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Zircon U-Pb age,trace element and Hf isotope composition of Sepon Au-Cu deposit, Laos:tectonic and metallogenic implications

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China Geology 2018年第1期1卷 36-48页

作者： Xin-yu Wang dian-hua cao Zong-qi Wang An-jian Wang Yu-dong Wu School of Earth Sciences and Resources China University of Geosciences (Beijing)Beijing 100083China MNR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mmeral ResourcesChinese Academy of Geological SciencesBeijing 100037China

The Truong Son Fold Belt,located at the northeastern margin of the Indochina Block,is considered to be tectonically linked to the subduction of the Paleotethys Ocean and subsequent *** is one of the most important super large deposits of the Truong Son Fold *** LA-ICP-MS zircon U-Pb dating results show that granodiorite porphyry samples from the Sepon deposit have ages of 302.1-4-2.9 Ma, which is a crucial phase for magmatic-tectonical activities from the Late Carboniferous to Early Permian and has avital influence on the mineralization of copper and *** from granodiorite porphyry yields εHf (t)values of 4.32 to 9.64,and TDM2 has an average age of 914 Ma,suggesting that the source of the granodiorite porphyry in the region were mainly mantle components but underwent mixing and contamination of crust *** Ce^4+/Ce^3+ value of zircon in the granodiorite porphyry varys greatly from 2.4 to 1438.29,which shows magma mixing might *** the characteristics of trace elements in the zircon and the whole rock geochemical characteristics of intrusion rocks as well as the characteristics of regional volcanic-sedimentary association,it is indicated that the tectonic setting may be the continental arc *** Sepon Au-Cu deposit is derived from emplacement of calc-alkaline intermediate-acid magma with coming from deep sources in the subduction process of the Paleotethys Ocean,forming porphyry Mo-Cu,skam Cu-Au mineralization and a hydrothermal sedimentary-hosted Au mineralization in the wall rocks.

关键词： Granodiorite porphyry Zircon U-Pb ages Hf isotope Trace elements Sepon Laos

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Zircon O isotope composition of Sepon Au-Cu deposit, Laos

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China Geology 2020年第2期3卷 348-349页

作者： Xin-yu Wang dian-hua cao Jian-hua Wang Chinese Academy of Geological Sciences Beijing 100037China Ministry of Natural Resources Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100037China Department of Terrestrial Magnetism Carnegie Institution for ScienceWashington D.C.20015USA

*** The Sepon Au-Cu deposit(Fig.1)is the largest polymetal deposit ever discovered in Laos,of which the resources of gold and copper is 102 t(Au:1.6 g/t)and 1.96×10^6 t(TCu:2%)(Zhu HP et al.,2013)*** Au-Cu deposit is one of the most important super large deposits of the Truong Son Fold *** Truong Son Fold Belt,located at the northeastern margin of the Indo-China terrane,is considered to be tectonically linked to the subduction of the Paleotethys Ocean and subsequent *** granodiorite porphyry samples from the Sepon deposit belong to I-type calc-alkaline series and tectonic settings are continental arc environment(Cromie PW,2010).LA-ICP MS zircon U-Pb dating results show that granodiorite porphyry samples from the Sepon deposit have ages of 302.1±2.9 *** in situ zirconεHf(t)values range from+4.32 to+9.64,and TDM2(Hf)has an average age of 914 Ma(Wang XY et al.,2018).In this study,the authors present new in situ zircon oxygen isotopic data to identify the source of the magma.

关键词： deposit zircon tectonic

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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： dian Jiao Lai Xu Zhen Gu hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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lncRNA SNHG4 enhanced gastric cancer progression by modulating miR-409-3p/CREB1 axis

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Oncology Research 2025年第1期33卷 185-198页

作者： ZHOUYANG CHENG YUCHEN hua YANG cao JUN QIN Department of General Surgery Affiliated Hospital of Nantong UniversityNantong226001China Department of Surgery Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China Department of Operation Affiliated Hospital of Nantong UniversityNantong226001China

Objective:Gastric cancer(GC)is a globally common cancer characterized by high incidence and mortality *** in the molecular understanding of GC provide promising targets for GC diagnosis and *** non-coding RNAs(lncRNAs)and their downstream regulators are regarded to be implicated in the progression of multiple types of *** have shown that the lncRNA small nucleolar RNA host gene 4(SNHG4)serves as a tumor promoter in various malignancies,while its function in GC has yet to be ***,our study aimed to explore the role and underlying mechanism of SNHG4 in ***:We used qRT-PCR to analyze SNHG4 expression in GC tissues and ***-Meier analysis was used to assess the correlation between SNHG4 expression and the survival rate of GC *** function experiments such as CCK-8,BrdU,colony formation,flow cytometry analysis,and transwell were performed to explore the effects of SNHG4 on GC cell proliferation,apoptosis,cell cycle,migration,and *** also established xenograft mouse models to explore the effect of SNHG4 on GC tumor ***,dual luciferase reporter assay was used to verify the interaction between SNHG4 and miR-409-3p and between miR-409-3p and cAMP responsive element binding protein 1(CREB1).Results:The results indicated that SNHG4 was overexpressed in GC tissues and cell lines,and was linked with poor survival rate of GC ***4 promoted GC cell proliferation,migration,and invasion while inhibiting cell apoptosis and cell cycle arrest in *** in vivo experiment indicated that SNHG4 facilitated GC tumor ***,SNHG4 was demonstrated to bind to ***,CREB1 was directly targeted by *** assays demonstrated that miR-409-3p deficiency reversed the suppressive impact of SNHG4 knockdown on GC cell ***,miR-409-3p was also revealed to inhibit GC cell proliferation,migration,and invasion by targeting CREB1

