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使用混合机构模型预测食管鳞状细胞癌根治性放化疗病人的完全缓解的影像组学和剂量组学

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国际医学放射学杂志 2024年第2期 255-255页

作者： D.Kawahara y.Murakami S.Awane y.Emoto K.Iwashita H.Kubota 王俊

摘要目的基于影像组学和剂量组学特征开发一种多机构预测模型，评估食管鳞状细胞癌（ESCC）接受确定性放疗后的局部缓解。方法局部缓解分为2组（不完全组和完全

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Recent Progress in Numerical Methods for the Poisson-Boltzmann Equation in Biophysical Applications

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Communications in Computational Physics 2008年第5期3卷 973-1009页

作者： B.Z.Lu y.C.Zhou M.J.Holst J.A.McCammon Howard Hughes Medical Institute University of CaliforniaSan Diego 9500 Gilman DriveDept.0112La JollaCA 92093-0112USA. Department of Mathematics University of CaliforniaSan Diego 9500 Gilman DriveDept.0112La JollaCA 92093-0112USA. Center for Theoretical Biological Physics University of CaliforniaSan Diego 9500 Gilman DriveDept.0112La JollaCA 92093-0112USA. Department of Chemistry and Biochemistry University of CaliforniaSan Diego 9500 Gilman DriveDept.0112La JollaCA 92093-0112USA. Department of Pharmacology University of CaliforniaSan Diego 9500 Gilman DriveDept.0112La JollaCA 92093-0112USA.

Efficiency and accuracy are two major concerns in numerical solutions of the Poisson-Boltzmann equation for applications in chemistry and *** developments in boundary element methods,interface methods,adaptive methods,finite element methods,and other approaches for the Poisson-Boltzmann equation as well as related mesh generation techniques are *** also discussed the challenging problems and possible future work,in particular,for the aim of biophysical applications.

关键词： Biomolecular electrostatics Poisson-Boltzmann equation numerical methods finite difference methods finite element methods boundary element methods adaptive methods hybrid methods mesh generation electrostatic forces

彭氏分筋推拿结合温针灸治疗寒湿型坐骨神经痛疗效研究

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彭氏分筋推拿结合温针灸治疗寒湿型坐骨神经痛疗效研究

作者：伍梓峰（Tszfung ng）广州中医药大学

学位级别：硕士

目的:本次研究基于临床时发现两种治疗方案疗效有差异,为判断两组治疗方案总体有无差异,将两种治疗方案“彭氏分筋推拿”手法结合温针灸治疗寒湿型坐骨神经痛,与传统推拿手法结合温针灸治疗寒湿型坐骨神经痛相比较,通过VAS疼痛评分、OD... 详细信息

