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Comparison of Apigenin,Quercetin and Kaempferol Accumulation and Total Flavonoid Content in Leaves,Embryogenic Cultures and Cell Suspension Cultures of parsley(petroselinum crispum)

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国际实验植物学杂志(英文) 2023年第10期92卷 2807-2823页

作者： Laura Isabel Arias-Rodríguez Martha Alicia Rodríguez-Mendiola Carlos Arias-Castro Federico Antonio Gutiérrez Miceli diana reséndez pérez María Celina Luján Hidalgo Juan JoséVillalobos Maldonado Norma Alejandra Mancilla Margalli Analytical Laboratory National Technological Institute of MexicoTuxtla Gutierrez CampusTuxtla GutierrezMexico plant Biotechnology Laboratory Instrumental Analysis LaboratoryPlant Biochemistry LaboratoryNational Technological Institute of MexicoTlajomulco de ZunigaMexico Department of Cellular Biology and Genetics Faculty of Biological SciencesAutonomous University of Nuevo LeonSan Nicolas delos GarzaMexico

In recent years,there has been a growing interest in exploring alternative treatments for bone *** tissue engineering has turned its attention to plant extracts containing osteogenic flavonoids as potential promoters of bone *** our study,we specifically investigated the extract of petroselinum crispum,a plant known for its abundance of osteogenic flavonoids such as apigenin,quercetin,and *** objective was to compare the total flavonoid content(TFC)and their accumulation in different *** obtained hydrolyzed aqueous extracts from the leaves of parsley plants(grown for 12 weeks in the field),weekly embryogenic cultures,and suspension cell *** TFC,measured in mg quercetin equivalent per gram of dry weight(QE mg/g dw),was found to be 53.81±0.97 for 52 g dw of leaves(1 kg plant fw),31.10±1.52 for 420 g dw of embryogenic cultures,and 11.80±0.76 for 210 g dw of cell ***,only the leaves and embryogenic cultures showed significant accumulation of osteogenic flavonoids,with apigenin levels of 1.8±0.3 and 0.32±0.02 mg/g dw,and kaempferol levels of 1.0±0.18 and 0.2±0.01 mg/g dw,*** findings indicate that embryogenic cultures have the potential to produce up to 40%more apigenin in 12 weeks compared to 1 kg of parsley plant,thanks to their superior biomass reproductive *** results present a promising biotechnological approach for generating extracts enriched with bioactive compounds,which can be further utilized in in vitro osteogenic testing.

关键词： parsley(petroselinum crispum)cultures osteogenic flavonoids bone regeneration aqueous extracts

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AN OpTIMAL CONTROL pROBLEM FOR A LOTKA-VOLTERRA COMpETITION MODEL WITH CHEMO-REpULSION

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Acta Mathematica Scientia 2024年第2期44卷 721-751页

作者： diana I.HERNÁndez Diego A.RUEDA-GOMEZ Élder J.VILLAMIZAR-ROA Universidad Industrial de Santander Escuela de MatemáticasA.A.678BucaramangaColombia

In this paper we study a bilinear optimal control problem for a diffusive Lotka-Volterra competition model with chemo-repulsion in a bounded domain of ℝ^(ℕ),N=2,*** model describes the competition of two species in which one of them avoid encounters with rivals through a chemo-repulsion *** prove the existence and uniqueness of weak-strong solutions,and then we analyze the existence of a global optimal solution for a related bilinear optimal control problem,where the control is acting on the chemical ***,we derive first-order optimality conditions for local optimal solutions using the Lagrange multipliers ***,we propose a discrete approximation scheme of the optimality system based on the gradient method,which is validated with some computational experiments.

关键词： Lotka-Volterra chemo-repulsion optimal control optimality conditions

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presynaptic endoplasmic reticulum architecture and hereditary spastic paraplegia

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Neural Regeneration research 2024年第3期19卷 485-486页

作者： Juan Josépérez-Moreno Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevillaand Departamento de Biología CelularFacultad de BiologíaUniversidad de SevillaSevilleSpain

Hereditary spastic paraplegia(HSp)is a clinically and genetically heterogeneous neurodegenerative disorder,characterized primarily by progressive spasticity and weakness in the lower *** ients can also experience peripheral neuropathy,cognitive impairment,and other neurological *** date,more than 80 genes have been implicated in HSp,encompassing various cellular components,although mutations in genes encoding endoplasmic reticulum(ER)-shaping proteins are the most prevalent(parodi et al.,2017).ER-shaping proteins are generally known for regulating the tubulation and curvation of the ER,but most of them show additional functions,including fusion of ER tubules,microtubule-severing,ER autophagy,lipid droplet synthesis,contact sites with other organelles(Öztürk et al.,2020).This highlights the complexity of studying the role of these proteins and the link between ER function and HSp.

