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Simulations of superconducting quantum gates by digital flux tuner for qubits

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Chinese Physics B 2024年第7期33卷 210-222页

作者：耿霄何楷泳刘建设陈炜 Laboratory of Superconducting Quantum Information Processing School of Integrated CircuitsTsinghua UniversityBeijing 100084China Beijing Innovation Center for Future Chips Tsinghua UniversityBeijing 100084China Beijing National Research Center for Information Science and Technology Beijing 100084China26

The interconnection bottleneck caused by limitations of cable number, inner space and cooling power of dilution refrigerators has been an outstanding challenge for building scalable superconducting quantum computers with the increasing number of qubits in quantum processors. To surmount such an obstacle, it is desirable to integrate qubits with quantum–classical interface(QCI) circuits based on rapid single flux quantum(RSFQ) circuits. In this work, a digital flux tuner for qubits(DFTQ) is proposed for manipulating flux of qubits as a crucial part of the interface circuit. A schematic diagram of the DFTQ is presented, consisting of a coarse tuning unit and a fine-tuning unit for providing magnetic flux with different precision to qubits. The method of using DFTQ to provide flux for gate operations is discussed from the optimization of circuit design and input signal. To verify the effectiveness of the method, simulations of a single DFTQ and quantum gates including a Z gate and an iSWAP gate with DFTQs are performed for flux-tunable transmons. The quantum process tomography corresponding to the two gates is also carried out to analyze the sources of gate error. The results of tomography show that the gate fidelities independent of the initial states of the Z gate and the iSWAP gate are 99.935% and 99.676%,respectively. With DFTQs inside, the QCI would be a powerful tool for building large-scale quantum computers.

关键词： quantum computation superconducting electronics quantum control

Predicting fatigue life of automotive adhesive bonded joints:a data-driven approach using combined experimental and numerical datasets

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Advances in Manufacturing 2024年第3期12卷 522-537页

作者： Chen-Di Wei Qiu-Ren Chen Min Chen Li Huang Zhong-Jie Yue Si-geng Li Jian Wang Li Chen Chao Tong Qing Liu School of Advanced Technology Xi’an Jiaotong-Liverpool UniversitySuzhou215123People’s Republic of China Key Laboratory for Light-weight Materials Nanjing Tech UniversityNanjing210009People’s Republic of China Material Academy JITRISuzhou215100People’s Republic of China Nanjing University of Science and Technology Nanjing210094People’s Republic of China

The majority of vehicle structural failures originate from joint *** loading is one of the primary factors in joint failures,making the fatigue performance of joints a critical consideration in vehicle structure *** use of traditional fatigue analysis methods is constrained by the absence of adhesive life data and the wide variety of joint ***,there is a pressing need for an accurate fatigue life estimation method for the joints in the automotive *** this work,we proposed a data-driven approach embedding physical knowledge-guided parameters based on experimental data and finite element analysis(FEA)*** machine learning(ML)algorithms are adopted to investigate the fatigue life of three typical adhesive joints,namely lap shear,coach peel and KSII *** the feature engineering and tuned process of the ML models,the preferable model using the Gaussian process regression algorithm is established,fed with eight input parameters,namely thicknesses of the substrates,line forces and bending moments of the adhesive bonded joints obtained from *** proposed method is validated with the test data set and part-level physical tests with complex loading states for an unbiased *** demonstrates that for life prediction of adhesive joints,the data-driven solutions can constitute an improvement over conventional solutions.

关键词： Fatigue life Adhesive bonded joints Finite element analysis(FEA) Machine learning(ML)

ITS and 16S rRNA Gene Revealed Multitudinous Microbial Contaminations of Residential Air Conditioning Filters in Megacity Shanghai,China

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Environment & Health 2024年第1期2卷 34-41页

作者： Xueyun geng Changliang Nie *Lina Wang Ling Li Dan Li Atsushi Nishino Jianmin Chen Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention(LAP^(3) Department of Environmental Science&EngineeringFudan Tyndall CentreInstitute of Atmospheric SciencesFudan UniversityShanghai 200438China IAQ Technologies Group Technology and Innovation CenterDaikin IndustriesLTD.Osaka 566-8585Japan Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention(LAP^(3) Department of Environmental Science&EngineeringFudan Tyndall CentreInstitute of Atmospheric Sciences and IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public HealthInstitute of Atmospheric SciencesFudan UniversityShanghai 200438China Institute of EcoChongming(IEC) Shanghai 200062China

Air conditioning is a crucial participant in indoor air circulation and harmful microorganism *** elucidate microbial contamination in air conditioning systems,bacteria,fungi,and pollens in residential air conditioning(AC)filters in Shanghai were *** concentrations of fungal ITS(1,972,037±5,025,505 copies/cm^(2))in most filter samples were considerably higher than the 16S rRNA gene(21,587±21,461 copies/cm^(2)).The multitudinous bacteria determined a higher richness,whereas the trend was not in line with fungi,owing to Aspergillus flourishing,with an average of 43.75%.Numerous bacteria that may often be prevalent in human skin,mucous membranes,and intestines,such as Enhydrobacter,Micrococcus,Staphylococcus,Streptococcus,and Haemophilus,were also discovered in AC *** pollens were affiliated with Streptophyta at phylum,and Humulus was the most abundant genus(mean value 67.84%),raising the possibility of allergic *** study provides a better understanding of the microbial characteristics of AC filters,enables more rational approaches for microbe contaminant control,and ultimately improves human health in megacities.

