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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： dian.Jiao Lai Xu Zhen Gu Hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： Haonan Zhang Cheng Hao Tongtong Fu dian.Yu Jane Howe Kaiwen Chen Ning Yan Hao Ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors

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Effect of order–disorder transition on thermodynamic and electronic properties of σ and χ phases in W–Re alloy: the first-principles calculation

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Tungsten 2025年第1期7卷 195-213页

作者： Zhi-Peng Zhu dian.Jia William Yi Wang Jun-Lei Yin Xing-Yu Gao Shu-Feng Yang Hai-Feng Song Jin-Shan Li State Key Laboratory of Solidification Processing Northwestern Polytechnical University Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

The Tungsten-Rhenium(W-Re) alloys,celebrated for their high melting point,strength at elevated temperatures,electrical resistivity,and radiation resistance,have been widely utilized in high-temperature components,aerospace,electronics,and nuclear *** constituents of the topologically close-packed(TCP) phases,the sigma phase(σ) and chi phase(χ) formed within W-Re alloys wield considerable influence on the mechanical properties and the stability of the *** calculations were utilized in the present work to explore the structural,thermodynamic,and electronic properties of both ordered and disordered configurations within the σ and χ phases,culminating in a systematic elucidation of the higher phase stability exhibited by the ordered *** is found that the bulk modulus of these two phases is directly proportional to the concentration of Re in the alloy,while the equilibrium volume is inversely *** thermodynamic parameters of the σ and χ phases are calculated via the mean-field potential *** similar trends observed in the isobaric heat capacity,enthalpy increment,and entropy change curves for these two phases suggest they possess comparable thermodynamic *** is noteworthy that the contribution of ionic vibrations predominantly affects the isobaric heat capacity,while the contribution of thermal electronic excitations increases linearly with *** the structure and thermodynamic properties of TCP phases in W-Re alloys at low temperatures has profound significance for optimizing material performance,microstructures features,establishing theoretical foundations,and predicting material behavior.

关键词： First-principles calculations Phase stability TCP phases Thermodynamic properties W–Re alloy

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碱激发高炉矿渣固化/稳定化Cr(VI)污染土试验研究

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岩土工程学报 2025年第1期47卷 57-64页

作者：张文杰金典郭兴璋李西斌台州学院建筑工程学院浙江台州318000 上海大学力学与工程科学学院上海200072 山东大学岩土与结构工程研究中心山东济南250061 浙江农林大学风景园林与建筑学院浙江杭州311300

碱激发高炉矿渣(GGBFS)替代水泥(PC)用于污染土固化处置,具有能耗低、碳排放少的特点,同时GGBFS中含的还原性硫可以将铬(Cr)从六价还原成三价,从而显著提高固化/稳定化效率。使用碱激发GGBFS固化/稳定化总Cr含量2000mg/kg(其中Cr(Ⅵ)121... 详细信息

碱激发高炉矿渣(GGBFS)替代水泥(PC)用于污染土固化处置,具有能耗低、碳排放少的特点,同时GGBFS中含的还原性硫可以将铬(Cr)从六价还原成三价,从而显著提高固化/稳定化效率。使用碱激发GGBFS固化/稳定化总Cr含量2000mg/kg(其中Cr(Ⅵ)1210mg/kg)的污染土,并与PC固化进行对比。通过浸出毒性、固定效率和无侧限抗压强度分析处理效果,借助pH、还原效率、化学形态、矿物成分和微观图像分析揭示了相关机理。结果表明,GGBFS固化污染土的Cr浸出浓度明显低于PC固化土,GGBFS掺量20%,养护龄期28 d时总Cr和Cr(Ⅵ)浸出浓度分别降至2.12,1.09 mg/L,满足填埋场进场浓度限值要求,且GGBFS固化污染土的强度明显高于PC固化土;还原效率分析表明,GGBFS中的S^(2-)可以有效地将Cr(Ⅵ)还原成Cr(Ⅲ),还原效率可达96.0%,从而很大程度上避免了Cr(Ⅵ)对水化过程的抑制作用,使用GGBFS固化/稳定化该含量的Cr(Ⅵ)污染土时不需额外添加还原剂;微观分析表明,与PC相比,GGBFS固化后更多不稳定态的Cr转化成稳定形态,Cr的迁移性显著降低,同时生成了更多水化凝胶,土颗粒胶结程度更高,因此具有更好的封固效果和更高强度。该研究为GGBFS固化/稳定化Cr(Ⅵ)污染土提供了科学依据。

