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Evolutionary Optimization Methods for High-Dimensional Expensive Problems:A Survey

IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1092-1105页

作者： MengChu Zhou Meiji Cui dian xu Shuwei Zhu Ziyan Zhao Abdullah Abusorrah Department of Electrical and Computer Engineering New Jersey Institute of TechnologyNewarkNJ 07102 USA School of Information and Electronic Engineering Zhejiang Gongshang UniversityHangzhou 310018China School of Intelligent Manufacturing Nanjing University of Science and TechnologyNanjing 210094China Institute of Systems Engineering Macao University of Science and TechnologyMacao 999078China School of Artificial Intelligence and Computer Jiangnan UniversityWuxi 214122China School of Information Science and Engineering Northeastern UniversityShenyang 110819China Center of Research Excellence in Renewable Energy and Power Systems Department of Electrical and Computer EngineeringFaculty of EngineeringKing Abdulaziz UniversityJeddah 21589Saudi Arabia K.A.CARE Energy Research and Innovation Center King Abdulaziz UniversityJeddah 21589Saudi Arabia

Evolutionary computation is a rapidly evolving field and the related algorithms have been successfully used to solve various real-world optimization problems.The past decade has also witnessed their fast progress to solve a class of challenging optimization problems called high-dimensional expensive problems(HEPs).The evaluation of their objective fitness requires expensive resource due to their use of time-consuming physical experiments or computer simulations.Moreover,it is hard to traverse the huge search space within reasonable resource as problem dimension increases.Traditional evolutionary algorithms(EAs)tend to fail to solve HEPs competently because they need to conduct many such expensive evaluations before achieving satisfactory results.To reduce such evaluations,many novel surrogate-assisted algorithms emerge to cope with HEPs in recent years.Yet there lacks a thorough review of the state of the art in this specific and important area.This paper provides a comprehensive survey of these evolutionary algorithms for HEPs.We start with a brief introduction to the research status and the basic concepts of HEPs.Then,we present surrogate-assisted evolutionary algorithms for HEPs from four main aspects.We also give comparative results of some representative algorithms and application examples.Finally,we indicate open challenges and several promising directions to advance the progress in evolutionary optimization algorithms for HEPs.

关键词： computer optimization evolutionary

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Deleterious variants in RNF111 impair female fertility and induce premature ovarian insufficiency in humans and mice

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Science China(Life Sciences) 2024年第7期67卷 1325-1337页

作者： Chengcheng Song Yingying Qin Yan Li Bingyi Yang Ting Guo Wenqing Ma dian xu Keyan xu Fangfang Fu Li Jin Yanhua Wu Shuyan Tang Xiaojun Chen Feng Zhang Obstetrics and Gynecology Hospital State Key Laboratory of Genetic EngineeringInstitute of Medical Genetics and GenomicsFudan UniversityShanghai 200011China Human Phenome Institute Zhangjiang Fudan International Innovation CenterFudan UniversityShanghai 201203China Center for Reproductive Medicine Cheeloo College of MedicineShandong UniversityJinan 250021China State Key Laboratory of Reproductive Medicine and Offspring Health Key Laboratory of Reproductive Endocrinology of Ministry of EducationNational Research Center for Assisted Reproductive Technology and Reproductive GeneticsShandong Key Laboratory of Reproductive MedicineShandong Provincial Clinical Research Center for Reproductive HealthShandong UniversityJinan 250021China Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China National Demonstration Center for Experimental Biology Education School of Life SciencesFudan UniversityShanghai 200433China Department of Gynecology the Tenth People’s Hospital of Tongji UniversityShanghai 200072China Soong Ching Ling Institute of Maternity and Child Health International Peace Maternity and Child Health Hospital of China Welfare InstituteShanghai 200030China

Premature ovarian insufficiency(POI)is a heterogeneous female disorder characterized by the loss of ovarian function before the age of 40.It represents a significant detriment to female fertility.However,the known POI-causative genes currently account for only a fraction of cases.To elucidate the genetic factors underlying POI,we conducted whole-exome sequencing on a family with three fertile POI patients and identified a deleterious missense variant in RNF111.In a subsequent replication study involving 1,030 POI patients,this variant was not only confirmed but also accompanied by the discovery of three additional predicted deleterious RNF111 variants.These variants collectively account for eight cases,representing 0.78%of the study cohort.A further study involving 500 patients with diminished ovarian reserve also identified two additional RNF111 variants.Notably,RNF111 encodes an E3 ubiquitin ligase with a regulatory role in the TGF-β/BMP signaling pathway.Our analysis revealed that RNF111/RNF111 is predominantly expressed in the oocytes of mice,monkeys,and humans.To further investigate the functional implications of RNF111 variants,we generated two mouse models:one with a heterozygous missense mutation(Rnf111+/M)and another with a heterozygous null mutation(Rnf111^(+/-)).Both mouse models exhibited impaired female fertility,characterized by reduced litter sizes and small ovarian reserve.Additionally,RNA-seq and quantitative proteomics analysis unveiled that Rnf111 haploinsufficiency led to dysregulation in female gonad development and negative regulation of the BMP signaling pathway within mouse ovaries.In conclusion,our findings strongly suggest that monoallelic deleterious variants in RNF111 can impair female fertility and induce POI in both humans and mice.

