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safety and efficiency of Wharton’s Jelly-derived mesenchymal stem cell administration in patients with traumatic brain injury:First results of a phase I study

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World Journal of stem Cells 2024年第6期16卷 641-655页

作者： serdar Kabatas ErdinçCivelek Osman Boyalı Gülseli Berivan sezen Omer Ozdemir Yeliz Bahar-Ozdemir Necati Kaplan Eyüp Can savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Türkiye Center for stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Türkiye Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Türkiye Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Türkiye Center for Regenerative Medicine and stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Traumatic brain injury(TBI)is characterized by a disruption in the normal function of the brain due to an injury following a trauma,which can potentially cause severe physical,cognitive,and emotional *** cell transplantation has evolved as a novel treatment modality in the management of TBI,as it has the potential to arrest the degeneration and promote regeneration of new cells in the ***’s Jelly-derived mesenchymal stem cells(WJ-MsCs)have recently shown beneficial effects in the functional recovery of neurological *** To evaluate the safety and efficiency of MsC therapy in *** We present 6 patients,4 male and 2 female aged between 21 and 27 years who suffered a *** 6 patients underwent 6 doses of intrathecal,intramuscular(i.m.)and intravenous transplantation of WJ-MsCs at a target dose of 1×106/kg for each application *** was assessed using the Modified Ashworth scale(MAs),motor function according to the Medical Research Council Muscle strength scale,quality of life was assessed by the Functional Independence Measure(FIM)scale and Karnofsky Performance status *** Our patients showed only early,transient complications,such as subfebrile fever,mild headache,and muscle pain due to ***,which resolved within 24 *** the one year follow-up,no other safety issues or adverse events were *** 6 patients showed improvements in their cognitive abilities,muscle spasticity,muscle strength,performance scores and fine motor skills when compared before and after the *** values,which we used to assess spasticity,were observed to statistically significantly decrease for both left and right sides(Pscale includes both motor scores(Pscores(Pshowed a significant increase in pretest posttest *** difference observed in the participants’Karnofsky Performance scale values pre and post the intervention was statistically si

关键词： Traumatic brain injury Wharton Jelly stem cell therapy Transplantation Mesenchymal stem cell

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Rotating effects on the photoionization cross-section of a 2D quantum ring

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Communications in Theoretical Physics 2024年第10期76卷 153-159页

作者： Carlos Magno O Pereira Frankbelson dos s Azevedo Luís Fernando C Pereira Edilberto O silva Departamento de Física Universidade Federal do Maranh?o

In this article, we investigate the nonrelativistic quantum motion of a charged particle within a rotating frame, taking into account the Aharonov–Bohm(AB) effect and a uniform magnetic field. Our analysis entails the derivation of the equation of motion and the corresponding radial equation to describe the system. solving the resulting radial equation enables us to determine the eigenvalues and eigenfunctions, providing a clear expression for the energy levels. Furthermore,our numerical analysis highlights the substantial influence of rotation on both energy levels and optical properties. specifically, we evaluate the photoionization cross-section with and without the effects of rotation. To elucidate the impact of rotation on the photoionization process of the system, we present graphics that offer an appealing visualization of the intrinsic nature of the physics involved.

关键词： Aharonov-Bohm effect photoionization cross-section quantum ring rotating effect

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Internet of Things Enabled DDos Attack Detection using Pigeon Inspired Optimization Algorithm with Deep Learning Approach

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Computers, Materials & Continua 2024年第9期80卷 4047-4064页

作者： Turki Ali Alghamdi saud s.Alotaibi Department of Computer science and Artificial Intelligence College of ComputingUmm Al-Qura UniversityMakkah21955Saudi Arabia