关键词： air conditioning system indoor air building microbiome DNA sequencing pathogens

An ensemble machine learning model to uncover potential sites of hazardous waste illegal dumping based on limited supervision experience

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Fundamental Research 2024年第4期4卷 972-978页

作者： Jinghua geng Yimeng Ding Wenjun Xie Wen Fang Miaomiao Liu Zongwei Ma Jianxun Yang Jun Bi State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023 China

With the soaring generation of hazardous waste(HW)during industrialization and urbanization,HW illegal dumping continues to be an intractable global *** in developing regions with lax regulations,it has become a major source of soil and groundwater *** dominant challenge for HW illegal dumping supervision is the invisibility of dumping sites,which makes HW illegal dumping difficult to be found,thereby causing a long-term adverse impact on the *** to utilize the limited historic supervision records to screen the potential dumping sites in the whole region is a key challenge to be *** this study,a novel machine learning model based on the positive-unlabeled(PU)learning algorithm was proposed to resolve this problem through the ensemble method which could iteratively mine the features of limited historic *** of the random forest-based PU model showed that the predicted top 30%of high-risk areas could cover 68.1%of newly reported cases in the studied region,indicating the reliability of the model *** novel framework will also be promising in other environmental management scenarios to deal with numerous unknown samples based on limited prior experience.

关键词： Hazardous waste Illegal dumping site Positive-unlabeled machine learning Probability prediction Model interpretation

A Case of Brucellosis Concomitant with Severe Fever with Thrombocytopenia Syndrome—Weifang City,Shandong Province,China,2023

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China CDC weekly 2024年第27期6卷 677-680页

作者： Qingqing Xu Cuiping Wu Hui Liu Chao geng Jinhui Zhang Dongri Piao Hongyan Zhao Yu Fan Guozhong Tian Hai Jiang National Key Laboratory of Intelligent Tracing and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Department of Infectious Diseases Yidu Central Hospital of WeifangWeifang CityShandong ProvinceChina Institute of Bacterial Disease Jinan Center for Disease Control and PreventionJinan CityShandong ProvinceChina Tongliao Center for Disease Control and Prevention Tongliao CityInner Mongolia Autonomous RegionChina

Summary What is already known about this topic?Brucellosis and severe fever with thrombocytopenia syndrome(SFTS)are neglected zoonoses,attributable respectively to Brucella and the SFTS virus(SFTSV).While the incidence of these diseases has been rising,instances of co-infection remain *** is added by this report?This represents the first documented case of a rare coinfection involving Brucella and SFTSV.

关键词： neglected instance Shandong

One More Stepo Taken Towards Picking up Second Pearl

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船舶经济贸易 2024年第6期 73-76页

作者： Qian Ping Lin geng CSSC Dalian Shipbuilding First LNG Carrier Undocked

The first ship of 175,000 m3 large LNG carriers built by Dalian Shipbuilding for China Merchants Energy Shipping Co Ltd smoothly undocked,one step closer to taking the second“Pearl on the Crown”for the shipbuilding *** ship is the first LNG carrier contracted in the history of Dalian Shipbuilding,marking the fact that Dalian Shipbuilding had officially entered the large LNG carrier construction domain,and taken an important step in the transformation and upgrading to achieve high-quality development.

关键词： Pearl smoothly upgrading

Berberine Enhances Intestinal Mucosal Barrier Function by Promoting Vitamin D Receptor Activity

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Chinese Journal of Integrative Medicine 2024年第2期30卷 143-151页

作者： HUANG Yong-quan LIU Jia-lin CHEN geng-xin SHEN Dan-ting ZHU Wang CHEN Xin-lin LIU Feng-bin HOU Qiu-ke Graduate School Guangzhou University of Chinese MedicineGuangzhou(510405)China Department of Orthopedics the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Preventive Medicine and Health Statistics Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Gastroenterology the First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510405)China