关键词： POI RNF111 female fertility ovarian reserve

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Honokiol Prevents Intestinal Barrier Dysfunction in Mice with Severe Acute Pancreatitis and Inhibits JAK/STAT1 Pathway and Acetylation of HMGB1

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Chinese Journal of Integrative Medicine 2024年第6期30卷 534-542页

作者： LI Jie CHEN Ya-feng GAO Lei LI Yi-jie FENG dian-xu Department of General Surgery Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai200062China

Objective To investigate the effect of honokiol(HON)and the role of high-mobility group protein B1(HMGB1)on the pathogenesis of severe acute pancreatitis(SAP).Methods Thirty mice were numbered according to weight,and randomly divided into 5 groups using a random number table,including control,SAP,SAP and normal saline(SAP+NS),SAP and ethyl pyruvate(SAP+EP),or SAP+HON groups,6 mice in each group.Samples of pancreas,intestine,and blood were collected 12 h after SAP model induction for examination of pathologic changes,immune function alterations by enzyme linked immunosorbent assay(ELISA),and Western blot.In vitro experiments,macrophages were divided into 5 groups,the control,lipopolysaccharide(LPS),LPS+DMSO(DMSO),LPS+anti-HMGB1 monoclonal antibody(mAb),and LPS+HON groups.The tight connection level was determined by transmission electron microscopy and fluorescein isothiocyanate-labeled.The location and acetylation of HMGB1 were measured by Western blot.Finally,pyridone 6 and silencing signal transducer and activator of the transcription 1(siSTAT1)combined with honokiol were added to determine whether the Janus kinase(JAK)/STAT1 participated in the regulation of honokiol on HMGB1.The protein expression levels of HMGB1,JAK,and STAT1 were detected using Western blot.Results Mice with SAP had inflammatory injury in the pancreas,bleeding of intestinal tissues,and cells with disrupted histology.Mice in the SAP+HON group had significantly fewer pathological changes.Mice with SAP also had significant increases in the serum levels of amylase,lipase,HMGB1,tumor necrosis factor-α,interleukin-6,diamine oxidase,endotoxin-1,and procalcitonin.Mice in the SAP+HON group did not show these abnormalities(P<0.01).Studies of Caco-2 cells indicated that LPS increased the levels of occludin and claudin-1 as well as tight junction permeability,decreased the levels of junctional adhesion molecule C,and elevated intercellular permeability(P<0.01).HON treatment blocked these effects.Studies of macrophages indicated that LPS led to low nucle

关键词： severe acute pancreatitis intestinal barrier dysfunction honokiol high-mobility group protein B1 Januskinase signal transducerand activatorof transcription1

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New analytic solutions to 2D transient heat conduction problems with/without heat sources in the symplectic space

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Applied Mathematics and Mechanics(English Edition) 2022年第8期43卷 1233-1248页

作者： dian xu Xinran ZHENG Dongqi AN Chao ZHOU Xiuwen HUANG Rui LI State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering Mechanicsand International Research Center for Computational MechanicsDalian University of TechnologyDalianLiaoning Province116024China

The two-dimensional(2D)transient heat conduction problems with/without heat sources in a rectangular domain under different combinations of temperature and heat flux boundary conditions are studied by a novel symplectic superposition method(SSM).The solution process is within the Hamiltonian system framework such that the mathematical procedures in the symplectic space can be implemented,which provides an exceptional direct rigorous derivation without any assumptions or predetermination of the solution forms compared with the conventional inverse/semi-inverse methods.The distinctive advantage of the SSM offers an access to new analytic heat conduction solutions.The results obtained by the SSM agree well with those obtained from the finite element method(FEM),which confirms the accuracy of the SSM.

