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Liquid-metal microgrid stretchable electronics based on bionic leaf veins with ultra-stretchability and high conductivity

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Rare Metals 2024年第6期43卷 2747-2757页

作者： Xi-di sun Jun-Yang An Yi-Qi sun Xin Guo Jing Wu Jiang-Bo Hua Meng-Rui Su Yi Shi Li-Jia Pan Collaborative Innovation Center of Advanced Microstructures School of Electronic Science and EngineeringNanjing UniversityNanjing 210093China

Stretchable electronics that monitor joint activity and treat diseases based on liquid metal could be used in the development of healthcare *** devices can be seamlessly integrated with human ***,most high-precision microstructures and complex patterns are difficult to fabricate due to the limitations of conventional fabrication solutions,resulting in suboptimal performance under practical ***,a liquid-metal stretchable system utilizing natural leaf veins was reported as microstructures,which was based on a biomimetic concept and utilized an all-solution process for the preparation of complex *** systems are ultra-high tensile(800%tensile strain),environmentally stable(20 days)and mechanically durable(300-cycle).The system can accurately recognize the wearer's finger bending level as well as simple gesture *** the same time,the system acts as a wearable heater,which can realize the fast heating behavior of heating up to 50℃in 3 min under the human body-safe voltage(1.5 V).The tensile stability is demonstrated by the heterogeneous integration of lasers(405 nm)with the system interconnects for a stretchable and wearable light source.

关键词： Stretchable electronics Liquid metal Stretchable conductor Vein Bionicist electronics

SIRT1 inhibits apoptosis of human lens epithelial cells through suppressing endoplasmic reticulum stress in vitro and in vivo

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1205-1216页

作者： Hui Cui di sun Sheng Meng Tian-Ju Ma Zi Ye Zhao-Hui Li Medical School of Chinese PLA Beijing 100089China Senior Department of Ophthalmology the Third Medical Center of PLA General HospitalBeijing 100853China

AIM:To explore the effect of silent information regulator factor 2-related enzyme 1(SIRT1)on modulating apoptosis of human lens epithelial cells(HLECs)and alleviating lens opacification of rats through suppressing endoplasmic reticulum(ER)***:HLECs(SRA01/04)were treated with varying concentrations of tunicamycin(TM)for 24h,and the expression of SIRT1 and C/EBP homologous protein(CHOP)was assessed using real-time quantitative polymerase chain reaction(RT-PCR),Western blotting,and *** morphology and proliferation was evaluated using an inverted microscope and cell counting kit-8(CCK-8)assay,*** the SRA01/04 cell apoptosis model,which underwent siRNA transfection for SIRT1 knockdown and SRT1720 treatment for its activation,the expression levels of SIRT1,CHOP,glucose regulated protein 78(GRP78),and activating transcription factor 4(ATF4)were *** potential reversal of SIRT1 knockdown effects by 4-phenyl butyric acid(4-PBA;an ER stress inhibitor)was *** vivo,age-related cataract(ARC)rat models were induced by sodium selenite injection,and the protective role of SIRT1,activated by SRT1720 intraperitoneal injections,was evaluated through morphology observation,hematoxylin and eosin(H&E)staining,Western blotting,and ***:SIRT1 expression was downregulated in TMinduced SRA01/04 ***,in SRA01/04 cells,both cell apoptosis and CHOP expression increased with the rising doses of *** stress was stimulated by TM,as evidenced by the increased GRP78 and ATF4 in the SRA01/04 cell apoptosis *** of SIRT1 by siRNA knockdown increased ER stress activation,whereas SRT1720 treatment had opposite results.4-PBA partly reverse the adverse effect of SIRT1 knockdown on *** vivo,SRT1720 attenuated the lens opacification and weakened the ER stress activation in ARC rat ***:SIRT1 plays a protective role against TM-induced apoptosis in HLECs and slows the progression of cataract in

关键词： silent information regulator factor 2-related enzyme 1 endoplasmic reticulum stress apoptosis human lens epithelial cells cataract

