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Epidemiology and Histopathology of Cancers of the Upper Aerodigestive Tract in the ENT and Head and Neck Surgery Department of the Ignace Deen National Hospital

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第4期13卷 259-274页

作者： Mamadou Mouctar Ramata diallo Oumou amadou diallo Raphan Madi Kaba Keita Ousmane Barry Abdoulaye Keita Alpha Oumar diallo Department of Otorhinolaryngology and Head and Neck Surgery Mamou Regional Hospital Mamou Guinea Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of Conakry Conakry Guinea Department of Otorhinolaryngology and Head and Neck Surgery Ignace Deen National Hospital Conakry Guinea Department of Otorhinolaryngology and Head and Neck Surgery NZrkor Regional Hospital NZrkor Guinea Department of Otorhinolaryngology and Head and Neck Surgery Donka National Hospital Conakry Guinea

Introduction: Head and neck cancers represent a significant burden of cancer, collectively ranking fourth for cancer incidence and second for cancer mortality worldwide. Objective: To study the epidemiological and histopathological aspects of head and neck cancers in the ENT-CCF department of Ignace Deen National Hospital. Materials and Methods: This was a descriptive retrospective study covering a period of 5 years from September 1, 2016, to September 30, 2021. Results: We collected 43 cases of head and neck cancers, representing a hospital frequency of 1.85%. The mean age was 45.21 ± 13.23 years. Males predominated, accounting for 65.12%, compared to 34.88% for females, with a male-to-female ratio of 1.87. Housewives accounted for 27.90%, followed by farmers at 23.26% and traders/merchants at 18.60%, with 41.86% being uneducated. The main risk factors were tobacco (37.21%) and alcohol (34.88%). Pain (53.49%), dysphonia (51.16%), and dyspnea (39.53%) were the main presenting symptoms. Squamous cell carcinoma (74.42%) and large cell lymphoma (18.60%) were the most commonly cited histological types. Conclusion: Head and neck cancers remain relatively common in our country. Improving prognosis depends on early diagnosis of the condition, resuscitation resources, and prompt management.

关键词： Cancer Head and Neck Histopathology Ignace Deen National Hospital

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Acute Otitis Media in Children Aged 0-5 Years, Epidemiological Aspects and Management in the Paediatrics Department of the Hospital National Ignace Deen (Conakry)

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Open Journal of Epidemiology 2024年第1期14卷 19-30页

作者： Oumou amadou diallo M’bemba Traore Mamadou Cire Barry Mamadou Mouctar Ramata diallo Hasmiou Dia Alpha Oumar diallo ENT Department Ignace Deen National Hospital Conakry Guinea Paediatrics Department Ignace Deen National Hospital Conakry Guinea ENT Department Mamou Regional Hospital Mamou Guinea

Introduction: Acute otitis media is an acute inflammation of the mucosa of the middle ear cavities. It is often secondary to nasopharyngitis, which favors the passage of infection through the Eustachian tube to the middle ear. The aim of our study was to improve the management of AOM in the Paediatric Department of the Hospital National Ignace Deen (Conakry). Patients and Methods: This was a prospective descriptive study lasting 6 months from 01 July to 31 December 2011;the study covered 525 cases out of a total of 6276 children, i.e. a frequency of 8.36%. Results: The most affected age group was 6 to 11 months. Males predominated (69.71%). 82.29% had a history of recurrent rhinopharyngitis. The most frequent reason for consultation was incessant crying (66.29%). Rhinopharyngitis and malaria were the most commonly associated pathologies (87.62% and 39.62% respectively). 72.19% of our patients were admitted with congestive AOM and received medical treatment. We recorded one case of otomastoiditis which was treated surgically. Conclusion: AOM is more common in children aged between 6 and 24 months. Good collaboration between paediatricians and ENT specialists is essential to reduce the morbidity of AOM.