关键词： heat conduction heat source symplectic superposition method(SSM)

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公共健康权益可及性对少数民族流动人口定居意愿的影响

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西北人口 2024年第1期45卷 35-47页

作者：刘金华王棫冰徐典四川省社会科学院社会学研究所成都610071 英国伦敦大学伯贝克学院

以人口高质量发展支撑中国式现代化,提高人口整体素质是关键。而流动人口公共健康权益的可获得性和可及性程度又是增强流动人口身体素质、定居意愿、城市融入的关键因素。通过分析2018年全国流动人口动态监测数据(China Migrants Dynami... 详细信息

以人口高质量发展支撑中国式现代化,提高人口整体素质是关键。而流动人口公共健康权益的可获得性和可及性程度又是增强流动人口身体素质、定居意愿、城市融入的关键因素。通过分析2018年全国流动人口动态监测数据(China Migrants Dynamic Survey,简称CMDS),聚焦少数民族流动人口在流入地公共健康权益的现状,进一步使用二分变量对数比回归模型实证分析少数民族流动家庭公共健康权益可及性对定居意愿发生比的影响,关注家庭主要劳动力(个体)和家庭其他成员(幼童、孕产妇)公共健康权益可及性对少数民族流动人口定居意愿的影响,并探讨不同特征的少数民族流动人口健康权益可及性对家庭定居意愿的异质性影响。研究发现:一是公共健康权益可获得性、可及性程度对少数民族流动人口定居意愿存在显著正向影响,且影响效应存在差异。家庭成员公共健康权益的影响效应大于个体影响效应,但孕产妇公共健康权益可获得性与家庭定居意愿没有显著相关关系。二是不同健康权益项目对单个个体健康权益可及性的影响权重不同。健康档案项目对个体公共健康权益的影响效应最大,疫苗接种项目对幼童公共健康权益的影响效应最大,孕产妇四项公共健康权益项目的作用相差不大。三是不同个体获得公共健康权益数量越多,其定居意愿发生比越高,但影响效应不同。公共健康权益可及性程度对于受教育程度低、夫妻两地分居、省内跨市流动的少数民族流动人口定居意愿的影响更大。

关键词：公共健康权益可及性定居意愿发生比少数民族流动人口

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On the symplectic superposition method for free vibration of rectangular thin plates with mixed boundary constraints on an edge

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Theoretical & Applied Mechanics Letters 2021年第5期11卷 273-279页

作者： dian xu Zhuofan Ni Yihao Li Zhaoyang Hu Yu Tian Bo Wang Rui Li State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering Mechanicsand International Research Center for Computational MechanicsDalian University of TechnologyDalian 116024China University of Michigan–Shanghai Jiao Tong University Joint Institute Shanghai Jiao Tong UniversityShanghai 200240China China Aircraft Strength Research Institute Xi’an 710000China

A novel symplectic superposition method has been proposed and developed for plate and shell problems in recent years.The method has yielded many new analytic solutions due to its rigorousness.In this study,the first endeavor is made to further developed the symplectic superposition method for the free vibration of rectangular thin plates with mixed boundary constraints on an edge.The Hamiltonian system-based governing equation is first introduced such that the mathematical techniques in the symplectic space are applied.The solution procedure incorporates separation of variables,symplectic eigen solution and superposition.The analytic solution of an original problem is finally obtained by a set of equations via the equivalence to the superposition of some elaborated subproblems.The natural frequency and mode shape results for representative plates with both clamped and simply supported boundary constraints imposed on the same edge are reported for benchmark use.The present method can be extended to more challenging problems that cannot be solved by conventional analytic methods.

关键词： Symplectic superposition method Free vibration Plates Mixed boundary constraints

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基于有法必依理念的深圳市地下管线管理顶层设计

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中国给水排水 2024年第10期40卷 45-51页

作者：徐延春刘江涛徐电葛德胜任翔宇深圳市规划国土发展研究中心广东深圳518034 深圳市规划和自然资源局广东深圳518034

地下管线管理是城市发展的一个难题,多年来,上到国家部委,下到各个城市管理部门对此进行了艰辛的探索,各地频频出台各类法规,希望实现地下管线的法制化管理。然而,多年过去地下管线管理难的情况却未见明显好转,出台的法规效力较低,缺乏... 详细信息

地下管线管理是城市发展的一个难题,多年来,上到国家部委,下到各个城市管理部门对此进行了艰辛的探索,各地频频出台各类法规,希望实现地下管线的法制化管理。然而,多年过去地下管线管理难的情况却未见明显好转,出台的法规效力较低,缺乏管控抓手,要么形同虚设,要么有法不依、有法难依。基于此,在深圳地下管线管理体制机制的顶层设计上进行了深入研究,对《深圳市地下管线管理暂行办法》的实施效果进行系统评估,紧抓核心症结,结合趋势需求,借鉴先进经验,优化完善关键机制,构建了深圳市地下管线管理体制机制顶层框架,并对《深圳市地下管线管理办法》的制定提出建议,力图实现地下管线管理由有法可依向有法必依的转变。