Objective:To evaluate if berberine can act on vitamin D receptors(VDR)and thereby regulate the expression of tight junction proteins(TJPs)in irritable bowel syndrome-diarrhea-predominant(IBS-D)***:The newborn rats were induced into IBS-D rat model via neonatal maternal separation combined with acetic acid chemical *** modeling,the model was evaluated and rats were divided into the control group and berberine treatment groups(0.85,1.7 and 3.4 mg/kg,once a day for 2 weeks).The distal colon was obtained and colonic epithelial cells(CECs)were isolated and cultured after IBS-D model *** vitamin D receptor response element(VDRE)reporter gene was determined in the CECs of IBS-D rats to analyze the effect of berberine on the VDRE *** overexpression or silencing technology was used to analyze whether VDR plays a role in promoting intestinal barrier repair,and to determine which region of VDR plays a role in berberine-regulated intestinal ***:The IBS-D rat model was successfully constructed and the symptoms were improved by berberine in a dose-dependent manner(P<0.05).The activity of VDRE promoter was also effectively promoted by berberine(P<0.05).Berberine increased the expression of TJPs in IBS-D CECs(P<0.05).VDR expression was significantly increased after transfection of different domains of VDR when compared to normal control and basic plasmid groups(all P<0.05).RT-qPCR and Western blot results showed that compared with the blank group,expressions of occludin and zonula occludens-1 were significantly higher in VDR containing groups(all P<0.05).Berberine plus pCMV-Myc-VDR-N group exerted the highest expression levels of occludin and zonula occludens-1(P<0.05).Conclusion:Berberine enhances intestinal mucosal barrier function of IBS-D rats by promoting VDR activity,and the main site of action is the N-terminal region of VDR.

关键词： berberine Chinese medicine irritable bowel syndrome-diarrhea-predominant vitamin D receptors intestinal mucosal barrier tight junction proteins

Molecular engineering of self-assembled monolayers for highly utilized Zn anodes

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eScience 2024年第2期4卷 70-79页

作者： Lei Zhang Jin Xiao Xilin Xiao Wenli Xin Yaheng geng Zichao Yan Zhiqiang Zhu State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Greater Bay Area Institute for Innovation Hunan UniversityGuangzhou 511300China School of Science Hunan University of TechnologyZhuzhou 412007China

Stabilizing the Zn anode under high utilization rates is highly applauded yet very challenging in aqueous Zn ***,we rationally design a zincophilic short-chain aromatic molecule,4-mercaptopyridine(4Mpy),to construct self-assembled monolayers(SAMs)on a copper substrate to achieve highly utilized Zn *** reveal that 4Mpy could be firmly bound on the Cu substrate via Cu–S bond to form compact and uniform SAMs,which could effectively isolate the water on the electrode surface and thus eliminate the water-related side *** addition,the short-chain aromatic ring structure of 4Mpy could not only ensure the ordered arrangement of zincophilic pyridine N but also facilitate charge transfer,thus enabling uniform and rapid Zn ***,the Zn/4Mpy/Cu electrode not only enables the symmetric cell to stably cycle for over 180 h at 10 mA cm^(-2) under a high depth-of-discharge of 90%,but also allows the MnO_(2)-paired pouch cell to survive for 100 cycles under a high Zn utilization rate of 78.8%.An anode-free 4Mpy/Cu||graphite cell also operates for 150 cycles without obvious capacity fading at 0.1 A g^(-1).This control of interfacial chemistry via SAMs to achieve high utilization rates of metal anodes provides a new paradigm for developing high-energy metal-based batteries.

关键词： Zn anodes Interfacial engineering Self-assembled monolayers Zincophilic aromatic molecules High utilization

Copper-Free Click Chemistry-Mediated Assembly of Single Quantum Dot Nanosensor for Accurately Monitoring Locus-Specific m^(6)A in Cancer Cells

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Chinese Journal of Chemistry 2024年第5期42卷 499-504页

作者： Yue-Ying Li Ning-Ning Zhao Yi-Xuan geng Qian Han Jian-Ge Qiu Bing-Hua Jiang Zi-Yue Wang Chun-Yang Zhang Translational Medicine Center The First Affiliated Hospital of Zhengzhou UniversityThe Academy of Medical SciencesHenan Institute of Medical and Pharmaceutical Sciences BGI CollegeZhengzhou UniversityZhengzhouHenan450052 China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinanShandong250014 China School of Chemistry and Chemical Engineering Southeast UniversityNanjingJiangsu211189 China

N6-methyladenosine(m^(6)A)plays an important role in embryogenesis,nuclear export,transcription splicing,and protein translation ***,we demonstrate a copper-free click chemistry-mediated assembly of single quantum dot(QD)nanosensor for accurately monitoring locus-specific m^(6)A in cancer *** m^(6)A-sensitive endoribonuclease MazF can digest the unmethylated A-RNA,and the intact m^(6)A-RNA then hybridizes with DNA probes a and b to produce a sandwich hybrid,initiating the click chemistry to generate probe a–b ligation product via first tandem ligation detection reaction(LDR)***,DNA probes c and d can hybridize with the probe a–b ligation product to generate the probe c–d ligation product via second LDR *** LDR cycles can be repeated through denaturation and annealing reaction to generate abundant biotin-/fluorophore-modified probe c–d ligation products that can easily assemble on the QD surface to induce distinct fluorescence resonance energy transfer(FRET)between QD and *** assay can be homogenously performed without the involvement of copper catalyst,m^(6)A-specific antibody,radioactive labeling,ligase enzyme,enzymatic reverse transcription,and next-generation ***,it can discriminate even 0.01% m^(6)A level in complex samples and accurately measure cellular m^(6)A-RNA expression,providing a promising avenue for clinical diagnostics and biomedical research.

关键词： RNA methylation Click chemistry Förster resonance energy transfer Biosensor Cancer