关键词： reticulum endoplasmic

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From prediction to prevention:Machine learning revolutionizes hepatocellular carcinoma recurrence monitoring

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World Journal of Gastroenterology 2024年第7期30卷 631-635页

作者： Mariana Michelle Ramírez-Mejía Nahum Méndez-Sánchez plan of Combined Studies in Medicine Faculty of MedicineNational Autonomous University of MexicoDistrito Federal 04510Mexico Liver research Unit Medica Sur Clinic&FoundationDistrito Federal 14050Mexico Faculty of Medicine National Autonomous University of MexicoDistrito Federal 04510Mexico

In this editorial,we comment on the article by Zhang et al entitled Development of a machine learning-based model for predicting the risk of early postoperative recurrence of hepatocellular *** carcinoma(HCC),which is characterized by high incidence and mortality rates,remains a major global health challenge primarily due to the critical issue of postoperative *** recurrence,defined as recurrence that occurs within 2 years posttreatment,is linked to the hidden spread of the primary tumor and significantly impacts patient *** predictive factors,including both patient-and treatment-related factors,have limited predictive ability with respect to HCC *** integration of machine learning algorithms is fueled by the exponential growth of computational power and has revolutionized HCC *** study by Zhang et al demonstrated the use of a groundbreaking preoperative prediction model for early postoperative HCC *** persist,including sample size constraints,issues with handling data,and the need for further validation and *** study emphasizes the need for collaborative efforts,multicenter studies and comparative analyses to validate and refine the *** these challenges and exploring innovative approaches,such as multi-omics integration,will enhance personalized oncology *** study marks a significant stride toward precise,efficient,and personalized oncology practices,thus offering hope for improved patient outcomes in the field of HCC treatment.

关键词： Hepatocellular carcinoma Early recurrence Machine learning XGBoost model predictive precision medicine Clinical utility personalized interventions

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Non-participation of asymptomatic candidates in screening protocols reduces early diagnosis and worsens prognosis of colorectal cancer

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World Journal of Gastroenterology 2024年第26期30卷 3198-3200页

作者： Sergio pérez-Holanda Office of Regional Viceministry of Health Regional Viceministry of HealthOviedo 33005AsturiasSpain

The Agatsuma et al’s study shows that despite the evidence of the benefits of an early colorectal cancer(CRC)diagnosis,through screening in asymptomatic subjects,up to 50%of candidates reject this option and many of those affected are diagnosed later,in advanced *** efficacy of screening programs has been well-established for several years,which reduces the risk of CRC morbidity and mortality,without taking into account the test used for screening,or other ***,a significant proportion of patients remain unscreened,so understanding the factors involved,as well as the barriers of the population to adherence is the first step to possibly modify the participation *** barriers could include a full range of social and political aspects,especially the type of financial provision of each health *** Japan,health services are universal,and this advantageous situation makes it easier for citizens to access to these services,contributing to the detection of various diseases,including ***,the symptomatic CRC group had a lower early-stage diagnosis rate than the patients detected during follow-up for other comorbidities,and symptomatic and cancer screening groups showed similar early-stage diagnosis.

关键词： Colorectal neoplasms Cancer registry Diagnostic route Cancer screening Stage at diagnosis

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Frontier of the paleo-Tethys Ocean in the western Mediterranean:Isotopic(Sm-Nd)constraints on sources of Devonian units from Menorca Island

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Geoscience Frontiers 2024年第5期15卷 323-338页

作者： Ricardo Arenas Jose M.Fuenlabrada Cristian Timoner Rubén Díez Fernández Esther Rojo-pérez Departamento de Mineralogía y petrología and Instituto de Geociencias(UCM CSIC)Universidad ComplutenseMadridSpain Unidad de Geocronología(CAI de Ciencias de la Tierra y Arqueometría) Universidad ComplutenseMadridSpain Bayerisches Geoinstitut University of BayreuthBayreuthGermany Instituto Geológico y Minero de España–CSIC SalamancaSpain

