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Risk factors for suicidal behaviour in late-life depression:A systematic review

World Journal of Psychiatry 2022年第1期12卷 187-203页

作者： Veronica Fernandez-Rodrigues Yolanda Sanchez-Carro Luisa Natalia Lagunas Laura Alejandra Rico-Uribe Andres Pemau Patricia diaz-Carracedo Marina diaz-Marsa Gonzalo Hervas Alejandro de la Torre-Luque Department of Psychology Universidad Complutense de MadridMadrid 28223Spain Department of Psychiatry Universidad Autonoma de MadridMadrid 28046Spain Centre for Biomedical Research in Mental Health(CIBERSAM) Madrid 28029Spain Department of Legal Medicine Psychiatry and PathologyUniversidad Complutense de MadridMadrid 28046Spain of Psychology La Rioja International UniversityLogrono 26006Spain Institute of Psychiatry and Mental Health San Carlos Clinical HospitalMadrid 28040Spain

BACKGROUND Suicide is a leading cause of preventable death worldwide,with its peak of maximum incidence in later *** often puts an individual at higher risk for suicidal *** turn,depression deserves particular interest in old age due to its high prevalence and dramatic impact on health and *** To gather integrated evidence on the potential risk factors for suicide behaviour development in depressive older adults,and to examine the effects of depression treatment to tackle suicide behaviour in this *** A systematic review of empirical studies,published from 2000 onwards,was *** behaviour was addressed considering its varying forms(i.e.,wish to die,ideation,attempt,and completed suicide).RESULTS Thirty-five papers were selected for review,comprising both clinical and epidemiological *** of studies focused on suicidal ideation(60%).The studies consistently pointed out that the risk was related to depressive episode severity,psychiatric comorbidity(anxiety or substance use disorders),poorer health status,and loss of *** social support and loneliness were also associated with suicide behaviour in depressive older ***,the intervention studies showed that suicidal behaviour was a robust predictor of depression treatment *** in suicidal ideation were moderated by reductions in risk factors for suicide *** To sum up,common and age-specific risk factors seem to be involved in suicide development in depressive older adults.A major effort should be made to tackle this serious public health concern so as to promote older people to age healthily and well.

关键词： Late-life depression Suicide behaviour Disability Chronic disease Loneliness

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The RNA binding proteins TIA1 and TIAL1 promote Mcl1 mRNA translation to protect germinal center responses from apoptosis

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Cellular & Molecular Immunology 2023年第9期20卷 1063-1076页

作者： Ines COsma-Garcia Mailys Mouysset Dunja Capitan-Sobrino Yann Aubert Martin Turner Manuel D.diaz-Muñoz Institute for Infectious and Inflammatory Diseases(INFINITy) Inserm UMR1291CNRS UMR5051University Paul SabatierCHU PurpanToulouse 31024France Immunology Program The Babraham InstituteCambridgeUK

Germinal centers(GCs)are essential for the establishment of long-lasting antibody *** B cells rely on post-transcriptional RNA mechanisms to translate activation-associated transcriptional programs into functional changes in the cell ***,the critical proteins driving these key mechanisms are still ***,we show that the RNA binding proteins TIA1 and TIAL1 are required for the generation of long-lasting GC ***1-and TIAL1-deficient GC B cells fail to undergo antigen-mediated positive selection,expansion and differentiation into B-cell clones producing high-affinity ***,TIA1 and TIAL1 control the transcriptional identity of dark-and light-zone GC B cells and enable timely expression of the prosurvival molecule ***,we demonstrate here that TIA1 and TIAL1 are key players in the post-transcriptional program that selects high-affinity antigen-specific GC B cells.

