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Application Potential of Mg–Zn–Nd Alloy as a Gastrointestinal Anastomosis nail Material

Acta Metallurgica Sinica(English Letters) 2022年第4期35卷 609-620页

作者： Lihui Song Ming Gao Lili Tan Zheng Ma Peng Ni Min Zhou di na Department of Surgical Oncology and General Surgery The First Hospital of China Medical UniversityKey Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors(China Medical University)Ministry of EducationShenyang 110001China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

Gastrointestinal tumors are common malignant tumors in the digestive tract, of which gastric cancer is the third leading cause of cancer death and colorectal cancer is the fourth most deadly cancer. Nowadays, surgical resection remains to be one of the main measures for treating digestive tract tumors, and gastrointestinal anastomosis remains to be a key step in gastrointestinal surgery. Mg and its alloys have great potentials to be used for gastrointestinal anastomosis as anastomotic nail materials due to their biodegradability, good mechanical properties and biocompatibility. In this study, Mg–2Zn–0.5Nd(ZN20) alloy fine wires showed great potential as surgical staples. When we performed in vitro corrosion experiments, drainage fluid was collected from different parts of the patient’s abdominal cavity after surgery for the first time to replace the traditional simulation fluid and to more realistically simulate the microenvironment required by the anastomotic nail. ZN20 alloy has an ultimate tensile strength of 256 MPa, an elongation rate of 12.56%, a tensile force in anastomosis of 16.8 N, and a rupture pressure after anastomosis at 17 kPa, which means that a sufficient mechanical support was provided after *** statistical analysis and histopathological analysis of biochemical tests indicate that ZN20 alloy has no adverse effect on the normal metabolism of liver, kidney and body, but has superior biocompatibility and biosafety. This work confirms that ZN20 possesses a great application potential in the clinical field as a new type of gastrointestinal anastomotic nail material.

关键词： Magnesium alloy Gastrointestinal tumor Absorbable Degradation rate

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Astragalus extract inhibits destruction of gastric cancer cells to mesothelial cells by anti-apoptosis

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World Journal of Gastroenterology 2009年第5期15卷 570-577页

作者： di na Fu-nan Liu Zhi-Feng Miao Zong-Min Du Hui-Mian Xu Department of Oncology The First Affiliated Hospital China Medical University Shenyang 110001 Liaoning Province China

AIM： To determine the inhibitory effect of Astragalus memebranaceushas on gastric cancer cell supernatant- induced apoptosis of human peritoneal mesothelial cells. METHODS： Human peritoneal mesothelial cell （HPMC） line HMrSV5 was co-incubated with gastric cancer cell supernatant （MKN45） and/or Astragalus memebranaceushas. Morphological changes in gastric cancer cells were observed under phase-contrast microscope. Quantitative cell damage was determined by MTT assay. Apoptosis was determined under transmission electron microscope and quantified by detectinr, acridine orange/ethidium bromide-stained （AO/EB） condensed nuclei under fluorescent microscope or by flow cytometry. Expressions of Bcl-2 and Bax were evaluated with immunostaining.

关键词： Peritoneal carcinomatosis Stomachneoplasm Astragalus plant Mesothelial cell Apoptosis

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Comparing Operational Efficiency of Mobile Operators in Brazil, Russia, India and China

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China & World Economy 2009年第5期17卷 104-120页

作者： Chun-Hsiung Liao diána B.González Department of Communication and Transportation Management and Institute of Telecommunications Management National Cheng Kung University Institute of International Management National Cheng Kung University

Using partial factor productivity and data envelopment analysis approaches, this study measures and compares the operational efficiency of the 10 dominant mobile operators in Brazil, Russia, India and China （BRIC） between 2002 and 2006. The results of data envelopment analysis indicate that the two leading Brazilian mobile operators, Vivo and TIM, are fully efficient throughout the entire period of study, however, Indian mobile operators are the least efficient among BRIC operators. Interestingly, the findings of this study verify that full operational efficiency can be achieved by operators with large revenues, such as China Unicorn, and by other, y with medium and small revenues, such as Hvo, TIM and Oi. Partial faetor productivity demonstrates that 3 of the 4 Brazilian mobile operators, Vivo, TIM and Oi, have remarkable productivity ratios, and that the state-owned operator, China Unicom, has the highest revenue per capital expenditure among BRIC operators. In contrast, Indian mobile operators ＇productivity ratios are generally low compared to other BRIC mobile carriers.

