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Six New 9,19-Cycloartane Triterpenoids from Cimicifuga foetida L.

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Natural Products and Bioprospecting 2016年第4期6卷 187-193页

作者： Guo-Lei zhu di-fan zhu Luo-Sheng Wan Xing-Rong Peng Ni-Man Bao Zhi-Run Zhang Lin Zhou Ming-Hua Qiu State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of Sciences(CAS)Kunming 650201People’s Republic of China Graduate University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Faculty of Life Science and Technology Kunming University of Science and TechnologyKunming 650500YunnanPeople’s Republic of China

Six new 9,19-cycloartane triterpene derivatives,as well as 3 known analogues(7–9),were isolated from the roots of Cimicifuga foetida *** structures were established on the basis of extensive spectroscopic analyses(IR... 详细信息

关键词： Cimicifuga foetida 9,19-Cycloartane triterpenoids Cycloartane-type

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei fan Mengxian Jia Jian Zhou Zhoule zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

使用合规农药能确保农产品“地头”质量安全吗?——基于豇豆农户的扎根理论分析

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海南大学学报（人文社会科学版） 2025年第1期43卷 119-128页

作者：樊孝凤张娇朱月季海南大学国际商学院海南海口570228

新的农产品质量安全法首次将小农户施药行为纳入监管范围,进一步厘清农户施药行为的影响机理与因素,有助于政府精准施策。通过对海南3个村32户农民豇豆种植过程的全程蹲点跟踪,对豇豆施药环节的参与式观察与深度访谈,运用扎根理论分析... 详细信息

新的农产品质量安全法首次将小农户施药行为纳入监管范围,进一步厘清农户施药行为的影响机理与因素,有助于政府精准施策。通过对海南3个村32户农民豇豆种植过程的全程蹲点跟踪,对豇豆施药环节的参与式观察与深度访谈,运用扎根理论分析了访谈资料。研究发现:农户施药环节是一个复杂的行为选择过程,即使施用合规农药也不能确保农产品在产地的质量安全。在合规农药视角下影响农户施药行为选择的最重要因素是信息渠道,其次是农产品质量安全管理的政策强度、农产品市场价格和农村劳动用工成本。同时,邻里效应在农户施药行为选择中的作用越来越弱。在此基础上提出,要增加农户用药信息的有效供给渠道,加强农产品质量安全的全面检测,坚持为农户提供形式多样的有针对性的有效培训,增加重要食用农产品质量安全关键技术供给与推广,加强农产品“优质优价”市场建设的政策建议,并进一步指出海南自贸港建设和RECP协议实施背景下提升海南农产品质量安全水平的紧迫性。

关键词：合规农药施药行为农产品质量安全扎根理论

Elemental Compositions of Clinopyroxenes from Southern Okinawa Trough Basalt:Implications for Magmatism and Structural Environment in an Initial Back-Arc Basin

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Journal of Ocean University of China 2024年第3期23卷 643-653页

作者： GUO Kun ZHAI Shikui fan di ZHANG Xia ZHANG Yu zhu Zhimin Laoshan Laboratory Qingdao 266237China Key Laboratory of Submarine Geosciences and Prospecting Techniques Ministry of EducationCollege of Marine GeosciencesOcean University of ChinaQingdao 266100China Key Laboratory of Submarine Geosciences&Second Institute of Oceanography Ministry of Natural ResourcesHangzhou 310012China

The major and trace elemental compositions of clinopyroxene from basalt were used to characterize the nature of the primitive magma and structural environment beneath the southern Okinawa Trough(SOT),which is an initial back-arc basin at a continental *** clinopyroxenes in the basalt were augite with variable Mg^(#)contents(73.37-78.22).The regular variations in major oxide contents(i.e.,CaO,FeO,TiO_(2),and Cr)with decreasing Mg#implied that the clinopyroxenes evolved from being enriched in Mg,Ca,and Cr to being enriched in Fe and *** clinopyroxenes had relatively low rare earth element concentrations(7.51×10^(-6) to 12.68×10^(-6))and negative Eu anomalies(δEu=0.67-0.95).The Kd_(cpx) values of clinopyroxenes(0.2-0.26),which were used to examine whether the clinopyroxene was equilibrated with its host basalt,demonstrate that these clinopyroxene phenocrysts were not captured crystals but were instead produced by crystallization differentiation of the *** calculated clinopyroxene crystallization temperatures showed a narrow range of 990-1061℃,and their crystallization pressures ranged from 2.0 to 3.2 *** geochemistry features of these clinopyroxenes indicated that the parent magma belonged to the subalkaline tholeiitic magma series and suggested that the magma experienced crystallization differentiation of olivine,plagioclase,and clinopyroxene,where the crystallization of plagioclase occurred earlier than that of *** with geophysical data,this research on primitive magma and its crystallization differentiation from clinopyroxene indicates that the SOT is in the stage of‘seafloor spreading’and that basaltic rocks produced from tholeiitic magma represent the generation of oceanic crust.

