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Identifying the potential transcriptional regulatory network in Hirschsprung disease by integrated analysis of microarray datasets

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World Journal of Pediatric Surgery 2023年第2期6卷 103-114页

作者： Wenyao xu Hui Yu dian Chen Weikang Pan Weili yang Jing Miao Wanying Jia Baijun Zheng Yong Liu Xinlin Chen Ya Gao Donghao Tian Department of Pediatric Surgery the Second Affiliated HospitalXi'an Jiaotong UniversityXi'anChina Institute of Neurobiology Environment and Genes Related to Diseases Key Laboratory of Chinese Ministry of EducationXi'an Jiaotong UniversityXi'anChina Department of Pulmonary and Critical Care Medicine Peking University Third HospitalPeking UniversityBeijingChina

Objective Hirschsprung disease(HSCR)is one of the common neurocristopathies in children,which is associated with at least 20 genes and involves a complex regulatory *** regulatory network(TRN)has been commonly reported in regulating gene expression and enteric nervous system development but remains to be investigated in *** study aimed to identify the potential TRN implicated in the pathogenesis and diagnosis of *** Based on three microarray datasets from the Gene Expression Omnibus database,the multiMiR package was used to investigate the microRNA(miRNA)-target interactions,followed by Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment ***,we collected transcription factors(TFs)from the TransmiR database to construct the TF-miRNA-mRNA regulatory network and used cytoHubba to identify the key ***,the receiver operating characteristic(ROC)curve was determined and the integrated diagnostic models were established based on machine learning by the support vector machine *** We identified 58 hub differentially expressed microRNAs(DEMis)and 16 differentially expressed mRNAs(DEMs).The robust target genes of DEMis and DEMs mainly enriched in several GO/KEGG terms,including neurogenesis,cell-substrate adhesion,PI3K-Akt,Ras/mitogen-activated protein kinase and Rho/ROCK ***,2 TFs(TP53and TWIST1),4 miRNAs(has-miR-107,has-miR-10b-5p,has-miR-659-3p,and has-miR-371a-5p),and 4 mRNAs(PIM3,CHUK,F2RL1,and CA1)were identified to construct the TF-miRNA-mRNA regulatory *** analysis revealed a strong diagnostic value of the key TRN regulons(all area under the curve values were more than 0.8).Conclusion This study suggests a potential role of the TF-miRNA-mRNA network that can help enrich the connotation of HSCR pathogenesis and diagnosis and provide new horizons for treatment.

关键词： diagnosis microarray network

On the symplectic superposition method for free vibration of rectangular thin plates with mixed boundary constraints on an edge

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Theoretical & Applied Mechanics Letters 2021年第5期11卷 273-279页

作者： dian xu Zhuofan Ni Yihao Li Zhaoyang Hu Yu Tian Bo Wang Rui Li State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering Mechanicsand International Research Center for Computational MechanicsDalian University of TechnologyDalian 116024China University of Michigan–Shanghai Jiao Tong University Joint Institute Shanghai Jiao Tong UniversityShanghai 200240China China Aircraft Strength Research Institute Xi’an 710000China

A novel symplectic superposition method has been proposed and developed for plate and shell problems in recent *** method has yielded many new analytic solutions due to its *** this study,the first endeavor is made to further developed the symplectic superposition method for the free vibration of rectangular thin plates with mixed boundary constraints on an *** Hamiltonian system-based governing equation is first introduced such that the mathematical techniques in the symplectic space are *** solution procedure incorporates separation of variables,symplectic eigen solution and *** analytic solution of an original problem is finally obtained by a set of equations via the equivalence to the superposition of some elaborated *** natural frequency and mode shape results for representative plates with both clamped and simply supported boundary constraints imposed on the same edge are reported for benchmark *** present method can be extended to more challenging problems that cannot be solved by conventional analytic methods.

关键词： Symplectic superposition method Free vibration Plates Mixed boundary constraints

Photoactive Poly（aryl ether）s Containing Azobenzene Moieties on Pendants for Fabrication of Thermal Stable Surface Relief Gratings

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Chemical Research in Chinese Universities 2013年第2期29卷 384-388页

作者： xu Da ZHANG Yu-xuan REN dian-fu CHEN Xing-bo ZHANG Hai-bo JIANG Zhen-hua College of Chemistry Jilin University Changchun 130012 P. R. China

A series of azobenzene functionalized poly（aryl ether） copolymers（azo-PAEs） containing azo moieties on pendants was prepared by direct copolymerization. The amount of azobenzene chromophores could be controlled by the feed ratio of azo-monomer. Their chemical structures and properties were characterized by means of infrared（IR） spectrometry, UV-Vis, hydrogen nuclear magnetic resonance（Ill NMR）, difference scanning calorimetry（DSC）, and thermogravimetric analysis（TGA）. The results suggest that azo-PAEs had high glass transition temperatures（Tgs） and good thermal stability. By exposing their spin-coated films to an interference pattern laser beam, azo-PAEs could be used for the fabrication of thermal stable surface relief gratings（SRGs）.