Risk stratification for radioactive iodine refractoriness using molecular alterations in distant metastatic differentiated thyroid cancer

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Chinese Journal of Cancer Research 2024年第1期36卷 25-35页

作者： Zhuanzhuan Mu Xin Zhang Dongquan Liang Jugao Fang Ge Chen Wenting Guo di sun Yuqing sun Zhentian Kai Lisha Huang Jun Liang Yansong Lin Department of Nuclear Medicine State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College(PUMC)HospitalChinese Academy of Medical Sciences&PUMCBeijing 100730China Beijing Key Laboratory of Molecular Targeted diagnosis and Therapy in Nuclear Medicine Beijing 100730China Pepperdine University Graduate School of Education and Psychology Los Angeles 90045USA Department of Head and Neck Surgery Affiliated Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of General Surgery State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College(PUMC)HospitalChinese Academy of Medical Sciences&PUMCBeijing 100730China Central Laboratory State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College(PUMC)HospitalChinese Academy of Medical Sciences&PUMCBeijing 100730China Department of Bioinformatics Zhejiang Shaoxing Topgen Biomedical Technology Co.LtdShanghai 201321China Department of Medicine Zhejiang Shaoxing Topgen Biomedical Technology Co.LtdShanghai 201321China Department of Oncology Peking University International HospitalBeijing 102206China

Objective: Patients with radioactive iodine-refractory differentiated thyroid cancer(RAIR-DTC) are often diagnosed with delay and constrained to limited treatment options. The correlation between RAI refractoriness and the underlying genetic characteristics has not been extensively ***: Adult patients with distant metastatic DTC were enrolled and assigned to undergo next-generation sequencing of a customized 26-gene panel(Thyro Lead). Patients were classified into RAIR-DTC or non-RAIR groups to determine the differences in clinicopathological and molecular characteristics. Molecular risk stratification(MRS) was constructed based on the association between molecular alterations identified and RAI refractoriness, and the results were classified as high, intermediate or low ***: A total of 220 patients with distant metastases were included, 63.2% of whom were identified as RAIRDTC. Genetic alterations were identified in 90% of all the patients, with BRAF(59.7% vs. 17.3%), TERT promoter(43.9% vs. 7.4%), and TP53 mutations(11.5% vs. 3.7%) being more prevalent in the RAIR-DTC group than in the non-RAIR group, except for RET fusions(15.8% vs. 39.5%), which had the opposite pattern. BRAF and TERT promoter are independent predictors of RAIR-DTC, accounting for 67.6% of patients with RAIR-DTC. MRS was strongly associated with RAI refractoriness(Pdiate to low MRS of 3.20(95% CI,1.01-10.14;P=0.041).Conclusions: Molecular alterations were associated with RAI refractoriness, with BRAF and TERT promoter mutations being the predominant contributors, followed by TP53 and diCER1 mutations. MRS might serve as a valuable tool for both prognosticating clinical outcomes and directing precision-based therapeutic interventions.

关键词： differentiated thyroid cancer distant metastases genetic alterations RAI refractoriness molecular risk stratification

The global regulation of c-di-GMP and cAMP in bacteria

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mLife 2024年第1期3卷 42-56页

作者： Cong Liu Rui Shi Marcus S.Jensen Jingrong Zhu Jiawen Liu Xiaobo Liu di sun Weijie Liu Jiangsu Key Laboratory of Phylogenomics&Comparative Genomics School of Life SciencesJiangsu Normal UniversityXuzhouChina Key Laboratory of Metabolic Engineering and Biosynthesis Technology Ministry of Industry and Information TechnologyNanjing University of Science and TechnologyNanjingChina