关键词： trace elements clinopyroxenes southern Okinawa Trough seafloor spreading back-arc basin

Measuring the flexibility matrix of an eagle’s flight feather and a method to estimate the stiffness distribution

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Chinese Physics B 2019年第7期28卷 305-311页

作者： di Tang Hai zhu Wei Yuan Zhongyong fan Mingxia Lei College of Mechanical Engineering Zhejiang University of Technology Hangzhou 310014 China High Speed Aerodynamic Institute China Aerodynamics Research and Development Center Mianyang 621000 China Zhejiang Museum of Natural History Hangzhou 310014 China

Flight feathers stand out with extraordinary mechanical properties for flight because they are lightweight but stiff *** elasticity has great effects on the aerodynamics, resulting in *** primary task is to figure out the stiffness distribution of the feather to study the aeroelastic *** feather shaft is simplified as a beam, and the flexibility matrix of an eagle flight feather is tested.A numerical method is proposed to estimate the stiffness distributions along the shaft length based on an optimal Broyden–Fletcher–Goldfarb–Shanno(BFGS) method with global *** analysis of the compressive behavior of the shaft based on the beam model shows a good fit with experimental *** stiffness distribution of the shaft is finally presented using a 5 th order polynomial.

关键词： feather stiffness distribution flexibility matrix optimal Broyden–Fletcher–Goldfarb–Shanno(BFGS)

Development of small-molecule materials for high-performance organic solar cells

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Science China Chemistry 2015年第6期58卷 922-936页

作者： Haijun fan Xiaozhang zhu Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences

With the rapid development in recent years, small-molecule organic solar cell is challenging the dominance of its counterpart, polymer solar cell. The top power conversion efficiencies of both single and tandem solar cells based on small molecules have surpassed 9%. In this mini review, achievements of small molecules with impressive photovoltaic performance especially reported in the last two years were highlighted. The relationship between molecular structure and device performance was analyzed, which draws some rules for rational molecular design. Five series of p- and n-type small molecules were selected based on the consideration of their competitiveness of power conversion efficiencies.

关键词： small-molecule solar cells small-molecule donors small-molecule non-fullerene acceptors power conversion efficiency

Hematopoietic effect of small molecular fraction of Polygoni multiflori Radix Praeparata in cyclophosphamide-induced anemia mice

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Chinese Journal of Natural Medicines 2019年第7期17卷 535-544页

作者： zhu Li-Li fan Luo-di HU Ming-Hua MA fang-Li QI Jin Jiangsu Key Laboratory of TCM Evaluation and Translational Research China Pharmaceutical University Nanjing 210009 China Infinitus Chinese Herbal Immunity Research Centre Infinitus (China) Company Limited. Guangzhou 510663 China

The aim of this study is to investigate the protective effects of a small molecular fraction(SMF) of Polygoni multiflori Radix Praeparata(PMRP) in a cyclophosphamide(CTX) induced anemia mouse model. Small molecular fraction of PMRP was prepared and identified by high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(HPLC-Q-TOF-MS). In pharmacology, we examined the peripheral hemogram and thymus and spleen index. The content of granulocyte-macrophage colony-stimulating factor(GM-CSF) in serum was mensurated by enzyme-linked immunosorbent assay(ELISA);The level of superoxide dismutase(SOD), catalase(CAT), total antioxidant capacity(T-AOC), and malondialdehyde(MDA) in serum and spleen tissue homogenate were detected, and glutathione peroxidase(GSH-PX) was assayed in spleen. The results show that SMF can significantly accelerate the recovery of peripheral hemogram, increase the activity of antioxidant enzymes and GM-CSF in serum and spleen. SMF also increases the number of spleen cells, improves bone marrow pathology. In conclusion, the SMF of PMRP promoted the recovery of hematopoietic function in a CTX-induced anemia mouse, which can support SMF to be used as an adjunct to chemotherapy to counteract its side effects.

关键词： Polygoni multiflori Radix Praeparata Small molecular fraction Cyclophosphamide Hemopoiesis

Fast TMRM:efficient multi-task recommendation model

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The Journal of China Universities of Posts and Telecommunications 2020年第5期27卷 13-22页

作者： zhu fan Yang Juan School of Computer Science and Technology Beijing University of Posts and TelecommunicationsBeijing 100876China

An improved multi-task learning recommendation algorithm-fast two-stage multi-task recommendation model boosted feature selection(Fast TMRM) is proposed based on auto-encoders in this paper. Compared to previous work, Fast TMRM improves the convergence speed and accuracy of training. In addition, Fast TMRM builds on previous work to introduce the auto-encoder to encode the important feature combination vector. That is how it can be used for the training of multi-task learning, which helps to improve the training efficiency of the model by nearly 67%. Finally, the nearest neighbor search is used to restore important feature expression.

关键词： recommendation algorithm feature combination auto-encoder

Least H-eigenvalue of adjacency tensor of hypergraphs with cut vertices

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Frontiers of Mathematics in China 2020年第3期15卷 451-465页

作者： Yizheng fan zhu zhu Yi WANG School of Mathematical Sciences Anhui UniversityHefei 230601China

Let G be a connected hypergraph with even uniformity,which contains cut *** G is the coalescence of two nontrivial connected sub-hypergraphs(called branches)at a cut *** A(G)be the adjacency tensor of *** least H-eigenvalue of A(G)refers to the least real eigenvalue of A(G)associated with a real *** this paper,we obtain a perturbation result on the least H-eigenvalue of A(G)when a branch of G attached at one vertex is relocated to another vertex,and characterize the unique hypergraph whose least H-eigenvalue attains the minimum among all hypergraphs in a certain class of hypergraphs which contain a fixed connected hypergraph.

关键词： Hypergraph adjacency tensor least H-eigenvalue eigenvector perturbation