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绍兴市基层医务人员吸烟调查

预防医学 2024年第2期36卷 181-184页

作者：见明智鲁迪绍兴市疾病预防控制中心健康教育所浙江绍兴312041

目的了解浙江省绍兴市基层医务人员吸烟情况,并分析其影响因素,为基层医疗机构有效开展控烟工作提供参考。方法于2023年5—6月,采用分层整群抽样方法在绍兴市6个县(市、区)各抽取4个街道(乡镇)的社区卫生服务中心(卫生院)18~60岁在职... 详细信息

目的了解浙江省绍兴市基层医务人员吸烟情况,并分析其影响因素,为基层医疗机构有效开展控烟工作提供参考。方法于2023年5—6月,采用分层整群抽样方法在绍兴市6个县(市、区)各抽取4个街道(乡镇)的社区卫生服务中心(卫生院)18~60岁在职医务人员为调查对象,通过问卷调查收集人口学信息、现在吸烟和戒烟情况等资料;采用多因素logistic回归模型分析基层医务人员吸烟的影响因素。结果发放问卷2 801份,回收有效问卷2 595份,问卷有效率为92.65%。调查男性719人,占27.71%;女性1 876人,占72.29%。年龄为(39.39±10.11)岁。现在吸烟119人,现在吸烟率为4.59%,每日吸烟数量M (QR)为10.00 (14.25)支,吸烟时间M (QR)为20.00 (15.00)年。有戒烟意愿52人,占43.70%;尝试戒烟51人,占42.86%。多因素logistic回归分析结果显示,性别(男,OR=22.998,95%CI:10.912~48.473)、饮酒(OR=3.907,95%CI:2.528~6.037)和工龄(≥15年,OR=3.115,95%CI:1.305~7.434)是基层医务人员现在吸烟的影响因素。结论绍兴市基层医务人员现在吸烟率为4.59%,且戒烟意愿不高;吸烟可能受性别、饮酒和工龄的影响。

关键词：基层医务人员吸烟影响因素

Effects of Fe3+ and Ca2+ on sorption of phenanthrene by Humin in karst soil,Southwest China

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Acta Geochimica 2023年第1期42卷 125-135页

作者： Xianjin An Wei Li Xinyue di Jiacheng Lan School of Karst Science Guizhou Normal University550001 GuiyangChina State Engineering Technology Institute for Karst Desertifi cation Control 550001 GuiyangChina Guiyang University 550005 GuiyangChina School of Geography and Environmental Engineering Gannan Normal University341000 GanzhouChina

Humin(HM) is the main organic matter component to af fect the migration and transformation of polycyclic aromatic hydrocarbons(PAHs) in soil. The study on infl uence of the morphology change of inorganic ions on the adsorption of PAHs in soil and its organic matter is still rare at microscopic scale. In this paper, yellow soil humin(YS-HM) and lime soil humin(LS-HM) were chosen as samples, then Fe^(3+) and Ca^(2+) were added into samples to facilitate the precipitation by changing the existing conditions of ions, and the mechanism by which inorganic precipitation changed adsorption capacity of karst soil was analyzed from the microscopic scale. The results showed that the adsorption capacity of HM reduced with the inorganic precipitation increasing. The precipitation of Ca^(2+)and Fe^(3+) both reduced the adsorption capacity of YS-HM and LS-HM by 61.71% and 71.83% on average, respectively. The results of scanning electron microscope-energy dispersive spectrometry(SEM-EDS) and pore analysis showed that the HM porosity decreased after formation of Ca^(2+) and Fe^(3+) precipitation. According to the value of Freundlich parameter n, it may be because the precipitation or colloid of Ca^(2+) and Fe^(3+) fi lled micropores and covers high-energy adsorption sites of the HM. This research provides theoretical support for studying the PAHs migration and bioavailability of Calcium-rich in karst soil.

关键词： Inorganic ions Humin Phenanthrene Adsorption Soil Karst

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抗体偶联药物在乳腺癌治疗中的研究进展

中国新药与临床杂志 2024年第3期43卷 161-170页

作者：赵诗迪冉然汪泉方杭新月杨谨杨姣西安交通大学医学院第一附属医院癌症中心陕西西安710061 西安交通大学医学院第一附属医院精准医学中心陕西西安710061 西安交通大学医学院第一附属医院肿瘤内科陕西西安710061 西安交通大学医学院第一附属医院药学部陕西西安710061

