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Assessment of compressive strength of jet grouting by machine learning

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 102-111页

作者： Esteban diaz Edgar Leonardo Salamanca-Medina Roberto Tomas Departamento de Ingeniería Civil Escuela Politécnica SuperiorUniversidad de AlicanteP.O.Box 99E-03080AlicanteSpain

Jet grouting is one of the most popular soil improvement techniques,but its design usually involves great uncertainties that can lead to economic cost overruns in construction *** high dispersion in the properties of the improved material leads to designers assuming a conservative,arbitrary and unjustified strength,which is even sometimes subjected to the results of the test *** present paper presents an approach for prediction of the uniaxial compressive strength(UCS)of jet grouting columns based on the analysis of several machine learning algorithms on a database of 854 results mainly collected from different research *** selected machine learning model(extremely randomized trees)relates the soil type and various parameters of the technique to the value of the compressive *** the complex mechanism that surrounds the jet grouting process,evidenced by the high dispersion and low correlation of the variables studied,the trained model allows to optimally predict the values of compressive strength with a significant improvement with respect to the existing ***,this work proposes for the first time a reliable and easily applicable approach for estimation of the compressive strength of jet grouting columns.

关键词： Jet grouting Ground improvement Compressive strength Machine learning

Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases

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Neural Regeneration Research 2024年第3期19卷 571-577页

作者： Sonia Irais Gonzalez-Cano Gonzalo Flores Jorge Guevara Julio Cesar Morales-Medina Samuel Treviño Alfonso diaz Faculty of Chemical Sciences Benemerita Autonomous University of PueblaPueblaMexico Institute of Physiology Benemerita Autonomous University of PueblaPueblaMexico Department of Biochemistry Faculty of MedicineNational Autonomous University of MexicoMexico CityMexico Animal Reproduction Research Center CINVESTAV-Autonomous University of TlaxcalaTlaxcalaMexico

Aging is a natural phenomenon characterized by a progressive decline in physiological integrity,leading to a deterioration of cognitive function and increasing the risk of suffering from chronic-degenerative diseases,including cardiovascular diseases,osteoporosis,cancer,diabetes,and *** is considered the major risk factor for Parkinson’s and Alzheimer’s disease ***,diabetes and insulin resistance constitute additional risk factors for developing neurodegenerative ***,no treatment can effectively reverse these neurodegenerative ***,some antidiabetic drugs have opened the possibility of being used against neurodegenerative *** the previous framework,Vanadium species have demonstrated a notable antidiabetic *** research group evaluated polyoxidovanadates such as decavanadate and metforminium-decavanadate with preventive and corrective activity on neurodegeneration in brain-specific areas from rats with metabolic *** results suggest that these polyoxidovanadates induce neuronal and cognitive restoration *** review aims to describe the therapeutic potential of polyoxidovanadates as insulin-enhancer agents in the brain,constituting a therapeutic alternative for aging and neurodegenerative diseases.

关键词： Alzheimer’s disease antidiabetic brain cognition diabetes insulin neurodegeneration neuroinflammation oxidative stress Vanadium species

Emerging and multifaceted potential contributions of polyphenols in the management of type 2 diabetes mellitus

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World Journal of Diabetes 2024年第2期15卷 154-169页

作者： Ileana González Cristian Lindner Ivan Schneider Erik diaz Miguel Angel Morales Armando Rojas Biomedical Research Laboratories Faculty of MedicineCatholic University of MauleTalca 34600000Chile Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile Centre of Primary Attention South Metropolitan Health ServiceSantiago 3830000Chile Faculty of Medicine Catholic University of MauleTalca 3460000Chile Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Type 2 diabetes mellitus(T2DM)is recognized as a serious public health concern with a considerable impact on human life,long-term health expenditures,and substantial health *** this context,the use of dietary polyphenols to prevent and manage T2DM is widely *** dietary compounds exert their beneficial effects through several actions,including the protection of pancreatic islet β-cell,the antioxidant capacities of these molecules,their effects on insulin secretion and actions,the regulation of intestinal microbiota,and their contribution to ameliorate diabetic complications,particularly those of vascular *** the present review,we intend to highlight these multifaceted actions and the molecular mechanisms by which these plant-derived secondary metabolites exert their beneficial effects on type 2 diabetes patients.