Internet of Things(IoTs)provides better solutions in various fields,namely healthcare,smart transportation,home,*** Denial of service(Dos)outbreaks in IoT platforms is significant in certifying the accessibility and integrity of IoT *** learning(DL)models outperform in detecting complex,non-linear relationships,allowing them to effectually severe slight deviations fromnormal IoT activities that may designate a Dos *** uninterrupted observation and real-time detection actions of DL participate in accurate and rapid detection,permitting proactive reduction events to be executed,hence securing the IoT network’s safety and ***,this study presents pigeon-inspired optimization with a DL-based attack detection and classification(PIODL-ADC)approach in an IoT *** PIODL-ADC approach implements a hyperparameter-tuned DL method for Distributed Denial-of-service(DDos)attack detection in an IoT ***,the PIODL-ADC model utilizes z-score normalization to scale input data into a *** handling the convolutional and adaptive behaviors of IoT,the PIODL-ADCmodel employs the pigeon-inspired optimization(PIO)method for feature selection to detect the related features,considerably enhancing the recognition’s ***,the Elman Recurrent Neural Network(ERNN)model is utilized to recognize and classify DDos ***,reptile search algorithm(RsA)based hyperparameter tuning is employed to improve the precision and robustness of the ERNN method.A series of investigational validations is made to ensure the accomplishment of the PIODL-ADC *** experimental outcome exhibited that the PIODL-ADC method shows greater accomplishment when related to existing models,with a maximum accuracy of 99.81%.

关键词： Internet of things denial of service deep learning reptile search algorithm feature selection

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On the Geometry of the Anti-canonical Bundle of the Bott–samelson–Demazure–Hansen Varieties

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Acta Mathematica sinica,English series 2024年第8期40卷 1920-1940页

作者： Indranil BIsWAs s.senthamarai KANNAN Pinakinath sAHA school of Mathematics Tata Institute of Fundamental Research1 Homi Bhabha RoadMumbai 400005India Chennai Mathematical Institute Plot H1SIPCOT IT ParkSiruseriKelambakkam603103India

Let G be a semi-simple simply connected algebraic group over the field C of complex *** T be a maximal torus of G,and let W be the Weyl group of G with respect to *** z(w,i)be the Bott–samelson–Demazure–Hansen variety corresponding to a tuple i associated to a reduced expression of an element w∈*** prove that for the tuple i associated to any reduced expression of a minuscule Weyl group element w,the anti-canonical line bundle on z(w,i)is globally *** consequence,we prove that z(w,i)is weak *** that G is a simple algebraic group whose type is different from *** s={α1,...,αn}be the set of simple *** w be such that support of w is equal to *** prove that z(w,i)is Fano for the tuple i associated to any reduced expression of w if and only if w is a Coxeter element and w^(−1)(Σ_(t=1)^(n)α_(t))∈−s.

关键词： Bott-samelson-Demazure-Hansen variety Coxeter element anti-canonical line bundle Fano weak Fano

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Data-Driven Learning Control Algorithms for Unachievable Tracking Problems

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IEEE/CAA Journal of Automatica sinica 2024年第1期11卷 205-218页

作者： zeyi zhang Hao Jiang Dong shen samer s.saab the school of Mathematics Renmin University of ChinaBeijing 100872China IEEE the school of Engineering Lebanese American UniversityByblos 2038Lebanon

For unachievable tracking problems, where the system output cannot precisely track a given reference, achieving the best possible approximation for the reference trajectory becomes the objective. This study aims to investigate solutions using the Ptype learning control scheme. Initially, we demonstrate the necessity of gradient information for achieving the best ***, we propose an input-output-driven learning gain design to handle the imprecise gradients of a class of uncertain systems. However, it is discovered that the desired performance may not be attainable when faced with incomplete *** address this issue, an extended iterative learning control scheme is introduced. In this scheme, the tracking errors are modified through output data sampling, which incorporates lowmemory footprints and offers flexibility in learning gain *** input sequence is shown to converge towards the desired input, resulting in an output that is closest to the given reference in the least square sense. Numerical simulations are provided to validate the theoretical findings.

