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Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu zhang Yuqi Liu fangxia Xu Chengcheng Zhou Kaimei Lu Bin fang Lijuan Wang Lina Huang Zifeng Xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

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Electrode/Electrolyte Optimization‑Induced Double‑Layered Architecture for High‑Performance Aqueous Zinc‑(Dual)Halogen Batteries

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Nano-Micro Letters 2025年第3期17卷 121-137页

作者： Chengwang Zhou Zhezheng ding Shengzhe Ying Hao Jiang Yan Wang Timing fang You zhang Bing Sun Xiao Tang Xiaomin Liu School of Textiles and Clothing School of Chemistry and Chemical EngineeringQingdao UniversityQingdao 266071ShandongPeople’s Republic of China Centre for Clean Energy Technology School of Mathematical and Physical SciencesFaculty of ScienceUniversity of Technology SydneyUltimoNSW 2007Australia School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007HenanPeople’s Republic of China

Aqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources,intrinsic safety,and high theoretical ***,the uncontrollable zinc dendrite growth and spontaneous shuttle effect of active species have prohibited their practical ***,a double-layered protective film based on zinc-ethylenediamine tetramethylene phosphonic acid(ZEA)artificial film and ZnF2-rich solid electrolyte interphase(SEI)layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic *** ZEA-based artificial film shows strong affinity for the ZnF2-rich SEI layer,therefore effectively suppressing the SEI breakage and facilitating the construction of double-layered protective film on the zinc metal *** double-layered architecture not only modulates Zn2+flux and suppresses the zinc dendrite growth,but also blocks the direct contact between the metal anode and electrolyte,thus mitigating the corrosion from the active *** employing optimized metal anodes and electrolytes,the as-developed zinc-(dual)halogen batteries present high areal capacity and satisfactory cycling *** work provides a new avenue for developing aqueous zinc-(dual)halogen batteries.

关键词： Zn metal anodes Double-layered protective film Electrode/electrolyte optimization Aqueous zinc-(dual)halogen batteries

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Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia fang Zhuangzhuang Li Pengjun Wang Xiaoxu zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

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Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第01期 297-307页

作者： Bin fang Limin Wang Haoqin Li Jiaxin zhang Yang ding Pan Pan Li Bo Peng Hua Bai Lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

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Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： Jiang-Yu Bian Yu-fang Feng Wen-Ting He Tong zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(Pdicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

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Nitrogen addition promotes soil carbon accumulation globally

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Science China Life Sciences 2025年第1期 284-293页

作者： Xuemei Yang Suhui Ma Erhan Huang Danhua zhang Guoping Chen Jiangling Zhu Chengjun Ji Biao Zhu Lingli Liu Jingyun fang Institute of Ecology College of Urban and Environmental Sciencesand Key Laboratory for Earth Surface Processes of the Ministry of EducationPeking University Ministry of Education Key Laboratory for Transboundary Ecosecurity of Southwest China School of Ecology and Environmental ScienceYunnan University State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of Sciences

Soil is the largest carbon(C) reservoir in terrestrial ecosystems and plays a crucial role in regulating the global C cycle and climate *** nitrogen(N) deposition has been widely considered as a critical factor affecting soil organic carbon(SOC) storage, but its effect on SOC components with different stability remains unclear. Here, we analyzed extensive empirical data from 304 sites worldwide to investigate how SOC and its components respond to N addition. Our analysis showed that N addition led to a significant increase in bulk SOC(6.7%), with greater increases in croplands(10.6%) and forests(6.0%) compared to grasslands(2.1%). Regarding SOC components, N addition promoted the accumulation of plant-derived C(9.7%–28.5%) over microbial-derived C(0.2%), as well as labile(5.7%) over recalcitrant components(–1.2%), resulting in a shift towards increased accumulation of plant-derived labile C. Consistently, N addition led to a greater increase in particulate organic C(11.9%) than mineral-associated organic C(3.6%), suggesting that N addition promotes C accumulation across all pools, with more increase in unstable than stable pools. The responses of SOC and its components were best predicted by the N addition rate and net primary productivity. Overall, our findings suggest that N enrichment could promote the accumulation of plant-derived and non-mineral associated C and a subsequent decrease in the overall stability of soil C pool, which underscores the importance of considering the effects of N enrichment on SOC components for a better understanding of C dynamics in soils.