关键词： Polyphenols Antioxidants Oxidative stress Type 2 diabetes mellitus Health benefits

非洲裔美国人隐蔽性高血压的发病率、影响因素和临床的重要性

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中华高血压杂志 2015年第11期23卷 1098-1098页

作者：练桂丽叶鹏 diaz km Veerabhadrappa P Brown MD Whited MC Dubbert PM Hickson DA

非洲裔美国人心血管病发病率高，部分原因可能是诊室血压检测未达理想目标。然而，目前尚未完全了解非洲裔美国人隐蔽性高血压的发病率。该研究旨在评估一个大型非洲裔美国人样本中隐蔽性高血压的发病率，探讨其影响因素及其与靶器官损... 详细信息

非洲裔美国人心血管病发病率高，部分原因可能是诊室血压检测未达理想目标。然而，目前尚未完全了解非洲裔美国人隐蔽性高血压的发病率。该研究旨在评估一个大型非洲裔美国人样本中隐蔽性高血压的发病率，探讨其影响因素及其与靶器官损害（targetorgandamage，TOD）指数的相关性。

关键词：非洲裔美国人影响因素发病率高血压隐蔽性临床靶器官损害心血管病

随诊间血压变异性与心血管疾病和全因死亡率的关系

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中华高血压杂志 2014年第9期22卷 816-816页

作者：戴伦叶鹏 diaz km Tanner RM Falzon L Levitan EB Reynolds K Shimbo D Muntner P

随诊间血压变异性与血压、心血管疾病（cardiovascular disease,CVD）、死亡率之间的相互关系仅在一些,但不是所有的研究中得到证实。该文对研究随诊间血压变异性与血压、CVD、全因死亡率之间相互关系的文献进行系统回顾与荟萃分析。方... 详细信息

随诊间血压变异性与血压、心血管疾病（cardiovascular disease,CVD）、死亡率之间的相互关系仅在一些,但不是所有的研究中得到证实。该文对研究随诊间血压变异性与血压、CVD、全因死亡率之间相互关系的文献进行系统回顾与荟萃分析。方法：搜索医学研究数据库截至2014年6月4日的资料文献,纳入的研究需符合下列入选标准：以成人为研究对象;随访中测量血压≥3次;随访CVD、冠状动脉性心脏病（冠心病）及脑卒中的发生或死亡率;随访结果需要通过数据库或死亡证明或事件鉴定委员会确认;对混杂因素进行调整。

关键词：血压变异性全因死亡率心血管疾病随诊冠状动脉性心脏病随访结果鉴定委员会荟萃分析

非洲裔美国人队列中长期空气污染与血压的相关性:Jackson心脏研究

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中华高血压杂志 2021年第2期29卷 114-114页

作者：袁源(译) 练桂丽(审校) Weaver AM Wang Y Wellenius GA Bidulescu A Sims M Vaidyanathan A Hickson DA Shimbo D Abdalla M diaz km Seals SR 不详

非洲裔美国人不同程度地受到高血压的影响,可能与空气污染暴露有关,如细颗粒物和臭氧。方法:在非洲裔美国人Jackson心脏研究参与者中,采用log-binomial回归,研究1年及3年平均细颗粒物及臭氧浓度与第1次(2000-2004,5191例)及第2次随访(20... 详细信息

非洲裔美国人不同程度地受到高血压的影响,可能与空气污染暴露有关,如细颗粒物和臭氧。方法:在非洲裔美国人Jackson心脏研究参与者中,采用log-binomial回归,研究1年及3年平均细颗粒物及臭氧浓度与第1次(2000-2004,5191例)及第2次随访(2005-2008,4105例)时高血压患病率及发病率的相关性。研究者采用线性回归和分层线性模型,在校正社会人口、行为和临床特征后,评估与收缩压、舒张压、脉压和平均动脉压的相关性。

关键词：非洲裔美国人高血压患病率细颗粒物空气污染线性回归臭氧浓度分层线性模型平均动脉压

Evolution of liver transplantation in the metabolic dysfunctionassociated steatotic liver disease era: Tracking impact through time

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World Journal of Transplantation 2024年第4期14卷 84-94页

作者： Karina Sato-Espinoza Perapa Chotiprasidhi Estefanía Liza Zuly Placido-Damian Javier diaz-Ferrer Division of Gastroenterology and Hepatology Department of MedicineMayo ClinicRochesterMN 55902United States Hepatology Service Department of Digestive DiseasesHospital Nacional Edgardo Rebagliati MartinsLima 15072Peru Medicine Faculty Universidad San Martin de PorresLima 02002Peru Gastroenterology Service Clinica InternacionalLima 02002Peru

Liver transplantation(LT)for metabolic dysfunction-associated steatotic liver disease(MASLD)is increasing globally due to rising rates of obesity and metabolic syndrome,posing significant *** patients typically present with advanced age,higher body mass index(BMI),and metabolic com-orbidities such as diabetes,hypertension,and *** pre-transplant evaluations are crucial for assessing surgical risks and preparing patients for *** patients with higher BMI may experience longer operative times,potentially affecting intraoperative *** the months following LT,MASLD recipients face persistent challenges,including a higher incidence of metabolic syndrome and cardiovascular events compared to non-MASLD ***,survival rates at 1-,3-,and 5-years post-LT do not markedly differ from other etiologies,indicating comparable surgical *** outcomes in MASLD patients undergoing LT demands a multidisciplinary approach from pre-transplant assessment to post-transplant *** must address metabolic comorbidities,manage cardiovascular health,and monitor steatosis recurrence,which can be exacerbated by obesity and *** approach aims to mitigate long-term graft complications and mortality risks,ultimately enhancing transplant success and patient *** research is essential to refine these approaches and meet the evolving challenges posed by MASLD as a leading indication for LT worldwide.

