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Prevalence of Diabetes and Other Cardiovascular Risk Factors in Patients Received at the COVID-19 Screening Center of Donka University Hospital, Guinea

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Open Journal of Endocrine and Metabolic Diseases 2024年第11期14卷 191-198页

作者： diallo mamadou Alpha diallo mamadou Dian Mamoudou Bah El’Hadj Zainoul Kake Amadou diallo Alpha mamadou cherif Ibrahima Sory Balde Djamilatou diallo mamadou cherif Barry Mody Abdoullaye diallo Amatoullaye Bah Kadidiatou diallo Abdoul Mazid Balde Maimouna Sonna Bah Amadou Dieng Kadidja Department of Endocrinology Metabolic Diseases and Nutrition Donka University Hospital Conakry Guinea Faculty of Health Sciences and Technology Gamal Nasser University of Conakry Conakry Guinea Ministry of Health and Public Hygiene National Program for the Fight Against Non-Communicable Diseases Conakry Guinea World Health Organization Conakry Guinea Labe Regional Hospital Conakry Guinea

The aim of this study was to determine the prevalence of diabetes and other cardiovascular risk factors (smoking, obesity and high blood pressure) and to evaluate the WHO Global Cardiovascular Risk Score in the population of people suspected of COVID-19 infection aged 40 years or older. Material and Methods: This was a descriptive cross-sectional study conducted at the Donka University Hospital from June 1 to July 4, 2020 on subjects received for COVID-19 screening. Results: The prevalence of diabetes in patients suspected of COVID-19 was 7.8% comprising 1.2% of known diabetics and 6.8% of new cases. The prevalence of active smoking was 14.0%. That of sedentary lifestyle and obesity were 10.6% and 17.2% respectively. We found a prevalence of hypertension estimated at 45%, it was unknown in 76.47% of cases. In this series, 33.2% of patients had a high and very high cardiovascular risk (WHO scores). Conclusion: This study reveals a fairly high prevalence of diabetes and other cardiovascular risk factors in the population of people suspected of COVID-19. This observation should lead to the implementation of effective strategies for the prevention of non-communicable diseases in Guinea.

关键词： Diabetes Risk Factors COVID-19 Cardiovascular Risk Score

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耐亚胺培南铜绿假单胞菌oprD2基因与金属酶的检测

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中国感染与化疗杂志 2008年第5期8卷 369-372页

作者： diallo mamadou cherif 魏殿军曹阳马全玲刘扬门昆武大伟天津医科大学第二医院实验诊断科 300211

目的研究oprD2基因与金属酶(MBL)在亚胺培南耐药机制中的作用。方法对天津地区3所综合医院临床分离60株亚胺培南耐药的铜绿假单胞菌,以2-巯基乙醇(2-MPA)为酶抑制剂,在MH平皿上用纸片扩散法进行抗生素协同敏感性检测,并用PCR检测MBL基因... 详细信息

目的研究oprD2基因与金属酶(MBL)在亚胺培南耐药机制中的作用。方法对天津地区3所综合医院临床分离60株亚胺培南耐药的铜绿假单胞菌,以2-巯基乙醇(2-MPA)为酶抑制剂,在MH平皿上用纸片扩散法进行抗生素协同敏感性检测,并用PCR检测MBL基因和oprD2基因。结果60株临床分离的耐亚胺培南铜绿假单胞菌(imipenem-resistant Pseudomonas aeruginosa,IRPA)中,2-MPA方法筛选出15株(25%)MBL阳性;以PCR方法检测,22株(36.4%)oprD2基因阳性,19株(31.7%)产生IMP-1型MBL,未发现VIM-2与IMP-2酶,7株IRPA同时含有IMP-1和oprD2基因。结论IMP-1为天津地区IRPA产MBL的主要类型,也是临床分离铜绿假单胞菌亚胺培南耐药的重要原因之一。

关键词：铜绿假单胞菌 oprD2基因金属酶

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Role of Nrf2 in chronic liver disease

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World Journal of Gastroenterology 2014年第36期20卷 13079-13087页

