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Tool-tip vibration prediction based on a novel convolutional enhanced transformer

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International Journal of Mechanical System Dynamics 2024年第1期4卷 34-47页

作者： Adeel Shehzad Xiaoting Rui Yuanyuan ding Yu Chang Jianshu Zhang Hanjing Lu Yiheng chen Institute of Launch Dynamics Nanjing University of Science&TechnologyNanjingChina Automotive Engineering Centre University of Engineering&TechnologyLahorePakistan School of Science Nanjing University of Science and TechnologyNanjingChina College of Engineering Peking UniversityBeijingChina

Superior surface finish remains a fundamental criterion in precision machining operations,and tool-tip vibration is an important factor that significantly influences the quality of the machined ***-based models heavily rely on assumptions for model simplification when applied to complex high-end ***,these assumptions may come at the cost of compromising the model's *** contrast,data-driven techniques have emerged as an attractive alternative for tasks such as prediction and complex system *** exploit the advantages of data-driven models,this study introduces a novel convolutional enhanced transformer model for tool-tip vibration prediction,referred to as *** effectiveness of this model is demonstrated through its successful application in ultra-precision fly-cutting(UPFC)*** distinct variants of the model,namely,guided and nonguided CeT-TV,were developed and rigorously tested on a data set custom-tailored for UPFC *** results reveal that the guided CeT-TV model exhibits outstanding performance,characterized by the lowest mean absolute error and root mean square error ***,the model demonstrates excellent agreement between the predicted values and the actual measurements,thus underlining its efficiency and potential for predicting the tool-tip vibration in the context of UPFC.

关键词： tool-tip vibration ultraprecision fly cutting data-driven modeling transformer

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基于纯音测听诊断噪声聋的临床研究

中国医学文摘（耳鼻咽喉科学） 2024年第5期39卷 69-72页

作者：陈韵吴健聪佛山市职业健康研究院广东佛山528000

目的探讨分析基于纯音测听诊断噪声聋方面的实际效果和临床价值,为更加有效准确地开展噪声聋诊断,防治职业性噪声聋提供参考依据。方法选取2021年1月2022年9月期间在我所进行噪声聋诊断分析的212例疑似职业性噪声聋患者为研究对象,对所... 详细信息

目的探讨分析基于纯音测听诊断噪声聋方面的实际效果和临床价值,为更加有效准确地开展噪声聋诊断,防治职业性噪声聋提供参考依据。方法选取2021年1月2022年9月期间在我所进行噪声聋诊断分析的212例疑似职业性噪声聋患者为研究对象,对所有研究对象进行三次纯音测听测试,将三次测试结果相比较,计算出三次听阀均值差别、频率差别范围标准差、均值,综合上述研究结果评估基于纯音测听测定在诊断噪声聋方面的实际效果和临床价值。结果以三次纯音听阈测试结果进行对比,通过对比结果可得出,183例研究对象(366耳)连续三次纯音测听结果听阈均值差除个别频率外,其余各频率均介于-0.2至1.4dB。最大标准差于3KHz处为16.9dB,三次听阈测定差值均在土5dB允许误差范围之内。结论纯音测听结果可以作为职业性噪声聋评定和鉴别的参照,整体可靠性和参照性较高,同时纯音测听测定检查方法简单易操作,同时具备快速、无创的优点,必要时可配合其他综合听力测试,进一步实现对职业性噪声聋的客观诊断判定。

关键词：纯音测听职业性噪声聋伪聋

Electrosynthesis of H_(2)O_(2)via two-electron oxygen reduction over carbon-based catalysts:From microenvironment control to electrode/reactor design

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Energy Reviews 2024年第2期3卷 117-135页

作者： Jingjing Jia Zhenxin Li yunrui Tian Xia Li Rui chen Jiachen Liu Ji Liang Key Laboratory of Advanced Ceramics and Machining Technology Ministry of EducationSchool of Materials Science and EngineeringTianjin UniversityTianjinChina

The electrochemical production of hydrogen peroxide(H_(2)O_(2))by the two-electron oxygen reduction(2e^(-)ORR)process has the advantages of high safety,low energy consumption,and environmental *** 2e^(-)ORR,the catalyst/electrode is the key component as it strongly affects catalytic performance and *** materials have the advantages of high electronic conductivity,good structural stability,easy control of nanostructures,and low ***,it has been regarded as a promising catalyst/electrode material for the electrosynthesis of H_(2)O_(2)via 2e^(-)*** addition,studies have also considered the optimization of the liquid/gas interface by tuning the electrode surface,electrolyte pH,and reactor configurations for further improving the activity and selectivity of *** this review,we provide an in-depth discussion of the recent research on the carbon-based electrocatalysts for 2e^(-)ORR,especially in terms of microenvironment tuning,catalyst/electrode interface engineering,and reactor design for achieving stable and efficient production of H_(2)O_(2).The challenges that we are still facing and the future development prospects will then be concluded,which we believe should help the future development in this field.

