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Modified ulcer debridement in the treatment of the superficial fungal infection of the cornea

International Journal of Ophthalmology(English edition) 2018年第2期11卷 223-229页

作者： Jun-Yi wang dian-qiang wang Xiao-Lin Qi Jun Cheng Li-Xin Xie Department of Comea Qingdao Eye HospitalShandong Eye InstituteShandong Academy of Medical SciencesQingdao 266071Shandong ProvinceChina

AIM： To evaluate the efficacy of modified corneal ulcer debridement in superficial fungal keratitis unresponsive to ***： A total of 209 patients（209 eyes） with fungal keratitis, involving no more than 50% of the stromal depth and not responding to antifungal agents for 2 wk, were recruited in this retrospective, noncomparative study. The patients were treated with modified corneal ulcer debridement. All visible corneal infiltrates were removed under an operating microscope to obtain a clean stromal bed and smooth incised edges. Antifungal drugs were used immediately after surgery. Healing time of the ulcers was recorded. Fungal recurrence, visual acuity, corneal thickness and risk factors for treatment failure were ***： The follow-up was 13.6±5.8m o. The corneal ulcers healed in 195 of 209 eyes（93.3%）, with a mean healing time of 8.4±6.8 d. The other 14 eyes were further treated by penetrating keratoplasty（PK）（1 eye）, anterior lamellar keratoplasty（LK）（7 eyes）, conjunctival flap covering（4 eyes） or amniotic membrane transplantation（2 eyes）. The best corrected visual acuity（BCVA） was ≥20/70 in 80.3% of the eyes, ≥20/40 in 56.9% of the eyes, and ≥20/25 in 27.3% of the eyes. The corneas at the lesions became thinner, but all in the safe range. No fungal recurrence or corneal ectasis developed during the follow-up. The risk of treatment failure was higher in patients with preoperative hypopyon（P=0.036） and ever using steroid（P=0.025）.CONCLUSION： Modified surgical debridement is a simple and effective method for the treatment of superficial fungal infection of the cornea, with improved visual acuity and no recurrence. Such an intervention in time can rapidly control fungal infection and largely shorten corneal ulcer healing time.

关键词： fungal keratitis superficial fungal infection debridement cornea ulcer corneal scraping

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A Chinese family with Axenfeld-Rieger syndrome:report of the clinical and genetic findings

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 847-853页

作者： Da-Peng Sun Yun-Hai Dai Xiao-Jing Pan Tao Shan dian-qiang wang Peng Chen Qingdao University Qingdao 266071 Shandong Province China State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Shandong Eye Institute Shandong Academy of Medical Sciences Qingdao 266071 Shandong Province China

AIM： To describe a Chinese family affected by a severe form of Axenfeld-Rieger syndrome （ARS） and characterize the molecular defect in PITX2 in the family. METHODS： Patients presented with typical ARS from a Chinese family were investigated. We performed genome- wide linkage scan and exome sequencing to identify the pathogenic mutations, Candidate mutations were verified for co-segregation in the whole pedigree using Sanger sequencing, Real-time polymerase chain reaction （RT- PCR） and Western blotting were performed to verify the expression of the pathogenic gene. RESULTS： Genome-wide linkage and exome sequencing analyses showed PITX2 as the disease candidate gene. A〉G substitution at position -11 of 3＇ss of exon 5 （IVS5- 11A〉G） that co-segregated with the disease phenotype was discovered in the family. The PITX2 messenger ribonucleic acid and protein levels were about 50% lower in patients with ARS than in unaffected family members in the family, CONCLUSION： Our findings implicate the first intronic mutation of the PITX2 gene in the pathogenesis of a severe form of ARS in a Chinese family. This study highlights the importance of a systematic search for intronic mutation in ARS cases for which no mutations in the exons of PITX2 have been found.

关键词： Axenfeld-Rieger syndrome exome sequencing linkage analysis PITX2 intronic mutation

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Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren Fei Zheng Tingwei Cao qiang wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

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Magnetron sputtered nickel oxide with suppressed interfacial defect states for efficient inverted perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 348-355页

作者： Guoqiang Ma Qin Tan Zhaoning Li Jingwei Xiu Jiafeng wang Tianle Cheng Dong He qiang Sun Xuhang Ma Francesco Lamberti Zhubing He Department of Materials Science and Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Research Facilities Southern University of Science and Technology Department of Chemical Sciences Department of Industrial Engineering University of Padova

Widely used spin-coated nickle oxide （NiOx） based perovskite solar cells often suffer from severe interfacial reactions between the NiOxand adjacent perovskite layers due to surface defect states,which inherently impair device performance in a long-term view,even with surface molecule *** this study,we developed high-quality magnetron-sputtered NiOxthin films through detailed process optimization,and compared systematically sputtered and spin-coated NiOxthin film surfaces from materials to *** sputtered NiOxfilms exhibit improved crystallinity,smoother surfaces,and significantly reduced Ni3+or Ni vacancies compared to their spin-coated ***,the interface between the perovskite and sputtered NiOxfilm shows a substantially reduced density of defect *** solar cells （PSCs） fabricated with our optimally sputtered NiOxfilms achieved a high power conversion efficiency （PCE） of up to 19.93%and demonstrated enhanced stability,maintaining 86.2% efficiency during 500 h of maximum power point tracking under one standard sun ***,with the surface modification using (4-(2,7-dibromo-9,9-dimethylacridin-10（9H）-yl)butyl)p hosphonic acid （DMAcPA）,the device PCE was further promoted to 23.07%,which is the highest value reported for sputtered NiOxbased PSCs so far.