作者： Wei Tang Yong-Fang Jiang Murugavel Ponnusamy mamadou diallo Liver Diseases Research Center The Second Xiangya Hospital Central South University Department of Medicine Rhode Island Hospital and Alpert Medical School of Brown University Providence RI 02903 United States Department of Immunology and Infectious Diseases Harvard School of Public Health Harvard UniversityBoston MA 02115-6018 United States

Nuclear erythroid 2-related factor 2(Nrf2) is a central regulator of antioxidative response elements-mediated gene expression. It has a significant role in adaptive responses to oxidative stress by interacting with the antioxidant response element, which induces the expression of a variety of downstream targets aimed at cytoprotection. Previous studies suggested oxidative stress and associated damage could represent a common link between different forms of diseases. Oxidative stress has been implicated in various liver diseases, including viral hepatitis, nonalcoholic fatty liver disease/steatohepatitis, alcoholic liver disease and drug-induced liver injury. Nrf2 activation is initiated by oxidative or electrophilic stress, and aids in the detoxification and elimination of potentially harmful exogenous chemicals and their metabolites. The expression of Nrf2 has been observed throughout human tissue, with high expression in detoxification organs, especially the liver. Thus, Nrf2 may serve as a major regulator of several cellular defense associated pathways by which hepatic cells combat oxidative stress. We review the relevant literature concerning the crucial role of Nrf2 and its signaling pathways against oxidative stress to protect hepatic cell from oxidative damage during development of common chronic liver diseases. We also review the use of Nrf2 as a therapeutic target to prevent and treat liver diseases.

关键词： Nuclear erythroid 2-related factor 2 Chronic liver disease Oxidative stress Reactive oxygen species Hepatic injury Hepatic protection

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Photoassisted Ozonation of Red Cationic X-GRL Dyeing Wastewater Treatment

Photoassisted Ozonation of Red Cationic X-GRL Dyeing Wastewa...

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作者： diallo mamadou DA? 浙江大学

学位级别：硕士

学位论文的主要内容及创新点：印染(阳离子红X-GRL)废水的特点是高的色度，高pH值和有机污染物质集中，从而造成景观质量变差。世界印染工业的高速发展带动了对印染废水处理的研究。然而，众所周知，印染(阳离子红X-GRL)废水... 详细信息

学位论文的主要内容及创新点：印染(阳离子红X-GRL)废水的特点是高的色度，高pH值和有机污染物质集中，从而造成景观质量变差。世界印染工业的高速发展带动了对印染废水处理的研究。然而，众所周知，印染(阳离子红X-GRL)废水很难被传统的处理方式(比如物化和生化方法)处理。臭氧氧化方法将会有助于在染工业方面保护环境和重复使用水。应用臭氧处理，虽然有很多优点，但是对许多难降解有机物却很难做到完全去除!尽管鼓励将O和UV结合起来。在这篇论文中，我们研究了这个高级氧化技术，以期达到处理的最优化，。研究了反应条件的影响：温度，时间，pH，色度，CODcr，BOD和反应机理被调查。实验的结果显示，作为一种深度处理的方式，臭氧对废水的氧化、除色以及循环使用都是非常有效的。将UV和臭氧结合起来，结果表明是很有效的。研究了臭氧+UV对印染(阳离子红X-GRL)废水的氧化处理情况。在相同的实验条件下，将这些系统的氧化产物和产量与臭氧氧化的产物和产量进行比较。臭氧氧化使得COD降解速度提高(在pH3下)。臭氧+UV体系对COD和BOD的降解都有很大的提高，这说明它是最好的氧化方式。无论是什么废水，氧化体系(脱色)与臭氧氧化本身比较。不同的动力学叁数也决定到对於被应用的氧化系统的废水反应度的量。 C，O=30mg/L，kobs=9743,66exp(-32610／RT)[HO]0.023(S) C，O=50mg／L，kobs=5024,53exp(-32610／RT)[HO]0.023(S) C，O=80mg／L kobs=3687.01exp(-32610／RT)[HO)0.023(S)

关键词：染料臭氧氧化废水处理技术研究阳离子红X-GRL 脱色反应动力学和反应机制涂颜色

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Health 2020年第1期12卷 63-70页

作者： Thierno mamadou cherif diallo Sory diallo Farel Aboki Namandjan Traore Unit of Legal Medicine Donka National Hospital Conakry Guinea Institute of Child Nutrition and Health Conakry Guinea Emergency Department Donka National Hospital Conakry Guinea