关键词： Oxygen reduction Hydrogen peroxide Carbon-based catalyst Electrode surface Reactor design

CRABP2 regulates infiltration of cancer-associated fibroblasts and immune response in melanoma

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Oncology Research 2024年第2期32卷 261-272页

作者： SHUANGSHUANG ZENG XI chen QIAOLI YI ABHIMANYU THAKUR HUI YANG YUANLIANG YAN SHAO LIU Department of Pharmacy Xiangya HospitalCentral South UniversityChangsha410008China National Clinical Research Center for Geriatric disorders Xiangya HospitalCentral South UniversityChangsha410008China Pritzker School of Molecular Engineering Ben May Department for Cancer ResearchUniversity of ChicagoChicagoILUSA Department of Pathology The Second Affiliated Hospital of Shandong First Medical UniversityTaian271000China

Finding biomarkers for immunotherapy is an urgent issue in cancer *** retinoic acid-binding protein 2(CRABP2)is a controversial factor in the occurrence and development of human ***,there is limited research on the relationship between CRABP2 and immunotherapy *** study found that negative correlations of CRABP2 and immune checkpoint markers(PD-1,PD-L1,and CTLA-4)were observed in breast invasive carcinoma(BRCA),skin cutaneous melanoma(SKCM),stomach adenocarcinoma(STAD)and testicular germ cell tumors(TGCT).In particular,in SKCM patients who were treated with PD-1 inhibitors,high levels of CRABP2 predicted poor ***,CRABP2 expression was elevated in cancer-associated fibroblasts(CAFs)at the single-cell *** expression of CRABP2 was positively correlated with markers of CAFs,such as MFAP5,PDPN,ITGA11,PDGFRα/βand THY1 in *** validate the tumor-promoting effect of CRABP2 in vivo,SKCM xenograft mice models with CRABP2 overexpression have been *** models showed an increase in tumor weight and *** analysis indicated that CRABP2 may be involved in immunerelated pathways of SKCM,such as extracellular matrix(ECM)receptor interaction and epithelial-mesenchymal transition(EMT).The study suggests that CRABP2 may regulate immunotherapy in SKCM patients by influencing infiltration of *** conclusion,this study provides new insights into the role of CRABP2 in immunotherapy *** findings suggest that CRABP2 may be a promising biomarker for PD-1 inhibitors in SKCM *** research is needed to confirm these findings and to explore the clinical implications of CRABP2 in immunotherapy.

关键词： CRABP2 Melanoma PD-1 Cancer-associated fibroblasts Immune infiltration

Effect of the mixing of s-wave and chiral p-wave pairings on electrical shot noise properties of normal metal/superconductor tunnel junctions

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Chinese Physics B 2024年第7期33卷 538-545页

作者：胡雨辰胡梁宾 Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials School of PhysicsSouth China Normal UniversityGuangzhou 510631China

We study theoretically the electrical shot noise properties of tunnel junctions between a normal metal and a superconductor with the mixture of singlet s-wave and chiral triplet p-wave pairing due to broken inversion symmetry. We investigate how the shot noise properties vary as the relative amplitude between the two parity components in the pairing potential is changed. It is demonstrated that some characteristics of the electrical shot noise properties of such tunnel junctions may depend sensitively on the relative amplitude between the two parity components in the pairing potential, and some significant changes may occur in the electrical shot noise properties when the relative amplitude between the two parity components is varied from the singlet s-wave pairing dominated regime to the chiral triplet p-wave pairing dominated regime. In the chiral triplet p-wave pairing dominated regime, the ratio of noise power to electric current is close to 2e both in the in-gap and in the out-gap region. In the singlet s-wave pairing dominated regime, the value of this ratio is close to 4e in the inner gap region but may reduce to about 2e in the outer gap region as the relative amplitude of the chiral triplet pairing component is increased. The variations of the differential shot noise with the bias voltage also exhibit some significantly different features in different regimes. Such different features can serve as useful diagnostic tools for the determination of the relative magnitude of the two parity components in the pairing potential.