关键词： Adaptive immunity Germinal centers Post-transcriptional gene regulation RNA binding proteins Cell identity Apoptosis/10.1038/s41423-023-01063-4

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Computational solution of an acid-mediated tumor-growth radial model under logistic growth regimes for normal and cancer cells

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International Journal of Biomathematics 2023年第3期16卷 45-62页

作者： Farhan Khan Mudassar Abbas Jorge E.Macias-diaz Muhammad Bilal Khan Safar M.Alghamdi Department of Mathematics and Computer Sciences University of Palermo 90133 PalermoItaly Department of Mathematics and Applications “R.Caccioppoli”University of Naples Federico iiVia Cintia 80126NaplesItaly Department of Mathematics School of Digital Technologies Tallinn University10120 TallinnEstonia Departamento de Matematicas y Fisica Universidad Autonoma de Aguascalientes AguascalientesAgs.20131Merico Department of Mathematics COMSATS University Islamabad Islambad44000 Pakistan Department of Mathematics and Statistics College of Science Taif University Taif 21944Saudi Arabia

Tumor invasion follows a complex mechanism which involves cell migration and *** study the processes in which primary and secondary metastases invade and damage the normal cells,mathematical models are often extremely *** this paper,we present a mathematical model of acid-mediated tumor growth consisting of radially symmetric reaction-diffusion *** assumption on the radial symmetry of the solutions is imposed here in view that tumors present spherical symmetry at the microscopic ***,we consider various empirical mechanisms which describe the propagation of tumors by considering cancer cells,normal cells,and the concentration of H+*** other assumptions,we suppose that these components follow logistictype growth ***,this is an important difference with respect to various other mathematical models for tumor growth available in the ***,we also add competition terms of normal and tumor cells *** carry out a balancing study of the equations of the model,and a numerical model is proposed to produce *** practical remarks derived from our assumptions are provided in the discussion of our simulations.

关键词： Cancer growth model radially symmetric system acid-mediated tumor growth computer simulations

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Mesenchymal stem cells and cell-free preparations for treating atopic dermatitis

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BIOCELL 2022年第11期46卷 2363-2367页

作者： TRINIDAD MONTERO-VILCHEZ MANUEL SANCHEZ-diaz CAROLINA MONTERO-VILCHEZ ALVARO SIERRA-SANCHEZ SALVADOR ARIAS-SANTIAGO Dermatology Department Virgen de las Nieves University HospitalGranadaSpain Instituto de Investigación Biosanitaria Granada GranadaSpain Pharmacy Department Virgen de las Nieves University HospitalGranadaSpain Dermatology Department Faculty of MedicineUniversity of GranadaGranadaSpain

Atopic dermatitis(AD)is a chronic cutaneous inflammatory disease caused by an interaction between genetic,immune and epidermal barrier *** treatments can be used to treat this disease but there are patients that do not respond to actual ***,there is a need to develop effective therapies for *** stem cells(MSCs)are non-hematopoietic multipotent adult progenitor cells with immunomodulatory power and self-regenerating capacity to repair tissue damage,so they could be a potential effective treatment for ***-Conditioned Medium(CM)and MSCs-exosomes are cell-free preparation with molecules secreted by stem cells that could be also beneficial for *** viewpoint reviews the actual development of MSCs,MSCs-CM and MSCs-exosomes for treating patients with AD.

关键词： Atopic dermatitis Conditioned medium Dermatology Mesenchymal stem cells Stem cells

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Changes in Olsen P in Relation to P Balance in Contrasting Agricultural Soils

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Pedosphere 2016年第5期26卷 636-642页

作者： Isabel diaz Jose TORRENT Departamento de Ingeniería Aeroespacial y Mecánica de Fluidos Escuela Tdcnica Superior de Ingeniería Agronómica(ETSIA)Universidad de SevillaCtra de Utrera km 141013 Sevilla(Spain) Departamento de Agronomia Universidad de CordobaEdificio C4Campus de Rabanales14071 Cordoba(Spain)