关键词： Azo polymer Poly(aryl ether) Surface relief grating Photoactive

A modified optimal sensor placement method based on the effective independence method

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A modified optimal sensor placement method based on the effe...

Electrolyte dependence for the electrochemical decarboxylation of medium-chain fatty acids (n-octanoic acid) into fuel on Pt electrode

2012年海峡两岸破坏科学/材料试验学术会议

作者： Youfa yang dian xu Shuai Li College of Civil Engineering of Chongqing University

In this paper the effective independence method based on the Fisher information matrix is *** capacity factor into account,deformation energy of specific stiffness is introduced to modify assignment *** formula of the effective independence method、kinetic energy method and three estimating criteria were ***,with the background of a steel truss,me above optimal approaches were used for sensor placement and their effects were evaluated according to the three estimating ***,the results show that the modified effective independence method is better than the others methods above,it can reflect structural character better.

关键词： Optimal Sensor Placement The Effective Independence Method Kinetic Energy Method Modified Effective Independence Method Steel Truss Estimating Criteria

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Materials Reports(Energy) 2024年第2期4卷 64-70页

作者： Zhenmin Zhang Dezhang Ren dian Zhang Tiantian Hu Congyuan Zeng Nengneng xu Zhibao Huo Jinli Qiao College of Marine Ecology and Environment Shanghai Ocean UniversityShanghai201306PR China Department of Mechanical Engineering Southern University and A&M CollegeBaton RougeLA70807USA State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Environmental Science and EngineeringDonghua UniversityShanghai201620PR China Shanghai Institute of Pollution Control and Ecological Security Shanghai200092PR China

The deoxygenation of organic acids, important biomass feedstocks and derivatives, to synthesize hydrocarbon products under mild electrochemical conditions, holds significant importance for the production of carbon-neutral biofuels. There is still limited research on the influential factors of the electrochemical decarboxylation reaction of medium-chain fatty acids. In this study, n-octanoic acid (OA) was chosen as the research subject to investigate the electrochemical decarboxylation behavior of OA on a platinum electrode, focusing on the influence of different alkali metal cations (Li^(+), Na^(+), K^(+)), common anions (SO^(4)^(2−), Cl^(−)), and electrolyte pH. It was found that KOH as an electrolyte exhibited the best performance for OA. Possibly, the larger size of K^(+) increased the alkalinity of the electrode surface, facilitating OA deprotonation. LiOH electrolyte reduced the solubility of OA, thereby inhibiting the decarboxylation reaction. SO^(4)^(2−) exhibited a weak promoting effect on the decarboxylation reaction of OA, while Cl^(−) showed no adverse effect although Cl^(−) may adsorb on the electrode surface. Furthermore, unlike short-chain fatty acids, medium-chain OA can only achieve efficient decarboxylation under alkaline conditions due to its solubility properties. This study provides references and foundations for future efforts to enhance the efficiency of electrochemical decarboxylation synthesis of hydrocarbon biofuels from medium-chain fatty acids.

关键词： Fatty acids Kolbe reaction Decarboxylation Hydrocarbon Electrolyte

Generation of ultrafast radially polarized pulses through chirp-assisted femtosecond optical parametric amplification

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Science China(Physics,Mechanics & Astronomy) 2022年第5期65卷 51-57页

作者： SaiSai Hu JieFeng Huang XinHao Ren ChangWen xu ShiXiang xu dianYuan Fan HaiZhe Zhong International Collaborative Laboratory of 2D Materials for Optoelectronic Science&Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Micro-Nano Photonic Information Technology College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China

Radially polarized beams characterized by an axially symmetric polarization distribution can be sharply focused to produce strong longitudinal fields in the *** applications of these beams will be facilitated by the availability of higher powers and shorter ***,the ultrafast radially polarized pulse is typically generated via wavefront reconstruction from conventional linearly polarized *** pulse duration and intensity limits are strictly dependent on extra-cavity ***,a chirp-assisted near-degenerate type-II parametric process is presented as a pulse-energy-scalable method of accessing ultrafast radially polarized *** a proof-of-principle experiment,the broadband gain balance between the orthogonally polarized signal components was realized via controlling the chirp of the pump *** an analogous pulseduration transfer effect,the radially polarized signal inherited the temporal and spectral characteristics of the pump pulse and maintained the radial polarization state of each frequency component of the *** a shorter pump pulse,the generation of few-cycle radially polarized pulses should be achievable,which may facilitate a wide range of ultrafast applications such as vacuum electron acceleration and high-harmonic generation.