关键词：粒化高炉矿渣 Cr(Ⅵ)污染土固化/稳定化浸出浓度还原效率

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定窑遗址出土制瓷原料的科学分析

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光谱学与光谱分析 2025年第1期45卷 72-81页

作者：陈殿崔剑锋秦大树黄信李鑫北京师范大学历史学院陶瓷考古与艺术研究中心北京100875 考古科学教育部重点实验室(北京大学) 北京100871 浙大城市学院考古学系浙江杭州310015 河北省文物考古研究院河北石家庄050031 中国社会科学院考古研究所北京100101

首次通过窑址发掘出土的制瓷原料,复原了定窑不同时代的胎釉配方。对2009年定窑作坊遗址考古发掘所出五代至宋金时期二十余种制瓷原料开展了ED-XRF成分分析和XRD结构分析等光谱学分析。ED-XRF成分分析显示,这些原料可能包括单一原料和... 详细信息

首次通过窑址发掘出土的制瓷原料,复原了定窑不同时代的胎釉配方。对2009年定窑作坊遗址考古发掘所出五代至宋金时期二十余种制瓷原料开展了ED-XRF成分分析和XRD结构分析等光谱学分析。ED-XRF成分分析显示,这些原料可能包括单一原料和混合原料两种。其中单一原料包括岩石、粘土以及草木灰。混合原料则包括胎料和釉料两种。XRD结构分析表明用于定窑白瓷生产高岭土类原料是含有蒙脱石和方解石的伴生石英的长石类矿物原料。高铁粘土类原料由于铁含量特别高,应当是用于配黑釉的粘土。钙质原料的分析与康葆强等学者对定窑配釉用的灰料可能使用了40%的白灰和60%的松木灰配制的结论相同。同时,还发现了釉灰,即草木煅烧石灰石后形成的混合灰料。在分析定窑白瓷釉时,认为五代的白瓷釉可能使用了釉灰配制,因此定窑釉灰的使用可能推早到五代,这是目前发现使用釉灰配釉最早的实例。对制胎原料XRD晶相分析的结果表明,除了石英和高岭石占主要比重外,还含有长石、蒙脱石、方解石等岩石类矿物。从对单一原料的X射线衍射的分析结果看,石英是粘土以及岩石这类单一原料中都含有的一类矿物,因此可能石英并非必须要添加的胎体原料。石英和高岭石是粘土原料中的主要成分,因此制胎原料应该主要以岩石类原料和粘土作为主要配料。定窑细白瓷胎料可能使用了粘土类原料配合第一类岩石类原料的配方,其配比在金代时大约为1∶1左右,北宋时期可能约为7∶3(粘土∶岩石),五代时大概为6∶4左右。对制釉原料分析结果表明,定窑配釉原料是岩石类原料与釉灰配合形成的,五代、北宋时岩石和灰的比例约为9∶1,金代时石:灰达到了9.5∶0.5。这使得我们对定窑鼎盛时期的白瓷胎釉配方有了更加清晰的了解,从而为开展定窑的复烧提供了确凿的依据。

关键词：定窑制瓷原料光谱学分析

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甲真菌病治疗的新概念

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临床皮肤科杂志 1993年第A60期22卷 48-49页

作者： dian.,R 李若瑜

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Extreme Wave Simulation with Iterative Adaptive Approach in Numerical Wave Flume

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China Ocean Engineering 2021年第1期35卷 61-71页

作者： LIU dian.yong Naval Architecture and Ocean Engineering College Dalian Maritime UniversityDalian 116026China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116023China

Extreme wave is highly nonlinear and may occur due to diverse reasons *** simulated results of extreme wave based on wave focusing,which were generated using high order spectrum method,are *** influences of the steepness,frequency bandwidth as well as frequency spectrum on focusing position shift were examined,showing that they can affect the wave focusing ***,controlled accurate generation of extreme wave at a predefined position in wave flume is a difficult but important *** this paper,an iterative adaptive approach is applied using linear dispersion theory to optimize the control signal of the *** performance of the proposed approach is numerically investigated for a wide variety of *** results demonstrate that this approach can reproduce accurate wave focusing effectively.