Maintaining soil phosphorus(P) at adequate levels for plant growth requires assessing how the long-term P balance(viz., the difference between P inputs and outputs) results in changes in soil test P. The hypothesis that routinely measured soil properties can help predict the conversion factor of P balance into Olsen P was tested at 39 sites in agricultural areas of the Mediterranean region in Spain. A set of soil samples from each site was analyzed for Olsen P, inorganic P(P extracted using 0.5 mol L^(-1) H_2SO_4), pseudototal P(P extracted using 0.5 mol L^(-1) H_2SO_4 following ignition at 550℃), and organic P(the difference between pseudototal P and inorganic P). Organic and Olsen P were uncorrelated in most of the 39 soil sets, which suggests that organic P content changed little with P inputs and outputs. The slopes of the regression lines of Olsen P against pseudototal and inorganic P, which were used as two different measures of the conversion factor, ranged widely(from 0.03 to 0.25 approximately), with their average values(about 0.10) being similar to those found in long-term experiments conducted in temperate areas. Neither conversion factor was significantly correlated with any routinely measured soil property; however, the conversion factor for inorganic P was significantly lower for calcareous soils than for noncalcareous soils. Our negative results suggest the need to isolate the influence of soil properties from that of management systems and environmental factors relating to P dynamics in future studies.

关键词：磷素平衡农业土壤 H2SO4 土壤性质土壤测试转换因子常规测量石灰性土壤

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Urokinase-type plasminogen activator promotes synaptic repair in the ischemic brain

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Neural Regeneration Research 2018年第2期13卷 232-233页

作者： ariel diaz manuel yepes department of neurology and center for neurodegenerative disease emory university school of medicineAtlantaGAUSA division of neuropharmacology and neurologic diseases yerkes national primate research centerAtlantaGAUSA department of neurology veterans affairs medical centerAtlantaGAUSA

The central nervous system has a very high energy requirement. Accord- ingly, despite representing only 2% of the body＇s mass, the brain uses 20% of the total oxygen consumption. Importantly, because most of this energy is used to maintain synaptic activity, even a mild decrease in its supply to the brain has deleterious implications for synaptic function.

关键词： Urokinase-type plasminogen activator promotes synaptic repair in the ischemic brain AR TSP OGD LRP

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Numerical and experimental investigation to design a novel morphing airfoil for performance optimization

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Propulsion and Power Research 2023年第1期12卷 83-103页

作者： Kiumars Khani Aminjan Maryam Ghodrat Milad Heidari Pooyan Rahmanivahid Shayan Naghdi Khanachah Mira Chitt Juan Pablo Escobedo-diaz Faculty of Aerospace Malek Ashtar University of TechnologyTehran 1774-15875Iran School of Engineering and Information Technology University of New South Wales CanberraCanberraACT 2610Australia Mechanical Engineering Department Global College of Engineering and Technology(GCET)P.O.Box 2546 CPO Ruwi 112MuscatSultanate of Oman School of Industrial Engineering Iran University of Science and TechnologyTehran 16846-13114Iran

Optimizing flying objects’wing performance has attracted a significant attention in the last few *** this article,some of the main mechanisms for changing the geometry of the wing were investigated and a new mechanism is proposed to improve the aerodynamic performance of the airplane *** designs have been simulated and analyzed from both aerodynamic and control points of *** aerodynamic simulations using CFD methods,two airfoils of NACA series 6 with specifications 65-212 and 65-2012 were *** results indicated that both airfoils used have a better performance compared to others in a certain range of the angle of ***,a new mechanism is proposed to change the wing geometry to optimize its *** the proposed mechanism,the structures of airfoils and wings consist of two fixed and moving parts,which can change their geometry with the help of a control *** fixed part has a grooved track,and as the moving part moves in the direction of the grooves,the curvature of the upper and lower parts of the wing *** design control circuit includes an angle sensor,a micro controller,and a *** CFD results are entered into the micro controller as *** any moment,the micro controller receives the angle data from the angle sensor and by comparing them with the CFD data,and issuing a command to the servomotor,it situates the wing curvature in the optimal state at all *** built mechanism was tested at an attack angle of 0°and 25°.The results showed that the different parts of the mechanism work with very high precision and put the geometric shape of the wing in an optimal state in a completely intelligent *** should be noted that the average error in test for t/c and Xt/c was 15.3% and 9%,respectively.