关键词： radially polarized beam optical parametric amplifier ultrafast lasers spectral broadening optical parametric phase

The Warming and Wetting Ecological Environment Changes over the Qinghai-Tibetan Plateau and the Driving Effect of the Asian Summer Monsoon

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Journal of Tropical Meteorology 2022年第1期28卷 95-108页

作者： SUN Chan xu Xiang-de WANG Pei-juan yang dian ZHANG Sheng-jun WANG Chun-zhu CAI Wen-yue Nanjing University of Information Science and Technology Nanjing 210044 China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081 China National Satellite Ocean Application Service Ministry of Natural ResourcesBeijing 100081 China Key Laboratory of Space Ocean Remote Sensing and Application Ministry of Natural ResourcesBeijing 100081 China Training Center China Meteorological AdministrationBeijing 100081 China National Climate Center China Meteorological AdministrationBeijing 100081 China

The impact of warming and wetting on the ecological environment of the Qinghai-Tibet Plateau(TP)under the background of climate change has been a concern of the global scientific *** this paper,the optimized interpolation variational correction approach is adopted for the analysis of monthly high-resolution satellite precipitation products and observations from meteorological stations during the past 20 *** a result,the corrected precipitation products can not only supplement the“blank area”of precipitation observation stations on the TP,but also improve the accuracy of the original satellite precipitation *** precipitation over the TP shows different spatial changes in the vegetation growing season,known as the time from May to *** precipitation in the vegetation growing season and leaf area index(LAI)in the following month show a similar change pattern,indicating a“one-month lag”response of LAI to precipitation on the *** analysis illustrates the influence of water vapor transport driven by the Asian summer *** vapor derived from trans-equatorial air flows across the Indian Ocean and Arabian Sea is strengthened,leading to the increase of precipitation in the central and northern TP,where the trend of warming and wetting and the increase of vegetation tend to be more *** contrast,as a result of the weakening trend of water vapor transport in the middle and low levels in southern TP,the precipitation decreases,and the LAI shows a downtrend,which inhibits the warming and wetting ecological environment in this area.

关键词： the Qinghai-Tibetan Plateau optimized interpolation variational precipitation warming and wetting Asian Summer Monsoon

基于扰动观测器的PMSM交流伺服系统低速控制

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中国电机工程学报 2005年第22期25卷 125-129页

作者：高扬杨明于泳徐殿国哈尔滨工业大学电气工程系黑龙江省哈尔滨市150001

针对交流伺服系统中通常采用的MT法测速在低速时存在的问题,采用了自适应扰动测器以获得低速下的连续转速,并利用波波夫超稳定性理论给出了一种简单的自适应律。该方法能实时观测负载转矩扰动和低速时的连续速度变化,计算量小。仿真和... 详细信息

针对交流伺服系统中通常采用的MT法测速在低速时存在的问题,采用了自适应扰动测器以获得低速下的连续转速,并利用波波夫超稳定性理论给出了一种简单的自适应律。该方法能实时观测负载转矩扰动和低速时的连续速度变化,计算量小。仿真和实验结果表明,应用该方法在低速情况下较之传统MT法测速具有良好的控制效果。

关键词：永磁同步电动机自适应观测器交流伺服系统低速控制连续速度

Hepatocellular Carcinoma with Hypersplenic Thrombocytopenia and Situs Inversus Totalis:A Case Report

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Chinese Medical Sciences Journal 2016年第2期31卷 134-136页

作者： Jian-bo xu Gang xu Guo-feng Chen dian-hua Gu Jian-huai Zhang Fu-zhen Qi Department of General Surgery Huai'an First People's Hospital Nanjing Medical University

SITUS inversus totalis （SIT） is a complete mirrorimage of the thoracic and abdominal viscera,occurring at an incidence of 1 in 5000-20 000live births.1, 2 It is supposed to originate from anabnormal rotation of the cardiac tube during *** SIT is a congenital anomaly, most of patients aredetected accidentally at the time of radiological *** carcinoma （HCC） is usually associated withliver cirrhosis and portal hypertension in Chinese. Presenceof hypersplenic thrombocytopenia is a common consequenceof long-term portal hypertension in cirrhoticpatients.

关键词： situs inversus totalis hepatocellular carcinoma hypersplenic thrombocytopenia