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Epidemiological, Diagnostic and Evolutionary Profile of Seizures in Young Infants at Albert Royer (Dakar/Senegal)

Open Journal of Pediatrics 2024年第6期14卷 1079-1089页

作者： Cissé Djénéba Fafa Dieng Yaay Joor diagne Guillaye Sow ndeye Fatou Kane Awa Mbaye Aminata Faye Papa Moctar Ly Fatou gueye Modou diagne-gueye ndeye rama Sylla Assane Ndiaye Ousmane Pediatrics Department Pikine National Hospital Dakar Senegal Neonatal Department Albert Royer National Childrens Hospital Dakar Senegal Pediatrics Department Dalal Jamm National Hospital Dakar Senegal Neonatal Department Diamniadio Childrens Hospital Dakar Senegal Pediatrics Department Abass Ndao National Hospital Dakar Senegal

Introduction: Seizures are one of the most common neurological complications in the infant period. The aim of our study was to describe the epidemiological, clinical, therapeutic and prognostic features of seizures in infants at the Albert Royer Children’s Hospital (Senegal). Materials and Methods: This was a retrospective, descriptive study from 1 January 2012 to 30 September 2018 of infants aged 0 days to 2 months who presented with seizures. Results: The hospital rate was 8.5%. Almost all the mothers (99.1%) had undergone at least 3 antenatal visits. Urogenital infection, gestational arterial hypertension and funicular anomalies were the main pregnancy-related pathologies. Delivery was vaginal in the majority of cases (80.9%). Most infants (43.6%) had not cried at birth. The majority of infants (63%) were born at term. Trophicity was normal in 68% of cases. The average age of the infants was 6.7 days. The main causes of seizures were hypoxic-ischemic encephalopathy (48.7%), metabolic disturbances (48.1%) and central ոеrvοսѕ system infections (15.6%). Phenobarbital was the 1st-line anticonvulsant. The case fatality rate was 39.5%. The main sequela observed were delayed psychomotor development (20.6%). Conclusion: Optimal management of infant seizures requires early diagnosis and etiological treatment by improving the quality of perinatal care to ensure better management of risk factors, as well as increasing the availability of neuroimaging equipment.

关键词： Seizures Infant Albert Royer Hospital

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Management of Severe Acute Malnutrition in a Senegalese Paediatric Hospital

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Open Journal of Pediatrics 2021年第2期11卷 198-207页

作者： Ndiogou Seck Idrissa Basse Djibril Boiro Younoussa Keïta Lamine Thiam Aliou Abdoulaye Ndongo Ndéye rama diagne-gueye Service de péDiatrie Centre Hospitalier Régional de Saint-Louis Saint-Louis Sénégal Hô pital pour Enfants de Diamniadio Bargny Sénégal Service de péDiatrie Centre Hospitalier Abass Ndao Dakar Sénégal Service de péDiatrie Hô pital Aristide Ledantec Dakar Sénégal Service de PéDiatrie H&ocirc pital de la Paix Boucoutte Ziguinchor Sénégal

Malnutrition is a global health problem. It is very common in developing countries where it contributes to an increase in morbidity and mortality, especially among children under five years of age. The main objective of this study was to describe the management of severe acute malnutrition (SAM) in children six months to five years of age hospitalized at Diamniadio Children’s Hospital (DCH). This was an epidemiological, retrospective, descriptive and cross-sectional study of children aged six to 59 months hospitalized at DCH for SAM. The study took place over a 12-month period (from January 1, 2018 to December 31, 2018). During the study period, 67 children were admitted for SAM, representing a hospital prevalence of 8.4%. The majority (88%) children were less than 24 months old. Reasons for consultations were dominated by diarrhea (57.5%) vomiting (38.8%). Complications related to SAM were mainly: anaemia (74.6%), infections (85%) and severe acute dehydration (40.3%). Factors associated with SAM were young age (infants under 24 months of age), poverty, the first four children of a sibling, poor behaviour of food diversification. The average length of hospitalization was 12 days. The nutritional recovery rate was 73.1% and lethality was 3%. Conclusion: The prevention of malnutrition must involve the fight against poverty, an optimal and well-diversified diet, monitoring the nutritional status of children up to five years of age.

关键词： Severe Acute Malnutrition Children Complications Risk Factors Lethality

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Measurement of strong phases, D-D mixing, and CP violation using quantum correlation at charm threshold

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Frontiers of physics 2016年第1期11卷 1-15页

作者： Matteo rama Sezione di Pisa dell'Istituto Nazionale di Fisica Nucleate Pisa Italy

We review the measurements of the D decay strong-phase parameters based on quantum-correlated D^0D^-0 pairs produced in the e^＋e^→（3770） →D^0D^-0 process, and we discuss their role in the measurements of Cabibbo-Kobayashi-Maskawa angle 7 and D-/9 mixing. In addition, we present estimates of the size of quantum-correlated datasets necessary to support the 7 and charm mixing measurements conducted at the LHCb and Belle Ⅱ experiments. Finally, we review the methods for measuring the D-D^- mixing and cP violation parameters at a high-luminosity charm factory, giving sensitivity estimates.

