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宫颈高危型人乳头瘤病毒感染的中医证候特征研究

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广州中医药大学学报 2024年第7期41卷 1669-1675页

作者：王嫱郭洁宋殿荣鲁娣天津中医药大学天津301617 天津中医药大学第二附属医院天津300250

【目的】探究宫颈高危型人乳头瘤病毒(HR-HPV)感染者中医证候特征,为临床辨证论治提供参考。【方法】收集2020年9月至2022年10月于天津中医药大学第二附属医院妇科就诊行HPV检测确诊为宫颈HR-HPV感染者进行中医证候调查,总结其病位、病... 详细信息

【目的】探究宫颈高危型人乳头瘤病毒(HR-HPV)感染者中医证候特征,为临床辨证论治提供参考。【方法】收集2020年9月至2022年10月于天津中医药大学第二附属医院妇科就诊行HPV检测确诊为宫颈HR-HPV感染者进行中医证候调查,总结其病位、病性特点及证型分布。【结果】宫颈HR-HPV感染者的临床特征主要以阴道分泌物异常为主,占63.40%。病位证素为胞宫、脾、肝、肾、经络、胃、心神、心,其中以胞宫、脾、肝最多见,分别占67.00%、58.80%和55.80%。病性证素为湿、热、气滞、血瘀、气虚、阳虚、阴虚、痰、寒,其中以湿、热、气滞、血瘀最多见,分别占66.40%、56.60%、36.00%和31.80%。各年龄段病位证素均以胞宫为主,病性证素均以湿、热为主。双病位证素以胞宫-脾最常见,三病位证素以胞宫-脾-肝最常见。双病性证素以湿-热最常见,三病性证素以湿-热-血瘀最常见。根据聚类分析结果,结合临床实际,发现宫颈HR-HPV感染者的主要证型分布为湿热瘀阻、肝郁气滞、心肾不交、脾胃阳虚。【结论】宫颈HR-HPV感染者的中医病位证素主要在胞宫,兼脾、肝、肾多脏腑合病;病性证素以湿、热为主,呈现虚实错杂的特点;中医证型主要是湿热瘀阻、肝郁气滞、心肾不交、脾胃阳虚。

关键词：人乳头瘤病毒(HPV)感染高危型人乳头瘤病毒(HR-HPV) 中医证候特征证素胞宫湿热瘀阻肝郁气滞心肾不交脾胃阳虚

多倍体肿瘤巨细胞对肿瘤耐药作用机制的研究进展

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国际妇产科学杂志 2024年第4期51卷 361-365页

作者：丁义玲鲁娣宋殿荣天津中医药大学 300250 天津中医药大学第二附属医院

化疗是肿瘤治疗的常用手段,在肿瘤治疗前期具有积极作用,但随着化疗疗程的增加,肿瘤细胞对化疗药物的敏感性逐步减弱,从而产生化疗耐药性。肿瘤耐药是多因素介导的复杂过程,目前认为其与肿瘤细胞干性、异质性、肿瘤免疫微环境和化疗药... 详细信息

化疗是肿瘤治疗的常用手段,在肿瘤治疗前期具有积极作用,但随着化疗疗程的增加,肿瘤细胞对化疗药物的敏感性逐步减弱,从而产生化疗耐药性。肿瘤耐药是多因素介导的复杂过程,目前认为其与肿瘤细胞干性、异质性、肿瘤免疫微环境和化疗药物转运与外排增加等有关,但具体的机制尚不清楚。多倍体肿瘤巨细胞(polyploid giant cancer cell,PGCC)是一类体积增大、胞核丰富的特殊肿瘤细胞亚群。研究发现PGCC普遍存在于结直肠癌、乳腺癌、卵巢癌等多种肿瘤中,与肿瘤的发生、转移、耐药和复发有着密切联系。阐述PGCC在肿瘤中的形成及意义,并从PGCC所具有的特殊机制、自噬、衰老和DNA修复等角度阐述PGCC引起耐药发生的可能机制,从而为改善肿瘤耐药提供可能策略。