关键词： Liver transplantation Metabolic dysfunction-associated steatotic liver disease Alcohol liver disease Hepatitis C Hepatitis B Hepatocellular carcinoma

Using Linear and Non-Linear Techniques to Characterize Gait Coordination Patterns of Two Individuals with NGLY1 Deficiency

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Case Reports in Clinical Medicine 2024年第9期13卷 391-409页

作者： Charles S. Layne Dacia Martinez diaz Christopher A. Malaya Brock Futrell Christian Alfaro Hannah E. Gustafson Bernhard Suter Department of Health and Human Performance University of Houston Houston TX USA Center for Neuromotor and Biomechanics Research University of Houston Houston TX USA Center for Neuro Engineering and Cognitive Science University of Houston Houston TX USA Research Center Parker University Dallas TX USA Blue Bird Circle Rett Center Texas Childrens Hospital Houston TX USA Baylor College of Medicine Houston TX USA

Individuals with NGLY1 Deficiency, an inherited autosomal recessive disorder, exhibit hyperkinetic movements including athetoid, myoclonic, dysmetric, and dystonic movements impacting both upper and lower limb motion. This report provides the first set of laboratory-based measures characterizing the gait patterns of two individuals with NGLY1 Deficiency, using both linear and non-linear measures, during treadmill walking, and compares them to neurotypical controls. Lower limb kinematics were obtained with a camera-based motion analysis system and bilateral time normalized lower limb joint time series waveforms were developed. Linear measures of joint range of motion, stride times and peak angular velocity were obtained, and confidence intervals were used to determine if there were differences between the patients and control. Correlations between participant and control mean joint waveforms were calculated and used to evaluate the similarities between patients and controls. Non-linear measures included: joint angle-angle diagrams, phase-portrait areas, and continuous relative phase (CRP) measures. These measures were used to assess joint coordination and control features of the lower limb motion. Participants displayed high correlations with their control counterparts for the hip and knee joint waveforms, but joint motion was restricted. Peak angular velocities were also significantly less than those of the controls. Both angle-angle and phase-portrait areas were less than the controls although the general shapes of those diagrams were similar to those of the controls. The NGLY1 Deficient participants’ CRP measures displayed disrupted coordination patterns with the knee-ankle patterns displaying more disruption than the hip-knee measures. Overall, the participants displayed a functional walking pattern that differed in many quantitative ways from those of the neurotypical controls. Using both linear and non-linear measures to characterize gait provides a more compre

关键词： NGLY1 Gait Disability Kinematics Angle-Angle Diagrams Phase Portraits

Quantifying Kinematic Tremor in an NGLY1-Deficient Individual: A Case Study

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Case Reports in Clinical Medicine 2024年第1期13卷 25-36页

作者： Brock Futrell Christopher Alexander Malaya Dacia Martinez diaz Christian Alfaro Hannah Elizabeth Gustafson Subhalakshmi Chandrasekaran Rhea Mohan Phatak Bernhard Suter Charles Shannon Layne Department of Health and Human Performance University of Houston Houston USA Center for Neuromotor and Biomechanics Research University of Houston Houston USA Department of Computer Science and Engineering Texas A&M University College Station USA Blue Bird Circle Rett Center Texas Children’s Hospital Houston USA Baylor College of Medicine Houston USA Center for NeuroEngineering and Cognitive Science University of Houston Houston USA

NGLY1 Deficiency is an autosomal recessive congenital disorder that has been identified in less than 100 individuals. Most individuals with NGLY1 Deficiency display hyperkinetic movement disorders, including choreiform, athetoid, dystonic myoclonic, dyskinetic, and dysmetric movements. Developing a consistent and concise consensus on the classification and evaluation of tremors is essential to forward the research and treatment of tremors. It has also been reported that some individuals with NGLY1 Deficiency demonstrate tremor, but such tremor has never been formally investigated. The primary objective of this study is to determine if an individual with NGLY1 Deficiency demonstrates an identifiable tremor during a series of arm movements and, if so, describe the frequency and power characteristics of that tremor. Arm movement kinematics were obtained using a 16-camera Vicon system, and time series trajectory waveforms for three planes of a marker placed on the hand were developed. Custom MATLAB scripts were utilized to compute Fast Fourier Transformations of the data within the identified waveform segments. A mean frequency of 2.30 Hz (SD = 1.05) with a mean power of 5.02 |P1(f)| (SD = 4.63) suggests that our participant’s kinematic data did display a persistent tremor in both hands across all tasks and movement planes. Analyses of the reaching hand and the non-reaching hand suggest the participant displayed an action tremor in both postural and intention (kinetic) tremors. Future directions should include assessing additional individuals with NGLY1 Deficiency to determine if the tremor is a distinguishable disorder behavior. Additionally, evaluating other anatomical sites, such as the elbow, head, and lower limbs, would provide further insights into the characteristics of this tremor.

关键词： Tremor NGLY Fast Fourier Transformation Reaching Hyperkinetic Movement