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Clinical analysis of the risk factors for recurrence of HCC and its relationship with HBV

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World Journal of Gastroenterology 2005年第14期11卷 2061-2066页

作者： di-PengOu lian-YueYang Geng-WenHuang Yi-MingTao Xiangding Zhi-GangChang LiverCancerLaboratory DepartmentofSurgeryXiangyaHospitalCentralSouthUniversityChangsha410008HunanProvinceChina

AIM: To comprehend the risk factors of recurrence of hepatocellular carcinoma (HCC) and its relationship with the infection patterns of hepatitis B virus (HBV). METHODS: All materials of 270 cases of postoperative HCC were statistically analyzed by SPSS software. Recurrence and metastasis were classified into early (≤2 years) and late phase (＞2 years). Risk factors for recurrence and metastasis after surgery in each group were ***: Out of 270 cases of HCC, 162 cases were followed up in which recurrence and metastasis occurred in 136 cases. There were a lot of risk factors related to recurrence and metastasis of HCC; risk factors contributing to early phase recurrence were serum AFP level, vascular invasion, incisal margin and operative transfusion, gross tumor classification and number of intrahepatic node to late phase recurrence. The HBV infective rate of recurrent HCC was 94.1%, in which 'HBsAg, HBeAb, HBcAb' positive pattern reached 45.6%. The proportion of HBV infection in solitary large hepatocellular carcinoma (SLHCC) evidently decreased compared to nodular hepatocellular carcinoma (NHCC) (P＜0.05).CONCLUSION: The early and late recurrence and metastasis after hepatectomy of HCC were associated with different risk factors. The early recurrence may be mediated by vascular invasion and remnant lesion, the late recurrence by tumor's clinical pathology propert, as multicentric carcinogenesis or intrahepatic carcinoma denovo. HBV replication takes a great role in this process. From this study, we found that SLHCC has more satisfactory neoplasm biological behavior than NHCC.

关键词： Hepatocellular carcinoma Recurrence and metastasis Risk factor Hepatitis B virus

The Second Conference of Global Chinese Scholars on Hydrodynamics(CCSH'2016)

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Journal of Hydrodynamics 2016年第1期28卷 170-171页

作者： lian-di ZHOU

Wuxi,Jiangsu,China November 11-14,2016（Revised）Call for Papers：Authors are kindly requested to submit abstracts of proposed papers in English not less than 1000 words,which should state clearly the purpose,methods,results and conclusions of the work,to the Secretary General at ccsh16@*** proceedings in English will be published with an International Standard Book Number（ISBN）and made available to all participants of the Conference.

关键词： abstracts Jiangsu submit proceedings conclusions Number Secretary welcomes acceptance clearly

The Second Conference of Global Chinese Scholars on Hydrodynamics(CCSH'2016)

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Journal of Hydrodynamics 2015年第5期27卷 996-997页

作者： lian-di ZHOU Wuxi Jiangsu China

Authors are kindly requested to submit abstracts of proposed papers in English not less than 1000 words, which should state clearly the purpose, methods, results and conclusions of the work, to the Secretary General at eeshl6@***. The proceedings in English will be published with an International Standard Book Number （ISBN） and made available to all participants of the Confere- nce.

关键词： work will The Second Conference of Global Chinese Scholars on Hydrodynamics CCSH’2016

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The Second Conference of Global Chinese Scholars on Hydrodynamics(CCSH'2016)

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Journal of Hydrodynamics 2015年第4期27卷 633-634页

作者： Zhou, lian-di Editorial Board of Journal of Hydrodynamics Shanghai China

Wuxi,Jiangsu,China November 20-23,2016Call for Papers：Authors are kindly requested to submit abstracts of proposed papers in English not less than 1000 words,which should state clearly the purpose,methods,results and conclusions of the work,to the Secretary General at ccsh16@*** proceedings in English will be published with an International Standard Book Number（ISBN）and made available to all participants of the Conference.