目的:本次研究基于临床时发现两种治疗方案疗效有差异,为判断两组治疗方案总体有无差异,将两种治疗方案“彭氏分筋推拿”手法结合温针灸治疗寒湿型坐骨神经痛,与传统推拿手法结合温针灸治疗寒湿型坐骨神经痛相比较,通过VAS疼痛评分、Odi功能障碍指数、JOA腰痛评分、中医寒湿证候评分四者作为观察工具,使用统计学的方法将治疗、对照两组的疗效及其效益,进行比较,最后根据结果分析“彭氏分筋推拿”手法结合温针灸治疗寒湿型坐骨神经痛的特色及优胜之处,提供寒湿型坐骨神经痛临床治疗的一种新思路,以供临床作参考。方法:根据寒湿型坐骨神经痛诊断标准、纳入标准、排除标准和剔除标准于广州中医药大学第一附属医院推拿科中诊断为寒湿型坐骨神经痛的60例患者,按1:1的比例,随机分配至治疗组和对照组,其中治疗组30例,对照组30例。分别对治疗组行“彭氏分筋推拿”手法结合温针灸治疗,对照组行传统推拿手法结合温针灸治疗。每周治疗3次,以10次为1个疗程,共1个疗程。在治疗前、10次治疗后(即1个疗程后)记录VAS疼痛评分、Odi功能障碍指数、JOA腰痛评分、中医寒湿证候评分,以Excel整理数据建立数据库后,以SPSS26.0软件进行数据分析,最后基于数据,分析总结两组治疗的临床疗效及效益。结果:(1)治疗前治疗组与对照组,性别、年龄、身高、VAS疼痛评分、Odi功能障指数、JOA腰痛评分、中医寒湿症候评分,P>0.05,统计学上无差异,可作比较。(2)两组间治疗后,VAS疼痛评分、Odi功能障指数、JOA腰痛评分、中医寒湿证候评分,Pdi功能障指数、JOA腰痛评分、中医寒湿证候评分,P<0.05,在统计学意义上具有差异。说明两组治疗寒湿型坐骨神经痛均有疗效,但“彭氏分筋推拿”手法结合温针灸疗效更明显。(3)完成1个疗程后,根据JOA腰痛评分,计算得出治疗改善率(%),根据标准作等级分类,比较两组治疗的疗效效益,P<0.05,“彭氏分筋推拿”手法结合温针灸疗效效益更优。结论:“彭氏分筋推拿”手法结合温针灸与传统推拿手法结合温针灸治疗寒湿型坐骨神经痛均有疗效,但“彭氏分筋推拿”手法结合温针灸疗效及效益更好。

关键词：坐骨神经痛寒湿型坐骨神经痛彭氏分筋推拿温针灸

Standard method design considerations for semi-quantification of total naphthenic acids in oil sands process affected water by mass spectrometry： A review

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Frontiers of Chemical Science and Engineering 2017年第3期11卷 497-507页

作者： Kevin A. Kovalchik Matthew S. MacLennan Kerry M. Peru John V. Headley David D.y. Chen Department of Chemistry University of British Columbia Vancouver BC V6T 1Z1 Canada Watershed Hydrology and Ecology Research division Water Science and Technology Directorate Science and Technology Branch Environment and Climate Change Canada Saskatoon SK S7N 3H5 Canada

Naphthenic acids are a complex class of thousands of naturally occurring aliphatic and alicyclic carboxylic acids found in oil sands bitumen and in the wastewater generated from bitumen processing. Dozens of analytical methods have been developed for the semiquantification of total naphthenic acids in water samples. However, different methods can give different results, prompting investigation into the comparability of the many methods. A review of important methodological features for analyzing total naphthenic acids is presented and informs the design of future standard methods for the semi- quantification of total naphthenic acids using mass spectrometry. The design considerations presented are a synthesis of discussions from an Environment and Climate Change Canada （ECCC） led taskforce of 10 laboratory experts from government, industry and academia during April 2016 and subsequent discussions between University of British Columbia and ECCC representatives. Matters considered are： extraction method, solvent, pH, and temperature; analysis instrumentation and resolution; choice of calibration standards; use of surrogate and internal standards; and use of online or offline separation prior to analysis. The design considerations are amenable to both time-of-flight and Orbitrap mass spectrometers.

关键词： total naphthenic acids environmental samples oil sands process affected water polar organics mass spectrometry

Degradation of Synthetic Dyeing Wastewater by Underwater Electrical discharge Processes

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Plasma Science and Technology 2013年第7期15卷 659-665页

作者： S.D.KIM D.I.JAng B.J.LIM S.B.LEE y.S.MOK yeongsan River Environment Research Center National Institute of Environmental ResearchGwangju 500-480 Korea Department of Chemical and Biological Engineering Jeju National UniversityJeju 690-756 Korea