抗体偶联药物(ADC)是一类治疗乳腺癌的新型靶向药物,由连接子将化疗药物同单克隆抗体(单抗)抗偶联而成,以单抗作为载体将化疗药物靶向运输至目标肿瘤细胞内发挥抗肿瘤作用。根据ADC作用于不同靶点的抗原,分为靶向人表皮生长因子受体2(HE... 详细信息

抗体偶联药物(ADC)是一类治疗乳腺癌的新型靶向药物,由连接子将化疗药物同单克隆抗体(单抗)抗偶联而成,以单抗作为载体将化疗药物靶向运输至目标肿瘤细胞内发挥抗肿瘤作用。根据ADC作用于不同靶点的抗原,分为靶向人表皮生长因子受体2(HER2)、人滋养细胞表面抗原2(Trop-2)及其他分子等类型。目前,全球范围内已有3种ADC获批治疗乳腺癌,除用于HER2阳性乳腺癌的曲妥珠单抗-美坦新偶联物(T-DM1)、曲妥珠单抗-德鲁替康(T-DXd)外,还有可使三阴性乳腺癌(TNBC)获益的戈沙妥珠单抗(SG)。ADC在HER2阳性乳腺癌治疗中疗效显著,同时在治疗晚期TNBC和部分HER2低表达的乳腺癌中也取得了重要进展,为不同乳腺癌分子分型的人群提供了更多选择。

关键词：乳腺肿瘤受体 erbB-2 临床研究抗体偶联药物

腰痹康颗粒联合塞来昔布对腰椎间盘突出症椎间孔镜术后残余症及椎间盘退变的影响

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安徽中医药大学学报 2024年第4期43卷 25-29页

作者：牛永涛樊新甫蒋伟薛娣安徽中医药高等专科学校附属医院安徽芜湖241000

目的探讨腰痹康颗粒对腰椎间盘突出症椎间孔镜术后残余症以及腰椎间盘退变的影响。方法将76例腰椎间盘突出症椎间孔镜术后残余症患者随机分为中药组38例和对照组38例,最终中药组35例、对照组34例完成随访。对照组给予塞来昔布胶囊口服,... 详细信息

目的探讨腰痹康颗粒对腰椎间盘突出症椎间孔镜术后残余症以及腰椎间盘退变的影响。方法将76例腰椎间盘突出症椎间孔镜术后残余症患者随机分为中药组38例和对照组38例,最终中药组35例、对照组34例完成随访。对照组给予塞来昔布胶囊口服,中药组在对照组基础上给予腰痹康颗粒口服,疗程均为1个月。比较两组患者治疗前后疼痛视觉模拟量表(visual analogue scale,VAS)评分,日本骨科协会(Japanese orthopaedic association,JOA)评分,血清细胞凋亡相关指标[B淋巴细胞瘤-2(B-cell lymphoma 2,Bcl-2)、Bcl-2相关的X蛋白(Bcl-2-associated X protein,Bax)、半胱氨酸蛋白酶-3(caspase-3,CASP3)]水平,两组患者髓核(nucleus pulposus,NP)区、纤维环(annulus fibrosus,af)区MRI T2值。结果与术后1 d比较,术后1周两组患者VAS评分显著降低,JOA评分显著升高,差异均有统计学意义(Paf区MRI T2值较术前显著降低(Paf区MRI T2值显著高于对照组(P<0.05)。结论腰痹康颗粒能有效改善腰椎间盘突出症椎间孔镜术后残余症,其作用机制可能是提高血清Bcl-2水平,降低血清Bax、CASP3水平。

关键词：腰痹康颗粒腰椎间盘突出症椎间孔镜术后术后残余症腰椎间盘退变

冷冻球囊前庭扩大消融治疗阵发性心房颤动患者的安全性和有效性

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中国心脏起搏与心电生理杂志 2024年第1期38卷 27-29页

作者：王群邸成业林文华泰达国际心血管病医院心内一科天津300457

目的探讨冷冻球囊(CBA)前庭扩大消融治疗阵发性心房颤动(简称房颤)患者的有效性及安全性。方法选择本院拟行CBA的阵发房颤患者共161例。根据不同的手术方式将其分为CBA常规消融(对照)组(n=81)与CBA常规消融+前庭扩大消融(试验)组(n=80)... 详细信息