关键词： Acute Otitis Media (AOM) Treatment Nasopharyngitis Eustachian Tube

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External Otitis: Epidemiological, Clinical, Etiological, and Therapeutic Aspects at the Oto-Rhino-Laryngology Department of Mamou Regional Hospital

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第3期13卷 213-224页

作者： Mamadou Mouctar Ramata diallo Sayon Kourouma Oumou amadou diallo Ibrahima diallo Francine Haba Alsény Cisse Raphan Madi Kaba Keita Abdoulaye Keita Alpha Oumar diallo ENT Department Mamou Regional Hospital Mamou Guinea ENT Department Conakry Military Hospital Conakry Guinea ENT Department IgnaceDeen National Hospital Conakry Guinea ENT Department Donka National Hospital Conakry Guinea ENT Department Lab&#233 Regional Hospital Lab&#233 Guinea ENT Department N&#8217Z&#233r&#233kor&#233 Regional Hospital N&#8217Z&#233r&#233kor&#233 Guinea

Introduction: External otitis (OE) is an acute or chronic inflammation or infection of the external ear resulting from an imbalance in the external auditory canal secondary to microtrauma, maceration, eczema, or a foreign body in the external auditory canal. Objective: To study cases of external otitis at the Mamou Regional Hospital. Materials and Methods: This was a prospective descriptive study conducted over a period of six (6) months from July 1st to December 31st, 2016. It included all patients admitted to the ENT department of the Mamou Regional Hospital. Results: During the study period, 712 patients were admitted to the department for various pathologies, of which 103 met our selection criteria, representing a frequency of 14.46%. The mean age of the patients was 33.74 years with a range of 1 to 90 years. Males predominated in the sample, accounting for 59.22%. The vast majority of patients resided in urban areas, constituting 61.17% of the sample. In our study, all patients consulted for otalgia (100%), and over half (53.39%) for hypoacusis. We formally identified rhinitis in 66.66% of cases, while diabetes was found in only 4 patients (11.11%). Otomycosis was the most commonly identified condition (53.39%), followed by furuncles (33.98%). Ear drops containing antibiotics were administered to all patients, although 66.60% received antibiotic therapy. Conclusion: External otitis is a relatively common condition, particularly among children and the elderly. Diagnosis can be made based on pain upon traction of the pinna and pressure on the tragus.

关键词： External Otitis ENT Mamou Regional Hospital

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Infectious ENT Emergencies: A One-Year Experience at the ENT Department of Mamou Regional Hospital

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第5期13卷 359-372页

作者： Mamadou Mouctar Ramata diallo Ibrahima diallo Oumou amadou diallo Alsény Cisse Mamadou Bailo Sow Raphan Madi Kaba Keita Abdoulaye Keita Alpha Oumar diallo ENT Department Mamou Regional Hospital Mamou Guinea Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of Conakry Conakry Guinea ENT Department Donka National Hospital Conakry Guinea ENT Department Ignace Deen National Hospital Conakry Guinea ENT Department Lab Regional Hospital Lab Guinea ENT Department NZrkor Regional Hospital NZrkor Guinea

Introduction: ENT infectious emergencies encompass all infectious pathologies affecting the ear, nose, sinuses, throat, and neck. A good understanding of these emergencies is essential for organizing appropriate care. In Guinea, few studies have described ENT infectious pathologies in rural areas. Objective: To study ENT infectious emergencies in the Otorhinolaryngology department of the Mamou Regional Hospital. Materials and Methods: This is a retrospective and prospective descriptive study, conducted from August 1, 2021, to July 31, 2022. All patients admitted to the ENT department of the Mamou Regional Hospital for an infectious emergency were included. Results: Among the 1854 recorded consultations, 261 cases involved ENT infectious emergencies, representing a prevalence of 14.07%. The most represented age group was 0 to 10 years (31.03%), with a majority of female patients (59%) and a predominantly urban origin (81.61%). Students accounted for 32.18% of the cases. The main reasons for consultation were odynophagia/dysphagia (32.42%) and otalgia (22.94%). The primary etiologies were tonsillitis (28.73%) and otitis (27.20%). Treatments administered included probabilistic antibiotic therapy (38.80%), analgesics (32.03%), and corticosteroid therapy (10.47%). The outcome was favorable in 98.85% of cases, with only 0.38% lost to follow-up. Conclusion: The results of our study confirm the frequency of ENT infectious pathologies. Their management requires joint actions for population awareness, staff training, and services equipment, particularly in rural areas.

