检索结果-南通市图书馆

Jianpi Decoction Combined with Medroxyprogesterone Acetate Alleviates Cancer Cachexia and Prevents Muscle Atrophy by directly Inhibiting E3 Ubiquitin Ligase

引用

Chinese Journal of Integrative Medicine 2024年第6期30卷 499-506页

作者： LI Qi KONG Zhao-di WANG huan GU hong-hui ChEN Zhong Li Shi-guang ChEN Yi-qi CAI Yu YANG Zhen-jiang Department of Oncology and hematology Shenzhen Traditional Chinese Medicine HospitalShenzhenGuangdong Province518033China College of Pharmacy/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of China Jinan UniversityGuangzhou510632China Guangdong Key Lab of Traditional Chinese Medicine Information Technology Jinan UniversityGuangzhou510632China

ObjectiveTo provide comprehensive evidence for the anti-cancer cachexia effect of Jianpi Decoction(JP)and to explore its mechanism of anti-cancer *** mouse model of colon cancer(CT26)-induced cancer cachexia(CC)was used to investigate the anti-CC effect of JP combined with medroxyprogesterone acetate(MPA).Thirty-six mice were equally divided into 6 groups:normal control,CC,MPA(100 mg·kg^(−1)·d^(−1)),MPA+low-dose(20 mg·kg^(−1)·d^(−1))JP(L-JP),MPA+medium-dose(30 mg·kg^(−1)·d^(−1))JP(M-JP),and MPA+high-dose(40 mg·kg^(−1)·d^(−1))JP(h-JP)*** successful modeling,the mice were administered by gavage for 11 *** body weight and tumor volume were measured and recorded every 2 d starting on the 8th day after *** liver,heart,spleen,lung,kidney,tumor and gastrocnemius muscle of mice were collected and *** pathological changes of the tumor was observed,and the cross-sectional area of the gastrocnemius muscle was *** protein expressions of STAT3 and E3 ubiquitinase in the gastrocnemius muscle were measured by Western *** addition,an in vitro C2C12 myotube formation model was established to investigate the role of JP in hindering dexamethasone-induced muscle *** vitro experiments were divided into control,model,and JP serum *** 2-d administration,microscopic photographs were taken and myotube diameters were *** blot was performed to measure the protein expressions of STAT3 and E3 *** combined with MPA restored tumor-induced weight loss(Phanistically,JP reduced the expression of atrophy-related proteins MuRF1 and MAFbx in tumor-induced muscle atrophy in vivo(Pdition,JP reduced the expression of atrophy-related proteins MuRF1 and MAFbx and p-STAT3 phosphorylation(Ph dexamethasone in *** of JP combined with MPA restores t

关键词： cancer cachexia muscle atrophy Jianpi Decoction Chinese medicine E3 ubiquitin ligases

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multiscale control of MnO_(2) growth via[WO_(6)]-perturbed[MnO_(6)]assembly toward a favorable balance between capacitance and rate performance

引用

Rare Metals 2024年第4期43卷 1658-1671页

作者： Jin-Kang Liu Tian-Shuo Yang Zhi-Bin Ren Adekunle-Adedapo Obisanya Xin-Yi Tan Yan-di Rao Jun-Shuang Zhou Fa-Ming Gao Jian-Ren Wang hebei Key Laboratory of Applied Chemistry Yanshan UniversityQinhuangdao066004China

Although pseudocapacitive manganese dioxide(MnO_(2))integrates the high-power merit of carbonaceous materials with the high-energy merit of battery-type materials,it still has a long way to go in achieving a more satisfactory balance of higher energy and power density,and in decoupling the relationship of structural characteristics with energy storage *** realize such goals,a bottom-up[WO_(6)]-perturbed[MnO_(6)]assembly strategy has been developed here due to their similar structure,yet mismatched lattice *** facile protocol is capable of finely controlling the morphology and crystal structure of MnO_(2)by adjusting its internal[WO_(6)]***,the as-prepared W_xMnO_(2)is treated as an ideal platform to scrutinize the correlations of the structure with the energy storage *** operando Raman spectra and finite element analysis have fully demonstrated the superiority of the locally ordered defects-enriched structure of W_(0.02)-MnO_(2),which could reach a favorable balance between the ion diffusion equilibrium time and the number of active *** a result,the W_(0.02)-MnO_(2)is able to deliver a high capacitance of 292 F·g^(-1)at a current density of 1 A·g^(-1)and a remarkable rate performance with a 60%capacity retention at a current density of 50 A·g^(-1).The further unveiled structure-performance relationship provides a guideline for the design of better pseudocapacitive energy storage devices.