关键词： work The Second Conference of Global Chinese Scholars on Hydrodynamics CCSH’2016

Efficient production of pronuclear embryos in breeding and nonbreeding season for generating transgenic sheep overexpressing TLR4

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Journal of Animal Science and Biotechnology 2017年第1期8卷 43-50页

作者： Yan Li di lian Shoulong Deng Xiaosheng Zhang Jinlong Zhang Wenting Li Hai Bai Zhixian Wang Hongping Wu Juncai Fu Hongbing Han Jianzhong Feng Guoshi Liu Ling lian Zhengxing lian Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture Beijing Key Laboratory for Animal Genetic Improvement College of Animal Science and Technology China Agricultural University Beijing 100193 China Department of Public Health Benedictine University Lisle IL 60532 USA State Key Laboratory of Reproductive Biology institute of Zoology Chinese Academy of Sciences Beijing 100101 China Tianjin Institute of Animal Sciences Tianjin 300381 China

Background： Brucella is a zoonotic Gram-negative pathogen that causes abortion and infertility in ruminants and humans. TLR4 is the receptor for LPS which can recognize Brucella and initiate antigen-presenting cell activities that affect both innate and adaptive immunity. Consequently, transgenic sheep over-expressing TLR4 are an suitable model to investigate the effects of TLR4 on preventing Brucellosis. In this study, we generated transgenic sheep overexpressing TLR4 and aimed to evaluate the effects of different seasons（breeding and non-breeding season） on superovulation and the imported exogenous gene on ***： In total of 43 donor ewes and 166 recipient ewes in breeding season, 37 donor ewes and 144 recipient ewes in non-breeding season were selected for super-ovulation and injected embryo transfer to generate transgenic *** results indicated the no. of embryos recovered of donors and the rate of pronuclear embryos did not show any significant difference between breeding and non-breeding seasons（P 〉 0.05）. The positive rate of exogenous TLR4 tested were 21.21 % and 22.58 % in breeding and non-breeding season by Southern blot. The expression level of TLR4 in the transgenic sheep was 1.5 times higher than in the non-transgenic group（P 〈 0.05）. The lambs overexpressing TLR4 had similar growth performance with non-transgenic lambs, and the blood physiological parameters of transgenic and non-transgenic were both in the normal range and did not show any ***： Here we establish an efficient platform for the production of transgenic sheep by the microinjection of pronuclear embryos during the whole year. The over-expression of TLR4 had no adverse effect on the growth of the sheep.

关键词： Growth Microinjection Pronuclear embryos Sheep Superovulation

SIMULATION OF 3-D FLOW AROUND A VAN-BODY TRUCK WITH RNG K-ε TURBULENCE MODEL

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Journal of Hydrodynamics 2001年第4期13卷 98-101页

作者： Du, Guang-Sheng Wang, De-Chang Lei, Li Zhou, lian-di Coll. of Water Conservancy Wuhan Univ. Ji'nan 250061 China

It is proved that the calculation precision of the outside flow field of the van-body truck using PNG k-Ε turbulence model is higher than that using standard k-Ε turbulence model by means of experiments. The calculation results of the outside flow field of a certain domestic van-body truck are given. And by analyzing and comparing the different tail flow plots, the tail flow structural characteristics and the relationship between the position and the intensity of the tail vortex and the aerodynamic drag is obtained, which can direct the design of the outside aerodynamic shape of the van-body truck.

关键词： Computer simulation Drag Mathematical models Turbulent flow

Impact of the COVID-19 kindergarten closure on overweight and obesity among 3-to 7-year-old children

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World Journal of Pediatrics 2023年第5期19卷 469-477页

作者： Xiang Long Xing-Ying Li Hong Jiang lian-di Shen Li-Feng Zhang Zheng Pu Xia Gao Mu Li Department of Woman and Child Health Care Jiading Maternal and Child Health Care Hospital1216 Gaotai RoadJiading DistrictShanghai 201821China School of Public Health Key Laboratory of Health Technology Assessment(National Health Commission of the People’s Republic of China)Fudan UniversityMailbox 175138 Yixueyuan RoadXuhui DistrictShanghai 200032China Department of Administrative Office Jiading Maternal and Child Health Care Hospital1216 Gaotai RoadJiading DistrictShanghai 201821China School of Public Health The University of SydneySydneyAustralia

