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The Effects of different Compatibilities of Qing'e Formula on Scopolamine-induced Learning and Memory Impairment in the Mouse

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World Journal of Traditional Chinese Medicine 2017年第3期3卷 12-17页

作者： Xiao-Ping Zheng fang-di Hu Li Yang Yu-Ling Ma Bo-Lu Sun Chang-Hong Wang Zheng-Tao Wang School of Pharmacy Lanzhou UniversityLanzhou 730000 The MOE Key Laboratory for Standardization of Chinese Medicines and the Key Laboratory for Pharmacology of Compound Chinese Medicine of Shanghai Institute of Chinese Materia MedicaShanghai University of Traditional Chinese Medicine Research Center for Traditional Chinese Medicine of Complexity System Shanghai University of Traditional Chinese MedicineShanghai 201302China

Background: The Qing'e formula(QEF) is a well-known traditional Chinese prescription that has been clinically employed for treatment of bone disease for hundreds of years. Objective: The present study aims to observe the effects of different compatibilities of QEF on the scopolamine-induced learning and memory impairment in the mouse, and further to explore its action mechanisms and compatibility *** and Methods: The learning and memory alterations in the mouse were evaluated using the step-down test and Morris water maze(MWM) test; the acetylcholinesterase(AChE) activity and brain-derived neurotrophic factor(BDNF) expression in the hippocampus were measured using colorimetric method or immunohistochemistry. Results: The results showed that different compatibilities of QEF significantly prolonged latency in the step-down test, shortened escape latency in the navigation test, increased the percentage of residence time, and the percentage of swimming distance in the target quadrant in the probe trial session. In addition, our results also found that different compatibilities of QEF remarkably inhibited AChE activity and increased BDNF expression in the hippocampus of mice. What's more, the group after being treated with whole recipe(QF) showed the highest level of improvement. Conclusions: These findings not only suggest that QEF may effectively ameliorate cognitive deficits through inhibiting AChE activity and increasing BDNF expression in the hippocampus but also elucidate the rationality of QEF.

关键词： Acetylcholinesterase brain-derived factor Learning and memory Qing’e formula

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肺炎患儿治疗后喘息发生风险预测评分价值分析

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中国妇幼保健 2024年第3期39卷 462-465页

作者：白敏黄烈平徐玉兰李艳华戴方娣韩宜姚舟山市妇女儿童医院儿科浙江舟山316000

目的探讨肺炎患儿治疗后喘息发生风险预测评分价值。方法选取2020年6月—2022年6月舟山市妇女儿童医院收治的肺炎患儿162例,参照《儿童社区获得性肺炎诊疗规范(2019年版)》予以治疗,并根据治疗后是否发生喘息分为喘息组(53例)和非喘息... 详细信息

目的探讨肺炎患儿治疗后喘息发生风险预测评分价值。方法选取2020年6月—2022年6月舟山市妇女儿童医院收治的肺炎患儿162例,参照《儿童社区获得性肺炎诊疗规范(2019年版)》予以治疗,并根据治疗后是否发生喘息分为喘息组(53例)和非喘息组(109例)。采用多因素logistic回归分析影响喘息风险的相关因素,根据比值比(OR)对每个风险因素进行赋分并构建喘息发生风险评分,绘制ROC曲线评价风险评分模型的预测价值。结果喘息组特应性体质、支原体感染占比及嗜酸性粒细胞水平高于非喘息组,血红蛋白、用力呼气中段流速预计值(FEF25%~75%pred)低于非喘息组,差异均有统计学意义(P1分为喘息高危人群。模型验证结果显示:曲线下面积为0.788(95%CI:0.715~0.861),灵敏度为56.60%,特异度为90.83%,低风险组喘息发生率(37.27%)低于高风险组(46.34%),差异有统计学意义(χ^(2)=5.109,P=0.024)。结论肺炎患儿治疗后喘息发生风险与特应性体质、支原体感染、高嗜酸性粒细胞、低血红蛋白及低肺功能有关。