The c.1000-m-thick pre-orogenic Devonian mainly metapelitic sequence of North Menorca Island shows a fairly complete stratigraphic *** rocks of this sequence indicate gradually increasing deeper marine conditions of sedimentation towards its uppermost ***,the obtained sedimentary characteristics resemble those related to a deep and narrow basin-associated *** sills of Ti-augite-bearing alkaline gabbros occur within the Devonian *** intensity of Variscan deformation increases downwards through the *** to the characteristics of the Devonian sequence and its location within the Variscan Orogen,a correlation with similar units located in the southern sectors of the Central Iberian Zone(Iberian Massif)is *** Devonian metapelitic rocks have geochemical characteristics suggesting that they represent moderately recycled mature siliciclastic sediments,generated from erosion of distant source areas belonging to an upper continental *** relatively narrow range of variation observed in initial^(143)Nd/^(144)Nd ratios supports a similar source for the Menorcan slates(0.51165–0.51182).However,a marked trend is observed in these isotope ratios,from lower values at the base of the stratigraphic column(minimum value of 0.511941)to higher values at the top(maximum value of 0.512131).The^(147)Sm/^(144)Nd ratios vary between 0.1074 and 0.1238,within the range defined for siliciclastic rocks with felsic crustal *** Nd model ages define a narrow range between 1496 Ma and 1754 Ma(Late paleoproterozoic–Early Mesoproterozoic),and they are consistently younger *** data rule out a provenance from the erosion of the West Africa Craton,as they are more compatible with a provenance from regions located in the Trans-Saharan Belt or Sahara *** characteristics of the Menorcan Devonian sequence are compatible with its deposition in a narrow and deep peri-Gondwanan transtensional basin,gener

关键词： Western paleo-Tethys frontiers Menorca Island Sm-Nd isotopic constraints Devonian sequence provenance in Gondwana

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Efficiency and effectiveness of systems for the treatment of domestic wastewater based on subsurface flow constructed wetlands in Jarabacoa, Dominican Republic

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Water Science and Engineering 2024年第2期17卷 118-128页

作者： Yvelisse pérez Enmanuel Vargas Daniel Garcia-Cortes William Hernandez Humberto Checo Ulises Jauregui-Haza Area de Ciencias Basicas y Ambientales Instituto Tecnologico de Santo Domingo(INTEC)Avenida de Los Proceres 49Los Jardines del NorteSanto Domingo 10602Dominican Republic Ministry of Environment and Natural resources Calle Cayetano Germosen esq.Ave.LuperonEl PedregalSanto Domingo 11107Dominican Republic plan Yaque Calle Estela Geraldino 14 AltosJarabacoa 41000Dominican Republic Institute of Technologies and Applied Sciences University of HavanaHavana 10400Cuba

Constructed wetlands(CwW)are well known nature-based systems for water *** study evaluated the efficiency and effectiveness of seven domestic wastewater treatment systems based on horizontal flow CWs in Jarabacoa,the Dominican *** results showed that the CWs were efficient in reducing the degree of contamination of wastewater to levels below the Dominican wastewater discharge standards for parameters such as the 5-day biochemical oxygen demand(BOD5)and chemical oxygen demand,but not for the removal of phosphorus and fecal *** addition,a horizontal flow subsurface wetland in the peri-urban area El Dorado was evaluated in terms of the performance of wastewater treatment in tropical climatic *** concentrations of heavy metals,such as zinc,copper,chromium,and iron,were found to decrease in the effluent of the wetland,and the concentrations for nickel and manganese tended to *** levels of heavy metals in the effluent were lower than the limit values of the Dominican wastewater discharge *** construction cost of these facilities was around 200 USD per population equivalent,similar to the cost in other countries in the same *** study suggested some solutions to the improved performance of CWs:selection of a microbial flora that guarantees the reduction of nitrates and nitrites to molecular nitrogen,use of endemic plants that bioaccumulate heavy metals,combination of constructed wetlands with filtration on activated carbon,and inclusion of water purification processes that allow to evaluate the reuse of treated water.

关键词： Domestic wastewater Constructed wetland BOD COD pathogens Heavy metals

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BaTiO_(3)solid solutions co-doped with Gd^(3+)and Eu^(3+):Synthesis,structural evolution and dielectric properties

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Journal of Rare Earths 2024年第10期42卷 1920-1926页

作者： R.Martínez-López M.pérez-Labra J.A.Romero-Serrano F.R.Barrientos-Hernández M.Reyes-pérez M.I.Valenzuela-Carrillo G.Urbano-Reyes V.E.Reyes-Cruz G.I.Dávila-pulido Academic Area of Earth Sciences and Materials Autonomous University of Hidalgo StateRoad Pachuca-Tulancingo Km 4.5 Mineral de La Reforma.Hidalgo42184Mexico Metallurgy and Materials Department ESIQIE-IPNUPALMZacatencoCiudad de Mexico07738Mexico Autonomous University of Coahuila Boulevard Adolfo López Mateos S/nNueva RositaCoahuila26800Mexico