关键词： extreme wave wave focusing numerical wave flume iterative adaptive approach

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A multi-constraints based pose coordination model for large volume components assembly

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Chinese Journal of Aeronautics 2020年第4期33卷 1329-1337页

作者： dian.WU Fuzhou DU School of Mechanical Engineering and Automation Beihang UniversityBeijing 100083China

In the assembly process of large volume product,engineering constraints limit the relative pose of components and serve as a standard for judging assembly ***,in the traditional process of target pose estimation,a general method is needed for establishing the correlation between engineering constraints and product pose,and it is difficult to evaluate pose by constraints ***,the process of target pose estimation and evaluation is *** this paper,a pose coordination model based on multi-constraints is proposed,which includes pre-processing,pose estimation,pose adjustment and ***,engineering constraints are decoupled into 4 types of Minimum Geometrical Reference Constraints(MGRC),and the inequalities for solving target pose are *** the Constraint Coordination Index(CCI)is defined as the optimization objective to solve the target ***,with CCI as the numerical index,the target pose is evaluated to illustrate the quality of *** the simulation experiment of wing-fuselage jointing as an example,the external and internal parameters of model are analyzed,and the pose estimation based on multi-constraints reduces the CCI by 12%,compared with the point-set-registration method.

关键词： Large volume components Measurement assisted assembly Multi-constraints Pose estimation Pose evaluation

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Fossil gastropods from the MGS3 stratigraphic segment in the Salawusu River Valley and their climatic and environmental implications

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Science China Earth Sciences 2008年第3期51卷 339-348页

作者： David dian Department of Geography and Geology the University of Hong Kong

Contemporaneous with MIS3, the MGS3 segment of the Milanggouwan stratigraphic section in the Salawusu River Valley, Mu Us Desert, China contains fossil gastropods (terrestrial and freshwater snails) in strata 33LS, 35LS, 37FL and 39LS. Examination of these fossils revealed 11 species belonging to 8 families and 10 genera. They can be classified as: (1) assemblage of Gyraulus and Galba mainly consisting of Gyraulus convexiusculus, Gyraulus sibiricus, Galba pervia and Galba superegra Gredler, etc. (2) assemblage of Vallonia mainly consisting of terrestrial snails, such as Vallonia patens, Pupilla muscorum and Discus paupe, etc. Based on the dating results, and the living habits, living conditions, and geographic distribution of their extant species, we suggest that: the ages of 33LS, 35LS, 37FL, and 39LS are 26000, 29000, 33000 and 38000 a, respectively, corresponding well to the interstadial period in GRIP 4, 5, 6 and 10 in terms of chronology and climatic characters; 33LS, 35LS and 39LS represent very warm-humid periods, while 37FL represents a less warm-humid period; the four periods of climatic fluctuations recorded in MGS3 were related to the strong impact of the summer monsoon in East Asia in Mu Us Desert of China during the interstadial of MIS3 on a global climatic background.

关键词： Salawusu River Valley Milanggouwan Section MGS3 stratigraphic segment fossil gastropods climatic environment

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Fuzzy Static Output Feedback H_∞ Control for Nonlinear Systems Subject to Parameter Uncertainties

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Journal of Systems Science & Complexity 2018年第2期31卷 343-371页

作者： ZHAO Tao dian.Songyi School of Electrical Engineering and Information Sichuan University

This study is concerned with the stabilization issue of nonlinear systems subject to parameter uncertainties. An interval type-2 T-S fuzzy model is used to represent the nonlinear systems subject to parameter uncertainties. An interval type-2 fuzzy static output feedback controller is designed to synthesize the interval type-2 T-S fuzzy systems. The membership-function-dependent stability conditions are derived by utilizing the information of upper and lower membership functions. The proposed stability conditions are presented in the form of linear matrix inequalities（LMIs）. LMI-based stability conditions for interval type-2 fuzzy static output feedback H_∞ control synthesis are also *** simulation examples are given to show the superiority of the proposed approach.

关键词： Interval type-2 fuzzy controller parameter uncertainties static output feedback control T-S fuzzy systems.

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