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From London buses to activity trackers:A reflection of 70 years of physical activity research

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Journal of Sport and Health Science 2024年第6期13卷 736-738页

作者： ding ding Ulf Ekelund Prevention Research Collaboration Sydney School of Public HealthFaculty of Medicine and HealthThe University of SydneyCamperdownNSW 2006Australia Charles Perkins Centre The University of SydneyCamperdownNSW 2006Australia Department of Sports Medicine Norwegian School of Sports SciencesOslo 0806Norway Department of Chronic Diseases Norwegian Institute of Public HealthOslo 0213Norway

In 1953,Morris et al.^(1)published their ground-breaking findings among London bus drivers and conductors,linking physical activity to a major chronic disease for the first *** seminal paper marked the birth of a new field—physical activity epidemiology.^(1)Since then,the field has flourished,evidenced by mounting scientific publications.^(2)Our knowledge about the role of physical activity in disease prevention has expanded from coronary heart disease in Morris et al.’s^(1)initial study to dozens of additional diseases and conditions,such as diabetes,cancers,and dementia.^(3)More than 7 decades and thousands of publications later,we critically reflect on several aspects of the progress in physical activity epidemiology.

关键词： epidemiology prevention linking

Towards human-leveled vision systems

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Science China Technological Sciences 2024年第8期67卷 2331-2349页

作者： ding JianHao HUANG TieJun State Key Laboratory of Multimedia Information Processing School of Computer Science Peking University

The human visual system is a complex and interconnected network comprising billions of neurons. It plays an essential role in translating environmental light stimuli into information that guides and shapes human perception and action. Research on the visual system aims to uncover the underlying neural structure principles of human visual perception and their possible ***, there are two main approaches: biological system analysis and simulation, artificial intelligence models based on deep learning. Here we aim to discuss the two approaches to human-level vision systems. Deep learning has significantly impacted the field of vision with achievements in representation, modeling, and hardware design. However, there is still a significant gap between deep learning models and the human visual system in terms of scalability, transferability, and sustainability. The progress of the biological visual system can help fill the gap by further understanding the properties and functions of different components of the system. We take the efforts of reconstructing the retina as an example to illustrate that even if we are unable to replicate the visual system on a computer right now, we can still learn a lot by combining existing research outcomes in neuroscience. At the end of the paper, we suggest tracing back to gradually build visual systems from the computational counterpart of biological structures to achieve a human-level vision system in the future.

关键词： human-leveled vision system deep learning biological visual system

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New advances in the study of Tethyan Geodynamic System

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Science China Earth Sciences 2024年第3期67卷 874-878页

作者： Lin ding State Key Laboratory of Tibetan Plateau Earth System Science(LATPES) Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

Tethyan Ocean was initially proposed by Austrian geologist Eduard Suess in 1893. The study of the Tethyan evolution by European geologists has led to the development of modern geology, but not to the establishment of plate tectonics theory(Trümpy, 2001). With the progress in various studies, the concept of Tethys has evolved from a Mesozoic ocean into three long-term evolving oceans:Proto-Tethys, Paleo-Tethys, and Neo-Tethys (Figure 1), and their life cycles cover the entire Phanerozoic era (Wu et al., 2020).

关键词： geology Mesozoic ocean

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Improvement for creep strength of a second-generation single crystal superalloy by design of heat treatments

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Rare Metals 2024年第1期43卷 342-350页

作者： Wan-Shun Xia xin-Bao Zhao Jia-Chen Xu Quan-Zhao Yue Qing-Qing ding Huan-Chang Duan Yue-Feng Gu Hong-Bin Bei Ze Zhang Institute of Superalloys Science and Technology School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Silicon and Advanced Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China

Design of heat treatments is related to the key technology for development of nickel-based single crystal superalloys(Ni-SXs). Based on the full understanding of the solidification characteristics, this work applies optimization design of heat treatments for a second-generation Ni-SX. Microstructure evolution and creep properties are compared in the material under conventional/standard(Std.) and optimized(Opt.) treatments. For the Std. sample,strong dendritic segregations determine inconsistent microstructure evolution in the dendritic(D) and interdendritic region(ID), while the latter serves as weak area to have the prior microcrack initiation, damaging overall performance of the alloy. The Opt. treatment applies higher homogenization temperature, leading to overall reduced segregations, while not inducing incipient melting. A lower temperature of first-step ageing is used to lower the size ofγ'particles. These help to form the more uniform microstructure in dendritic and interdendritic region and relieve the inconsistent microstructure evolution. The balanced local strength makes ID no longer as the weak area,thus restricting microcrack initiation. Great improvement of high temperature and low stress property is obtained by this progress, leading to the pronounced increase of creep rupture life under 1100 °C/140 MPa.