关键词： Gastric cancer Small nucleolar RNA host gene 4(SNHG4) MicroRNA-409-3p(miR-409-3p) cAMP responsive element binding protein 1(CREB1)

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Universal design of three-dimensional porous graphene-iron based promotors for kinetically rationalized lithium-sulfur chemistry

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Journal of Energy Chemistry 2025年第1期100卷 192-200页

作者： hua Gao Yunfeng Zhang Menglei Wang Ruoxuan Yang Shuai Feng Xuan cao Yaping Zhang Zhongyuan Lu Yingze Song State Key Laboratory of Environment-Friendly Energy Materials School of Materials and Chemistry Southwest University of Science and Technology School of Material Science and Engineering Henan University of Technology College of Chemistry and Chemical Engineering Taishan University

Lithium-sulfur （Li-S） batteries are widely deemed to be one of the most potential candidates for future secondary batteries because of their remarkable energy ***,notorious polysulfide shuttling and retarded sulfur reaction kinetics pose significant obstacles to the further application of Li-S *** rationally designed highly active electrocatalysts can facilitate polysulfide conversion,the universal and scalable synthesis strategies need to be ***,a universal synthetic strategy to construct a series of three-dimensional （3D） porous graphene-iron （3DGr-Fe） based electrocatalysts involving 3DGr-FeP,3DGr-Fe3C,and 3DGr-Fe3Se4is exploited for manipulating the Li-S redox *** has been observed that the implementation of a 3D porous Gr architecture leads to the well-designed conductive networks,while the uniformly dispersed iron nanoparticles introduce an abundance of active sites,fostering the lithium polysulfide conversion,thereby bolstering the overall electrochemical *** Li-S battery with the 3DGr-Fe based electrocatalyst exhibits remarkable capacity retention of 94.8%upon 100 times at 0.2 ***,the soft-packaged Li-S pouch cell based on such a 3DGr-Fe electrocatalyst delivers superior capacity of 1060.71 mA h g-1and guarantees for the continuous 30 min work of fan *** investigation gives comprehensive insights into the design,synthesis,and mechanism of 3DGr-Fe based electrocatalysts with high activity toward efficient and durable Li-S batteries.

关键词： Redox reactions

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Positive effect of Mo on mechanical properties of a Ni-42W-10Co-x Mo medium heavy alloy

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China Foundry 2025年

作者： Guo-xin cao Jian-xin Dong Yong-sheng He He Jiang Fang Hao Zhi-hua Nie Teng-fei Ma Bao-quan Fu School of Materials Science and Engineering University of Science and Technology Beijing Xi'an Superalloy Technology Co. Ltd. School of Materials Science and Engineering Beijing Institute of Technology Key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou University

In this study,a novel Ni-W-Co-Mo medium heavy alloy (MHA) was designed to improve its mechanical strength via Mo *** the Ni-42W-10Co-xM o alloy series,where x represents the weight percent of Mo and varies between 0,1,2,5,and 10,the microstructure transitions from a dendritic structure to a hypoeutectic structure as the Mo content increases from 0 to 5wt.%.Moreover,as the Mo content increases from 0to 10wt.%,the distribution of theμ-phase shifts from being individually dispersed to forming aggregates,and its volume fraction rises from 0.5%to 7.9%.Notably,theμ-phase evolves into an eutectic microstructure,which helps in minimizing the segregation of *** change is accompanied by a substantial enhancement in mechanical properties;specifically,the compressive yield strength at room temperature increases from 350 MPa to 646 MPa,indicating a significant 85%***,the microhardness increases from 230 HV to 304 *** dynamics simulations further reveal that the strengthening mechanism of Ni-42W-10Co-xM o alloys is Mo-induced solid solution strengthening and precipitation strengthening.

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Simplified Weighted Velocity Field for Prediction of Hot Strip Rolling Force by Taking into Account Flattening of Rolls

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Journal of Iron and Steel Research International 2014年第7期21卷 637-643页

作者： dian-hua ZHANG Jian-zhao cao Jiu-jing XU Wen PENG De-wen ZHAO State Key Laboratory of Rolling and Automation Northeastern University

The weighted velocity field was simplified for analysis of hot strip rolling. Using the field and GM （geometric midline） yield criterion, the deformation power, friction power and shear power were obtained respectively. Summing the partial power contributions, the total deformation power for strip rolling was presented. Then, by minimizing the power function, the rolling force was obtained; meanwhile, considering the effect of roll elastic flattening, iterative calculation of the roll radius was carried out until the radius was convergent. On line data were corn pared with the calculated results to verify the model accuracy. It was indicated that the calculated rolling forces were basically in agreement with the measured ones since the maximum error was less than 10.0%. Moreover, the effects of various rolling conditions such as thickness reduction, friction factor and shape factor, upon separating force, location of neutral angle, and stress state coefficient were discussed systematically.