关键词： Data-driven algorithms incomplete information iterative learning control gradient information unachievable problems

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A review on transition metal oxides based photocatalysts for degradation of synthetic organic pollutants

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Journal of Environmental sciences 2024年第5期139卷 389-417页

作者： Athira Krishnan Anna swarnalal Divine Das Midhina Krishnan Viswanathan s.saji sMAshibli Department of Chemistry Amrita Vishwa VidyapeethamAmritapuriKerala690525India Interdisciplinary Research Center for Advanced Materials King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Department of Chemistry University of KeralaKariavattom CampusThiruvananthapuramKerala695581India

This review provides insight into the current research trend in transition metal oxides(TMOs)-based photocatalysis in removing the organic colouring matters from *** easy understanding,the research progress has been presented in four generations according to the catalyst composition and mode of application,viz:single component TMOs(the firstgeneration),doped TMOs/binary TMOs/doped binary TMOs(the second-generation),inactive/active support-immobilized TMOs(the third-generation),and ternary/quaternary compositions(the fourth-generation).The first two generations represent suspended catalysts,the third generation is supported catalysts,and the fourth generation can be suspended or *** review provides an elaborated comparison between suspended and supported catalysts,their general/specific requirements,key factors controlling degradation,and the methodologies for performance *** the plausible fundamental and advanced dye degradation mechanisms involved in each generation of catalysts were *** existing challenges in TMOs-based photocatalysis and how the researchers approach the hitch to resolve it effectively are *** research trends are also presented.

关键词： Photocatalysis Dye degradation Transition metal oxides and composites supported catalysts suspended catalysts

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Machine Learning Analysis of Impact of Western us Fires on Central us Hailstorms

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Advances in Atmospheric sciences 2024年第7期41卷 1450-1462页

作者： Xinming LIN Jiwen FAN Yuwei zHANG zJason HOU Pacific Northwest National Laboratory RichlandWA 99354USA Argonne National Laboratory LemontIL 60439USA

Fires,including wildfires,harm air quality and essential public services like transportation,communication,and *** fires can also influence atmospheric conditions,including temperature and aerosols,potentially affecting severe convective ***,we investigate the remote impacts of fires in the western United states(Wus)on the occurrence of large hail(size:≥2.54 cm)in the central us(Cus)over the 20-year period of 2001–20 using the machine learning(ML),Random Forest(RF),and Extreme Gradient Boosting(XGB)*** developed RF and XGB models demonstrate high accuracy(>90%)and F1 scores of up to 0.78 in predicting large hail occurrences when Wus fires and Cus hailstorms coincide,particularly in four states(Wyoming,south Dakota,Nebraska,and Kansas).The key contributing variables identified from both ML models include the meteorological variables in the fire region(temperature and moisture),the westerly wind over the plume transport path,and the fire features(i.e.,the maximum fire power and burned area).The results confirm a linkage between Wus fires and severe weather in the Cus,corroborating the findings of our previous modeling study conducted on case simulations with a detailed physics model.

关键词： wildfire severe convective storm hailstorm machine learning

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Neuropsychological Profile of a Patient with Acquired Brain Damage Following Vascular Lesion of the Left Anterior Cingulate Cortex

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Neuroscience & Medicine 2024年第1期15卷 66-75页

作者： Jimmy zúñiga-Márquez Lina Borda-Camargo Diego Buitrago-Mora Lorely Guerra-Valdés Laura González Patricia Quintero-Cusgüen Nataly Gutierrez-Ávila Hospital Universitario de la samaritana Bogotá Colombia Neuropsychological Assessment and Diagnosis Graduate Program School of Psychology Universidad San Buenaventura Bogotá Bogotá Colombia

stroke is a physiological alteration associated with changes in blood flow that can result in sudden-onset cognitive impairment. It has a heterogenous clinical presentation with varying degrees of severity correlated with specific central nervous system zones or areas, and its prognosis is uncertain. This case study describes a 62-year-old male patient with acquired brain damage of the anterior cingulate cortex as a result of an ischemic event in the territory of the left anterior cerebral artery. Cognitive function was assessed using the neuropsychological executive function and frontal lobe test battery (BANFE-2) as well as other neuropsychological tests. The results show a profile of higher mental functions characterized by the presence of dysexecutive syndrome with marked behavioral alteration and diencephalic amnesia. .

