined exactly as in their work, except thatinternal actions are not allowed. However, in order to obtain the desired notion of friendlytesting this restriction is not enough and we also have to relax the conditions to pass a *** we obtain a new testing semantics and a new preorder between processes which is strictlyweaker than the relation must. Moreover, we present an alternative characterization of ournew testing semantics by defining a modification of acceptance sets.

关键词： Process algebra semantics of concurrency testing conformance.

Hydrogen storage in a rare-earth perovskite-type oxide La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_3 for battery applications

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Rare Metals 2018年第12期37卷 1003-1013页

作者： John Henao Oscar Sotelo Maura Casales-diaz Lorenzo Martinez-Gomez CONACYT-CIATEQ A.C. Av. Manantiales 23-AParque Industrial Bernardo Quintana Instituto de Ciencias Fisicas (ICF) Universidad Nacional Autonoma de Mexico (UNAM)-Campus Morelos

Recently, rare-earth perovskite-type oxides with the general formula ABO(A rare earth element, B transition metal, O oxygen) are regarded as promising materials for Ni/oxide batteries due to their hydrogen storage ability. In the present study, the hydrogen storage properties of the rare-earth perovskite-type oxide LaSrCoFeOwere evaluated in alkaline solution and at various temperatures. The hydrogen storage properties were investigated electrochemically by applying galvanostatic charge/discharge currents. Electrochemical pressurecomposition-temperature isotherms were constructed using the Nernst equation. The exchange current density and proton hydrogen diffusion coefficient were calculated using linear polarization measurements and the potential-step method, respectively. Interestingly, the maximum hydrogen absorption capacity, re-calculated from the electrochemical capacity, is 1.72 wt% at 333 K and 6 mol·LKOH. In addition, the hysteresis value, calculated from pressure-composition-temperature isotherms, was429 J·molat 333 K,while the self-discharge rate was about 25% after 24-h storage at open circuit and at 333 K.

关键词： Hydrogen storage Rare earths Perovskites Ni/oxide batteries

Clinical and Demographic Profile of Women with Uterine Fibroids Living in Puerto Rico

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Open Journal of Obstetrics and Gynecology 2024年第9期14卷 1347-1362页

作者： Edwin Y. Soto-Velázquez Alexander J. Jaramillo-Cañas Shania N. Aponte-Paris Gabriela V. Martínez-Marrero Irazu S. Guinan Gabrielle A. Rivera-Maldonado Alexandra Novas Pedro L. Cruz-Rosa Idhaliz Flores-Caldera Maricarmen Colón-diaz Department of Physiology and Pathology San Juan Bautista School of Medicine Caguas Puerto Rico United States Ponce Research Institute Ponce Health Sciences University Ponce Puerto Rico United States

Introduction: Uterine leiomyomas, or fibroids, are prevalent benign tumors affecting up to 70% of reproductive-age women in the United States, significantly impacting productivity and quality of life. Despite their commonality, the epidemiology and clinical patterns of leiomyomas in Puerto Rico remain inadequately researched. Methods: This study conducted a secondary data analysis using clinical, menstrual cycle characteristics, and demographic data from self-administered questionnaires of women undergoing diagnostic laparoscopy for endometriosis in Puerto Rico. Chi-square tests and t-tests analyzed categorical and continuous variables, respectively (p Results: Among 1,610 endometriosis cases, 312 included uterine fibroids. Prevalence estimates were 10.3% (40 years). Primiparous women averaged 22.14 years, with 40.71% having 2 - 3 pregnancies and 26.28% experiencing miscarriages. Symptoms included infertility (29.5%), dyspareunia (40.7%), severe pain (50%), and dysmenorrhea (75.6%). Comorbidities included ovarian cysts (52.2%) and abnormal uterine bleeding (37.8%). Conclusions: Advanced age, parity, and comorbidities like diabetes and hypertension were prevalent in our cohort. Understanding the epidemiological profile of women living in Puerto Rico with uterine fibroids is crucial for improving diagnostic awareness and enhancing patient care.

关键词： Uterine Fibroids Puerto Rico Epidemiology Dysmenorrhea Abnormal Uterine Bleeding

Variability in Latent Heat Flux over the Tropical Pacific in Association with Recent Two ENSO Events

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Advances in Atmospheric Sciences 1992年第3期9卷 351-358页

作者：符淙斌 Henry diaz 范慧君 Institute of Atmospheric Physics Academia Sinica and CIRES University of Colorado Boulder CO 80309 USA NOAA / ERL 325 Broadway Boulder CO 80303 USA State Meteorological Administration Beijing 100081his paper analyzed the variations of latent heat flux (LHF) over the tropical Pacific in the period 1978-1988 by using COADS (Comprehensive Ocean and Atmospheric Data Set). It has been founded that the interannual variabili ty of LHF exhibits strong ENSO signal with the significant increasing LHF during the recent two warm events i.e. 1982 / 83 and 1986 / 87 and decreasing LHF in the cold episodes. However the longitudinal distribution of the LHF departures varies from event to event. In the eastern Pacific the specific humidity difference at air-sea interface (qs -qa) makes a dominant contribution to the interannual variability of LHF ( r = 0.73 ) while in the western Pacific the surface wind speed W and the qs - qa make nearly equal contribution to that of LHF.

This paper analyzed the variations of latent heat flux (LHF) over the tropical Pacific in the period 1978-1988 by using COADS (Comprehensive Ocean and Atmospheric Data Set). It has been founded that the interannual variabili ty of LHF exhibits strong ENSO signal, with the significant increasing LHF during the recent two warm events, i.e., 1982 / 83 and 1986 / 87 and decreasing LHF in the cold episodes. However the longitudinal distribution of the LHF departures varies from event to event. In the eastern Pacific, the specific humidity difference at air-sea interface (qs -qa) makes a dominant contribution to the interannual variability of LHF ( r = 0.73 ), while in the western Pacific the surface wind speed, W and the qs - qa make nearly equal contribution to that of LHF.

关键词： over Variability in Latent Heat Flux over the Tropical Pacific in Association with Recent Two ENSO Events ENSO

Nonlinear parabolic predator-prey coupled system with convection

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International Journal of Biomathematics 2021年第2期14卷 83-118页

作者： Jose Luis diaz Palencia Mariano Fernandez Lopez University Foundation San Pablo CEU Spain

The aim of this work is to provide a formulation of two related nonlinear diffusive convective models in the form of coupled reaction-absorption ***,the postulated models are studied with an analytical *** on,numerical evidences are considered to account for a precise *** problem(P)analyzed is of the form:ut=δΔu+c⋅∇u+v^(n),vt=ϵΔv+c⋅∇v−um,n,m∈(0,1),u_(0)(x),v_(0)(x)>0∈L^(1)_(loc)(RN)∩L^(∞)(R^(N)).(0.1)Afterwards,a related problem P_(T)is studied:ut=δΔu+c⋅∇u−v^(n)(u−d),vt=ϵΔv+c⋅∇v−u^(m)v,n,m∈(0,1),u_(0)(x),v_(0)(x)>0∈L^(1)_(loc)(R^(N))∩L^(∞)(R^(N)).(0.2)The principal aspects for analysis are related to the existence and the derivation of particular solutions to reproduce the dynamic of the interacting *** the problem PT,we make use of the TW approach to study existence of solutions and precise evolution of *** that the term predator is used to refer to an invasive behavior,while the term prey is used for the invaded species.

关键词： Nonlinearity reaction absorption coupled system diffusion,traveling waves