关键词：肺炎喘息特应性体质嗜酸性粒细胞

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Evaluation preparation technology of Xiaochaihu granules using fingerprint-peak pattern matching

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Journal of Pharmaceutical Analysis 2011年第2期1卷 119-124页

作者： Yu-Qiong Wu Yu- Qiang Gou Jing Han Ying-Yan Bi Shi-Lan Feng fang-di Hu Chun- Ming Wang School of Pharmacy Lanzhou University Lanzhou 730000 China the Second People's Hospital of Gansu Province Lanzhou 730000 China Center for disease Control and Prevention Lanzhou Military Area Command of Chinese People's Liberation Army Lanzhou 730000 China College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 China

An approach was proposed to evaluate preparation technology by means of fingerprint-peak matching technology of high performance liquid chromatography with diode array detector （HPLC-DAD）. Similarity and hierarchical clustering analysis （HCA） were applied to identify the 15 batches of Xiaochaihu granules from different manufacturers and our laboratory, and peak pattern matching between the composite formulae and Radix Bupleuri Chinensis, which was one of the main ingredients of Xiaochaihu granules, was utilized to evaluate the preparation technology of Xiaochaihu granules via the indexes of the relative deviation of retention time （RT） and UV spectrum feature similarity of their corresponding peaks. Eleven matching peaks were found between Xiaochaihu granules and Radix Bupleuri Chinensis. However, the saikosaponin A and saikosaponin D, which are the important active components in Radix Bupleuri Chinensis, were not found in Xiaochaihu granules from any manufacturers. The peak areas of 11 characteristic peaks of Xiaochaihu granules samples formed a matrix of 11 × 15. The result of HCA showed that Xiaochaihu granules samples were divided into four kinds of category. Xiaochaihu granules samples from the same manufacturer were basically clustered of the same category. The results suggested that the saikosaponin A and saikosaponin D are prone to structural transformation under the condition of decoction and in the presence of the organic acidic components. These active components, existing in raw herb, might transform to a series of non-active secondary saikosaponin due to unfavourable preparation technology. So the conventional decoction-based preparation technology of Xiaochaihu granules might greatly affect its quality and therapeutic effectiveness. This study demonstrates that fingerprint-peak matching technology can not only be used for quality control of this composite formulae, but also provide some guidance for preparation technology of Xiaochaihu granules.

关键词： Xiaochaihu granules Radix Bupleuri Chinensis fingerprint-peak matching hierarchical clustering analysis

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温度对制革污泥的生物淋滤除铬效果的影响

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环境科学 2006年第7期27卷 1455-1458页

作者：方迪周立祥南京农业大学资源环境学院环境工程系南京210095

温度对利用嗜酸性硫杆菌脱除污泥中重金属的生物淋滤技术有着重要影响．本试验采用序批式摇床培养，在12～36℃范围内，研究温度对生物淋滤法脱除制革污泥中重金属铬效果的影响．结果表明，随着温度升高，污泥pH值下降以及ORP和SO4^2-... 详细信息

温度对利用嗜酸性硫杆菌脱除污泥中重金属的生物淋滤技术有着重要影响．本试验采用序批式摇床培养，在12～36℃范围内，研究温度对生物淋滤法脱除制革污泥中重金属铬效果的影响．结果表明，随着温度升高，污泥pH值下降以及ORP和SO4^2-上升的速率均显著提高，污泥中Cr的溶出率相应加快．反应温度在28～36℃时，制革污泥中接种嗜酸性硫杆菌同时添加4g／L的S粉作为能源物质，生物淋滤反应8d，Cr的溶出率可高达100％．控温在28℃较适宜今后的工程应用。

关键词：制革污泥生物淋滤嗜酸性硫杆菌铬温度

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Effect of a systemic intervention combined with a psychological intervention in stroke patients with oropharyngeal dysfunction

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World Journal of Psychiatry 2024年第6期14卷 904-912页