关键词：肿瘤多倍体肿瘤巨细胞抗药性,肿瘤自噬 DNA修复

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滨江道路软基处理设计及现场监测分析

低温建筑技术 2024年第5期46卷 116-119页

作者：贾瑞雨王聪宋典尹祖超长江勘测规划设计研究有限责任公司武汉430010 武汉城建集团建设管理有限公司武汉430022

滨江道路一般地基软土层分布深厚,在填土荷载和交通荷载作用下,易产生较大的沉降或不均匀沉降。为研究滨江道路的软基处理方法和处理效果,文中以某滨江道路工程为背景,从技术和经济角度比选了预应力混凝土管桩和水泥土搅拌桩方案,采用... 详细信息

滨江道路一般地基软土层分布深厚,在填土荷载和交通荷载作用下,易产生较大的沉降或不均匀沉降。为研究滨江道路的软基处理方法和处理效果,文中以某滨江道路工程为背景,从技术和经济角度比选了预应力混凝土管桩和水泥土搅拌桩方案,采用水泥土搅拌桩方案,并对水泥土搅拌桩复合地基进行了稳定性分析、沉降计算和现场监测。根据现场静载试验及沉降监测结果,水泥土搅拌桩复合地基承载力高,工后沉降小,满足工程要求,且建设工期短,工程造价合理,具有良好的工程效果和社会效益,可为类似滨江道路软基处理提供参考。

关键词：地基软土层水泥土搅拌桩预应力混凝土管桩

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RANKL诱导内皮间质化促进乳腺癌骨转移

中国矫形外科杂志 2024年第13期32卷 1215-1221页

作者：李勇爱孟通宋滇文杨正峰岳智颖尹华斌上海交通大学医学院附属第一人民医院脊柱外科上海201620 上海交通大学医学院附属第一人民医院临床转化研究院上海201620

[目的]探讨核因子κB受体活化因子配体(receptor activator of nuclear factor-κB ligand,RANKL)在乳腺癌骨转移中的作用及其机制。[方法]MDA-MB-231,BT549和MCF-7乳腺癌细胞体外培养,加入终浓度为200 ng/ml RANKL(RANKL组),或同体积双蒸水(Ctrl组),行transwell、单细胞钙成像、PCR和western blot检测。分离小鼠骨髓细胞(bone marrow stromal cells,BMSCs),在培养其中加入乳腺癌细胞上清,行TRAP、ALP和von Kossa染色。[结果]RANKL在MDA-MB-231细胞[(1.7±0.1)个vs(1.0±0.1)个,P=0.002]、BT549细胞[(1.6±0.1)个vs(1.0±0.1)个,P=0.027]的相对迁移数显著高于Ctrl组。RANKL-200组MCF7[阳性数/总数(%),58/127(45.7)vs 3/118(2.5),PRANKL-200组>Ctrl组(P0.05)。[结论]RANKL诱导的钙信号经NF-κB通路增强乳腺癌细胞EMT过程进而促进乳腺癌的骨转移。

关键词： RANKL 乳腺癌骨转移钙振荡 EMT NF-κB信号通路

领导底线心智对员工环保行为的影响:目标掩蔽的视角

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珞珈管理评论 2024年第3期54卷 38-53页

作者：李思贤王廷喜宋典段锦云华东师范大学心理与认知科学学院上海200062 西交利物浦大学西浦国际商学院苏州215123 苏州大学政治与公共管理学院苏州215031

基于目标掩蔽理论,本研究旨在探究领导底线心智对员工环保目标的掩蔽作用,并提出员工长期导向对该掩蔽效果的缓解作用。通过分析296份“领导—员工”多时段配对样本,本研究发现:领导者追求经济效益的底线心智通过负向预测员工环保要求感... 详细信息

基于目标掩蔽理论,本研究旨在探究领导底线心智对员工环保目标的掩蔽作用,并提出员工长期导向对该掩蔽效果的缓解作用。通过分析296份“领导—员工”多时段配对样本,本研究发现:领导者追求经济效益的底线心智通过负向预测员工环保要求感知,进而对员工环保行为起到消极作用;此外,员工的高长期导向可缓解该负向作用。研究结果启示,企业应关注领导者底线心智带来的负面效应,培养领导和员工对经济绩效和环保行为的辩证观及长期导向意识,重视企业的长期发展并践行领导者、员工和企业在“双碳”背景下的社会责任。

关键词：底线心智目标掩蔽理论环保要求感知环保行为长期导向

Resistance of grid steel-tube-confined concrete targets against projectile impact: Experimental investigation and analytical engineering model

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Defence Technology（防务技术） 2022年第9期18卷 1622-1642页