目的探讨冷冻球囊(CBA)前庭扩大消融治疗阵发性心房颤动(简称房颤)患者的有效性及安全性。方法选择本院拟行CBA的阵发房颤患者共161例。根据不同的手术方式将其分为CBA常规消融(对照)组(n=81)与CBA常规消融+前庭扩大消融(试验)组(n=80)。术后第1、3、6、12个月,进行门诊或电话随访。对比两组患者不同时间房颤复发率,以及手术并发症发生率。结果两组术后3、6、12个月房颤复发率比较,差异均无统计学意义(分别为6.2%vs 5.0%、11.1%vs 8.8%、18.5%vs 15%,P均>0.05)。两组患者术后并发症发生率分别为7.4%(6/81)、10.0%(8/80),差异无统计学意义(P>0.05)。结论对于阵发性房颤患者,CBA在常规消融的基础上行前庭扩大补充消融并未改善患者房颤复发率,两者安全性无明显差异。

关键词：心血管病学冷冻球囊消融术阵发性心房颤动心房扑动肺静脉电隔离术

Effect of low-temperature ausforming on bainitic transformation and mechanical properties in ultrahigh-strength bainitic steel

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Journal of Iron and Steel Research International 2023年第9期30卷 1843-1853页

作者： Tian-yu Zhang Ling-yu Wang Yu Wang Jun Hu Hong-shuang di Wei Xu State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina

Low-temperature ausforming(LT-af)prior to bainitic transformation leads to a noticeable acceleration of bainitic transformation kinetics;however,the effect of LT-af on the retained austenite(RA)features and the resulting mechanical properties is still ***-af was applied to ultrahigh-strength bainitic steel before *** deformation behavior and the resulting dislocation substructures were investigated by thermomechanical simulator and transmission electron microscopy(TEM).The planar dislocation structures produced during deformation at 350℃ accelerate the bainitic transformation kinetics during isothermal *** effect of LT-af on the bainitic transformation kinetics and the features of RA was elucidated via dilatometer measurement,TEM,scanning electron microscopy,and X-ray *** is observed that LT-af not only retains more RA content but also facilitates improved RA *** trend is mainly due to the large amounts of planar dislocations in RA and bainitic laths inherited from undercooled austenite caused by LT-af,the decrease in bainitic sheaves size,and the increase in filmy RA content compared to the sample without ausforming.A large fraction of filmy RA with high stability and the refinement of bainitic sheaves obtained by LT-af remarkably enhance the strain hardening capacity and achieve significantly better ductility compared to the directly austempered sample.

关键词： Ultrahigh-strength bainitic steel Bainitic transformation Low-temperature ausforming Retained austenite Strain hardening rate

Prevention of atrial fibrillation with renin-angiotensin system inhibitors on essential hypertensive patients:a meta-analysis of randomized controlled trials

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The Journal of Biomedical Research 2015年第6期29卷 475-485页

作者： di Zhao Ze-Mu Wang Lian-Sheng Wang Department of Cardiology The First Affiliated Hospital of Nanjing Medical University

We aimed to investigate the effectiveness and safety of angiotensin-converting enzyme inhibitors （ACEIs） or angiotensin Ⅱ receptor blockers （ARBs） on preventing atrial fibrillation in essential hypertensive patients. Systematic literature retrieval was carried out to obtain randomized controlled trials on the effects of ACEI/ ARBs on essential hypertensive patients before December, 2013. Data extraction and quality evaluation were performed. Meta-analysis was performed by Review Manager 5.2.3. Ten high quality studies （11 articles） with a total of 42,892 patients （20,491 patients in the ACEI/ARBs group and 22,401 patients in the β-blocker or the calcium antagonist group） met the inclusion criteria and were included in the meta-analysis. The results showed that ACEI/ARBs reduced the incidence of atrial fibrillation （af） recurrence compared to calcium antagonists （RR=0.48; 95%CI, 0.40-0.58; P〈0.00001） or β-blockers （RR=0.39; 95%CI, 0.20-0.74; P=0.005） in long-term follow-up, respectively. Furthermore, ACEI/ARBs reduced the incidence of conges- tive heart failure （RR=0.86; 95%CI, 0.77-0.96; P=0.007）. However, no significant effects were observed on the incidence of new af, cardiac death, myocardial infarction, and stroke. Our results suggest that ACEI/ ARBs may reduce the incidence of af recurrence and congestive heart failure, with fewer serious adverse effects.