关键词： quantum correlation charm mixing CP violation

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A numerical modelling approach to assess the behaviour of underground cavern subjected to blast loads

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International Journal of Mining Science and Technology 2018年第6期28卷 975-983页

作者： Saikat Kuili Vedala rama Sastry Department of Civil Engineering National Institute of Technology Karnataka Department of Mining Engineering National Institute of Technology Karnataka

The paper gives an insight into the behaviour of large underground caverns which are subjected to blast loads. Caverns are generally constructed in hard rock formation which compels us to use blasting methods for the excavation works. Comparative study was done between models with intact rock mass and discontinuities to assess the stability of cavern as a result of blast loads. Numerical modelling was performed with 3 dimensional distinct element code(3 DEC) to analyse the performance of cavern walls in terms of displacement and to compute peak particle velocities(PPV) both around the cavern periphery and at surface of models. Results showed that the velocity wave with higher frequency exhibited large displacements around the periphery of cavern. Computation of PPV showed that model with horizontal joint sets showed lower PPV in comparison to model with intact rock mass. PPV values were also analysed on the surface for model consisting vertical joints spaced at 4 m intervals. Comparative study of PPV on surface vertically above the blast location between models with horizontal joints spaced at 4 m and vertical joints at 4 m intervals were conducted. Results depicted higher magnitudes of PPV for model with vertical joints in comparison to model with horizontal joints.

关键词： Large underground caverns Hard rock formation Numerical modelling 3 dimenssional distinct element code Peak particle velocities

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Biological and mechanical investigation of novel flax/silk protein-based nanofibrous scaffold for bone regeneration

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Progress in Natural Science:Materials International 2022年第4期32卷 443-455页

作者： M.rama U.Vijayalakshmi Department of Chemistry School of Advanced Sciences Vellore Institute of Technology

The process of bone tissue regeneration involves an intricate network of a biological macromolecules that includes proteins and peptides to support stimulation and healing response. Here, we have fabricated a novel flaxseed/silk fibroin based(dual protein) composite nanofibers using β-TCP to improve the biological properties and promote cartilage tissue regeneration along with a controllable rate of biodegradation. The physiochemical properties of PVA/β-TCP/FP:SF were characterized by FTIR, XRD, SEM, porosity, contact angle measurements and mechanical evaluation etc. This study demonstrates the biological performance of the developed nanofibers by using hemocompatibility, biodegradation ability, and apatite deposition in stimulated body fluid. Moreover, the cell viability assay was performed on MG-63 osteoblast cells and long-term antibacterial rate against E. coli and S. aureus was analysed. Docking results of flax protein and silk fibroin protein further confirmed the stable modes of intramolecular bonding and the most stable electrostatic values using theoretical calculations. Taken together,the experimental results proved that the dual protein-based fibrous scaffold was found to be up-regulated in terms of biological activity with enhanced cell adhesion and proliferation.

关键词： Flax protein Silk fibroin β-TCP Electrospinning Docking Bone regeneration

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MULTIMOORA strategy for solving multi-attribute group decision making (MAGDM) in trapezoidal neutrosophic number environment

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CAAI Transactions on Intelligence Technology 2020年第3期5卷 150-156页

作者： Surapati Pramanik rama Mallick Mathematics Nandalal Ghosh B.T.CollegeKolkataWest BengalIndia Mathematics Indian Institute of Engineering Science and TechnologyShibpurHowrahWest BengalIndia Mathematics Umeschandra CollegeSurya Sen StreetKolkata-700012West BengalIndia

The main purpose of this study is to bring in a new extension of multi-objective optimisation on the basis of ratio analysis plus full multiplicative form(MULTIMOORA)in trapezoidal neutrosophic number(TrNN)*** strategy provides high efficiency and effectiveness in *** new MULTIMOORA strategy consists of three *** components are ratio system approach,reference point approach,and full multiplicative *** develop the proposed strategy,the authors find out three ranking order of alternatives using the three *** final ranking order of the alternatives is based on dominance *** study is original as it first develops the MULTIMOORA strategy in the TrNN environment,which they call *** solve a realistic banking problem involving multi-attribute group decision making in the TrNN environment to reflect the applicability and proficiency of the developed *** also present a comparison between the proposed strategy and the existing tomada de decisao interativa e multicritévio and VlseKriterijumska Optimizcija I Kaompromisno Resenje strategies.