关键词： ENT Infection Emergency Mamou Regional Hospital

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塞内加尔尼洛罗非鱼遗传多样性的微卫星分析

塞内加尔尼洛罗非鱼遗传多样性的微卫星分析

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作者： diallo amadou 宁波大学

学位级别：硕士

做卫星是通用的遗传标记，它在遗传多样性的研究中有着广泛的运用。因为DNA复制过程中聚合酶会产生滑动，所以做卫星标记会有高度的多态性。至今为止的研究表明，做卫星在很多种类中部大量存在，据估计，它们在鱼类DNA中每10kh就会出现... 详细信息

做卫星是通用的遗传标记，它在遗传多样性的研究中有着广泛的运用。因为DNA复制过程中聚合酶会产生滑动，所以做卫星标记会有高度的多态性。至今为止的研究表明，做卫星在很多种类中部大量存在，据估计，它们在鱼类DNA中每10kh就会出现一次。本研究打算探索塞内加尔罗非鱼的两个群体间和群体内的遗传多态性(塞内加尔河和吉耶尔湖)。为了跟两个塞内加尔野生种群进行遗传多样性对比，两个中国养殖种群(宁波和吉富)也包含在研究范围内。运用了8个做卫星标记分别对塞内加尔河，吉耶尔湖，宁波和GIFT的罗非鱼群体进行遗传多态性的研究。结果表明，吉耶尔湖群体的观测杂合度Ho值为O 875，接着是塞内加尔河群体的Ho值为O 873，吉富群体的H。值为O 808，宁波的群体的H。值为O 750。所有位点部显著的偏离了哈迪温伯格平衡。吉耶尔湖群体的平均PIc值比较高(O 712)，接下来是吉富群体(O 689)，塞内加尔河群体(O 617)和宁波群体(O 588)。吉耶尔湖群体的多态性比塞内加尔河的群体更高。遗传距离分析结果表明，塞内加尔河和吉耶尔湖群体的遗传距离是最近的，而塞内加尔河和GIFT群体的遗传距离是最远的。分子生物学方差分析表明17％的变异产生于塞内加尔的群体的种间变异而83％的变异产生于种内变异。在uPGMA系统树图中，塞内加尔河群体和吉耶尔湖群体构成一个组，同时，宁波和吉富群体构成了另外一个组。塞内加尔河群体和吉耶尔湖群体的基因流水平仍然是很低的(Nm=2 219)。本研究为塞内加尔尼罗河罗非鱼种群的遗传学背景的研究起了开头的作用。这些结果同样可以在渔业管理和塞内加尔未来的分子标记辅助育种项目中被利用起来。

关键词：塞内加尔罗非鱼微卫星遗传多态性

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High-dimensional supervised classification in a context of non-independence of observations to identify the determining SNPs in a phenotype

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Infectious Disease Modelling 2023年第4期8卷 1079-1087页

作者： Aboubacry Gaye Abdou Ka Diongue Lionel Nanguep Komen amadou diallo Seydou Nourou Sylla Maryam Diarra Cheikh Talla Cheikh Loucoubar Laboratory for Studies and Research in Statistics and Development Gaston Berger University of Saint LouisSenegal Epidemiology Clinical Research and Data Science UnitInstitute Pasteur de Dakar220DakarSenegal African Institute for Mathematical Sciences(AIMS) Senegal Information and Communication Technologies for Development Alioune Diop University of BambeySenegal

This work addresses the problem of supervised classification for highly correlated highdimensional data describing non-independent observations to identify SNPs related to a *** use a general penalized linear mixed model with a single random effect that performs simultaneous SNP selection and population structure adjustment in highdimensional prediction ***,the model simultaneously selects variables and estimates their effects,taking into account correlations between *** nucleotide polymorphisms(SNPs)are a type of genetic variation and each SNP represents a difference in a single DNA building block,namely a *** research has shown that SNPs can be used to identify the correct source population of an individual and can act in isolation or simultaneously to impact a *** this regard,the study of the contribution of genetics in infectious disease phenotypes is of great *** this study,we used uncorrelated variables from the construction of blocks of correlated variables done in a previous work to describe the most related observations of the *** model was trained with 90%of the observations and tested with the remaining 10%.The best model obtained with the generalized information criterion(GIC)identified the SNP named rs2493311 located on the first chromosome of the gene called PRDM16((PR/SET domain 16))as the most decisive factor in malaria attacks.