In this paper,the synthesis,structural evolution,and dielectric properties of BaTiO_(3)solid solutions codoped with rare earth elements(Gd^(3+)and Eu^(3+))prepared using the solid-state reaction method are *** pure precursor powders of BaCl_3,TiO_(2),Gd_(2)O_(3),and Eu_(2)O_(3)were mixed in stoichiometric proportions,ground in an agate mortar before being uniaxially pressed at 250 Mpa and sintered at 1300℃in air atmosphere for 6 h to obtain Ba_(1-3x)Gd_(2x)Ti_(1-3x)Eu_(4x)O_(3)(x=0,0.0015,0.01 and0.1).X-ray diffraction(XRD)and Rietveld's refinement results reveal the crystal phase ferroelectric tetragonal BaTiO_(3)for the samples with x=0,0.0015 and 0.01,as well as a consistent increment in the lattice parameters caused by the *** solubility limit of Gd^(3+)and Eu^(3+)in the BaTiO_(3)structure is reached for the sample with x>0.01,and the orthorhombic Eu_2TiO_(5)and monoclinic BaTi_(2)O_(5)secondary phases were *** Raman results show the characteristic peaks of ferroelectric tetragonal BaTiO_(3)around 716 cm^(-1)(LO of A1 symmetry),515 cm^(-1)(TO of A1 symmetry),and 305 cm^(-1)(B1).The maximum relative permittivity measured at 1 kHz was recorded to be 6151.8 for the sample with x=0.0015,and a decrease in the Curie temperature to 105℃with respect to the undoped sample was *** punctual microanalysis for the samples with x=0.0015,0.01,and 0.1 reveals grains composed of Ba,Ti,O,Gd,and Eu homogeneously distributed in the BaTiO_(3)*** Ba/Ti ratios for samples with x=0.0015,0.01 and 0.1 are 2.86,2.91,and 0.68,respectively,indicating substitution at the Ti site for samples with x=0.0015 and 0.01 and a substitution at the Ba site for the sample with x=0.1.

关键词： BaTiO_(3) Doping Gadolinium Europium Synthesis Rare earths

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High-repetition-rate source of nanosecond duration kA-current pulses driven by relativistic laser pulses

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High power Laser Science and Engineering 2024年第3期12卷 106-115页

作者： Michael Ehret Jakub Cikhardt philip Wykeham Bradford Iuliana-Mariana Vladisavlevici Tomas Burian Diego de Luis Jose Luis Henares Rubén Hernández Martín Jon Imanol Apiñaniz Roberto Lera JoséAntonio pérez-Hernández João Jorge Santos Giancarlo Gatti Centro de Láseres pulsados(CLpU) VillamayorSpain Czech Technical University in prague Faculty of Electrical EngineeringPragueCzech Republic Univ.Bordeaux-CNRS-CEA Centre Lasers Intenses et Applications(CELIA)UMR 5107TalenceFrance Department of Radiation and Chemical physics FZU-Institute of Physics of the Czech Academy of SciencesPragueCzech Republic

We report the first high-repetition-rate generation and simultaneous characterization of nanosecond-scale return currents of kA-magnitude issued by the polarization of a target irradiated with a pW-class high-repetition-rate titanium:sapphire laser system at relativistic *** present experimental results obtained with the VEGA-3 laser at intensities from5×10^(18)to 1.3×10^(20)W cm^(-2).A non-invasive inductive return-current monitor is adopted to measure the derivative of return currents of the order of kA ns-1and analysis methodology is developed to derive return *** compare the current for copper,aluminium and Kapton targets at different laser *** data show the stable production of current peaks and clear prospects for the tailoring of the pulse shape,which is promising for future applications in highenergy-density science,for example,electromagnetic interference stress tests,high-voltage pulse response measurements and charged particle beam *** compare the target discharge of the order of hundreds of nC with theoretical predictions and a good agreement is found.

关键词： current pulses electromagnetic pulse application high-power laser relativistic laser plasma

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Calibration of the DEM sliding friction and rolling friction parameters of a cohesionless bulk material

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particuology 2024年第9期92卷 126-139页

作者： Jonatan Marín pérez Tugrul Comlekci Yevgen Gorash Donald MacKenzie University of Strathclyde 75 Montrose StreetG11XJGlasgowUnited Kingdom

The discrete element method(DEM)has become a valuable tool for understanding the mechanical behaviour of granular assemblies,however,the accuracy of the DEM simulations depends on several interaction parameters such as the sliding friction and rolling friction ***,these parameters are estimated using bulk calibration approach(BCA)where the draw down test has been suggested as an effective way to approach these *** test provides up to four bulk criteria,the angle of repose,shear angle,mass flow rate and the mass loss which are used to narrow down the possible ***,there is still more research needed around it to fully understand how this methodology *** experimental and numerical study was carried out using the draw down test to assess the influence of different mass flow rates and particle shapes on DEM parameters for a cohesionless bulk *** is concluded that use of multi-sphere particles and three aperture sizes in the draw down test to calibrate the sliding and rolling friction parameters of a cohesionless bulk material can converge to a small feasible region in which a single combination of the friction coefficients can be *** calibrated sliding and rolling friction coefficients were validated using multi-sphere particles,where the maximum deviation was 5.9%from the experimental values.

关键词： Discrete element method Calibration Draw down Sliding friction Rolling friction particle shape

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