关键词： Single crystal superalloy Heat treatment Segregation Solidification Creep property

SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2285-2297页

作者： Hui Qian Chen-Hong ding Fang Liu Shi-Jie Chen Chen-Kai Huang Meng-Chao Xiao Xia-Lu Hong Ming-Chen Wang Fang-Zhi Yan Kai ding Ya-Lu Cui Bai-Nan Zheng Jin ding Cheng Luo xin Zhang Wei-Fen Xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Gastroenterology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Drug Discovery and Design Center CAS Key Laboratory of Receptor ResearchState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina Department of Gastroenterology First Affiliated Hospital of Nanchang UniversityNanchangChina Clinical Cancer Institute Center for Translational MedicineNaval Medical UniversityShanghaiChina

The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor ***,the precise molecular mechanisms governing the nuclear import of YAP are not fully *** this study,we have uncovered a crucial role of SOX9 in the activation of ***9 promotes the nuclear translocation of YAP by direct ***,we have identified that the binding between Asp-125 of SOX9 and Arg-124 of YAP is essential for SOX9-YAP interaction and subsequent nuclear entry of ***,we have discovered a novel asymmetrical dimethylation of YAP at Arg-124(YAP-R124me2a)catalyzed by ***-R124me2a enhances the interaction between YAP and SOX9 and is associated with poor prognosis in multiple ***,we disrupted the interaction between SOX9 and YAP using a competitive peptide,S-A1,which mimics anα-helix of SOX9 containing Asp-125.S-A1 significantly inhibits YAP nuclear translocation and effectively suppresses tumor *** study provides the first evidence of SOX9 as a pivotal regulator driving YAP nuclear translocation and presents a potential therapeutic strategy for YAP-driven human cancers by targeting SOX9-YAP interaction.

关键词： interaction interaction precise

Equivalent linear model for seismic damage evaluation of single-degree-of-freedom systems representing reinforced concrete structures considering cyclic degradation behavior

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 637-648页

作者： Lulu Yan ding-Hao Yu Research Center for Geotechnical and Structural Engineering Technology of Liaoning Province Dalian UniversityDalian116622China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

In this study,a novel equivalent damping ratio model that is suitable for reinforced concrete(RC)structures considering cyclic degradation behavior is developed,and a new equivalent linearization analysis method for implementing the proposed equivalent damping ratio model for use in seismic damage evaluation is *** this end,Ibarra’s peak-oriented model,which incorporates an energy-based degradation rule,is selected for representing hysteretic behavior of RC structure,and the optimized equivalent damping for predicting the maximum displacement response is presented by using the empirical method,in which the effect of cyclic degradation is ***,the relationship between the hysteretic energy dissipation of the inelastic system and the elastic strain energy of the equivalent linear system is established so that the proposed equivalent linear system can be directly integrated with the Park-Ang seismic model to implement seismic damage *** to the simplicity of the equivalent linearization method,the proposed method provides an efficient and reliable way of obtaining comprehensive insight into the seismic performance of RC *** verification demonstrates the validity of the proposed method.

关键词： degrading system equivalent linear system equivalent damping seismic damage RC structures

SsdchA is a novel secretory cellobiohydrolase driving pathogenicity in Sclerotinia sclerotiorum

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The Crop Journal 2024年第2期12卷 493-502页

作者： Yangui Chen Yijuan ding Siqi Zhao Nan Yang Zhaohui Wu Ping Zhang Hongmei Liao Mengquan dong Yang Yu Huafang Wan Wei Qian Integrative Science Center of Germplasm Creation in Western China(Chongqing)Science City College of Agronomy and BiotechnologySouthwest UniversityChongqing 400715China Academy of Agricultural Sciences Southwest UniversityChongqing 400715China Engineering Research Center of South Upland Agriculture Ministry of EducationChongqing 400715China College of Plant Protection Southwest UniversityChongqing 400715China

The necrotrophic fungus, Sclerotinia sclerotiorum, employs an array of cell wall-degrading enzymes(CWDEs), including cellulase, to dismantle host cell walls. However, the molecular mechanisms through which S. sclerotiorum degrades cellulose remain elusive. Here, we unveil a novel secretory cellobiohydrolase, SsdchA, characterized by a signal peptide and a Glyco_hydro_7(GH7) domain. SsdchA exhibits a robust expression of during early infection stages. Interestingly, colony morphology and growth rates remain unaffected across the wild-type, SsdchA deletion strains and SsdchA overexpression strains on potato dextrose agar(PDA) medium. Nevertheless, the pathogenicity and cellobiohydrolase activity decreased in the SsdchA deletion strains, but enhanced in the SsdchA overexpression strains. Moreover,the heterologous expression of SsdchA in Arabidopsis thaliana leads to reduced cellulose content and heightened susceptibility to S. sclerotiorum. Collectively, our data underscore the pivotal role of the novel cellobiohydrolase SsdchA in the pathogenicity of S. sclerotiorum.