关键词： angiotensin-converting enzyme inhibitors angiotensin Ⅱ receptor blockers hypertension atrialfibrillation meta-analysis

CD44v8-10 is a marker for malignant traits and a potential driver of bone metastasis in a subpopulation of prostate cancer cells

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Cancer Biology & Medicine 2021年第3期18卷 788-807页

作者： Rosaria A.Fontanella Silvia Sideri Chiara di Stefano Angiolina Catizone Silvia di Agostino Daniela F.Angelini Gisella Guerrera Luca Battistini Giulia Battafarano Andrea Del Fattore Antonio Francesco Campese Fabrizio Padula Paola De Cesaris Antonio Filippini Anna Riccioli Department of Anatomy HistologyForensic Medicine and OrthopaedicsUnit of Histology and Medical EmbryologySapienza UniversityRome 00161Italy Department of Health Sciences School of Medicine-"Magna Graecia"University of Catanzaro Catanzaro 88100Italy IRCCS Fondazione Santa Lucia Rome 00143 Bone Physiopathology Research Unit Genetics and Rare Diseases Research DivisionBambino GesùChildren’s HospitalIRCCSRome 00146Italy Department of Molecular Medicine Sapienza UniversityRome 00161Italy Department of Life Health and Environmental SciencesUniversity of L’AquilaL'Aquila 67100Italy

Objective:Bone metastasis is a clinically important outcome of prostate carcinoma(PC).We focused on the phenotypic and functional characterization of a particularly aggressive phenotype within the androgen-independent bone metastasis-derived PC3 cell *** cells,originated from the spontaneous conversion of a CD44-negative subpopulation,stably express the CD44 v8-10 isoform(CD44 v8-10 pos)and display stem cell-like features and a marked invasive phenotype in vitro that is lost upon CD44 v8-10 ***:Flow cytometry,enzyme-linked immunoassay,immunofluorescence,and Western blot were used for phenotypic and immunologic ***-time quantitative polymerase chain reaction and functional assays were used to assess ***:Analysis of epithelial–mesenchymal transition markers showed that CD44 v8-10 pos PC3 cells surprisingly display epithelial phenotype and can undergo osteomimicry,acquiring bone cell phenotypic and behavioral *** of specific si RNA evidenced the ability of CD44 v8-10 variant to confer osteomimetic features,hence the potential to form bone-specific ***,the ability of tumors to activate immunosuppressive mechanisms which counteract effective immune responses is a sign of the aggressiveness of a *** we report that CD44 v8-10 pos cells express programmed death ligand 1,a negative regulator of anticancer immunity,and secrete exceptionally high amounts of interleukin-6,favoring osteoclastogenesis and immunosuppression in bone ***,we identified a novel pathway activated by CD44 v8-10,involving tafazzin(TAZ)and likely the Wnt/TAZ axis,known to play a role in upregulating osteomimetic ***:CD44 v8-10 could represent a marker of a more aggressive bone metastatic PC population exerting a driver role in osteomimicry in bone.A novel link between TAZ and CD44 v8-10 is also shown.

关键词： Metastasis epithelial phenotype EMT MET IL-6 TAZ

芪参益气滴丸治疗冠心病心绞痛的有效性和安全性:系统评价与Meta分析

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中国循证心血管医学杂志 2024年第6期16卷 667-673页

作者：卢恩仕何丽云雒琳张迪王鑫吴东宁中国中医科学院中医临床基础医学研究所北京100700

目的系统评价芪参益气滴丸治疗冠状动脉粥样硬化性心脏病(冠心病)心绞痛的有效性和安全性。方法共检索7个中英文数据库,从中收集芪参益气滴丸治疗冠心病心绞痛的随机对照试验(RCTs),检索时间为建库至2023年1月1日,并采用RevMan 5.4.1软... 详细信息

目的系统评价芪参益气滴丸治疗冠状动脉粥样硬化性心脏病(冠心病)心绞痛的有效性和安全性。方法共检索7个中英文数据库,从中收集芪参益气滴丸治疗冠心病心绞痛的随机对照试验(RCTs),检索时间为建库至2023年1月1日,并采用RevMan 5.4.1软件进行Meta分析。结果共纳入17项研究,涉及1817例受试者。相较于常规西药治疗,芪参益气滴丸能够更好的改善冠心病心绞痛患者的中医证候疗效(OR=6.43,95%CI:4.17~9.90,Paf、TS,DP评分,并能够降低超敏c-反应蛋白(hs-CRP)水平(MD=-1.88,95%CI:-2.81~-0.96,P<0.0001),提高左室射血分数(LVEF)水平(MD=2.53,95%CI:0.76~4.30,P=0.005)。亚组分析显示,当治疗时间为6个月时,芪参益气滴丸在升高LVEF方面具有更好的疗效(MD=2.53,95%CI:0.76~4.30,P=0.005,I^(2)=83%)。两组均未发生严重不良反应,在安全性方面无明显差异。结论芪参益气滴丸联合常规西药治疗对冠心病心绞痛具有更好的临床疗效,且无严重不良反应。但上述结论仍需更多高质量研究进一步验证。

关键词：芪参益气滴丸冠心病心绞痛随机对照试验 Meta分析