关键词： Ischemic stroke Anterior Cingulate Cortex Neuropsychology Acquired Brain Damage

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Body Contour in the Post-Bariatric Male Patient

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Modern Plastic surgery 2024年第2期14卷 15-22页

作者： Erick zúñiga-Garza Israel salgado-Adame Claudio D. Rojas-Gutiérrez Laura María Rodríguez-Barrios Guillermo Álvarez-sánchez Eduardo Camacho-Quintero Department of Plastic surgery National Medical Center &#822020 de Noviembre&#8221 Mexico City Mexico

Background: Obesity is currently considered a public health problem. Bariatric procedures have become an important part of obesity management and, consequently, the number of male patients seeking post-bariatric reconstructive procedures have increased. Therefore, the clinical approach and understanding of the body contour of this population have become more relevant. The goal of post-bariatric reconstruction is to enhance the male silhouette through removal of skin and adipose tissue excess, and abdominal rectus diastasis repair. Material and Methods: We conducted a retrospective study at the Plastic and Reconstructive surgery Department of the National Medical Center “20 de Noviembre”. All male patients referred to our department to start a post-bariatric reconstruction protocol from January 2018 to December 2022 were included in this study. Results: In total, 15 patients who underwent corporal contouring procedures were included;median age was 49.2 years with minimum of 33 years, and a maximum of 57 years. Median Body mass index was 28.4 kg/msup>2sup> with minimum of 22 kg/msup>2sup> and maximum of 38 kg/msup>2sup>. All patients were treated 18 months after their bariatric surgery. All patients underwent an abdominoplasty as a body contouring procedure. 4 (26.7%) patients presented complications related to the surgery. Conclusion: We described a comprehensive and systematic approach to massive weight loss for male patients, suggesting an abdominal marking based on the patient’s clinical features and the expected results avoiding feminization of the abdominal body contour.

关键词： Massive Weight Loss Post-Bariatric Male Abdominoplasty Contouring

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Thermodynamic Analysis and Optimization of Flat Plate solar Collector using TiO_(2)/Water Nanofluid

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Journal of Harbin Institute of Technology(New series) 2024年第4期31卷 61-73页

作者： Firas F.Qader Falah z.Mohammed Barhm Mohamad Technical Engineering College-Kirkuk Northern Technical UniversityKirkuk 36001Iraq Medical Device Technology Engineering AL-Qalam University CollegeKirkuk 36001Iraq Department of Petroleum Technology Koya Technical InstituteErbil Polytechnic UniversityErbil 44001Iraq

To research solar energy's efficiency and environmental benefits,the thermal efficiency,exergy,and entropy of solar collectors were *** experiment involved two glass-topped collectors,fluid transfer tubes,and aluminum heat-absorbing *** wool insulation minimized heat loss.A 0.5% TiO_(2)/Water nanofluid was created using a mechanical and ultrasonic *** showed that solar radiation increased thermal efficiency until midday,reaching 48.48% for water and 51.23% for the *** increasing mass flow rates from 0.0045 kg/s to 0.02 kg/s,thermal efficiency improved from 16.26% to 47.37% for water and from 20.65% to 48.76% for the *** water provided 380 W and 395 W of energy in March and April,while the nanofluid increased it to 395 W and 415 W during these *** flow generated energy,and the Reynolds number raised *** noon exergy efficiency for nanofluids was 50%-55%,compared to 30% for *** noon,the broken exergy measured 877.53 W for the nanofluid and 880.12 W for *** Kirkuk,Iraq,the 0.5% TiO_(2)/Water nanofluid outperformed water in solar collectors.

关键词： energy exergy entropy generation nanofluid flat plate solar collector

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