关键词： normal metal/superconductor tunnel junctions shot noise mixing of s-wave and chiral p-wave pairing spin–orbit coupling

Preparation of Environmentally Friendly Urea-Hexanediamine-Glyoxal(HUG)Resin Wood Adhesive

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Journal of Renewable Materials 2024年第2期12卷 235-244页

作者： Qianyu Zhang Shi chen Long Cao Hong Lei Antonio Pizzi Xuedong Xi Guanben Du yunnan Key Laboratory of Wood Adhesives and Glue Products College of Material Science and EngineeringSouthwest Forestry UniversityKunming650224China International Joint Research Center for Biomass Materials Southwest Forestry UniversityKunming650224China College of Chemical and Materials Engineering Zhejiang A&F UniversityHangzhou311300China LERMAB University of LorraineEpinal88000France

Using non-toxic,low-volatile glyoxal to completely replace formaldehyde for preparing urea-glyoxal(UG)resin adhesive is a hot research topic that could be of great interest for the wood ***,urea-glyoxal(UG)resins prepared by just using glyoxal instead of formaldehyde usually yields a lower degree of *** results in a poorer bonding performance and water resistance of UG resins.A good solution is to pre-react urea to preform polyurea molecules presenting already a certain degree of polymerization,and then to condense these with glyoxal to obtain a novel UG ***,in this present work,the urea was reacted with hexamethylene diamine to form a polyurea named HU,and then this was used to react it with different amounts of glyoxal to synthesize hexamethylenediamine-urea-glyoxal(HUG)polycondensation resins,and to use this for bonding *** results show that the glyoxal can well react with HU polyuria via addition and schiff base reaction,and also the HUG resin exhibits excellent bonding strength and water *** shear strength of the plywood bonded with this HUG at 160°C hot press temperature as high as 1.93 MPa,2.16 MPa and 1.61 MPa,respectively,which meets the requirement of the China national standard GB/T 9846-2015(≥0.7 MPa),and can be a good choice as a wood adhesive for industrial application.

关键词： Urea-glyoxal resin hexamethylene diamine wood adhesives water resistance

茵陈蒿汤对自身免疫性肝炎小鼠肝细胞铁死亡的抑制作用及其机制分析

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临床肝胆病杂志 2024年第3期40卷 502-508页

作者：李竹蓉陈晨郭地吕思学武嘉文杨娜刘杨山西中医药大学基础医学院山西晋中030619

目的探讨茵陈蒿汤对自身免疫性肝炎小鼠肝细胞铁死亡的抑制作用及机制。方法选取SPF级雌性C57BL/6小鼠18只,采用随机数字表法分为正常组、模型组、治疗组,每组6只。模型组和治疗组采用刀豆蛋白A(Con A)尾静脉注射制备自身免疫性肝炎... 详细信息

目的探讨茵陈蒿汤对自身免疫性肝炎小鼠肝细胞铁死亡的抑制作用及机制。方法选取SPF级雌性C57BL/6小鼠18只,采用随机数字表法分为正常组、模型组、治疗组,每组6只。模型组和治疗组采用刀豆蛋白A(Con A)尾静脉注射制备自身免疫性肝炎小鼠模型,正常组注射生理盐水。治疗组于造模前14天,给予茵陈蒿汤(4.68 g生药/kg)预防性灌胃治疗,末次灌胃给药后注射Con A。分别检测ALT、AST、IFN-γ、TNF-α、铁离子、GSH、ROS、ATP、MDA水平,计算肝脏指数、脾脏指数,并观察GPX4、SLC7A11的表达;比较各组小鼠肝脏病理组织变化。正态分布的计量资料3组间比较采用单因素方差分析,进一步两两比较采用LSD-t检验。结果与正常组比较,模型组肝脏指数、脾脏指数、ALT、AST、IFN-γ、TNF-α、铁离子、ROS、MDA水平均升高(P值均<0.05),GSH、ATP含量及GPX4、SLC7A11蛋白表达水平降低(P值均<0.05)。与模型组比较,治疗组肝脏指数、脾脏指数、ALT、AST、IFN-γ、TNF-α、铁离子、ROS、MDA水平均降低(P值均<0.05),GSH、ATP含量及GPX4、SLC7A11蛋白表达水平升高(P值均<0.01)。HE染色结果显示,与正常组比较,模型组小鼠肝脏出现大面积肝细胞变性、坏死、门管区炎细胞聚集,治疗组处理的小鼠肝脏坏死和炎性浸润程度较模型组有所减轻。结论 Con A诱导肝组织损伤可能与铁死亡有关。茵陈蒿汤可以增加SLC7A11/GPX4蛋白的表达水平进而抵抗Con A诱导的肝细胞铁死亡。

关键词：肝炎,自身免疫性茵陈蒿汤铁死亡谷胱甘肽过氧化酶小鼠,近交C57BL

All-optical logic gates based on hierarchical photonic crystal modulated photoluminescence of perovskite nanocrystals

