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Tumor-suppressor microRNA-139-5p restrains bladder cancer cell line ECV-304 properties via targeting Connexin 43

Chinese Medical Journal 2019年第19期132卷 2354-2361页

作者： Qiang Chi Zhi-Yong Wang Hong-Yang Li dian-bin song Hui Xu Guang Ma Ze-Min Wang Xiu-Ming Li Department of Urology Affiliated Hospital of Chengde Medical UniversityChengdeHebei 067000China

Background:In our previous paper,we demonstrated that Connexin 43(CX43)was highly expressed in bladder cancer(BC)*** the molecular mechanism about microRNAs(miRNAs)regulation upstream of CX43 in BC has not been well elucidated and remains to be further ***-139-5p(miR-139-5p)is a tumor suppressor in progression of multifarious cancers including ***,the underlying mechanisms of CX43/miR-139-5p in tumorigenesis of BC are still not well *** specific objective of our study was to inquiry the effect of CX43/miR-139-5p on BC progression and its underlying ***:The bioinformatics analysis softwares were applied to predict the miRNAs in the upstream of ***,the expression levels of miR-139-5p in BC tissues(tumor)and paracancer tissues(normal)were investigated using the data from The Cancer Genome Atlas *** reverse transcription-polymerase chain reaction(qRT-PCR)was used to detect the mRNA expression level of miR-139-5p in three human BC cell lines 5637,T24,ECV-304 and a human bladder epithelial immortalized cell line SV-HUC-1(normal control).Then si-CX43,si-control,miR-139-5p mimic,and its negative control(NC)were transfected into BC cell line *** relationship of miR-139-5p and CX43 was analyzed by dual-luciferase reporter *** qRT-PCR and Western blotting were used to test the mRNA and protein expression level of *** proliferation of ECV-304 and T24 cells were examined by cell counting *** migration and invasion of ECV-304 cells were tested by transwell *** determine whether miR-139-5p would affect cell proliferation,migration and invasion by targeting CX43,we executed the rescue *** comparison between two groups was analyzed by Student’s t test,and comparisons among multiple samples were performed by oneway analysis of variance and a Bonferroni post hoc ***:The expression of miR-139-5p was remarkably down-regulated in BC tissues(tumor ***,2.28

关键词： Bladder cancer Connexin 43 MicroRNAs

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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao bin Dai Lei Ye Tao song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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基于多分支增强和融合注意力机制的水下图像增强算法

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陕西科技大学学报 2025年第1期43卷 193-202页

作者：姚斌韩典芝徐轩李婉陕西科技大学电子信息与人工智能学院陕西西安710021

由于水对光的折射和吸收,水下图像通常会出现严重的退化,如色偏、模糊、能见度低等.为了提高水下图像的可视性,提出了一种基于多分支增强和融合注意力机制的水下图像增强网络MBFA-GAN.首先,通过分析水下图像的色彩退化和模糊因素,设计... 详细信息

由于水对光的折射和吸收,水下图像通常会出现严重的退化,如色偏、模糊、能见度低等.为了提高水下图像的可视性,提出了一种基于多分支增强和融合注意力机制的水下图像增强网络MBFA-GAN.首先,通过分析水下图像的色彩退化和模糊因素,设计了青品色温修复模块和模糊恢复模块对水下图像进行色彩矫正和模糊恢复.然后,基于对多个分支特征的互补性考虑,采用循环合并策略将多个分支增强的特征利用自适应融合模块进行融合,逐步增强图像细节.最后,设计了融合注意力模块,用于深度挖掘图像在通道维度和像素维度的相关性矩阵,以提高增强图像的真实性.实验结果表明,与现有算法相比,提出的水下图像增强算法去模糊效果较好且颜色更真实,可以有效改善水下图像色偏和模糊的问题.

关键词：水下图像增强多分支增强融合注意力生成对抗网络

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Active event-driven reliable defense control for interconnected nonlinear systems under actuator faults and denial-of-service attacks

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Science China(Information Sciences) 2022年第6期65卷 155-171页

作者： bin GUO songyi dian Tao ZHAO College of Electrical Engineering Sichuan University

This study investigates the reliable control design for a class of interconnected nonlinear systems subjected to actuator faults, disturbances, and denial-of-service(DoS) attacks. DoS attacks are carried out in both sensor and controller channels. An integrated event-observer-based security sliding mode fault-tolerant control approach is presented to defend against DoS attacks and compensate for faults and *** be more specific, the fuzzy logic system(FLS) theory is used to approximate the unknown nonlinear component first. Using the output measurement and sensor channel triggered output information, an FLS aided nonlinear estimator is put forward, in which the faults and disturbances are reconstructed. Then, to achieve the trajectory tracking purpose in the presence of DoS attacks, actuator faults, and disturbances, an adaptive sliding mode manifold is established, based on which an event-driven mechanism is established and a reliable controller is designed. In the controller scheme, the fault compensation and disturbance rejection mechanisms are also included synchronously. The tracking ability is analyzed using the Lyapunov method and the FLS theory, followed by applications to an interconnected power network system and an interconnected inverted pendulum system to demonstrate the applicability of the proposed method.