作者： dian-yi song Qing-hua Tan Chao-mei Meng Yi-min Huang Yang-yueye Cao Zhi-gang Jiang Undergraduate School National University of Defense TechnologyChangsha410072PR China College of Aerospace Science and Engineering National University of Defense TechnologyChangsha410073PR China College of Aerospace Engineering Air Force Engineering UniversityXi'an710038PR China

Steel-tube-confined concrete(STCC) targets are provided with excellent anti-penetration performance over semi-infinite concrete(SIC) targets since the steel tube imposes passive restraint on the in-filled concrete during the penetration process. Grid STCC system with square steel tubes is a potential solution to protective structures. In this paper, experiments of 9-cell grid STCC targets penetrated by 12.7 mm Armor Piercing Projectile(APP) were performed. The influence of side length and thickness of steel tube,steel ratio and impact velocity on anti-penetration performance were taken into account. Additionally,single-cell square STCC targets were also designed and tested for comparison with the 9-cell grid STCC targets. Damage modes and parameters of the tested targets were measured and discussed. Moreover,the stiffness of radial confinement of grid STCC targets is achieved according to the elastic solution of infinite cylindrical shell in Winkler medium. Furthermore, the penetration resistance and depth of penetration(DOP) for grid STCC targets are obtained on the basis of the dynamic finite spherical cavityexpansion(FSCE) models including radial confinement effect. It is shown that the 9-cell grid STCC targets with optimal dimension match of thickness and side length of steel tube can reduce the DOP by about17 % and 23 % in comparison with the SIC targets and single-cell square STCC targets, respectively, due to both the confinement of square steel tube to concrete in the impacted cell and the additional confinement of the surrounding cells to the impacted cell;the penetration resistance and DOP of the grid and cellular STCC targets with similar steel ratio is close, and thus the grid STCC targets with simpler manufacturing process and excellent in-plane expandability are preferred in engineering practice;moreover, the predicted results of DOP model based on the FSCE models agree well with the tested results with the maximum disparity less than 12 % and the prop

关键词： Penetration mechanics Grid structural system Steel-tube-confined concrete(STCC)targets Armor piercing projectile(APP) Depth of penetration(DOP) Finite spherical cavity expansion(FSCE)

Fabrication of a three-dimensional micro/nanocarbon structure with sub-10 nm carbon fiber arrays based on the nanoforming and pyrolysis of polyacrylonitrile-based jet fibers

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Microsystems & Nanoengineering 2023年第5期9卷 333-343页

作者： Jufeng Deng Chong Liu dian song Marc Madou Key Laboratory of Advanced Manufacturing Technology of the Ministry of Education Guizhou UniversityGuiyangChina School of Mechanical Engineering Dalian University of TechnologyDalianChina Chemical and Biomolecular Engineering University of CaliforniaIrvineUSA Mechanical and Aerospace Engineering University of CaliforniaIrvineUSA School of Engineering and Science Tecnologico de MonterreyMonterreyMexico

To produce a three-dimensional micro/nanocarbon structure,a manufacturing design technique for sub-10 nm carbon fiber arrays on three-dimensional carbon micropillars has been developed;the method involves initiating electrostatic jetting,forming submicron-to-nanoscale PAN-based fibers,and maximizing the shrinkage from polyacrylonitrile(PAN)-based fibers to carbon *** and nanodepositing methods for polyacrylonitrilebased jet fibers as precursors of carbon fibers are proposed for the processing design of electrostatic jet initiation and for the forming design of submicron-to-nanoscale PAN-based fibers by establishing and analyzing mathematical models that include the diameter and tensile stress values of jet fibers and the electric field intensity values on the surfaces of carbon *** accordance with these methods,an array of jet fibers with diameters of~80 nm is experimentally formed based on the thinning of the electrospinning fluid on top of a dispensing needle,the poking of drum into an electrospinning droplet,and the controlling of the needle–drum *** converting thin PANbased jet fibers to carbon fibers,a pyrolysis method consisting of the suspension of jet nanofibers between carbon micropillars,the bond between the fibers and the surface of the carbon micropillar,and the control of micropillar spacing,stabilization temperature,and carbonation rate is presented to maximize the shrinkage from PAN-based fibers to carbon fibers and to form sub-10 nm carbon fiber arrays between three-dimensional carbon *** manufacturing design of a three-dimensional micro/nanocarbon structure can produce thin PAN-based jet nanofibers and nanofiber arrays aligned on micropillar surfaces,obtain shrinkage levels reaching 96%and incorporate sub-10 nm carbon fibers into three-dimensional carbon micropillars;these actions provide new research opportunities for correlated three-dimensional micro/nanocarbon structures that have not previousl