Electrical discharge treatments of synthetic dyeing wastewater were carried out with two different systems： underwater pulsed electrical discharge （UPED） and underwater dielectric barrier discharge （UDBD）. Reactive Blue 4 （RB4） and Acid Red 4 （AR4） were used as model contaminants for the synthetic wastewater. The performance of the aforementioned systems was compared with respect to the chromaticity removal and the energy requirement. The results showed that the present electrical discharge systems were very effective for degradation of the dyes. The dependences of the dye degradation rate on treatment time, initial dye concentration, electrical energy, and the type of working gas including air, 02, and N2 were examined. The change in the initial dye concentration did not largely affect the degradation of either RB4 or AR4. The energy delivered to the UPED system was only partially utilized for generating reactive species capable of degrading the dyes, leading to higher energy requirement than the UDBD system. Among the working gases, the best performance was observed with O2. As the degradation proceeded, the concentration of total dissolved solids and the solution conductivity kept increasing while pH showed a decreasing trend, revealing that the dyes were effectively mineralized.

关键词： degradation dyeing wastewater pulsed electrical discharge dielectric barrierdischarge

Piper betle leaf extract enhances the cytotoxicity effect of 5-fluorouracil in inhibiting the growth of HT29 and HCT116 colon cancer cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第8期15卷 692-700页

作者： Pek Leng ng Nor Fadilah RAJAB Sue Mian THEN yasmin Anum MOHD yUSOF Wan Zurinah WAN ngAH Kar y.ng PIN Mee Lee LOOI Department of Biomedical Sciences Faculty of Allied Health Universiti Kebangsaan Malaysia (UKM) Jalan Raja Muda Abdul Aziz50300 Kuala Lumpur Malaysia UKM Medical Molecular Biology Institute (UMBI) Universiti Kebangsaan Malaysia (UKM) Jalan Yaacob Latiff Bandar Tun Razak Cheras56000 Kuala Lumpur Malaysia School of Biomedical Science University of Nottingham Malaysia Campus43500 Semenyih Selangor Malaysia Department of Biochemistry Faculty of Medicine Universiti Kebangsaan Malaysia (UKM) Jalan Raja Muda Abdul Aziz50300 Kuala Lumpur Malaysia Forest Research Institute Malaysia (FRIM) 52109 Kuala Lumpur Kepong Malaysia School of Biosciences Taylor’s University Lakeside Campus47500 Subang Jaya Selangor Malaysia

Objective： The combination effect of Piperbetle （PB） and 5-fluorouracil （5-FU） in enhancing the cytotoxic potential of 5-FU in inhibiting the growth of colon cancer cells was investigated. Methods： HT29 and HCT116 cells were subjected to 5-FU or PB treatment. 5-FU and PB were then combined and their effects on both cell lines were observed after 24 h of treatment. PB-5-FU interaction was elucidated by isobologram analysis. Apoptosis features of the treated cells were revealed by annexin V/PI stain. High-performance liquid chromatography （HPLC） was performed to exclude any possible chemical interaction between the compounds. Results： In the presence of PB extract, the cytotoxicity of 5-FU was observed at a lower dose （IC^0 12.5 pmol/L） and a shorter time （24 h） in both cell lines. Both cell lines treated with 5-FU or PB alone induced a greater apoptosis effect compared with the combination treatment. Isobologram analysis indicated that PB and 5-FU interacted synergistically and antagonistically in inhibiting the growth of HT29 and HCT116 cells, respectively. Conclusions： In the presence of PB, a lower dosage of 5-FU is required to achieve the maximum drug effect in inhibiting the growth of HT29 cells. However, PB did not significantly reduce 5-FU dosage in HCT116 cells. Our result showed that this interaction may not solely contribute to the apoptosis pathway.

关键词： Piperaceae Piper beUe L. 5-Fiuorouracil Isobologram analysis Herb-drug interaction

Search for Double γ-Vibrational Bands in Neutron-Rich ^105Mo Nucleus

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Chinese Physics Letters 2006年第12期23卷 3222-3225页

作者：丁怀博朱胜江 J. H. Hamilton A. V. Ramayya J. K. Hwang y. X. Luo J. O. Rasmussen I. y. Lee 车兴来陈永静李明亮 Department of Physics Tsinghua University Beijing 100084 Department of Phvsics Vanderbilt University Nashville Tennessee 37235 USA Lawrence Berkeley National Laboratory Berkeley California 94720 USA

Levels in the neutron-rich ^105Mo nucleus have been investigated by observing prompt γ-rays following the spontaneous fission fragments of^252 Cf with the Gammasphere detector array. The yrast band has been confirmed and updated. The other two collective bands with the band head levels at 870.5 and 1534.6 keV are newly observed, and they are suggested as the candidates for one-phonon K= 9/2 and two-phonon K = 13/2 double γ-vibrational bands, respectively. Systematic characteristics of these bands have been discussed.