关键词： Morphing airfoil Lift force Optimization Computational fluid dynamics Micro controller Angle sensor

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Avian preference for close proximity to human habitation and its ecological consequences

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Current Zoology 2018年第5期64卷 623-630页

作者： Anders Pape MOLLER Mario diaz Ecologie Systematique Evolution CNRS Universite Paris-Sud AgroParisTech Universite Pari-Saclay 0rsay Cedex F-91400 France Department of Biogeography and Global Change (BGC-MNCN-CSIC) National Museum of Natural Sciences CSIC c/Serrano 155bis Madrid E-28006 Spain

Human proximity often have negative consequences for wildlife. However, animals may also benefit from human proximity in terms of availability of resources and protection against predators and parasites. We recorded the distance between all birds detected during the breeding season along 18 5-km transects and the nearest inhabited house in three areas of 50 km in Spain, France, and Denmark. More than three quarters of birds were located closer than 100 m to the nearest house, while the null expectation was less than a third. Mean distance for species was correlated with degree of bird urbanization and with flight initiation distance. Habitat specialist species with small breeding territories tended to live closer to houses. Birds from species having more broods per year, larger annual fecundity and lower nest predation rate lived closer to human habitation. Breeding range size, population density, and continental breeding population sizes were larger for species living closer to human habitation. Most relationships between distance to houses and bird traits had a strong phylogenetic signal, but most additive trait effects remained after phylogenetic correction. Proximity to human habitation was a main driver of the distribution of birds, with most individuals and species tightly linked to inhabited houses. Living close to human habitation was associated with success in the colonization of urban habitats and with consistent changes in distribution, abundance, behavior, and life history. Replicated measurements of the spatial and temporal variation in these distributions may be useful for monitoring and analyzing the ongoing process of organisms' urbanization.

关键词：居住鸟偏爱生态繁殖季节野生动物人口密度种系发生

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Hepatobiliar manifestations in inflammatory bowel disease: A practical approach

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World Journal of Hepatology 2022年第2期14卷 319-337页

作者： Paulina Núñez F Fabiola Castro Gabriel Mezzano Rodrigo Quera Diego diaz Lorena Castro Universidad de los Andes Inflammatory Bowel Disease ProgramDigestive Disease CenterSantiago 7600976RMChile Inflammatory Bowel Disease Program Hospital San Juan de DiosUniversidad de ChileSantiago 7701230RMChile Universidad de los Andes Hepatology ProgramDigestive Disease CenterSantiago 7600976RMChile Department of Gastroenterology Hospital del Salvador/Universidad de ChileSantiago 7600976RMChile Universidad de los Andes Santiago 770976RMChile

Inflammatory bowel diseases(IBD)are associated with various hepatobiliary *** can occur at any moment in the course of the disease or associated with the *** prevalence of liver dysfunction can reach up to 50%in different *** fatty liver disease is considered the most common hepatobiliary complication in IBD,while primary sclerosing cholangitis is the most *** of hepatic manifestations in IBD involves a multidisciplinary approach that includes a high index of suspicion and joint management with *** medical confrontation with abnormal liver tests must include an exhaustive study to determine if these patterns can be related to IBD,associated diseases or to the therapies used.

关键词： Extraintestinal manifestations Inflammatory bowel disease Sclerosing primary cholangitis Hepatic steatosis Liver toxicity

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Analytical Solution for Waves Propagation in Heterogeneous Acoustic/Porous Media. Part I: The 2D Case

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Communications in Computational Physics 2010年第3期7卷 171-194页

作者： Julien diaz Abdelaaziz Ezziani Project-team Magique-3D INRIA Bordeaux Sud-Ouest LMA Pau CNRS UMR 5142I.P.R.A-Universit´e de Pau et des Pays de l’Adouravenue de l’Universit´e BP 1155-64013 PAU CEDEXFrance

Thanks to the Cagniard-de Hoop’s method we derive the solution to theproblem of wave propagation in an infinite bilayered acoustic/poroelastic media, wherethe poroelastic layer is modelled by the biphasic Biot’s model. This first part is dedi-cated to solution to the two-dimensional problem. We illustrate the properties of thesolution, which will be used to validate a numerical code.

关键词： Biot’s model poroelastic waves acoustic waves acoustic/poroelastic coupling ana-lytical solution Cagniard-de Hoop’s technique 2D

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