关键词： hot strip rolling rolling force simplified weighted velocity field GM yield criterion elastic flattening analytical solution

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Optimization of Temperature and Force Adaptation Algorithm in Hot Strip Mill

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Journal of Iron and Steel Research International 2014年第3期21卷 300-305页

作者： Wen PENG Zi-ying LIU Xi-lin YANG Jian-zhao cao dian-hua ZHANG State Key Laboratory of Rolling and Automation Northeastern University Central Iron and Steel Research Institute

Abstract： In the hot strip rolling control system, the temperature distribution and deformation resistance are the main parameters affecting prediction of rolling force. In order to improve the model prediction precision, an optimiza- tion algorithm based on objective function was put forward, in which the penalty function index was adopted. During the adaptation process, the temperature distribution and deformation resistance were taken as the optimized parame ters, and the Nelder-Mead simplex algorithm was used to search the optimal solution of the objective function. Fur thermore, the temperature adaptation and force adaptation were solved simultaneously. Application results show that the method can improve the accuracy of the rolling force model obviously, and it can meet the demand of the indus trial production and has a good application prospect.

关键词： hot strip mill adaptation temperature distribution~ force prediction~ objective function~ simplex algo-rithm

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True Amplitude Extraction Technology and Its Application in Pre-Stack Seismic Data

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Journal of Earth Science 2015年第4期26卷 522-529页

作者： Xiaohui Yang Siyuan cao dian Yuan CNPC Key Laboratory of Geophysical Prospecting China University of Petroleum

Common-reflection-point （CRP） gather is a bridge that connects seismic data and petro- physical parameters. Pre-stack attributes extraction and pre-stack inversion, both of them are impor- tant means of reservoir prediction. Quality of CRP gather usually has great impact on the accuracy of seismic exploration. Therefore, pre-stack CRP gathers noise suppression technology becomes a major research direction. Based on the vector decomposition principle, here we propose a method to suppress noise. This method estimates optimal unit vectors by searching in various directions and then sup- presses noise through vector angle smoothing and restriction. Model tests indicate that the proposed method can separate effective signal from noise very well and suppress random noise effectively in single wavenumber case. Application of our method to real data shows that the method can recover effective signal with good amplitude preserved from pre-stack noisy seismic data even in the case of low signal to noise ratio （SNR）.

关键词： vector decomposition noise suppression angle smooth spline function.

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Resistance of grid steel-tube-confined concrete targets against projectile impact: Experimental investigation and analytical engineering model

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Defence Technology（防务技术） 2022年第9期18卷 1622-1642页

作者： dian-yi Song Qing-hua Tan Chao-mei Meng Yi-min huang Yang-yueye cao Zhi-gang Jiang Undergraduate School National University of Defense TechnologyChangsha410072PR China College of Aerospace Science and Engineering National University of Defense TechnologyChangsha410073PR China College of Aerospace Engineering Air Force Engineering UniversityXi'an710038PR China

Steel-tube-confined concrete(STCC) targets are provided with excellent anti-penetration performance over semi-infinite concrete(SIC) targets since the steel tube imposes passive restraint on the in-filled concrete during the penetration process. Grid STCC system with square steel tubes is a potential solution to protective structures. In this paper, experiments of 9-cell grid STCC targets penetrated by 12.7 mm Armor Piercing Projectile(APP) were performed. The influence of side length and thickness of steel tube,steel ratio and impact velocity on anti-penetration performance were taken into account. Additionally,single-cell square STCC targets were also designed and tested for comparison with the 9-cell grid STCC targets. Damage modes and parameters of the tested targets were measured and discussed. Moreover,the stiffness of radial confinement of grid STCC targets is achieved according to the elastic solution of infinite cylindrical shell in Winkler medium. Furthermore, the penetration resistance and depth of penetration(DOP) for grid STCC targets are obtained on the basis of the dynamic finite spherical cavityexpansion(FSCE) models including radial confinement effect. It is shown that the 9-cell grid STCC targets with optimal dimension match of thickness and side length of steel tube can reduce the DOP by about17 % and 23 % in comparison with the SIC targets and single-cell square STCC targets, respectively, due to both the confinement of square steel tube to concrete in the impacted cell and the additional confinement of the surrounding cells to the impacted cell;the penetration resistance and DOP of the grid and cellular STCC targets with similar steel ratio is close, and thus the grid STCC targets with simpler manufacturing process and excellent in-plane expandability are preferred in engineering practice;moreover, the predicted results of DOP model based on the FSCE models agree well with the tested results with the maximum disparity less than 12 % and the prop

关键词： Penetration mechanics Grid structural system Steel-tube-confined concrete(STCC)targets Armor piercing projectile(APP) Depth of penetration(DOP) Finite spherical cavity expansion(FSCE)

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