Background Knowledge on the impact of the temporary kindergarten closure policy under COVID-19 in 2020 on childhood overweight and obesity is *** aimed to examine differences in rates of overweight and obesity from 2018 to 2021 among kindergarten children aged 3–7 *** Overweight was defined as body mass index(BMI)>1 standard deviation(SD)for age and sex,and obesity was defined as BMI>2 SD for age and *** linear mixed modeling was used for *** A total of 44,884 children and 71,216 growth data points from all 57 public kindergartens in Jiading district,Shanghai,China were *** rates of obesity from 2018 to 2021 were 6.9%,6.6%,9.5%,and 7.3%in boys and 2.8%,2.8%,4.5%,and 3.1%in girls,*** rates of overweight from 2018 to 2021 were 14.3%,14.3%,18.2%,and 15.3%in boys and 10.6%,10.9%,13.9%,and 11.6%in *** rates of obesity and overweight among kindergarten children in 2020 were significantly higher than those in 2018,2019,and *** to 2020,the odds ratios of the obesity rate in 2018,2019,and 2021 were 0.67[95%confidence interval(CI)=0.58–0.77,P<0.001],0.72(95%CI=0.64–0.80,P<0.001)and 0.81(95%CI=0.72–0.92,P=0.001),*** odds ratios of the overweight rate in 2018,2019,and 2021 were 0.75(95%CI=0.69–0.82,P<0.001),0.78(95%CI=0.72–0.84,P<0.001),and 0.89(95%CI=0.81–0.97,P=0.008),respectively,compared to *** The rates of overweight and obesity significantly increased among kindergarten children in 2020 after the 5-month kindergarten *** was critical to provide guidance to caregivers on fostering a healthy lifestyle for children at home under public health emergencies.

关键词： Childhood obesity Childhood overweight Coronavirus disease 2019(COVID-19) Kindergarten closure

Effect of miR-184 and miR-205 on the tumorigenesis of conjunctival mucosa associated lymphoid tissue lymphoma through regulating RasL10B and TNFAIP8

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 1-8页

作者： Yu-Zhen Li Pei Mou Ya Shen lian-di Gao Xin-Xin Chen Rui-Li Wei Department of Ophthalmology Second Affiliated Hospital of Naval Medical UniversityShanghai 200003China Department of Nursing Second Affiliated Hospital of Naval Medical UniversityShanghai 200003China

AIM:To explore the effect of miR-184 and miR-205 on the proliferation and metastasis of conjunctival mucosa associated lymphoid tissue(MALT)***:Tissue of tumor and adjacent normal control from 5 patients with conjunctival MALT was ***8226 cell line was selected to verify the effect of mi RNAs in B *** function of micro RNA on the RPMI8226 cell apoptosis,migration and invasion was evaluated by apoptosis assay and Transwell *** m RNA and protein expression were examined by quantitative RT-PCR and Western *** effect of micro RNA on regulation of downstream gene expression was evaluated by luciferase report ***:A decreased level of miR-184 and miR-205 was observed in MALT lymphoma *** miR-184 and miR-205 analogues promoted apoptosis,and inhibited the survival,migration,and invasion of RPMI8226 ***-184 and miR-205 inhibitor reversed the *** RNA and protein level of Ras L10 B and TNFAIP8 were downregulated in MALT lymphoma *** exogenous of miR-184 and miR-205 promoted the expression of Ras L10 B and ***,inhibition of miR-184 and miR-205 repressed the expression of target gene,Ras L10 B and ***:miR-184 and miR-205 suppresses the tumorigenesis of conjunctival MALT lymphoma through regulating Ras L10 B and TNFAIP8.

关键词： mucosa associated lymphoid tissue lymphoma microRNA migration Ras L10B TNFAIP8

Primary Meningeal Melanocytoma Located in Foramen Magnum:a Case Report and Review of the Literatures

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Chinese Medical Sciences Journal 2012年第2期27卷 115-120页

作者： Ming-chao Fan Jing-feng Wang Wei-wei Fu Ke Liu lian-di Li Peng Sun Department of Neurosurgery Intensive Care Unit the Affiliated Hospital of Medical CollegeQingdao UniversityQingdao 266003China Department of Neurosurgery the Affiliated Hospital of Medical CollegeQingdao UniversityQingdao 266003China Department of Pathology the Affiliated Hospital of Medical CollegeQingdao UniversityQingdao 266003China

LIMAS and Tio1 proposed the term meningeal melanocytoma first time in 1972 to describe a primary melanotic tumor of the leptomeninges with prolonged clinical course and benign *** melanocytoma of the central nervous system is rare and benign primary meningeal melanocytoma (PMM) is more exceptional,and also less usual than the malignant types.2 This rare tumor falls under the subclassification of primary melanocytic lesions in the World Health Organization's classification of central nervous system tumors.3 PMM located in the foramen magnum region is an unusual cause of bulbus medullae and fourth ventricle *** we report a 48-year-old man with a PMM which is located in the foramen magnum inducing supratentorial obstructive hydrocephalus.

关键词： foramen magnum meningeal melanocytoma histopathology neuroimaging obstructive hydrocephalus