作者： Jie Song Jian-Dong Wang di Chen Jing Chen Jin-Feng Huang Mao fang Second Ward Department of NeurologyThe Second Affiliated Hospital of Qiqihar Medical CollegeQiqihar 161006Heilongjiang ProvinceChina Third Ward Department of NeurologyThe Second Affiliated Hospital of Qiqihar Medical CollegeQiqihar 161006Heilongjiang ProvinceChina

BACKGROUND Stroke frequently results in oropharyngeal dysfunction(OD),leading to difficulties in swallowing and eating,as well as triggering negative emotions,malnutrition,and aspiration pneumonia,which can be detrimental to ***,routine nursing interventions often fail to address these issues *** and psychological interventions can improve dysphagia symptoms,relieve negative emotions,and improve quality of ***,there are few clinical reports of systemic interventions combined with psychological interventions for stroke patients with *** To explore the effects of combining systemic and psychological interventions in stroke patients with *** This retrospective study included 90 stroke patients with OD,admitted to the Second Affiliated Hospital of Qiqihar Medical College(January 2022–December 2023),who were divided into two groups:regular and *** function grading(using a water swallow test),swallowing function[using the standardized swallowing assessment(SSA)],negative emotions[using the selfrating anxiety scale(SAS)and self-rating depression scale(SDS)],and quality of life(SWAL-QOL)were compared between groups before and after the intervention;aspiration pneumonia incidence was *** Post-intervention,the coalition group had a greater number of patients with grade 1 swallowing function compared to the regular group,while the number of patients with grade 5 swallowing function was lower than that in the regular group(Pditionally,the total SWAL-QOL score in both groups increased,with a more significant increase observed in the coalition group(P<0.05).During the intervention period,the total incidence of aspiration and aspiration pneumonia in the coalition group was lower than that in the control group(4.44%vs 20.00%;P<0.05).CONCLUSION Systemic int

关键词： Stroke Oropharyngeal dysfunction Systemic interventions Psychological intervention Curative effect Negative emotion

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Reynosin protects neuronal cells from microglial neuroinflammation by suppressing NLRP3 inflammasome activation mediated by NADPH oxidase

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Chinese Journal of Natural Medicines 2024年第6期22卷 486-500页

作者： YANG Yanqiu CHE Yue fang Mingxia YAO Xiaohu ZHOU di WANG Feng CHEN Gang LIANG Dong LI Ning HOU Yue Key Laboratory of Bioresource Research and Development of Liaoning Province College of Life and Health SciencesNorth-eastern UniversityShenyang 110000China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Key Laboratory of Data Analytics and Optimization for Smart IndustryMinistry of EducationNortheastern UniversityShenyang 110000China School of Traditional Chinese Materia Medica Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning provinceKey Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang CityShenyang Pharmaceutical UniversityShenyang 110000China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541000China

Neuroinflammation,mediated by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing-3(NLRP3)inflammasome,is a significant contributor to the pathogenesis of neurodegenerative diseases(NDDs).Reynos-in,a natural sesquiterpene lactone(SL),exhibits a broad spectrum of pharmacological effects,suggesting its potential therapeutic ***,the effects and mechanism of reynosin on neuroinflammation remain *** current study explores the effects and mechanisms of reynosin on neuroinflammation using mice and BV-2 microglial cells treated with lipopolysaccharide(LPS).Our findings reveal that reynosin effectively reduces microglial inflammation in vitro,as demonstrated by decreased CD11b expression and lowered interleukin-1 beta(IL-1β)and interleukin-18(IL-18)mRNA and protein ***,in vivo,results showed a re-duction in the number of Iba-1 positive cells and alleviation of morphological alterations,alongside decreased expressions of IL-1βand *** analysis indicates that reynosin inhibits NLRP3 inflammasome activation,evidenced by reduced transcription of NLRP3 and caspase-1,diminished NLRP3 protein expression,inhibited apoptosis-associated speck-like protein containing a CARD(ASC)oli-gomerization,and decreased caspase-1 ***,reynosin curtailed the activation of nicotinamide adenine dinuc-leotide phosphate(NADPH)oxidase,demonstrated by reduced NADP^(+)and NADPH levels,downregulation of gp91^(phox) mRNA,pro-tein expression,suppression of p47^(phox) expression and translocation to the ***,reynosin exhibited a neuroprotective effect against microglial inflammation in vivo and in *** collective findings underscore reynosin’s capacity to mitigate mi-croglial inflammation by inhibiting the NLRP3 inflammasome,thus highlighting its potential as a therapeutic agent for managing neuroinflammation.