关键词： fibers fiber carbon

Fabrication of crystalline submicro-to-nano carbon wire for achieving high current density and ultrastable current

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Microsystems & Nanoengineering 2022年第1期8卷 223-235页

作者： Jufeng Deng Chong Liu dian song Marc Madou School of Mechanical Engineering Dalian University of TechnologyDalian 116023China Mechanical and Aerospace Engineering University of CaliforniaIrvineCA 92617USA Chemical and Biomolecular Engineering University of CaliforniaIrvineCA 92517USA School of Engineering and Science Tecnologico de MonterreyMonterreyNM 64849Mexico

Crystalline carbon nanowire arrays were fabricated taking advantage of near-field electrospinning and stress decyanation.A novel fabrication method for carbon nanowires with radii ranging from~2.15μm down to~25 nm was developed based on implementing nitrogen pretreatment on the silica surface and then aligning polymer nanofibers during near-field electrospinning at an ultralow *** decyanation was implemented by subsequently pyrolyzing a polymer nanofiber array on the silica surface at 1000°C for 1 h in an N_(2)atmosphere,thus obtaining a crystalline carbon nanowire array with a nanostructured *** crystalline nanostructures were fabricated on the nanowire surface,and their electrochemical performance was evaluated by cyclic voltammetry(CV)and electrochemical impedance spectroscopy(EIS).Crystalline carbon wires with diameters ranging from micrometers to submicrometers displayed carbon nanoelectrode-like behavior with their CV curve having a sigmoidal shape.A highly crystalline carbon nanowire array showed distinct behavior,having a monotonically increasing straight line as its CV curve and a semicircular EIS spectrum;these results demonstrated its ultrastable current,as determined by electron ***,nanocrystalline-structured carbon wires with diameters of~305 nm displayed at least a fourfold higher peak current density during CV(4000 mA/m2)than highly crystalline carbon nanowires with diameters of~100 nm and porous microwires with diameters of~4.3μm.

关键词： nanowires crystalline carbon

Low Selenium and Low Protein Exacerbate Myocardial Damage in Keshan Disease by Affecting the PINK1/Parkin-mediated Mitochondrial Autophagy Pathway

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Current Medical Science 2024年第1期44卷 93-101页

作者： Li-wei ZHANG Hong-qi FENG song-bo FU dian-jun SUN Center for Endemic Disease Control Chinese Center for Disease Control and PreventionHarbin Medical UniversityNHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University)Key Lab of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceHarbin 150086China

Objective Keshan disease(KD)is a myocardial mitochondrial disease closely related to insufficient selenium(Se)and protein *** induced putative kinase 1(PINK1)/Parkin mediated mitochondrial autophagy regulates various physiological and pathological processes in the *** study aimed to elucidate the relationship between PINK1/Parkin-regulated mitochondrial autophagy and KD-related myocardial *** A low Se and low protein animal model was *** hundred Wistar rats were randomly divided into 5 groups(control group,low Se group,low protein group,low Se+low protein group,and corn from KD area group).The JC-1 method was used to detect the mitochondrial membrane potential(MMP).ELISA was used to detect serum creatine kinase MB(CK-MB),cardiac troponin I(cTnI),and mitochondrial-glutamicoxalacetic transaminase(M-GOT)***-PCR and Western blot analysis were used to detect the expression of PINK1,Parkin,sequestome 1(P62),and microtubule-associated proteins1A/1B light chain 3B(MAP1LC3B).Results The MMP was significantly decreased and the activity of CK-MB,cTnI,and M-GOT significantly increased in each experimental group(low Se group,low protein group,low Se+low protein group and corn from KD area group)compared with the control group(P<0.05 for all).The mRNA and protein expression levels of PINK1,Parkin and MAP1LC3B were profoundly increased,and those of P62 markedly decreased in the experimental groups compared with the control group(P<0.05 for all).Conclusion Low Se and low protein levels exacerbate myocardial damage in KD by affecting the PINK1/Parkin-mediated mitochondrial autophagy pathway.

关键词： Keshan disease low selenium and low protein myocardial mitochondrial injury PTEN induced putative kinase 1(PINK1)/Parkin mitochondrial autophagy