关键词： BRIC data envelopment analysis mobile operator operational efficiency partial factor productivity

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Apolipoprotein A1 suppresses the hypoxia-induced angiogenesis of human retinal endothelial cells by targeting PlGF

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 33-39页

作者： Jie Hu Zhu-Ting Chen Kun-Yi Su Yu Lian Lin Lu An-di-na Hu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina

AIM:To investigate the anti-angiogenic effect of apolipoprotein A1(apoA1)on primary human retinal vascular endothelial cells(HRECs)and explore the possible ***:The primary HRECs were transfected with apoA1-GFP recombinant lentiviral and were compared with cells undergoing transfection with empty lentiviral *** chambers were used to simulate the anoxic environment of cells under pathological *** concentrations of secreted vascular endothelial growth factor(VEGF)and placental growth factor(PlGF)were measured by enzyme-linked immunosorbent assay(ELISA).Cell migration ability was detected by wound healing *** sprouting of HRECs was determined by tube formation *** protein levels of extracellular signal regulated kinase 1/2(ERK1/2)and phosphor ylated ERK1/2(p-ERK1/2)were measured by Western ***:Overexpressed apoA1 in hypoxia-induced HRECs significantly suppressed PlGF(0.67±0.10 folds,P=0.007).Overexpressed apoA1 also attenuated hypoxiainduced cell migration(0.32±0.11 folds,Pnase kinase(MEK)inhibitor(U0126)further reduced the PlGF and angiogenesis in hypoxia-induced ***:ApoA 1 inhibits the angiogenesis at least in part by inactivating ERK1/2 in hypoxia-induced ***,apoA1 suppresses the PlGF expression,which selectively associated with pathological angiogenesis.

关键词： apolipoprotein A1 retinal neovascularization placental growth factor MEK/ERK signaling pathway

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The mechanical property and corrosion resistance of Mg-Zn-Nd alloy fine wires in vitro and in vivo

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Bioactive Materials 2021年第1期6卷 55-63页

作者： Ming Gao di na Xiangqiao Ni Lihui Song Iniobong PEtim Ke Yang Lili Tan Zheng Ma School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China Institute of Metal Research Chinese Academy of SciencesShenyang110016China The First Hospital of China Medical University Department of Surgical OncologyChina

Titanium and its alloy are commonly used as surgical staples in the reconstruction of intestinal tract and stomach,however they cannot be absorbed in human body,which may cause a series of complications to influence further *** and its alloy have great potential as surgical staples,because they can be degraded in human body and have good mechanical properties and *** this study,Mg-2Zn-0.5Nd(ZN20)alloy fine wires showed great potential as surgical *** ultimate tensile strength and elongation of ZN20 alloy fine wires were 248 MPa and 13%,respectively,which could be benefit for the deformation of the surgical staples from U-shape to *** bursting pressure of the wire was about 40 kPa,implying that it can supply sufficient mechanical support after *** test and histological analysis illustrated good biocompatibility and biological safety of ZN20 alloy fine *** residual tensile stress formed on the outside of ZN20 fine wire during drawing would accelerate the *** second phase had a negative influence on corrosion property due to galvanic *** corrosion rate in vitro was faster than that in vivo due to the capsule formed on the surface of ZN20 alloy fine wire.

关键词： Magnesium Surgical staple Anastomosis Corrosion resistance In vivo

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World Journal of diabetes 2021年第5期12卷 658-672页

作者： Nikolett Bódi diána Mezei Payal Chakraborty Zita Szalai Bence Pál Barta János Balázs Zsolt Rázga Edit Hermesz Mária Bagyánszki Department of Physiology Anatomy and NeuroscienceFaculty of Science and InformaticsUniversity of SzegedSzeged 6726Hungary Department of Biochemistry and Molecular Biology Faculty of Science and InformaticsUniversity of SzegedSzeged 6726Hungary Department of Pathology Faculty of MedicineUniversity of SzegedSzeged 6720Hungary

BACKGROUND The importance of the neuronal microenvironment has been recently highlighted in gut region-specific diabetic enteric neuropathy. Regionally distinct thickening of endothelial basement membrane(BM) of intestinal capillaries supplying the myenteric ganglia coincide with neuronal damage in different intestinal segments. Accelerated synthesis of matrix molecules and reduced degradation of matrix components may also contribute to the imbalance of extracellular matrix dynamics resulting in BM thickening. Among the matrix degrading proteinases, matrix metalloproteinase 9(MMP9) and its tissue inhibitor(TIMP1) are essential in regulating extracellular matrix *** To evaluate the intestinal segment-specific effects of diabetes and insulin replacement on ganglionic BM thickness, MMP9 and TIMP1 *** Ten weeks after the onset of hyperglycaemia gut segments were taken from the duodenum and ileum of streptozotocin-induced diabetic, insulin-treated diabetic and sex-and age-matched control rats. The thickness of BM surrounding myenteric ganglia was measured by electron microscopic morphometry. Wholemount preparations of myenteric plexus were prepared from the different gut regions for MMP9/TIMP1 double-labelling fluorescent immunohistochemistry. Post-embedding immunogold electron microscopy was applied on ultrathin sections to evaluate the MMP9 and TIMP1 expression in myenteric ganglia and their microenvironment from different gut segments and conditions. The MMP9 and TIMP1 messenger ribonucleic acid(m Rna) level was measured by quantitative polymerase chain *** Ten weeks after the onset of hyperglycaemia, the ganglionic BM was significantly thickened in the diabetic ileum, while it remained intact in the duodenum. The immediate insulin treatment prevented the diabetes-related thickening of the BM surrounding the ileal myenteric ganglia. Quantification of particle density showed an increasing tendency for MMP9 and a decreasing tenden