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先进氧化法处理海水的试验研究

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水处理技术 2005年第2期31卷 13-16,20页

作者：白敏菂邓淑芳张芝涛白希尧大连海事大学环境工程研究所辽宁大连116026

先进氧化方法是对传统的氧化化学思维的更新和发展。它是从源头上解决环境污染问题。采用常压强电场电离放电方法,把HO、O加工成高浓度、大产量的OH·等自由基,成功解决了先进氧化OH·处理水22的工程化疑难问题,实现了在低浓度(0.6mg/L... 详细信息

先进氧化方法是对传统的氧化化学思维的更新和发展。它是从源头上解决环境污染问题。采用常压强电场电离放电方法,把HO、O加工成高浓度、大产量的OH·等自由基,成功解决了先进氧化OH·处理水22的工程化疑难问题,实现了在低浓度(0.6mg/L)、快速(2.8s)条件下大幅度改善水质,对水中亚硝酸盐、铵盐减少98.4%和99.5%,COD未检出,由于羟基对细胞残骸的氧化分解,才促使TOC有所上升,水中金属离子Cd2+、Pb2+、Hg2+、Fe2+和Fe3+以及非金属As等有不同程度减少。对水中单胞藻、原生动物、细菌致死均达到100%,又把生物尸体分解成HO、CO和微量无机盐,水中剩余羟基将分解成HO、O。从上述试验数据表明,2222强电离放电先进氧化剂OH·处理海水达到了绿色化学12条原则的要求。

关键词： COD 强电离放电氧化法 Cd^2+ 环境污染问题 pb^2+ Hg^2+ 处理检出致死

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自媒体时代教师博主行为的失范与规范

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教学与管理 2025年第2期 20-23页

作者：张婷李芳中国教育报刊社融媒体协调中心北京师范大学中国教育与社会发展研究院

教师博主是自媒体时代的产物，在缺乏管理的情形下，教师的特殊身份引发了诸多争议，特别是基础教育学段的教师博主受到公众诸多批评，如教师形象过度功利化、利用学生赚取流量等。当前，基础教育学段教师博主的规范处于法律法规监管的... 详细信息

教师博主是自媒体时代的产物，在缺乏管理的情形下，教师的特殊身份引发了诸多争议，特别是基础教育学段的教师博主受到公众诸多批评，如教师形象过度功利化、利用学生赚取流量等。当前，基础教育学段教师博主的规范处于法律法规监管的真空地带，存在上位管理文件缺失、教育部门监管难度大、跨部门协调监管难等问题。因此，急需加强立法与制度体系建设，为依法管理提供依据；持续推进师德师风建设，增强自我约束的内在动力；健全多渠道监督机制，构建规范行事的外部约束网络等，从而明晰教师博主的权责界限，发挥社交平台正向的育人功能。

关键词：教师博主网红教师基础教育教师师德师风

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High‑Efciency g‑C_(3)N_(4) Based Photocatalysts for CO_(2) Reduction:Modifcation Methods

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Advanced Fiber Materials 2022年第3期4卷 342-360页

作者： Qingtong Wang Zixi fang Wang zhang di zhang State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong University800#Dongchuan Rd.Shanghai 200240People’s Republic of China

Photocatalysis is an efective means to solve the greenhouse efect caused by the large amount of carbon dioxide(CO_(2))emissions from fossil fuel *** carbon nitride(g-C_(3)N_(4))has the advantages of suitable band gap,easy preparation,low price,and good stability,making it a promising semiconductor ***,bulk g-C3N4 also has disadvantages such as low gas adsorption,low photocatalytic efciency,narrow spectral response,and easy recombination of electron–hole *** modifcation method based on g-C_(3)N_(4) photocatalyst helps to improve the above-mentioned *** review summarizes the research progress in recent years from four aspects:morphology adjustment,co-catalysts,heterostructures and *** aspect includes the pros and cons of diferent improvement methods,the comparison of theoretical calculations and experimental results,the application of diferent characterization methods,and the detailed listing of product yield and *** to this,there was an explanation of the basic theory of semiconductor photocatalytic CO_(2) ***,the future challenges and development prospects are also briefy prospected.

关键词： g-C_(3)N_(4) Photocatalytic CO_(2)reduction Morphology adjustment Co-catalysts Heterostructures Doping

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Restoration of Ultimate Strength of Dented Hemispheres Under External Hydrostatic Pressure

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China Ocean Engineering 2022年第3期36卷 500-507页

作者： HUANG Chen zhang Jian WANG fang di Chen-yang School of Mechanical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Shanghai Engineering Research Center of Hadal Science and Technology Shanghai Ocean UniversityShanghai 201306China

This study aimed to restore the ultimate strength of dented stainless-steel hemispheres with a radius of 90 mm and a thickness of 0.86 *** of the hemispheres were subjected to external hydrostatic *** stainless-steel stiffened caps were used to eliminate the effect of indention on the ultimate *** caps had a radius of 36 mm,a thickness of 0.76 mm,and a height of 10.44 *** hemispherical samples,including two intact hemispheres,two dented hemispheres without stiffening,and two dented hemispheres with stiffening,were *** hemi-sphere was geometrically measured for shape and thickness,hydrostatically tested for destruction,and numerically evaluated for *** experimental and numerical data agreed well with each *** a result,a spherical cap can effectively restore the ultimate strength of dented hemispheres under external hydrostatic *** proposed restoration approach can be used to strengthen underwater pressure hulls with large local geometric imperfections.

关键词： hemisphere restoration ultimate strength hydrostatic pressure buckling

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