关键词： Double γ-Vibrational Bands Systematic characteristics

Enhanced acetone sensing performance of nanostructured Sm2O3 doped SnO2 thick films

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Journal of Rare Earths 2017年第8期35卷 813-823页

作者： F.I.Shaikh L.P.Chikhale J.y.Patil I.S.Mulla S.S.Suryavanshi School of Physical Sciences Solapur University Solapur 413255 (M.S.) lndia Council of Scientific and Industrial Research Pashan Pune 411008 India

In the present work, we synthesized Sm2O3 doped SnO2 in order to prepare a selective acetone sensor with fast response, quick recovery and good repeatability. Pure as well as 2 mol.%, 4 mol.%, 6 mol.% and 8 mol.% Sm2O3 doped SnO2 nanostructured samples were synthesized by using a co-precipitation method. The characterization of the samples was done by thermogravimetric and differential thermo-gravimetric analysis（TG-DTA）, X-ray diffraction（XRD）, field emission gun-scanning electron microscopy（FEG-SEM）, energy dispersive analysis by X-rays（EDAX）, high resolution scanning electron microscopy（HR-TEM）, selected area X-ray diffraction（SAED）, Brunauer-Emmet-Teller（BET） and ultraviolet-visible-near infrared（UV-Vis-NIR） spectroscopy techniques. The gas response studies of liquid petroleum gas, ammonia, ethanol and acetone vapor were carried out. The results showed that Sm doping systematically lowered operating temperature and enhanced the gas response and selectivity for acetone. The response and recovery time for 6 mol.% Sm2O3 doped SnO2 thick film at the operating temperature of 250 °C were 15 and 24 s, respectively.

关键词： tin oxide samarium oxide screen printing thick film acetone sensor rare earths

Hydrodynamics of three-phase fluidization of homogeneous ternary mixture in a conical conduit-Experimental and statistical analysis

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Chinese Journal of Chemical Engineering 2016年第10期24卷 1335-1343页

作者： R.K.Padhi D.T.K.Dora y.K.Mohanty G.K.Roy B.Sarangi Department of Chemical Engineering GIETGunupur-765 022RayagadaOdishaIndia Department of metallurgical Engineering ICITSarangaDhenkanalOdishaIndia

Hydrodynamics of conical fluidized bed differ from that of columnar beds by the fact that a velocity gradient exists along the axial direction of the *** gas–liquid–solid fluidized bed has emerged in recent years as one of the most promising devices for three-phase *** a device is of considerable industrial importance as evident from its wide applications in chemical,refining,petrochemical,biochemical processing,pharmaceutical and food *** explore this,a series of experiments have been carried out for homogeneous well-mixed ternary mixtures of dolomite of vary.ng compositions in a three-phase conical fluidized *** hydrodynamic characteristics determined included the bed pressure drop,bed fluctuation and bed expansion *** single and combined effects of operating parameters such as superficial gas velocity,superficial liquid velocity,initial static bed height,average particle size and cone angle on the responses have been analyzed using response surface methodology(RSM).A 25 full factorial central composite experimental design has been *** of variance(ANOVA) showed a high coefficient of determination value and satisfactory prediction second-order regression models have been *** values of bed pressure drop,bed fluctuation and bed expansion ratios have been found to agree well with the developed correlations.

关键词： Gas-liquid-solid fluidization Conical bed Bed pressure drop Bed fluctuation ratio and bed expansion ratio ANOVA