关键词： number decision MULTIMOORA

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Orchestration between ILC2s and Th2 cells in shaping type 2 immune responses

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Cellular & Molecular Immunology 2019年第3期16卷 225-235页

作者： rama Krishna Gurram Jinfang Zhu Molecular and Cellular Immunoregulation Section Laboratory of Immune System BiologyNational Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMD 20892USA

The type 2 immune response is critical for host defense against large parasites such as *** the other hand,dysregulation of the type 2 immune response may cause immunopathological conditions,including asthma,atopic dermatitis,rhinitis,and ***,a balanced type 2 immune response must be achieved to mount effective protection against invading pathogens while avoiding *** classical model of type 2 immunity mainly involves the differentiation of type 2 T helper(Th2)cells and the production of distinct type 2 cytokines,including interleukin-4(IL-4),IL-5,and *** 2 innate lymphoid cells(ILC2s)were recently recognized as another important source of type 2 *** eosinophils,mast cells,and basophils can also express type 2 cytokines and participate in type 2 immune responses to various degrees,the production of type 2 cytokines by the lymphoid lineages,Th2 cells,and ILC2s in particular is the central event during the type 2 immune *** this review,we discuss recent advances in our understanding of how ILC2s and Th2 cells orchestrate type 2 immune responses through direct and indirect interactions.

关键词： Type 2 immune response type 2 T helper cell(Th2) Group 2 innate lymphoid cell(ILC2) Allergy and asthma

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Tribological Properties of A356.2/RHA Composites

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Journal of Materials Science & Technology 2012年第4期28卷 367-372页

作者： D. Siva Prasad A. rama Krishna Department of Mechanical Engineering GITAM University Visakhapatnam Andhra Pradesh India Department of Mechanical Engineering ANDHRA University Visakhapatnam Andhra Pradesh India

Rice husk ash （RHA） is one of the industrial waste byproduct available abundantly in the world. In the present work, an attempt is made to incorporate the RHA particles in the molten aluminum A356,2 alloy. The RHA particles were added into the matrix melt by creating a vortex with the help of a mechanical stirrer and the melt temperature was maintained between 800 and 850 ℃. Dry sliding wear experiments were performed in a pin on disc wear equipment against a chromium steel disc at 30 ℃. Scanning electron microscopy is used to study the wear characteristics of the unreinforced AI alloy and the A356.2/RHA composites. From the experiments it is observed that the composites exhibit higher hardness and resistance to wear as compared to unreinforced AI alloy,

关键词： Rice husk ash A356.2 Aluminum alloy Wear

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Induction of osteoblast differentiation in human adipose derived stem cells by lanthanum ions

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Journal of Rare Earths 2014年第11期32卷 1080-1088页

作者： Harini D Indra R Rajaram A rama Rajaram Department of Biochemistry Central Leather Research Institute Department of Biophysics Central Leather Research Institute

Adipose derived stem cells represent a readily available source of adult stem cells for various biomedical applications. In this study, the proliferation and osteogenic differentiation potential of lanthanum nitrate（La3＋） on human adipose derived mesenchymal stem cells（hADSCs） were investigated for the first time and compared with that of dexamethasone（Dex）. Our results provided evidence that La3＋ at 50 μmol/L concentration promoted proliferation of hADSCs upto 2.4 fold when treated for 21 d in DMEM medium. Treatment of hADSCs with La3＋ containing osteogenic induction medium（α-MEM with ascorbic acid and β-glycerophosphate） for 7 d resulted in higher calcium deposition than that in the presence of Dex（0.1 μmol/L） as shown by Alizarin red S and von Kossa staining. Scanning electron micrographs also showed more extracellular matrix mineralization in the presence of La3＋. After 7 d of treatment with La3＋（10 μmol/L） the expression of RunX2, osteopontin（OP） and osteocalcin（OC） increased 3.4, 5.5 and 2.7 fold respectively. Our results provided evidence that in the presence of La3＋ osteogenic differentiation occurred earlier than that in the presence of Dex.

关键词： hADSCs lanthanum osteoblast differentiation genes calcium deposition SEM RunX2 rare earths

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Performance analysis of ASR system in hybrid DNN-HMM framework using a PWL euclidean activation function

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Frontiers of Computer Science 2021年第4期15卷 185-195页

作者： Anirban DUTTA Gudmalwar ASHISHKUMAR Ch V rama RAO Department of Electronics and Communication Engineering National Institute of Technology MeghalayaShillong 793003India

Automatic Speech Recognition(ASR)is the process of mapping an acoustic speech signal into a human readable text *** systems exploit the Acoustic Component of ASR using the Gaussian Mixture Model-Hidden Markov Model(GMM-HMM)*** NeuralNetwork(DNN)opens up new possibilities to overcome the shortcomings of conventional statistical *** studies modeled the acoustic component of ASR system using DNN in the so called hybrid DNN-HMM *** the context of activation functions used to model the non-linearity in DNN,Rectified Linear Units(ReLU)and maxout units are mostly used in ASR *** paper concentrates on the acoustic component of a hybrid DNN-HMM system by proposing an efficient activation function for the DNN *** by previous works,euclidean norm activation function is proposed to model the non-linearity of the DNN *** non-linearity is shown to belong to the family of Piecewise Linear(PWL)functions having distinct *** functions can capture deep hierarchical features of the *** relevance of the proposal is examined in depth both theoretically and *** performance of the developed ASR system is evaluated in terms of Phone Error Rate(PER)using TIMIT *** results achieve a relative increase in performance by using the proposed function over conventional activation functions.

关键词： deep learning euclidean piecewise linear speech recognition activation function

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