关键词： Type 1 diabetes diabetic enteric neuropathy Neuronal microenvironment Basement membrane Matrix metalloproteinase 9 Tissue inhibitor of metalloproteinase 1

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Local Application of Combined Drugs of natural Essential Oils for the Prevention of Acute Pharyngitis

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第5期13卷 311-320页

作者： diāna Katoviča Marks Ronis Beāte Rundāne Pauls Stradins Clinical University Hospital Riga Latvia Childrens Clinical University Hospital Riga Latvia Faculty of Medicine Rga Stradi University Riga Latvia

Objective: Viral pharyngitis, commonly known as a sore throat, is a widespread condition affecting people of all ages globally. This study aimed to assess the effectiveness of a medical device containing the combined drugs of natural essential oils (CDNEO) formulation in managing throat pain in patients with acute viral pharyngitis. With the growing resistance to traditional antibacterial treatments, essential oils have attracted interest for their potential analgesic, anti-inflammatory, and antibacterial properties. Results: The study involved 81 patients randomly divided into two groups: those taking a medical device containing combined drugs of natural essential oils (CDNEO) and those taking a placebo. A questionnaire was used to assess throat pain among the participants, with 45 receiving the CDNEO and 36 the placebo. The CDNEO group experienced a significant reduction in throat pain, with the average VAS score decreasing from 5.36 to 1.09, compared to the placebo group, which saw a decrease from 4.97 to 2.19. This difference, with p Conclusion: By using a double-blind research method, it was possible to evaluate the effectiveness of the oils more objectively, since there was also a control placebo group. The study shows that CDNEO significantly reduces throat pain and decreases the need for additional pain relief medication in patients with acute viral pharyngitis. The findings suggest that natural essential oils could serve as an alternative treatment for pharyngitis, particularly in efforts to minimize NSAID use and combat antibiotic resistance.

关键词： Sore Throat Essential Oils NSAID Acute Viral Pharyngitis natural Treatment

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中国碳密集型产业的出口战略研究——基于欧盟碳泄漏的视角

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软科学 2016年第11期30卷 29-33,39页

作者：邸玉娜北京工商大学经济学院北京100048

运用世界投入产出表数据对碳密集型产业进行了识别,测度结果表明:2005年以来中国各产业碳排放强度已下降40%,完成中国自主贡献目标一半以上。碳排放量较高的6类产业累计碳泄漏量占欧盟对中国碳泄漏总量的70%以上。其中,大部分碳密集型... 详细信息

运用世界投入产出表数据对碳密集型产业进行了识别,测度结果表明:2005年以来中国各产业碳排放强度已下降40%,完成中国自主贡献目标一半以上。碳排放量较高的6类产业累计碳泄漏量占欧盟对中国碳泄漏总量的70%以上。其中,大部分碳密集型产业目前虽然出口量大,但已经不具有对欧盟出口的比较优势。而其他非金属矿物等产业虽具有出口竞争力,但却属于新兴技术产业亟需的稀缺资源,应对其出口规模加以限制。产业调整的同时,也需积极应对碳泄漏背景下的相关贸易壁垒,为碳密集型产业出口战略转型获取发展空间。

关键词：碳密集型产业碳泄漏出口战略

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人道主义干涉的概念界定及其争议的学术审思

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湖南科技大学学报（社会科学版） 2020年第4期23卷 114-120页

作者：狄英娜《求是》杂志社北京100072

人道主义干涉是当前国际政治发展所面临的重大问题,也是回答“世界怎么了,我们怎么办”这一问题时不容回避的重要命题。“人道主义”概念自诞生以来,其内涵经历了存在和实证的多重发展,有一个不断丰富和发展的过程。学界关于人道主义干... 详细信息

人道主义干涉是当前国际政治发展所面临的重大问题,也是回答“世界怎么了,我们怎么办”这一问题时不容回避的重要命题。“人道主义”概念自诞生以来,其内涵经历了存在和实证的多重发展,有一个不断丰富和发展的过程。学界关于人道主义干涉争诉不断的关键原因在于,未能从理论上界定清楚人道主义干涉、人道主义干预、人道主义援助之间的联系与区别。对人道主义干涉基本概念理论内涵的清晰界定,是科学透视后冷战时代人道主义干涉的两种不同发展路向的理论基础。西方人道主义理论是“干涉”的理论,其实质是把人道主义当成干涉的借口。把生命权、发展权作为维护基本人权的出发点,才是真正的人道主义关怀。

关键词：人道主义干涉概念界定学术争议发展路向

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中国汽车保险奖惩系统的严厉性比较

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统计研究 2005年第8期22卷 48-52页

作者：邸娜天津农学院经济管理系

The author calculates the internationally common indicators to evaluate severeness of encouraging and punishing system,compares and analyzes the severeness of automobile insurance of 5 property insurance companies of ... 详细信息

关键词：中国汽车保险奖惩系统严厉性指标保险公司无赔款优待条款

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