关键词： Microglia NLRP3 inflammasome Reactive oxygen species NADPH oxidase Neuron Reynosin

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基于特征图谱、化学计量学和多指标成分测定的不同商品规格葛花质量差异分析

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药物分析杂志 2024年第5期44卷 903-911页

作者：张立军李鹏李隆海张新玥马冬妮张转平胡芳弟王磊柯红梅李鹏刘丽吴春燕李小安兰州大学药学院兰州730000 陕西省安康市食品药品检验检测中心安康725000 商洛市药品检验所商洛726000 旬阳市金寨镇农业综合服务站旬阳725751 北京中医药大学中药学院北京1000294 甘肃省敦煌市医院敦煌736200 安康市天源植物提取有限公司安康725000

目的:建立能有效区分葛花(Pueraria lobata(Willd.)Ohwi)、粉葛花(Pueraria thomsonii Benth.)及其混淆品种的特征图谱和多指标成分测定分析方法,用于葛花药材的整体质量控制。方法:采用高效液相色谱法(HPLC)对不同商品规格葛花中主要... 详细信息

目的:建立能有效区分葛花(Pueraria lobata(Willd.)Ohwi)、粉葛花(Pueraria thomsonii Benth.)及其混淆品种的特征图谱和多指标成分测定分析方法,用于葛花药材的整体质量控制。方法:采用高效液相色谱法(HPLC)对不同商品规格葛花中主要化学成分进行分析,确定最佳色谱条件,建立特征图谱;利用主成分分析(PCA)和偏最小二乘判别分析(PLS-DA)对不同商品规格葛花特征图谱数据进行分析,筛选确认差异性标志物;通过与对照品比对,对差异性标志物进行指认,进行定量分析,并分析测定结果。结果:建立了葛花、粉葛花、葛麻姆花及紫藤花的特征图谱,分别匹配了18、27、18及8个共有峰,指认出葛根素(Pu)、大豆苷(Da)、大豆苷元(Dae)、染料木苷(Ge)、染料木素(Gee)、葛花苷(Ka)、glycitin(Gl)、tectoridin(Td)、tectorigenin(Tg)及tectorigenin-7-O-xylosylglucoside(Tx)10个色谱峰,并同时建立了上述10个成分的含量测定方法。PCA和PLS-DA结果可将4种不同商品规格葛花样品明显区分,以Gl、Tx、Ge、Td、Ka及未知化合物(6号峰)为差异性标志物。葛花、粉葛花所含成分明显区别其混淆品,葛花中Ka含量为粉葛花的10倍,Ge含量为粉葛花的50%,未检测到Da、Gl。结论:所建立的特征图谱结合化学计量学及多指标成分测定分析方法简便、可行,可客观、有效地用于葛花药材质量控制,作为修改葛花质量标准提供参考。

关键词：葛花粉葛花混淆品特征图谱化学计量学质量控制差异性标志物葛花苷染料木苷

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试论中国西藏与南亚相邻国家经济文化合作交流的原则与对策

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西藏大学学报（社会科学版） 2016年第3期31卷 100-106页

作者：狄方耀西藏民族大学南亚研究所陕西咸阳712082

2015年3月28日国家三部委对外公开发布了《推动共建丝绸之路经济带和21世纪海上丝绸之路的愿景与行动》(the Belt and Road简称"一带一路"战略)。该文件中对位处祖国西南边疆的西藏自治区的具体任务确定为"推进西藏与尼泊尔等国家边境... 详细信息