关键词： interconnected nonlinear system actuator fault DoS attack disturbance fault-tolerant control event-driven control

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Solubilization of potassium containing minerals by high temperature resistant Streptomyces *** from earthworm's gut

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Acta Geochimica 2016年第3期35卷 262-270页

作者： dian Feng Liu bin Lian bin Wang Jiangsu Key Laboratory for Microbes and Functional Genomics Jiangsu Engineering and Technology Research Center for Microbiology College of Life Sciences Nanjing Normal University No. 1 Wenyuan Road Department of Bioengineering Puyang Vocational & Technical Institute State Key Laboratory of Environmental Geochemistry Institute of Geochemistry Chinese Academy of Sciences Department of Bio-Engineering Henan Institute of Science and Technology

A potassium solubilizing bacterial strain des- ignated EGT, which is tolerant of high temperature, was isolated from an earthworm＇s gut to obtain a bacterium that can weather potassium-bearing rock effectively through solid-state fermentation. Molecular phylogeny and 16S rRNA gene sequence analysis demonstrated the bacterial strain was a member of the Streptomyces genus. To assess its potential to release potassium from silicate minerals, this strain was used to degrade potassium-bearing rock powder by solid-state fermentation. After fermentation, the amount of water-soluble A1, Fe and K of the substrate with active inoculum was higher than those of the control, which had autoclaved inoculum, and those of the fresh substrate. The result indicated that the strain had the ability to weather potassium-bearing rock and could be used as an inoculum in the production of potassium bio-fertilizer, due to its potassium release activity from rock and tolerance to high temperature.

关键词： Weathering Potassium solubilizing bacteria Streptomyces

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MSCTA联合术中超声在小肾癌后腹腔镜肾部分切除手术中的应用价值

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中国现代医学杂志 2019年第3期29卷 118-121页

作者：宋殿宾王志勇张晶晶李红阳马光刘英承德医学院附属医院河北承德067000

目的探讨多层螺旋CT血管成像(MSCTA)联合术中超声在小肾癌后腹腔镜肾部分切除术(LPN)中的应用价值。方法选择影像学显示肿瘤直径≤4.0 cm的小肾癌患者55例,其均采用后腹腔镜肾部分切除术。根据术中是否行超声,将其分为超声组(28例)和非... 详细信息

目的探讨多层螺旋CT血管成像(MSCTA)联合术中超声在小肾癌后腹腔镜肾部分切除术(LPN)中的应用价值。方法选择影像学显示肿瘤直径≤4.0 cm的小肾癌患者55例,其均采用后腹腔镜肾部分切除术。根据术中是否行超声,将其分为超声组(28例)和非超声组(27例)。左肾肿瘤33例,右肾肿瘤22例;肿瘤直径为1.5～5.0 cm,平均3.0 cm。比较两组手术时间、出血量、术中热缺血时间、微小癌灶发现率、术后漏尿、切缘阳性率及肾小球滤过率(GFR)功能。结果超声组手术时间少于非超声组(P 0.05),非超声组术前、术后患肾GFR分别为(55.8±7.0)和(50.4±6.5)ml/min(P>0.05)。结论术中超声可快速准确的定位肿瘤组织,尽可能的保留肾单位、减少切缘阳性率,有利于术后患肾功能的恢复。

关键词：小肾癌腹腔镜肾部分切除术多层螺旋CT血管成像术中超声

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An Adaptive Design to Assess the Reliability of the Pyrotechnic Control Subsystem in Opening the Solar Array

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Acta Mathematicae Applicatae Sinica 2014年第4期30卷 1037-1048页

作者： dian-peng WANG Yu-bin TIAN School of Mathematics Beijing Institute of Technology

The pyrotechnic control subsystem plays an important role in opening the solar array of a satellite. Assessing the reliability of the subsystem requires determining the level of a control factor that is needed to cause the desired response and energy output with high probability. A two-phase adaptive design to estimate the level of interest is proposed and studied. The convergence of the design is obtained. A simulation study shows that the estimate is very close to its population value and is robust to the initial guess of the design. As an application, the design is used to assess the reliability of a real pyrotechnic control subsystem.