关键词： Supercapacitors Pseudocapacitive materials MnO_(2) Tungsten doping Crystal structure regulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

hydrogen production from hydrolysis of NaBh_(4) solution over Co-Fe-B@g-C_(3)N_(4)/NF thin film catalyst

引用

Rare Metals 2024年第6期43卷 2648-2659页

作者： Yan Wang Jia-Xin Ma Jian Ren di Zhang Feng-Yan Xu Ke Zhang Zhong-Qiu Cao Qiu-Ju Sun Guo-De Li Shi-Wei Wu hong-hui Chen College of Chemistry and Chemical Engineering Shenyang Normal UniversityShenyang 110034China Experimental Center Shenyang Normal UniversityShenyang 110034China hunan Shande Energy Storage New Materials Research Institute Limited Company Changde 415000China

In this study,the double loaded Co-Fe-B@g-C_(3)N_(4)/NF(NF:Ni foam)thin film catalysts were prepared for the first time via chemical deposition method at room *** optimizing the reducing agent concentration to 0.9 mol·L^(-1),the as-obtained Co-Fe-B@g-C_(3)N_(4)/NF exhibited the twisted ribbon structure with more distinct three-dimensional hierarchy and the smaller particle size,showing the good catalytic property for the hydrolysis of NaBh_(4)*** h_(2)generation rate of Co-Fe-B@g-C_(3)N_(4)/NF and binary Co-B@g-C_(3)N_(4)/NF under visible light irradiation surpassed the value under natural *** apparent activation energy of Co-Fe-B@g-C_(3)N_(4)/NF(45.0 kJ·mol^(-1))under visible light irradiation was obviously reduced when compared with the natural condition(48.4 kJ·mol^(-1))and binary Co-B@g-C_(3)N_(4)/NF(60.6 kJ·mol^(-1))under visible light ***,the catalytic performance of the optimized Co-Fe-B@g-C_(3)N_(4)/NF thin film catalyst was superior to most of the reported non-noble metal and even noble metal ***,it illustrated that the catalytic h_(2)production performance of Co-Fe-B@g-C_(3)N_(4)/NF thin film was distinctly improved after the introduction of light and multicomponent recombination.

关键词： Sodium borohydride Co-Fe-B@g-C_(3)N_(4)/NF catalyst Chemical deposition hydrogen production

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Robust hybrid bismuth perovskites as potential photocatalysts for overall water splitting

引用

Nano Research 2024年第5期17卷 4593-4601页

作者： Antonio J.Chacón-García herme G.Baldovi Artem A.Babaryk Antonio Rodríguez-diéguez Sergio Navalón Yolanda Pérez hermenegildo García Patricia horcajada Advanced Porous Materials Unit IMDEA Energy InstituteAvda.Ramón y Cajal 328935 MóstolesMadridSpain Departamento de Química Universitat Politècnica de València46022 ValènciaSpain Departamento Química Inorgánica Universidad de Granada1807GranadaSpain Departamento de Biología y Geología Física y Química Inorgánica.ESCET.Universidad Rey Juan Carlos28933 MóstolesMadridSpain Instituto de tecnología química CSIC-UPV Universitat Politècnica de València(UPV)46022Spain

Organic-inorganic hybrid perovskites have gained great attention as promising photocatalysts for hydrogen ***,due to their poor stability in water,the use of aqueous hydrohalic acid solutions is specifically required for an efficient hydrogen ***,three novel photoactive lead-free hybrid perovskites based on bismuth and triazolium cations(denoted as IEF-15,IEF-16,and IEF-17(IEF stands for IMDEA energy frameworks))were synthesized and fully characterized(structural,compositional,optical,etc.).Further,these solids were proposed as photocatalysts for the challenging gas phase overall water splitting(OWS)***,IEF-16 thin films exhibited a remarkable photocatalytic activity in both h_(2) and O_(2) evolution,as a consequence of its appropriate bandgap and energy-band alignment,achieving hydrogen evolution rates ofμmol·g_(h_(2))^(-)1846 and 360 after 24 h under ultraviolet-visible(UV-vis)irradiation or simulated solar irradiation,*** study additionally highlights the remarkable structural and photochemical stability of IEF-16 under different operational conditions(*** volume,irradiation and temperature),paving the way for green hydrogen production from OWS using perovskite-based photocatalysts.