Two-wheeled motorized road accidents are becoming increasingly frequent and are responsible for high mortality among a young and active population in developing countries. The objective of this study was to determine the mortality rate related to motorcycle accidents and to identify socio-demographic factors and accidental mechanisms. Methodology: This was a retrospective descriptive and analytical study involving 16,655 patients, including 312 deaths due to motorcycle accidents. The study took place from January 1, 2013 to December 31, 2017. Not all patients who died as a result of accidents involving equipment other than two motorized wheels were included in our study. The data were entered and analyzed using the *** version software. For the comparison of qualitative data, we used Pearson’s khi2. Results: We recorded 312 cases of death or 1.87% out of a total of 16,655 victims. Of the deceased victims, only 112 wore a protective helmet and 200 did not. The male predominance was clear (p p Conclusion: This study shows that two-wheeled motor vehicle accident mortality is a public health problem. Gender, occupation and time of occurrence of the accidents were most common factors associated with mortality. The effective establishment of an emergency medical assistance service (SAMU) in Conakry could improve the pre-hospital care of these traumatised people.

关键词： Accident Mortality Motorcycle Donka

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Hypothyroidism in Conakry: Epidemiological, Clinical and Therapeutic Aspects

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Open Journal of Internal Medicine 2022年第1期12卷 38-45页

作者： Amadou Kaké Djibril Sylla Alpha mamadou diallo mamadou Mansour diallo diallo Kourouma Amadou Diango mamadou Alpha diallo Elhadj Zainoul Bah mamadou cherif diallo Kadija Dieng Mody Abdoulaye Barry Naby Moussa Baldé Department of Endocrinology and Metabolic Diseases Donka University Hospital Conakry Guinea Department of Internal Medicine Donka University Hospital Conakry Guinea

Hypothyroidism is a frequent endocrine disorder that can occur at any age and predominantly affects women. The etiologies are diverse and may vary according to the geographical and socio-demographic context. The objective of our work was to describe the epidemiological, clinical and therapeutic characteristics of hypothyroidism in Conakry, Guinea. Materials and Method: This was a descriptive study with prospective data collection, over the period from December 2016 to May 2021. It focused on patients seen at the endocrinology consultation of Conakry University Hospital. Epidemiological, clinical, etiological, therapeutic, and evolutionary variables of patients diagnosed or followed-up for hypothyroidism were collected and analyzed. The diagnosis of hypothyroidism was defined by elevated TSH and/or decreased FT4/FT3. Results: Out of a total of 290 patients who consulted for thyroid pathology, hypothyroidism concerned 49 patients, i.e. , a frequency of 14%. Women were the most affected with a sex ratio of 0.13. The mean age of patients was 48.65 ± 19.93 years with extremes of 2 years and 80 years. Hypo-metabolic syndrome was the main clinical sign and was manifested mainly by constipation found in 48.89% of cases. TSH was elevated in all cases with a mean level of 24.56 ± 14.17 mIU/ml. Hypertension was the most frequently associated pathology (57%). Three etiological groups of hypothyroidisms were found. These were thyroidectomy in 42.85% of cases, thyroiditis in 34.69% of cases and post synthetic antithyroid hypothyroidism. All patients were treated with L-thyroxin, with a favorable clinical course. Follow-up was regular in 16 patients (32.65%). Conclusion: Hypothyroidism is common in this population, and primarily affects women. Thyroid surgery was the main cause of hypothyroidism in this work.