关键词： reliability binary response adaptive design D-optimal criterion stochastic approximation

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Fabrication of a three-dimensional micro/nanocarbon structure with sub-10 nm carbon fiber arrays based on the nanoforming and pyrolysis of polyacrylonitrile-based jet fibers

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Microsystems & Nanoengineering 2023年第5期9卷 333-343页

作者： Jufeng Deng Chong Liu dian song Marc Madou Key Laboratory of Advanced Manufacturing Technology of the Ministry of Education Guizhou UniversityGuiyangChina School of Mechanical Engineering Dalian University of TechnologyDalianChina Chemical and Biomolecular Engineering University of CaliforniaIrvineUSA Mechanical and Aerospace Engineering University of CaliforniaIrvineUSA School of Engineering and Science Tecnologico de MonterreyMonterreyMexico

To produce a three-dimensional micro/nanocarbon structure,a manufacturing design technique for sub-10 nm carbon fiber arrays on three-dimensional carbon micropillars has been developed;the method involves initiating electrostatic jetting,forming submicron-to-nanoscale PAN-based fibers,and maximizing the shrinkage from polyacrylonitrile(PAN)-based fibers to carbon *** and nanodepositing methods for polyacrylonitrilebased jet fibers as precursors of carbon fibers are proposed for the processing design of electrostatic jet initiation and for the forming design of submicron-to-nanoscale PAN-based fibers by establishing and analyzing mathematical models that include the diameter and tensile stress values of jet fibers and the electric field intensity values on the surfaces of carbon *** accordance with these methods,an array of jet fibers with diameters of~80 nm is experimentally formed based on the thinning of the electrospinning fluid on top of a dispensing needle,the poking of drum into an electrospinning droplet,and the controlling of the needle–drum *** converting thin PANbased jet fibers to carbon fibers,a pyrolysis method consisting of the suspension of jet nanofibers between carbon micropillars,the bond between the fibers and the surface of the carbon micropillar,and the control of micropillar spacing,stabilization temperature,and carbonation rate is presented to maximize the shrinkage from PAN-based fibers to carbon fibers and to form sub-10 nm carbon fiber arrays between three-dimensional carbon *** manufacturing design of a three-dimensional micro/nanocarbon structure can produce thin PAN-based jet nanofibers and nanofiber arrays aligned on micropillar surfaces,obtain shrinkage levels reaching 96%and incorporate sub-10 nm carbon fibers into three-dimensional carbon micropillars;these actions provide new research opportunities for correlated three-dimensional micro/nanocarbon structures that have not previousl

关键词： fibers fiber carbon

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Fabrication of crystalline submicro-to-nano carbon wire for achieving high current density and ultrastable current

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Microsystems & Nanoengineering 2022年第1期8卷 223-235页

作者： Jufeng Deng Chong Liu dian song Marc Madou School of Mechanical Engineering Dalian University of TechnologyDalian 116023China Mechanical and Aerospace Engineering University of CaliforniaIrvineCA 92617USA Chemical and Biomolecular Engineering University of CaliforniaIrvineCA 92517USA School of Engineering and Science Tecnologico de MonterreyMonterreyNM 64849Mexico

Crystalline carbon nanowire arrays were fabricated taking advantage of near-field electrospinning and stress decyanation.A novel fabrication method for carbon nanowires with radii ranging from~2.15μm down to~25 nm was developed based on implementing nitrogen pretreatment on the silica surface and then aligning polymer nanofibers during near-field electrospinning at an ultralow *** decyanation was implemented by subsequently pyrolyzing a polymer nanofiber array on the silica surface at 1000°C for 1 h in an N_(2)atmosphere,thus obtaining a crystalline carbon nanowire array with a nanostructured *** crystalline nanostructures were fabricated on the nanowire surface,and their electrochemical performance was evaluated by cyclic voltammetry(CV)and electrochemical impedance spectroscopy(EIS).Crystalline carbon wires with diameters ranging from micrometers to submicrometers displayed carbon nanoelectrode-like behavior with their CV curve having a sigmoidal shape.A highly crystalline carbon nanowire array showed distinct behavior,having a monotonically increasing straight line as its CV curve and a semicircular EIS spectrum;these results demonstrated its ultrastable current,as determined by electron ***,nanocrystalline-structured carbon wires with diameters of~305 nm displayed at least a fourfold higher peak current density during CV(4000 mA/m2)than highly crystalline carbon nanowires with diameters of~100 nm and porous microwires with diameters of~4.3μm.

关键词： nanowires crystalline carbon

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Maximally Generalized Yang-Mills Model and Dynamical Breaking of Gauge Symmetry

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Communications in Theoretical Physics 2006年第2期45卷 297-300页

作者： WANG dian-Fu song He-Shan Department of Physics Dalian Maritime University Dalian 116024 China Department of Physics Dalian University of Technology Dalian 116024 China

A maximally generalized Yang-Mills model, which contains, besides the vector part Vμ, also an axial-vector part Aμ, a scalar part S, a pseudoscalar part P, and a tensor part Tμv, is constructed and the dynamical breaking of gauge symmetry in the model is also discussed. It is shown, in terms of the Nambu Jona-Lasinio mechanism, that the gauge symmetry breaking can be realized dynamically in the maximally generalized Yang-Mills model. The combination of the maximally generalized Yang-Mills model and the NJL mechanism provides a way to overcome the difficulties related to the Higgs field and the Higgs mechanism in the usual spontaneous symmetry breaking theory.

关键词： Yang-Millstheory dynamical-symmetry breaking

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