关键词： Perovskite

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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli Zhang Tian Li Jie Miao Zhina Zhang Mingxuan Yang Zhuoran wang Bo Yang Jiawei Zhang Haiting Li qiang Su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin wang Fangyuan Cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-Yu wang Ka Lu Ju-Song Yang Fu-Min Zhang Ai-Jun Ma Bao Du Yong-qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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破解“古今中西之争”的学理逻辑:以近代以来体用关系为线索

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学习论坛 2025年第1期 110-117页

作者：王强王舒悦上海交通大学马克思主义学院上海200240

“体用”关系贯穿中华文明的现代转型发展,是破解“古今中西之争”的学理逻辑主线。回顾百年中国学术史,“古今中西之争”围绕“体用”关系展开,这集中表现在两个转变上:一是面临三千年之大变局的“天下—中国”世界观遭受挑战,中华文... 详细信息

“体用”关系贯穿中华文明的现代转型发展,是破解“古今中西之争”的学理逻辑主线。回顾百年中国学术史,“古今中西之争”围绕“体用”关系展开,这集中表现在两个转变上:一是面临三千年之大变局的“天下—中国”世界观遭受挑战,中华文明内部的“夷夏之辨”转变为中西关系的“体用之辩”;二是“体用之辩”从中国哲学的“道器”“理气”“心物”形而上学层面,转变为“中国向何处去”的政治论争,提出了“中体西用”“西体中用”以及“中西各有体用”等不同主张。但是,在传统文化视域中,无法破解中华文明的主体性与现代化道路选择上的“两难困境”。在引入了马克思主义以后,中国人在精神上由被动转入主动,为破解“古今中西之争”提供了唯物主义的历史观和认识论基础。作为习近平文化思想理论品格的“明体达用、体用贯通”,是对中国传统“体用”关系的创造性转化、创新性发展,既赋予了“体用”以新的文化生命体的生存本体论基础,同时也为破解“古今中西之争”提供了方法论前提。

关键词： “古今中西之争” “体用”关系习近平文化思想学理逻辑

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A Method of Minimum Reusability Estimation for Automated Software Testing

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Journal of Shanghai Jiaotong university(Science) 2013年第3期18卷 360-365页

作者： KAN Hong-xing wang Guo-qiang wang Zong-dian DING Shuai School of Medical Information Technology Anhui University of Traditional Chinese Medicine Hefei 230038 China School of Management Hefei University of Technology Hefei 230009 China

Through reusing software test components, automated software testing generally costs less than manual software testing. There has been much research on how to develop the reusable test components, but few fall on how to estimate the reusability of test conlponents for automated testing. The purpose of this paper is to present a method of minimum reusability estimation for automated testing based on the return on investment （ROI） model. Minimum reusability is a benchmark for the whole automated testing process. If the reusability in one test execution is less than the minimum reusability, some new strategies must be adopted ill the next test execution to increase the reusability. Only by this way, we can reduce unnecessary costs and finally get a return on the investment of automated testing.

关键词： automated software testing manual software testing mean maintenance costs multiplier reusable software test components threshold minimum reusability estimation

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Experimental study on jet pulse assembly design and numerical simulation

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Petroleum Science 2020年第1期17卷 222-231页

作者： Liang Xue Hu Han dian wang Xian-Bo Liu He Liu Zhi-qiang Yu China University of Petroleum–Beijing Beijing 102249China Bohai Drilling Engineering Technology Research Institute Tianjin 300280China

Jet pulse assembly is one of the main components of jet hydraulic *** pressure wave characteristics produced by jet pulse assembly have an important influence on the performance of the *** this paper,the structure and working principle of jet pulse assembly are studied,the mechanical analysis model of piston rod is established,the dynamic resistance ratio formula of jet pulse assembly is deduced,and the numerical simulation test of 89-mm jet pulse assembly structure parameters is carried *** results show that the piston rod downward stroke is driven by both the jet element driving force and the throttle plate load driving force,and can stably *** driving force of the piston rod upward stroke jet element is opposite to the load acting force of the throttle disc,and the jet driving force needs to be greater than the load resistance of the throttle disc to stably *** dynamic resistance ratio formula is *** the area of the end of the piston rod is reduced,the resistance of the throttle disc is reduced and the jet power is increased,thus solving the problem of insufficient power of the piston rod in the upstroke and ensuring the normal operation of the *** groups of numerical simulation tests were carried out,and it was found that the pressure amplitude and pressure drop of the tool decreased significantly with the increase of the tool size,and the error between the numerical simulation value and the theoretical calculation value was less than 9%,which verified the correctness of the *** is suggested to select tools on site according to the drilling construction situation to ensure the drilling effect.

关键词： Friction reduction and torsion Jet pulse assembly Dynamic resistance ratio formula Pressure amplitude Numerical simulation

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