关键词： Hypothyroidism Goiter Hashimoto Guinea

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Nutritional Profile of Children with Major Sickle Cell Syndrome at the Centre of Medical and Health Advice of Kipé, Conakry, 2018

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Case Reports in Clinical Medicine 2024年第3期13卷 73-84页

作者： mamadou Aliou Doukoure Ibrahima Sory diallo M’mah Aminata Bangoura Amadou Oury Toure mamadou Moustapha Diop Fatoumata Binta diallo Mohamed Sama cherif Thierno Saidou diallo Saidouba cherif Camara Abdoulaye Toure Faculty of Health Science and Technology Gamal Abdel Nasser University Conakry Guinea National AIDS Control Programme Ministry of Health Gamal Abdel Nasser University Conakry Guinea

Introduction: Growth is a reflection of a child’s health and nutritional status. Children with sickle cell disease often have slower statural and weight development. The aim of this study was to evaluate the nutritional profile of children with sickle cell disease (SCD) registered in the CEMECO centre database. Methodology: This was a cross-sectional study with simple random sampling of children aged 1 to 16 years registered in the clinic database. Results: We collected information on 208 children, 121 of whom had sickle cell disease and 87 of whom were normal, with a sex ratio of 1.02. The mean age of the sickle cell patients was 8.7 ± 4.4 years, while that of the non-sickle cell patients was 9.5 ± 4 years. Haemoglobin electrophoresis revealed 103 homozygous (SS), 18 double heterozygous (SC, SBetaThal, SE) and 87 normal (AA) and/or sickle cell trait (AS) sickle cell cases. We observed a significant difference in the height/age ratio (P ¥). Conclusion: The results of our study revealed stunted growth in children with sickle cell disease.

关键词： Sickle Cell Disease Nutrition Growth Puberty Guinea

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Diabetes Screening and Cardiovascular Risk in Tuberculosis Patients in Conakry and Surrounding Towns

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Open Journal of Endocrine and Metabolic Diseases 2024年第1期14卷 7-13页

作者： mamadou Chérif diallo mamadou Dian Mamoudou diallo Mody Abdoulaye Barry Kadija Dieng Alpha mamadou diallo mamadou Mansour diallo Oumou diallo Amadou Kaké Gamal Abdel Nasser University of Conakry Conakry Guinea Endocrinology-Diabetology Department of Donka University Hospital Conakry Guinea Foundation for The Fight against Diabetes and Non-Communicable Diseases Conakry Guinea

Objective: To determine the prevalence of diabetes and the level of cardiovascular risk in tuberculosis patients treated in Conakry and surrounding towns. Method: This was a cross-sectional study carried out at tuberculosis treatment centers in Conakry and surrounding towns (Coyah and Dubréka) on World TB Day, November 14, 2022, among 350 tuberculosis patients. We determined the proportion of TB patients with diabetes and high hyperglycemia. We determined the Chi-square to identify the factors associated with the occurrence of diabetes in tuberculosis patients, and a significance threshold with p Results: The average age of participants was 33.5 ± 14.5 years, and they were predominantly male (59.7%). The majority of participants lived in Conakry (96.3%). 5.7% were known diabetics and 4.6% were known hypertensives. We found a prevalence of diabetes of 9.4%. Among diabetics, 39% were diabetes discoveries. 30% were hypertensive or had high blood pressure. Of these hypertensive patients, 26.4% were unrecognized hypertensives. Age and hypertension were statistically significantly associated with the onset of diabetes in tuberculosis patients. Medium, high and very high levels of cardiovascular risk were present in 23.4%, 8.9% and 3.4% respectively. Conclusion: Diabetes is common in tuberculosis patients. Cardiovascular risk factors, notably hypertension and cardiovascular risk level, are frequently associated with tuberculosis. Tuberculosis patients with cardiovascular risk factors should be screened for diabetes.

关键词： Screening Diabetes Tuberculosis Cardiovascular Risk Conakry

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Frequency and Risk Factors of Neonatal Macrosomia at Labe Regional Hospital in Guinea

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Open Journal of Endocrine and Metabolic Diseases 2024年第2期14卷 26-32页

作者： mamadou Dian Mamoudou diallo mamadou Mansour diallo mamadou Chérif diallo Alpha mamadou diallo Kadija Dieng Mody Abdoulaye Barry mamadou Alpha diallo Kadidiatou Bah Abdou Mazid diallo El’hadj Zainoul Bah mamadou Malal Bori diallo mamadou Sanou Sylla Amadou Kaké Diabetes Unit Labe Regional Hospital Labe Guinea Faculty of Health Sciences and Technology University of Conakry Conakry Guinea Department of Diabetes and Endocrinology Donka Hospital and University Center Conakry Guinea Neonatology Unit Labe Regional Hospital Labe Guinea