Nucleotide second messengers are highly versatile signaling molecules that regulate a variety of key biological processes in *** best-studied examples are cyclic AMP(cAMP)and bis-(3'-5')-cyclic dimeric guanosine monophosphate(c-di-GMP),which both act as global *** regulatory frameworks of c-di-GMP and cAMP in bacteria show several parallels but also significant *** this review,we llustrate the global regulatory models of the two nucleotide second messengers,compare the different regulatory frameworks between c-di-GMP and cAMP,and discuss the mechanisms and physiological significance of cross-regulation between c-di-GMP and cAMP.c-di-GMP responds to numerous signals de-pendent on a great number of metabolic enzymes,and it regulates various signal transduction pathways through its huge number of effectors with varying *** contrast,due to the limited quantity,the cAMP metabolic enzymes and its major effector are regulated at different levels by diverse *** performs its global regulatory function primarily by controlling the transcription of a large number of genes via cAMP receptor protein(CRP)in most *** review can help us understand how bacteria use the two typical nucleotide second messengers to effectively coordinate and integrate various physiological processes,providing theoretical guidelines for future research.

关键词： bacteria cAMP c-di-GMP cross-regulation CRP

Controlling hydrogenation of C=C and C=O bonds in cinnamaldehyde using Pt_(1)/Ni and Pt_(1)/Co single-atom alloy catalysts

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Rare Metals 2024年第6期43卷 2859-2868页

作者： Huan-Shi Lan Yi-Da Yang Qing-di sun Hao Zhang Ying Zhang Qian He Ran Chen Guo-Yi Bai Xiao-Hui He Hong-Bing Ji School of Chemistry and Chemical Engineering Guangxi UniversityNanning 530004China Key Laboratory of Bioinorganicand Synthetic Chemistry of Ministry of Education Fine Chemical Industry Research InstituteSchool of ChemistryIGCMESun Yat-sen UniversityGuangzhou510275China UBFC CNRSENSMMFEMTO-ST Institute25030 Besancon CEDEXFrance College of Chemistry and Materials Science Hebei UniversityBaoding 071002China State Key Laboratory Breeding Base of Green-Chemical Synthesis Technology Institute of Green Petroleum Processing and Light Hydrocarbon ConversionCollege of Chemical EngineeringZhejiang University of TechnologyHangzhou 310014China

Selective hydrogenation of C=C and C=O bonds in cinnamaldehyde(CAL)to produce desired products is a challenging task due to the complex conjugate system of the two unsaturated functional *** this study,a simple ball milling method is presented for synthesizing Pt-based single-atom alloy catalysts(SAAs)that can function as a control switch for the selective hydrogenation of CAL into highly valuable products.

关键词： alloy hydrogenation conjugate

与自然比肩而行——传统笔墨的自律与画家的自觉

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美术 2024年第1期 138-140页

作者：孙涤首都师范大学美术学院

绘画创作的一般规律是画家将其感受与心绪附着在某一题材上,根据内容和题材而生发出与之契合的笔墨语言。传统画家通过不断的人生探索和技艺修炼,体会到艺术与自然、与内心达成秩序上的同构。艺术自觉的画家可抛开客观物象的挟制,用笔... 详细信息

绘画创作的一般规律是画家将其感受与心绪附着在某一题材上,根据内容和题材而生发出与之契合的笔墨语言。传统画家通过不断的人生探索和技艺修炼,体会到艺术与自然、与内心达成秩序上的同构。艺术自觉的画家可抛开客观物象的挟制,用笔墨去同构自然的气势和生命的力量,传达其内心感悟的过程,这一开放的过程衍生出显现写意本质和特性的创作现象与规律,笔墨的自律即是其中一个重要的规律。

关键词：中国画笔墨艺术自律主体自觉

Cardiotoxicity induced by fluoropyrimidine drugs in the treatment of gastrointestinal tumors

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 251-254页

作者： Mo-Wei Kong Feng-di sun Zhen-Ying Pei Li Xu Ze-Bi Wang Yan Chen Shu-Qing Tang Ting-Fang Yang Guo-Xiang He Department of Cardiology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina Department of Oncology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina

In this editorial,we review the article published in World J Gastrointest Oncol 2019,11:*** specifically focus on the occurrence,clinical characteristics,and risk factors of fluoropyrimidine drug-related cardiotoxicity in patients with gastrointestinal *** significant advancements in diagnostic and therapeutic techniques that have reduced mortality rates associated with digestive system tumors,the incidence and mortality rates of treatment-related car-diotoxicity have been increasing,severely impacting the survival and prognosis of cancer *** drugs are widely used as antimetabolites in the treatment of malignant tumors,including gastrointestinal tumors,and they represent the second largest class of drugs associated with ***,there is often a lack of awareness or understanding regarding their cardiotoxic effects and associated risks.