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中国科学:技术科学英文版 2023年第9期66卷 2735-2742页

作者： WANG yun ZHA YanFang YANG yunYi LIU CiHui di yunSong CAO GuiYuan WEI ShiBiao chen ZhiHui GAN ZhiXing Center for Future Optoelectronic Functional Materials School of Computer and Electronic InformationSchool of Artificial IntelligenceNanjing Normal UniversityNanjing 210023China Centre for Translational Atomaterials School of ScienceSwinburne University of TechnologyHawthorn VIC 3122Australia Nanophotonics Research Center Shenzhen Key Laboratory of Micro-Scale Optical Information TechnologyShenzhen UniversityShenzhen 518060China Key Laboratory of Advanced Transducers and Intelligent Control Systems Ministry of Education and Shanxi ProvinceCollege of Electronic Information and Optical EngineeringTaiyuan University of TechnologyTaiyuan 030024China

Halide perovskites exhibit high performance in all sorts of optoelectronic and photonic areas, suggesting their huge potential in integrated photonic devices. However, until now, all optical logic gates based on perovskites are still rarely explored, hindering the development of all-optical networks and computing. Herein, a new concept of all-optical logic gates is proposed based on the modulation of photoluminescence(PL) from perovskite nanocrystals(PNCs). A hierarchical photonic crystal(Hie PhC) is developed by self-assembling polystyrene(PS) and SiO2nanoparticles, which exhibit a higher PL enhancement than that of a monolayer PhC. Moreover, the light-controlled PL is realized by taking advantage of the high thermal response of the PL from PNCs/Hie PhC on polyethylene(PE) substrate, assisted by a graphene layer for light-heat conversion. Consequently, optical diode and triode are achieved based on the modulated PL, which exhibit contrast ratios(CR) of 24.7 and 74.0 dB, ***-optical logic gates, including “AND”, “OR” and “NOT”, are realized based on the optical diode and triode.

关键词： perovskite nanocrystals photonic crystals all-optical logic gates modulation of photoluminescence

Droplet Laplace valve-enabled glaucoma implant for intraocular pressure management

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Droplet 2024年第2期3卷 125-137页

作者： Yuyang Wang Zecong Fang Sen Li Kexin Lin Zhifeng Zhang Junyi chen Tingrui Pan Center for Intelligent Medical Equipment and Devices(iMED) Institute for Innovative Medical DevicesUniversity of Science and Technology of ChinaHefeiChina Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhouChina Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefeiChina Bionic Sensing and Intelligence Center(BSIC) Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina School of Engineering Hangzhou Normal UniversityHangzhouChina School of Biomedical Engineering Division of Life Science and MedicineUniversity of Science and Technology of ChinaHefeiChina Engineering Science and Mechanics Department Penn State UniversityUniversity ParkPennsylvaniaUSA Department of Ophthalmology and Visual Science Eye and ENT HospitalShanghai Medical CollegeFudan UniversityShanghaiChina NHC Key Laboratory of Myopia Chinese Academy of Medical Sciences and Shanghai Key Laboratory of Visual Impairment and Restoration(Fudan University)ShanghaiChina

Glaucoma,the leading cause of irreversible blindness worldwide,is closely linked to aqueous overaccumulation and elevated intraocular pressure(IOP).For refractory glaucoma,aqueous shunts with valves are commonly implanted for effective aqueous drainage control and IOP ***,existing valved glaucoma implants have the disadvantages of inconsistent valve opening/closing pressures,poor long-term repeatability due to their reliance on moving parts,and complex architectures and fabrication ***,we propose a novel valving concept,the droplet Laplace valve(DLV),a three-dimensional printable moving-parts-free microvalve with customizable and consistent threshold valving *** DLV uses a flow discretization unit governed by capillarity,comprising a droplet-forming nozzle,and a separated reservoir to digitize continuous flow into quantifiable *** the classic one-time-use Laplace valves,the DLV's unique design allows for its *** opening pressure is adjustable by varying the nozzle size,like the classic Laplace valves(following the Young–Laplace equation),while the closing pressure can be modified by tuning the separation distance and the reservoir *** DLVs with customizable opening pressures from 5 to 11 mmHg have been demonstrated,with opening/closing pressure differences suppressed down toditions).Thanks to its moving-parts-free nature and digitized flow properties,the DLV shows a highly repeatable valving performance(dictable linear flow rate–pressure correlation(R2>0.99).Preliminary ex vivo validation in an enucleated porcine eye confirms the DLV's efficiency in aqueous shunting and prompt IOP *** DLV technology holds great promise in glaucoma implants for IOP management and various microsystems for flow control.

关键词： holds irreversible inconsistent