关键词： bismuth-based hybrid perovskites thin films photocatalysis overall water splitting green hydrogen

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

hexavalent Chromium Cr (VI) Removal from Water by Mango Kernel Powder

引用

Journal of Materials Science and Chemical Engineering 2024年第1期12卷 84-103页

作者： Amadou Sarr Gning Cheikh Gaye Antoine Blaise Kama Pape Abdoulaye diaw diène diégane Thiare Modou Fall Laboratoire de Chimie Physique Organique et d’Analyses Environnementales (LCPOAE) Université Cheikh Anta Diop Dakar Sénégal Equipe Chimie des Matériaux Inorganique et Organique (ECMIO) Université Alioune Diop Bambey Sénégal Equipe des Matériaux Electrochimie et Photochimie Analytiques (EMEPA) Université Alioune Diop Bambey Sénégal Laboratoire de Photochimie et d’Analyse (LPA) Université Cheikh Anta Diop Dakar Sénégal

Metal trace elements (MTE) are among the most harmful micropollutants of natural waters. Eliminating them helps improve the quality and safety of drinking water and protect human health. In this work, we used mango kernel powder (MKP) as bioadsorbent material for removal of Cr (VI) from water. Uv-visible spectroscopy was used to monitor and quantify Cr (VI) during processing using the Beer-Lambert formula. Some parameters such as ph, mango powder, mass and contact time were optimized to determine adsorption capacity and chromium removal rate. Adsorption kinetics, equilibrium, isotherms and thermodynamic parameters such as ΔG˚, Δh˚, and ΔS˚, as well as FTIR were studied to better understand the Cr (VI) removal process by MKP. The adsorption capacity reached 94.87 mg/g, for an optimal contact time of 30 min at 298 K. The obtained results are in accordance with a pseudo-second order Freundlich adsorption isotherm model. Finally FTIR was used to monitor the evolution of absorption bands, while Scanning Electron Microscopy (SEM) and Energy dispersive X-ray Spectroscopy (EDS) were used to evaluate surface properties and morphology of the adsorbent.

关键词： Adsorption Chromium Mango Kernel Powder Spectroscopy Analysis Water Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advanced hepatocellular carcinoma in a patient with neurofibromatosis type 1 and malignant peripheral nerve sheath tumor

引用

hepatobiliary & Pancreatic diseases International 2024年第5期23卷 530-532页

作者： Ahmad Alhaskawi Yan-Zhao Dong Xiao-di Zou Sohaib hasan Abdullah Ezzi Ze-Wei Wang hai-Ying Zhou Sahar Ahmed Abdalbary hui Lu Department of Orthopedics the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Chinese Medicine the Second Affiliated HospitalZhejiang Chinese Medical UniversityHangzhou 310005China Department of Orthopedics the Third Xiangya HospitalCentral South UniversityChangsha 410083China Zhejiang University School of Medicine Hangzhou 310000China Department of Orthopedic Physical Therapy Faculty of Physical TherapyNahda University in Beni SuefBeni SuefEgypt

To the Editor: Neurofibromatosis type 1(NF-1), or Von Recklinghausen disease, is a genetic disorder inherited in an autosomal dominant pattern. It is caused by a mutation in the neurofibromin gene located on chromosome 17, accounting for 96% of all neurofibromatosis cases. This condition can affect multiple systems and often leads to the formation of tumors along the nervous system [1]. Patients with NF-1 may exhibit various symptoms, including Lisch nodules, neurofibromas, scoliosis, café au lait spots, learning disabilities, vision disorders, and epilepsy.

关键词： epilepsy hepatocellular malignant

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

改良悬雍垂腭咽成形术对体位依赖性和非体位依赖性OSA疗效差异性和预测因素分析

引用

临床耳鼻咽喉头颈外科杂志 2024年第8期38卷 703-709页

作者：张荧赵迪浙江大学医学院附属第二医院耳鼻咽喉科杭州310000

目的:分析影响体位依赖性(positional obstructive sleep apnea,POSA)和非体位依赖性OSA(non-positional OSA,NPOSA)患者悬雍垂腭咽成形术疗效的因素,并探讨二者影响因素之间的差异。方法:回顾性分析2020年11月-2023年11月在浙江大学医... 详细信息