关键词：地下管线管理体制机制顶层设计管控抓手

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10MW三次再热空气透平技术特点

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汽轮机技术 2024年第2期66卷 95-96,124页

作者：邢冠一徐鹏余海鹏徐殿吉魏红阳哈尔滨汽轮机厂有限责任公司哈尔滨150046 哈电发电设备国家工程研究中心有限公司哈尔滨150046

综述了10MW三次再热空气透平开发、研制的技术路线及其独特性、先进性。阐述了全滑压范围内满负荷运行的研究方法,描述了双缸双转速的结构布局。该空气透平的开发对大容量机组的发展具有重要意义。

关键词：空气透平双缸双转速全滑压满负荷

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血府逐瘀汤缓解肋骨骨折疼痛临床观察

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中国中西医结合杂志 2024年第1期44卷 107-110页

作者：吴伟鹏许钿蔡锐涛吴晓鹏陈权韩陈臻洪伟武广东省汕头市中心医院中医骨伤科广东515000 广东省汕头市中心医院中药房广东515000 广东省汕头市中心医院中医科广东515000

肋骨骨折是常见的骨折类型之一。中医学认为,肋骨骨折时胸壁皮肉筋骨损伤、脏腑经络受损、气血运行紊乱、气滞血瘀、筋络阻塞等,不通则痛,治疗的关键在于活血化瘀、理气止痛[1]。血府逐瘀汤是临床非常常用的活血化瘀方剂之一,具有很好... 详细信息

肋骨骨折是常见的骨折类型之一。中医学认为,肋骨骨折时胸壁皮肉筋骨损伤、脏腑经络受损、气血运行紊乱、气滞血瘀、筋络阻塞等,不通则痛,治疗的关键在于活血化瘀、理气止痛[1]。血府逐瘀汤是临床非常常用的活血化瘀方剂之一,具有很好的活血化瘀、行气止痛作用,能显著减低血浆D-二聚体、纤维蛋白原(fibrinogen,FIB)水平,调节患者凝血功能,改善微循环血液流变性[2]。

关键词：肋骨骨折理气止痛气滞血瘀脏腑经络活血化瘀方剂血府逐瘀汤行气止痛血液流变性

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Urolithin A alleviates blood-brain barrier disruption and attenuates neuronal apoptosis following traumatic brain injury in mice

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Neural Regeneration Research 2022年第9期17卷 2007-2013页

作者： Qiu-Yuan Gong Lin Cai Yao Jing Wei Wang dian-xu Yang Shi-Wen Chen Heng-Li Tian Department of Neurosurgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghaiChina

Urolithin A(UA)is a natural metabolite produced from polyphenolics in foods such as pomegranates,berries,and nuts.UA is neuroprotective against Parkinson’s disease,Alzheimer’s disease,and cerebral hemorrhage.However,its effect against traumatic brain injury remains unknown.In this study,we established adult C57BL/6J mouse models of traumatic brain injury by controlled cortical impact and then intraperitoneally administered UA.We found that UA greatly reduced brain edema;increased the expression of tight junction proteins in injured cortex;increased the immunopositivity of two neuronal autophagy markers,microtubule-associated protein 1A/B light chain 3A/B(LC3)and p62;downregulated protein kinase B(Akt)and mammalian target of rapamycin(mTOR),two regulators of the phosphatidylinositol 3-kinase(PI3K)/Akt/mTOR signaling pathway;decreased the phosphorylation levels of inhibitor of NFκB(IκB)kinase alpha(IKKα)and nuclear factor kappa B(NFκB),two regulators of the neuroinflammation-related Akt/IKK/NFκB signaling pathway;reduced blood-brain barrier permeability and neuronal apoptosis in injured cortex;and improved mouse neurological function.These findings suggest that UA may be a candidate drug for the treatment of traumatic brain injury,and its neuroprotective effects may be mediated by inhibition of the PI3K/Akt/mTOR and Akt/IKK/NFκB signaling pathways,thus reducing neuroinflammation and enhancing autophagy.

关键词： autophagy blood-brain barrier cerebral edema controlled cortical impact model neuronal apoptosis neuropharmacology neuroprotection tight junction protein traumatic brain injury urolithin A

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