关键词： Cardiotoxicity Gastrointestinal tumors Risk factors Fluoropyrimidine Chest pain

T-CPS下考虑人驾车行为影响的混行车辆协同控制

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控制与决策 2024年第5期39卷 1424-1432页

作者：黄帅孙棣华赵敏重庆大学自动化学院重庆400030 重庆大学信息物理社会可信服务计算教育部重点实验室重庆400030 重庆邮电大学先进制造工程学院重庆400065

由于传统人驾车(traditional human-driven vehicles, HVs)驾驶行为会受到驾驶员的心理和生理活动的不确定性影响,可能使得车辆频繁地加减速,进而导致混合交通条件下网联自动车(connected and automated vehicles, CAVs)很难快速跟踪此... 详细信息

由于传统人驾车(traditional human-driven vehicles, HVs)驾驶行为会受到驾驶员的心理和生理活动的不确定性影响,可能使得车辆频繁地加减速,进而导致混合交通条件下网联自动车(connected and automated vehicles, CAVs)很难快速跟踪此行为.针对这一问题,首先提出一种提前预测传统人驾车行为的组合神经网络.在此基础上,考虑通信时延和车辆运动学特性,设计一种基于交通信息物理系统(transportation-cyber physical system, T-CPS)的混行车群内车辆协同控制策略,使其能够快速跟踪上传统人驾车行为,并对混行车群内网联自动车之间的串稳定性进行分析.最后,在混合交通条件下设置由1辆传统人驾车、1辆领头网联自动车和4辆跟随网联自动车形成的混行车群,利用下一代交通仿真(next generation simulation, NGSIM)车辆轨迹数据选出高质量传统人驾车状态,并通过仿真实验验证所提协同控制策略的有效性和可行性.由仿真实验结果可知,所提协同控制策略可以保证所有的网联自动车能够快速跟踪上传统人驾车行为,为解决新型混合交通带来的新问题提供一定的理论指导和借鉴.

关键词：混合交通交通信息物理系统人驾车行为协同控制组合神经网络 NGSIM

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多切入机制下基于信息物理系统的混合车群协同控制

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控制与决策 2024年第1期39卷 17-25页

作者：黄帅孙棣华赵敏重庆大学自动化学院重庆400030 重庆大学信息物理社会可信服务计算教育部重点实验室重庆400030

传统人驾车(HVs)为了能够快速行驶到目标车道,常常会向目标车道进行强制换道,这一过程被视为传统人驾车的切入机制.然而,该过程会影响目标车道中由传统人驾车和网联自动车(CAVs)组成的混合车群稳定性.当一个车道上由多个传统人驾车组成... 详细信息

传统人驾车(HVs)为了能够快速行驶到目标车道,常常会向目标车道进行强制换道,这一过程被视为传统人驾车的切入机制.然而,该过程会影响目标车道中由传统人驾车和网联自动车(CAVs)组成的混合车群稳定性.当一个车道上由多个传统人驾车组成的车群同时切入到目标车道上的混合车群中时会对混合车群的稳定性影响较大.针对这一问题,首先对车辆动力学模型进行刻画,以描述车辆行驶的平稳性和混合车群的稳定性.然后,为了确保由多个传统人驾车组成的车群同时切入到混合车群时的稳定性,从信息物理系统(CPS)的视角出发,并基于一致性约束和通信拓扑结构,提出一种考虑通信时延和反应时延的混合车群协同控制方法;同时,利用Lyapunov-Krasovskiis理论进一步分析所提出控制方法满足的稳定性条件.最后,通过仿真实验结果表明了所提出控制方法的有效性和可行性.

关键词：混合交通信息物理系统混合车群切入机制协同控制李雅普诺夫理论