目的:分析影响体位依赖性(positional obstructive sleep apnea,POSA)和非体位依赖性OSA(non-positional OSA,NPOSA)患者悬雍垂腭咽成形术疗效的因素,并探讨二者影响因素之间的差异。方法:回顾性分析2020年11月-2023年11月在浙江大学医学院附属第二医院耳鼻咽喉科接受治疗并追踪随访的101例OSA患者的临床资料,其中45例POSA患者,56例NPOSA患者,均行夜间睡眠呼吸监测及三维计算机断层扫描(3D-CT)评估上气道解剖结构。患者均接受保留悬雍垂的改良腭咽成形术(han-uvulopalatopharyngoplasty,h-UPPP),术后3个月随访。结果:手术总体有效率为55.45%,接受h-UPPP的POSA手术成功率(30/45,66.7%)高于NPOSA(26/56,46.4%),2组比较差异有统计学意义(P=0.042)。POSA的h-UPPP疗效与腭咽部气道最小左右径(r=-0.505,Ph-UPPP手术疗效高于NPOSA。舌咽部mLAT是影响POSA疗效的重要预测因素。年龄是影响NPOSA疗效的预测因素。

关键词：体位改良悬雍垂腭咽成形术阻塞性睡眠呼吸暂停低通气治疗结果

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Elaborating strengthen mechanism of Pt-Ir solid solution superalloy at finite temperature

引用

Rare Metals 2024年第3期43卷 1243-1256页

作者： Wei Yu Xiao-Yu Chong Yun-Xuan Zhou Meng-di Gan Ying-Xue Liang Yan Wei Ai-Min Zhang Chang-Yi hu Xing-Yu Gao Li Chen hai-Feng Song Jing Feng Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming650093China Yunnan Precious Metals Laboratory Co.LTD Kunming650106China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing100088China

Pt-Ir alloy is potential superalloys used above 1300℃because of their high strength and creep ***,the ductility of Pt-Ir alloy has rapidly deteriorated with the increase of Ir,resulting in poor *** work quantitatively evaluated the solid solution strengthening(SSS)and grain refinement strengthening(GRS)of Pt-Ir alloy using first-principles calculations combined with experimental ***,the stretching force constants in the second nearest neighbor region(SFC^(2nd))of pure Ir(193.7 eV·nm^(-2))are 3.40 times that of pure Pt(57.0 eV·nm^(-2)),i.e.,the interatomic interaction is greatly enhanced with the increase of Ir content,which leads to the decrease of ductility,and modulus misfit plays a dominant role in ***,the physical mechanisms responsible for the hardness(h_(V))of Pt-Ir alloy,using the power-law-scaled function of electron work function coupled SSS and GRS,are attributed to the electron redistribution caused by different Ir ***,a thorough assessment of the thermodynamic characteristics of Pt-Ir binary alloy was conducted,culminating in development of a mapping model that effectively relates enmposition,temperature and *** results revealed that the compressive strength incrcases with the Ir content,and the highest strength was observed in Pt_(0.25)Ir_(0.75).This study provides valuable insights into the Pt-Ir alloy system.

关键词： Elastic properties Phonon Solid solution strengthen Force constants CALPhAD

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

福州都市圈市域铁路网络架构研究

引用

城市轨道交通研究 2024年第4期27卷 11-16页

作者：胡迪中铁上海设计院集团有限公司上海200070

[目的]为应对福州都市圈的发展要求,需构建与其他轨道交通方式高效融合的市域(郊)铁路网,大幅提升福州市中心城区与外围组团、临近郊县之间的空间效应,缩短福州都市圈内交通出行时间,满足福州都市圈主圈层1 h通勤圈的交通需求。[方法]... 详细信息

[目的]为应对福州都市圈的发展要求,需构建与其他轨道交通方式高效融合的市域(郊)铁路网,大幅提升福州市中心城区与外围组团、临近郊县之间的空间效应,缩短福州都市圈内交通出行时间,满足福州都市圈主圈层1 h通勤圈的交通需求。[方法]在阐述福州都市圈社会经济及轨道交通概况的基础上,参考国内外都市圈的发展经验,对福州都市圈圈层尺度进行识别,将福州都市圈分为1个主圈层(含交通半径为40 km的通勤圈、交通半径为70 km的辐射圈)和4个次圈层。采用以“功能层次法”为基础、以“节点锚固法”+“点线面法”为支撑的技术方法,提出了福州都市圈主圈层市域铁路网络规划方案,并对该方案进行了效果评价。[结果及结论]该方案对促进福州都市圈内新型城镇化建设、拓宽中心城市发展空间、扩大城市轨道交通辐射半径、提高福州都市圈1 h通勤圈协同发展水平均具有重要的支撑意义。

关键词：市域铁路福州都市圈网络架构圈层交通节点

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

引用

Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina hromada Patrick heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.heinzel Antal Nógrádi Andreas h.Teuschl-Woller David hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). however, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：