关键词： Non independence of observations Correlated variables High-dimensional supervised classification SNP Phenotype

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Indications and Results of Parotidectomies in the Orl Department of the Idrissa Pouye General Hospital in Dakar. Concerning 31 Cases

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International Journal of Otolaryngology and Head & Neck Surgery 2023年第6期12卷 375-384页

作者： Oumou amadou diallo Aliou Faty Hady Tall Alimou Synayoko Alpha Oumar diallo Malick Ndiaye Bay Karim diallo ENT Department of The Saint Louis Regional Hospital Saint Louis Senegal ENT Department Heinrich Regional Hospital Diourbel Senega ENT Department H&#244pital National Ignace Deen Guinea Conakry Guinea ENT Department Diamniadio Children’s Hospital Dakar Senegal ENT Department Albert Royer Children’s Hospital Dakar Senegal

Introduction: The parotid tumors are benign or malignant, primary or secondary neoformations developed at the expense of the parotid gland. The aim of the present study was to describe the indications and results of parotidectomies in the ENT department of the Idrissa Pouye General Hospital in Dakar. Patients & Methods: We conducted a retrospective study between January 1, 2004 and December 31, 2012, including all patients who had been consulted for a parotid tumor with or without histological evidence collected in the otolaryngology and anatomy-pathology department of the Idrissa Pouye General Hospital in Dakar. Results: We collected 31 patient files. The mean age was 47.45 years, with extremes of 16 and 74 years. Females predominated, with a sex ratio of 0.82. Swelling of the parotid region was the main reason for consultation in 100% of cases. Parotidectomy was the most frequently performed procedure, accounting for 41.93%. Benign tumors accounted for 72% of cases, the majority being pleomorphic adenomas (50%). The outcome was favorable in 67.74% of cases. Conclusion: Management of parotid tumors at HOGIP would be improved by informing and educating patients to consult early, and by upgrading the technical platform.

关键词： Parotid Gland Parotid Tumor Pleomorphic Adenoma Epidemiology Clinic Treatment Dakar

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大黄鱼肌肉生长抑制素基因原核表达及多克隆抗体的制备

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台湾海峡 2011年第2期30卷 196-202页

作者：董海阳叶秀丽薛良义 diallo amadou 宁波大学生命科学与生物工程学院浙江宁波315211

肌肉生长抑制素抑制动物肌肉的生长发育.根据本实验室克隆的大黄鱼(Pseudosciaena cro-cea)肌肉生长抑制素(MSTN)基因编码序列设计引物,用RT-PCR扩增目的片段,构建MSTN-pET-28 a重组表达质粒,将其转化到大肠杆菌BL21上并用1.0 mmol/dm3I... 详细信息

肌肉生长抑制素抑制动物肌肉的生长发育.根据本实验室克隆的大黄鱼(Pseudosciaena cro-cea)肌肉生长抑制素(MSTN)基因编码序列设计引物,用RT-PCR扩增目的片段,构建MSTN-pET-28 a重组表达质粒,将其转化到大肠杆菌BL21上并用1.0 mmol/dm3IPTG诱导表达,SDS-PAGE电泳检测该目的蛋白大小约为44 kDa,与理论值大小符合.用0.25 mol/dm3KCl染色后从凝胶中切取该蛋白且回收.该回收蛋白与弗氏佐剂等量混合后注射ICR小鼠制备多克隆抗体,并用Westernblot检测该抗体.免疫印迹结果在44 kDa的位置上出现棕色条带,表明大黄鱼肌肉生长抑制素的多克隆抗体制备成功.这为今后对肌肉生长抑制素功能的研究奠定了基础.