关键词： Cellobiohydrolase Cellulose Pathogenicity Sclerotinia sclerotiorum Secretory protein SsdchA

Hapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping

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Journal of Pharmaceutical Analysis 2024年第3期14卷 335-347页

作者： ding-Jun Hao Yue Qin Shi-Jie Zhou Bu-Huai dong Jun-Song Yang Peng Zou Li-Ping Wang Yuan-Ting Zhao Department of Spine Surgery Honghui HospitalXi'an Jiaotong UniversityXi'an710054China Department of Anesthesiology Honghui HospitalXi'an Jiaotong UniversityXi'an710054China Department of Cardiovascular Medicine Honghui HospitalXi'an Jiaotong UniversityXi'an710054China State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy West China HospitalSichuan UniversityChengdu610041China

Hyaluronan and proteoglycan link protein 1(Hapln1)supports active cardiomyogenesis in zebrafish hearts,but its regulation in mammal cardiomyocytes is *** study aimed to explore the potential regulation of Hapln1 in the dedifferentiation and proliferation of cardiomyocytes and its therapeutic value in myocardial infarction with human induced pluripotent stem cell(hiPSC)-derived cardiomyocytes(CMs)and an adult mouse model of myocardial ***-CMs and adult mice with myocardial infarction were used as in vitro and in vivo models,*** single-cell RNA sequencing data were retrieved for bioinformatic *** results showed that recombinant human Hapln1(rhHapln1)promotes the proliferation of hiPSC-CMs in a dose-dependent *** a physical binding protein of Hapln1,versican interacted with Nodal growth differentiation factor(NODAL)and growth differentiation factor 11(GDF11).GDF11,but not NODAL,was expressed by ***11 expression was unaffected by rhHapln1 ***,this molecule was required for rhHapln1-mediated activation of the transforming growth factor(TGF)-β/Drosophila mothers against decapentaplegic protein(SMAD)2/3 signaling in hiPSC-CMs,which stimulates cell dedifferentiation and *** mouse Hapln1(rmHapln1)could induce cardiac regeneration in the adult mouse model of myocardial *** addition,rmHapln1 induced hiPSC-CM *** conclusion,Hapln1 can stimulate the dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping and subsequent activation of the TGF-β/SMAD2/3 signaling ***1 might be an effective hiPSC-CM dedifferentiation and proliferation agent and a potential reagent for repairing damaged hearts.

关键词： Hapln1 Versican GDF11 iPSC-CMs Cardiomyocyte proliferation

Electrical uniformity analyses on 12-inch Si-based Hf0.5Zr0.5O2 ferroelectric capacitor devices by atomic layer deposition

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Progress in Natural Science:Materials International 2024年第3期34卷 598-605页

作者： Wen-Juan ding Yu Liu Zhi-Qiang Xiao Li Gao Yu-Chen Li Lin Zhu Xiang Li Wei-Min Li Shuang Chen Ai-dong Li National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences and Collaborative Innovation Center of Advanced MicrostructuresNanjing University Jiangsu Leadmicro Nano-Technology Co. Ltd. Semiconductor Manufacturing North China Corp. Kuang Yaming Honors School Nanjing University

The study on the uniformity of electrical performance of large wafer-scale Hf0.5Zr0.5O2（HZO） ferroelectric capacitors is still lacking yet now. In this work, TiN/HZO/TiN metal-ferroelectric-metal（MFM） devices on 12-inch silicon wafers have been fabricated by thermal atomic layer deposition. The correlation of thickness uniformity with device-to-device variation of electrical properties and yield of the 12-inch MFM system was investigated. It was found that the uniformity of ferroelectric properties is closely related to the variation of HZO thickness of the MFM system, the concentration of oxygen vacancies in the micro-region of the HZO film, and the ferroelectric phase micro-distribution on 12-inch Si wafer. This work provides some important information for the performance optimization of HfO2-based ferroelectric random access memories.

关键词： 12-Inch Si wafer Atomic layer deposition Electrical uniformity Ferroelectric random access memory Hf0.5Zr0.5O2 ferroelectric thin film