Macrosomia is defined as a term birth weight greater than or equal to 4000 grams, or greater than the 90 percentile of intrauterine growth curves. Excessive weight has harmful consequences for the newborn and is a major health concern. Objectives: To determine the frequency of neonatal macrosomia, describe risk factors and neonatal and maternal complications. Materials and methods: This was a cross-sectional study carried out between January and December 2022, involving newborns whose birth weight was greater than or equal to 4000 grams admitted to the neonatology unit of the Labe regional hospital. Results: 591 deliveries were recorded, 15 of which were macrosomic, representing a frequency of 2.54%. The average age of the women was 30.26 years. History of fetal macrosomia and diabetes was 93.33 and 71.43% respectively. The mean gestational age was 38.71 ± 0.75 SA, the mean antenatal consultation was 3 ± 0.8 and the mode of delivery was caesarean section (66.67%). Third-trimester ultrasound was performed in 53.33% of cases. Macrosomic newborns were male in 80% of cases. Neonatal complications were asphyxia (60%), hypoglycemia (20%) and hypocalcemia (13.33%). Factors associated with neonatal macrosomia were diabetes (P < 0.001), history of macrosomia (P Conclusion: this study shows that the frequency of neonatal macrosomia is 2.54% with high neonatal morbidity among newborns hospitalized in the neonatology unit of the Labé regional hospital. Screening for macrosomia risk factors during pregnancy is essential to prevent perinatal complications.

关键词： Frequency Macrosomia Labe

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Causes and Prognosis of Cases of Acute Obstructive Renal Failure Managed at the Donka National Hemodialysis Center

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Open Journal of Nephrology 2024年第2期14卷 136-146页

作者： Amadou Yaya diallo mamadou Mouctar diallo mamadou Dian Barry Kadiatou mamadou Bobo Barry Saikou Oumar diallo Djenabou diallo Soriba Bangoura mamadou Malal diallo Thierno mamadou Oury diallo Mohamed Lamine Kaba Alpha Oumar Bah Department of Nephrology-Hemodialysis CHU Donka Conakry Guinea Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of the Republic of Guinea Conakry Guinea Department of Urology-Andrology CHU Ignace Deen Conakry Guinea

Introduction: Acute obstructive renal failure (AORF) is a frequent clinical situation, secondary to obstruction of the urinary excretory tract. Whatever the cause, urinary tract obstruction suddenly opposes glomerular filtration and is responsible for tubulointerstitial lesions. It accounts for 10% of acute renal failure (ARF). The aim of this study was to identify the causes and prognosis of cases of acute obstructive renal failure managed at the Centre National d’hémodialyse Donka. Material and Methods: This was a prospective descriptive study lasting 6 months, from September 1, 2022 to February 29, 2023. All patients undergoing haemodialysis for acute obstructive renal failure who agreed to participate in the study and whose medical records were complete were included. Results: During the course of the study, we registered 97 haemodialysis patients, including 20 cases (20.62%) of acute obstructive renal failure. The mean age of the patients was 57.8 ± 10.54 years, with a male predominance of 11 cases (55%) and a sex ratio of 1.22. The reasons for consultation were dominated by physical asthenia 11 cases (55%), lumbar pain 9 cases (50%), vomiting 6 cases (30%) and acute urine retention 6 cases (30%). Arterial hypertension 16 cases (80%) and urinary tract infection 10 cases (50%) were the most common antecedents. The etiologies of RAOI were dominated by lithiasis 10 cases (50%), neoplasia 6 cases (30%) and benign prostatic hypertrophy 3 cases (15%). mean creatinine was 1267.60 ± 710.76 μmol/l with extremes of 243 μmol/l and 2822 μmol/l, mean urea was 39.56 ± 18.36, hyperkalemia in 14 cases (70%) and hyponatremia in 8 cases (40%). After hemodialysis, 9 cases (45%) recovered renal function, 4 cases (20%) became chronic and 7 cases (35%) died. Conclusion: The frequency of AKI remains non-negligible in our department, and early detection and prompt management would considerably reduce the morbidity and mortality associated with this pathology.

关键词： Acute Obstructive Renal Failure Hemodialysis Prognosis Donka

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