关键词：海洋生物学肌肉生长抑制素原核表达多克隆抗体免疫印迹大黄鱼

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Therapeutic Itinerary of Patients Living with Viral Hepatitis B and C in Guinea

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Open Journal of Gastroenterology 2022年第10期12卷 299-306页

作者： diallo Kadiatou Barry Fatoumata Diaraye diallo Thierno Saidou diallo Djenabou Sow Ousmane diallo Mamadou Sarifou Sylla Mariétou Salifou Sylla Djibril Leno Niouma Nestor diallo Alpha amadou Sank Tounkara Thierno Mamadou Faculty of Health Sciences and Techniques Gamal Abdel Nasser University Conakry Guinea Department of Internal Medicine and Hepato-Gastroenterology National Hospital Donka Conakry Guinea National Programme for the Fight against HIV and Viral Hepatitis Ministry of Health and Public Hygiene Conakry Guinea Inter-Army Medical and Surgical Centre Conakry Guinea Department of Dermatology-MST National Hospital Donka Conakry Guinea

Introduction: The therapeutic pathway affects the patient who changes care facilities. This change is linked to factors such as financial means, geographical accessibility of care facilities, quality of care and the socio-cultural perception of the patient. In countries with limited resources such as Guinea, the therapeutic itinerary remains multiple and hampered by obstacles. The objective of this study was to describe the therapeutic itinerary of patients living with hepatitis B and C at the Donka National Hospital. Material and methods: This was a retrospective, descriptive study lasting 43 months (24 January 2017 - 27 August 2020);it focused on patients living with hepatitis B or C or viral cirrhosis. We collected sociodemographic, clinical and treatment history variables. The data were analysed with SPSS software version 21.0. Results: Out of 5400 patients, the proportion of viral hepatitis B or C represented 393 patients (7.3%). The mean age of our patients was 35 ± 10 years, with extremes of 16 - 77 years. The sex ratio was 2.5. Three hundred and forty-two patients (87%) had recourse to modern medicine, mostly in private facilities (50.6%). One hundred and twenty-five patients (31.8%) had received previous treatment, half of whom (57.6%) had received inappropriate treatment. The delay in treatment was long in 45% of cases. The main reasons for delaying treatment were feeling unwell in 33.3%;not knowing to consult a specialist in 29.9% and feeling that they were being treated with useful drugs in 24.3%. Conclusion: The lack of training of general practitioners on the management of viral hepatitis and the scarcity of awareness campaigns on viral hepatitis contributed to the inadequacy of the management.

关键词： Therapeutic Itinerary Hepatitis B Hepatitis C Guinea

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GISAID’s Role in Pandemic Response

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China CDC weekly 2021年第49期3卷 1049-1051页

作者： Shruti Khare Céline Gurry Lucas Freitas Mark B Schultz Gunter Bach amadou diallo Nancy Akite Joses Ho Raphael TC Lee Winston Yeo GISAID Core Curation Team Sebastian Maurer-Stroh GISAID Global Data Science Initiative(GISAID) MunichGermany Bioinformatics Institute Agency for Science Technology and ResearchSingapore Oswaldo Cruz Foundation(FIOCRUZ) Rio de JaneiroBrazil Institut Pasteur de Dakar DakarSenegal National Institutes of Biotechnology Malaysia SelangorMalaysia Smorodintsev Research Institute of Influenza St.PetersburgRussia Genome Institute of Singapore Agency for Science Technology and ResearchSingapore China National GeneBank ShenzhenChina A*STAR Infectious Disease Labs(ID Labs) Singapore National Public Health Laboratory National Centre for Infectious DiseasesMinistry of HealthSingapore Department of Biological Sciences National University of SingaporeSingapore.

GISAID is a global data science initiative and the primary source of genomic and associated metadata of all influenza viruses,Respiratory Syncytial Virus(RSV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the pandemic coronavirus causing coronavirus disease 2019(COVID-19).GISAID’s publicly accessible data sharing platform enables collaboration of over 42,000 participating researchers from 198 nations and data generators from over 3,500 institutions across the *** the first wholegenome sequences were made available by China CDC through GISAID on January 10.

关键词： acute respiratory AID

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