2015年3月28日国家三部委对外公开发布了《推动共建丝绸之路经济带和21世纪海上丝绸之路的愿景与行动》(the Belt and Road简称"一带一路"战略)。该文件中对位处祖国西南边疆的西藏自治区的具体任务确定为"推进西藏与尼泊尔等国家边境贸易和旅游文化合作。"当年8月下旬,第六次西藏工作座谈会提出:"将西藏建设成为我国面向南亚开放的重要通道",这是在"一带一路"战略提出后中央对西藏在新形势下所赋予新的历史使命。文章就西藏如何以发展与尼泊尔等南亚国家的边境贸易和旅游文化交流合作为抓手,着力推动"面向南亚开放的重要通道"建设过程中应当坚持的原则与对策建议等进行了论述。

关键词：西藏南亚 “一带一路” 原则对策

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对置·乡愁:马勒《第六交响曲》之空间意义

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南京艺术学院学报（音乐与表演版） 2021年第4期 37-40页

作者：方迪上海音乐学院上海200031

特定的声音产生于特定的空间,且制造特定的空间感。音响场景,正是由音响的空间性构建起来的。音响场景的转换,也是作曲家意识的转换,是音乐作品叙事动机和中心的转移。马勒的《第六交响曲》以多个特征鲜明的主题建构了多重的声音空间。... 详细信息

特定的声音产生于特定的空间,且制造特定的空间感。音响场景,正是由音响的空间性构建起来的。音响场景的转换,也是作曲家意识的转换,是音乐作品叙事动机和中心的转移。马勒的《第六交响曲》以多个特征鲜明的主题建构了多重的声音空间。其间,既有属于马勒本人记忆的声音空间,又有作曲家有意构建的声音空间,以及更广大的由音响所指征的精神空间。本文试从马勒《第六交响曲》的空间维度出发,探究其音乐修辞之对置手法、乡愁情愫。

关键词：马勒《第六交响曲》对置乡愁空间意义

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Elucidating and manipulating pressure-induced water intrusion–extrusion in tunable hydrophobic Co/Zn bimetallic ZIFs:Roles of pore size and hydrogen bond

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Nano Research 2024年第1期17卷 344-353页

作者： diyi fang Chuanlei Liu Yu Chen Qilong Peng Kongguo Wu Yuxiang Chen Hao Jiang Yuan Wu Benxian Shen Qiumin Wu di Wu Hui Sun International Joint Research Center of Green Energy Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China Alexandra Navrotsky Institute for Experimental Thermodynamics The Gene and Linda Voiland School of Chemical Engineering and BioengineeringMaterials Science and Engineeringand Department of ChemistryWashington State UniversityWashington 99163USA

Porous heterogeneous lyophobic systems(HLSs)find potential applications in energy restoring,dissipating,and ***,the development of controllable HLSs still lacks rational structure design of nanoporous materials matching the molecular sizes of adopted *** that,thoroughly understanding the underlying transportation mechanism in the confined nano channels is greatly *** this work,a series of Co/Zn bimetallic zeolitic imidazolate frameworks(ZIFs)with tunable structures were synthesized via regulating the Co to Zn ratios and employed to investigate the intrusion–extrusion of liquid water in confined *** characterizations confirm the heterometallic coordination in the Co/Zn-doped *** intrusion–extrusion experiments unlock the relationship between the intrusion pressure and the nanopore size and realize the evolution of the HLSs between molecular spring and *** addition,cycling tests indicate the reversible structure change of Co/Zn ZIFs encountering pressure-induced water *** combination with molecular dynamics simulations,we present that the water multimers intrude into nanopores of ZIFs in chain-like forms along with dissociation of hydrogen bonds(HBs).Water molecules in the pre-intrusion state exhibit reduced HBs in response to the increase of pressure and linear structure with 1.6–3.0 HBs on *** transition to the post-intrusion situation,the associative configuration of water tends to exhibit the tetrahedral ***,we highlight the roles of pore size and HB in synergically dominating the pressure-induced intrusion–extrusion of liquid water in hydrophobic ***,the present work can also guide the development of functional guest–host systems based on porous architectures.

关键词： heterometallic zeolitic imidazolate frameworks nanopore intrusion hydrogen bonds

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